The influence of subunit composition on the interaction of neurosteroids with GABAA receptors

Neuropharmacology

Volumn 43, Issue 4, 2002, Pages 651-661

  Belelli, Delia ^a   Casula, Anna ^a   Ling, Alice ^a   Lambert, Jeremy J ^a  

^a UNIVERSITY OF DUNDEE   (United Kingdom)

Author keywords

GABAA receptors; Neurosteroid; Oocyte; Pregnane steroids; Voltage clamp

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; 5 ALPHA PREGNAN 3 ALPHA OL 20 ONE; BENZODIAZEPINE RECEPTOR AFFECTING AGENT; DRUG RECEPTOR; ELTANOLONE; NEUROSTEROID; RECOMBINANT RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CONCENTRATION RESPONSE; DRUG EFFECT; DRUG POTENCY; ELECTRODE; EMBRYO; HUMAN; NONHUMAN; OOCYTE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN INTERACTION; VOLTAGE CLAMP; XENOPUS LAEVIS;

ALGORITHMS; ANIMALS; ELECTROPHYSIOLOGY; FEMALE; HUMANS; MEMBRANE POTENTIALS; OOCYTES; PATCH-CLAMP TECHNIQUES; PREGNANES; RATS; RECEPTORS, GABA-A; STEROIDS; TRANSCRIPTION, GENETIC; XENOPUS;

EID: 0036754980     PISSN: 00283908     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0028-3908(02)00172-7     Document Type: Article

References (46)

