Alteration of ethanol drinking in mice via modulation of the GABA A receptor with ganaxolone, finasteride, and gaboxadol

Alcoholism: Clinical and Experimental Research

Volumn 35, Issue 11, 2011, Pages 1994-2007

  Ramaker, Marcia J ^a   Ford, Matthew M ^a   Fretwell, Andrea M ^a   Finn, Deborah A ^a,b  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^b PORTLAND VA MEDICAL CENTER   (United States)

Author keywords

Alcohol; Extrasynaptic; Lickometer; Mice; Neurosteroid

Indexed keywords

3ALPHA HYDROXY 5ALPHA PREGNAN 20 ONE; 4 AMINOBUTYRIC ACID A RECEPTOR; ALCOHOL; FINASTERIDE; GABOXADOL; GANAXOLONE;

ALCOHOL CONSUMPTION; ANIMAL EXPERIMENT; ARTICLE; ATTENUATION; BINDING AFFINITY; CONTROLLED STUDY; DOSE RESPONSE; DRINKING BEHAVIOR; DRUG BINDING; DRUG EFFICACY; DRUG WITHDRAWAL; FLUID INTAKE; LICKING; LOCOMOTION; MALE; MOUSE; NEUROMODULATION; NONHUMAN; PRIORITY JOURNAL; SENSITIVITY ANALYSIS;

ALCOHOL DRINKING; ANIMALS; BEHAVIOR, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRINKING BEHAVIOR; FINASTERIDE; GABA-A RECEPTOR AGONISTS; ISOXAZOLES; MALE; MICE; MICE, INBRED C57BL; MODELS, ANIMAL; PREGNANOLONE; RECEPTORS, GABA-A;

MUS;

EID: 80055107709     PISSN: 01456008     EISSN: 15300277     Source Type: Journal    
DOI: 10.1111/j.1530-0277.2011.01551.x     Document Type: Article

References (65)