1. A receptors. Mohler H., Pharmacology of GABA and Glycine Transmission, Vol. 150. 2001;79-99 Springer, Berlin.
2. Belelli D., Bolger M.B., Gee K.W. Anticonvulsant profile of the progesterone metabolite 5α-pregnan-3α-ol-20-one. European Journal of Pharmacology. 166:1989;325-329.
3. A receptors by pregnanediols. Neuropharmacology. 35:1996;1223-1231.
4. Belelli D., Callachan H., Hill-Venning C., Peters J.A., Lambert J.J. Interaction of positive allosteric modulators with human and Drosophila recombinant GABA receptors expressed in Xenopus laevis oocytes. British Journal of Pharmacology. 118:1996;563-576.
5. Belelli D., Lambert J.J., Peters J.A., Wafford K., Whiting P.J. The interaction of the general anesthetic etomidate with the γ-aminobutyric acid type A receptor is influenced by a single amino acid. Proceedings of the National Academy of Science U S A. 94:1997;11031-11036.
6. A receptor subunit expression and function in temporal lobe epilepsy. Nature Medicine. 4:1998;1166-1172.
7. A receptors. British Journal of Pharmacology. 136:2002;965-974.
8. A-receptor function in the adult brain: insights from the oxytocin neurone. Trends in Neuroscience. 23:2000;190-195.
9. A IPSCs during development in rat hippocampal or cerebellar slices. Journal of Physiology (Lond). 521:(Pt 2):1999;437-449.
10. Davies P.A., Hanna M.C., Hales T.G., Kirkness E.F. Insensitivity to anaesthetic agents conferred by a class of GABA(A) receptor subunit. Nature. 385:1997;820-823.
11. A receptors. Journal of Physiology. 537:2001;101-113.
12. Do-Rego J.L., Mensah-Nyagan G.A., Beaujean D., Vaudry D., Sieghart W., Luu-The V., Pelletier G., Vaudry H. γ-Aminobutyric acid acting through γ-aminobutyric acid type A receptors, inhibits the biosynthesis of neurosteroids in the frog hypothalamus. Proceedings of the National Academy of Science U S A. 97:2000;13925-13930.
13. Fancsik A., Linn D.M., Tasker J.G. Neurosteroid modulation of GABA IPSCs is phosphorylation dependent. Journal of Neuroscience. 20:2000;3067-3075.
14. Gasior M., Carter R.B., Witkin J.M. Neuroactive steroids: potential therapeutic use in neurological and psychiatric disorders. Trends in Pharmacological Sciences. 20:1999;107-112.
15. Goodchild C.S., Robinson A., Nadeson R. Antinociceptive properties of neurosteroids IV: pilot study demonstrating the analgesic effects of alphadolone administered orally to humans. British Journal of Anaesthesia. 86:2001;528-534.
16. Hadingham K.L., Wingrove P.B., Wafford K.A., Bain C., Kemp J.A., Palmer K.J., Wilson A.W., Wilcox A.S., Sikela J.M., Ragan C.I. Role of the beta subunit in determining the pharmacology of human γ-aminobutyric acid type A receptors. Molecular Pharmacology. 44:1993;1211-1218.
17. Hamann M., Rossi D.J., Attwell D. Tonic and spillover inhibition of granule cells control information flow through cerebellar cortex. Neuron. 33:2002;625-633.
18. 6 subunit gene inactivation inhibits δ subunit expression. Journal of Neuroscience. 17:1997;1350-1362.
19. Korpi E.R., Luddens H. Regional gamma-aminobutyric acid sensitivity of t-butylbicyclophosphoro[35S]thionate binding depends on gamma-aminobutyric acid A receptor alpha subunit. Molecular Pharmacology. 44:1993;87-92.
20. A receptor function. Trends in Pharmacological Sciences. 16:1995;295-303.
21. A receptors by endogenous and synthetic neuroactive steroids. Brain Research Brain Research Reviews. 37:2001;68-80.
22. A receptor function by neuroactive steroids. Brain Research. 819:1999;75-82.
23. Makela R., Uusi-Oukari M., Homanics G.E., Quinlan J.J., Firestone L.L., Wisden W., Korpi E.R. Cerebellar γ-aminobutyric acid type A receptors: pharmacological subtypes revealed by mutant mouse lines. Molecular Pharmacology. 52:1997;380-388.
24. Matsumoto K., Uzunova V., Pinna G., Taki K., Uzunov D.P., Watanabe H., Mienville J.M., Guidotti A., Costa E. Permissive role of brain allopregnanolone content in the regulation of pentobarbital-induced righting reflex loss. Neuropharmacology. 38:1999;955-963.
25. Mellon S.H., Griffin L.D., Compagnone N.A. Biosynthesis and action of neurosteroids. Brain Research Brain Research Reviews. 37:2001;3-12.
26. Mihalek R.M., Banerjee P.K., Korpi E.R., Quinlan J.J., Firestone L.L., Mi Z.P., Lagenaur C., Tretter V., Sieghart W., Anagnostaras S.G., Sage J.R., Fanselow M.S., Guidotti A., Spigelman I., Li Z., DeLorey T.M., Olsen R.W., Homanics G.E. Attenuated sensitivity to neuroactive steroids in γ-aminobutyrate type A receptor delta subunit knockout mice. Proceedings of the National Academy of Science U S A. 96:1999;12905-12910.
27. Mohler H., Fritschy J.M., Rudolph U. A new benzodiazepine pharmacology. Journal of Pharmacology and Experimental Therapeutics. 300:2002;2-8.
28. A receptor currents in a rat model of chronic temporal lobe epilepsy. Journal of Physiology (Lond). 537:2001;453-465.
29. Nusser Z., Mody I. Selective modulation of tonic and phasic inhibitions in dentate gyrus granule cells. Journal of Neurophysiology. 87:2002;2624-2628.
30. Paul S.M., Purdy R.H. Neuroactive steroids. FASEB Journal. 6:1992;2311-2322.
31. A receptor agonist muscimol. Neuropharmacology. 39:2000;440-448.
32. A receptors: immunocytochemical distribution of 13 subunits in the adult rat brain. Neuroscience. 101:2000;815-850.
33. A receptor subunit composition? Receptors and Channels. 1:1993;135-142.
34. A receptor function and seizure susceptibility. Journal of Neuroscience. 22:2002;3795-3805.
35. Rosciszewska D., Buntner B., Guz I., Zawisza L. Ovarian hormones, anticonvulsant drugs, and seizures during the menstrual cycle in women with epilepsy. Journal of Neurology, Neurosurgery and Psychiatry. 49:1986;47-51.
36. A receptor subtypes. Trends in Pharmacological Sciences. 21:2000;411-413.
37. Smith S.S., Gong Q.H., Hsu F.C., Markowitz R.S., Ffrench-Mullen J.M., Li X. GABAA receptor α4 subunit suppression prevents withdrawal properties of an endogenous steroid. Nature. 392:1998;926-930.
38. A receptor α4 subunit in association with increased anxiety. Journal of Neuroscience. 18:1998;5275-5284.
39. 2δ GABAA receptors are targets for alcohol. Nature Neuroscience. 5:(8):2002;721-722.
40. A receptor in rat thalamus. Molecular Pharmacology. 56:1999;110-115.
41. A receptor ε subunit results in insensitivity to anaesthetics. Neuropharmacology. 43:2002;663-669.
42. Wang M., Seippel L., Purdy R.H., Backstrom T. Relationship between symptom severity and steroid variation in women with premenstrual syndrome: study on serum pregnenolone, pregnenolone sulfate, 5α-pregnane-3,20-dione and 3α-hydroxy-5α- pregnan-20-one. Journal of Clinical Endocrinology and Metabolism. 81:1996;1076-1082.
43. A receptor subtypes. International Review of Neurobiology. 38:1995;95-138.
44. A receptor subunit conferring atypical functional properties. Journal of Neuroscience. 17:1997;5027-5037.
45. A receptors containing the δ subunit. Journal of Neuroscience. 22:2002;1541-1549.
46. A receptors. Journal of Neuroscience. 16:1996;6648-6656.