1. Anton RF, Drobes DJ, Voronin K, Durazo-Avizu R, Moak D (2004) Naltrexone effects on alcohol consumption in a clinical laboratory paradigm: temporal effects of drinking. Psychopharmacology (Berl) 173:32-40.
2. Beekman M, Ungard JT, Gasior M, Carter RB, Dijkstra D, Goldberg SR, Witkin JM (1998) Reversal of behavioral effects of pentylenetetrazol by the neuroactive steroid ganaxolone. J Pharmacol Exp Ther 284:868-877.
3. Besheer J, Lindsay TG, O'Buckley TK, Hodge CW, Morrow AL (2010) Pregnenolone and ganaxolone reduce operant ethanol self-administration in alcohol-preferring P rats. Alcohol Clin Exp Res 34:2044-2052.
4. Bobak M, Room R, Pikhart H, Kubinova R, Malyutina S, Pajak A, Kurilovitch S, Topor R, Nikitin Y, Marmot M (2004) Contribution of drinking patterns to differences in rates of alcohol related problems between three urban populations. J Epidemiol Community Health 58:238-242.
5. Borghese CM, Harris RA (2007) Studies of ethanol actions on recombinant δ-containing γ-aminobutyric acid type A receptors yield contradictory results. Alcohol 41:155-162.
6. Borghese CM, Storustovu S, Ebert B, Herd MB, Belelli D, Lambert JJ, Marshall G, Wafford KA, Harris RA (2006) The δ subunit of γ-aminobutyric acid type A receptors does not confer sensitivity to low concentrations of ethanol. J Pharmacol Exp Ther 316:1360-1368.
7. Boyle AE, Segal R, Smith BR, Amit Z (1993) Bidirectional effects of GABAergic agonists and antagonists on maintenance of voluntary ethanol intake in rats. Pharmacol Biochem Behav 46:179-182.
8. Brooks-Kayal AR, Shumate MD, Jin H, Lin DD, Rikhter TY, Holloway KL, Coulter DA (1999) Human neuronal γ-aminobutyric acid(A) receptors: coordinated subunit mRNA expression and functional correlates in individual dentate granule cells. J Neurosci 19:8312-8318.
9. A receptors. Br J Pharmacol 136:965-974.
10. A receptors of rat cerebellum granule cells in culture. Neurosci Lett 414:273-276.
11. A receptor alpha 4 subunits mediate extrasynaptic inhibition in thalamus and dentate gyrus and the action of gaboxadol. Proc Natl Acad Sci USA 103:15230-15235.
12. 5 benzodiazepine inverse agonist antagonizes the neurobehavioral actions of alcohol. Alcohol Clin Exp Res 29:1390-1401.
13. Cooney AS, Fitzsimons JT (1996) Increased sodium appetite and thirst in rat induced by the ingredients of liquorice, glycyrrhizic acid and glycyrrhetinic acid. Regul Pept 66:127-133.
14. Cremers T, Ebert B (2007) Plasma and CNS concentrations of Gaboxadol in rats following subcutaneous administration. Eur J Pharmacol 562:47-52.
15. Deitrich RA, Dunwiddie TV, Harris RA, Erwin VG (1989) Mechanism of action of ethanol: initial central nervous system actions. Pharmacol Rev 41:489-537.
16. A receptors. Nat Rev Neurosci 6:215-229.
17. Finn DA, Beadles-Bohling AS, Beckley EH, Ford MM, Gililland KR, Gorin-Meyer RE, Wiren KM (2006) A new look at the 5α-reductase inhibitor finasteride. CNS Drug Rev 12:53-76.
18. Finn DA, Beckley EH, Kaufman KR, Ford MM (2010) Manipulation of GABAergic steroids: sex differences in the effects on alcohol drinking- and withdrawal-related behaviors. Horm Behav 57:12-22.
19. Finn DA, Mark GP, Fretwell AM, Gililland-Kaufman KR, Strong MN, Ford MM (2008) Reinstatement of ethanol and sucrose seeking by the neurosteroid allopregnanolone in C57BL/6 mice. Psychopharmacology (Berl) 201:423-433.
20. Finn DA, Phillips TJ, Okorn DM, Chester JA, Cunningham CL (1997a) Rewarding effect of the neuroactive steroid 3α-hydroxy-5α-pregnan-20-one in mice. Pharmacol Biochem Behav 56:261-264.
21. Finn DA, Roberts AJ, Lotrich F, Gallaher EJ (1997b) Genetic differences in behavioral sensitivity to a neuroactive steroid. J Pharmacol Exp Ther 280:820-828.
22. Finn DA, Sinnott RS, Ford MM, Long SL, Tanchuck MA, Phillips TJ (2004) Sex differences in the effect of ethanol injection and consumption on brain allopregnanolone levels in C57BL/6 mice. Neuroscience 123:813-819.
23. A receptors. Neurosci Lett 383:127-130.
24. Ford MM, Beckley EH, Nickel JD, Eddy S, Finn DA (2008a) Ethanol intake patterns in female mice: influence of allopregnanolone and the inhibition of its synthesis. Drug Alcohol Depend 97:73-85.
25. Ford MM, Nickel JD, Finn DA (2005a) Treatment with and withdrawal from finasteride alter ethanol intake patterns in male C57BL/6J mice: potential role of endogenous neurosteroids? Alcohol 37:23-33.
26. A receptors differentially modulate ethanol intake patterns in male C57BL/6J mice. Alcohol Clin Exp Res 29:1630-1640.
27. Ford MM, Yoneyama N, Strong MN, Fretwell A, Tanchuck M, Finn DA (2008b) Inhibition of 5α-reduced steroid biosynthesis impedes acquisition of ethanol drinking in male C57BL/6J mice. Alcohol Clin Exp Res 32:1408-1416.
28. Gabriel KI, Cunningham CL, Finn DA (2004) Allopregnanolone does not influence ethanol-induced conditioned place preference in DBA/2J mice. Psychopharmacology (Berl) 176:50-56.
29. Gasior M, Carter RB, Goldberg SR, Witkin JM (1997) Anticonvulsant and behavioral effects of neuroactive steroids alone and in conjunction with diazepam. J Pharmacol Exp Ther 282:543-553.
30. Gasior M, Carter RB, Witkin JM (1999) Neuroactive steroids: potential therapeutic use in neurological and psychiatric disorders. Trends Pharmacol Sci 20:107-112.
31. Gmel G, Klingemann S, Muller R, Brenner D (2001) Revising the preventive paradox: the Swiss case. Addiction 96:273-284.
32. Gorin-Meyer RE, Wiren KM, Tanchuck MA, Long SL, Yoneyama N, Finn DA (2007) Sex differences in the effect of finasteride on acute ethanol withdrawal severity in C57BL/6J and DBA/2J mice. Neuroscience 146:1302-1315.
33. A receptors in the acute and chronic effects of ethanol. Psychopharmacology (Berl) 139:2-19.
34. Harris RA, Mihic SJ (2004) Alcohol and inhibitory receptors: unexpected specificity from a nonspecific drug. Proc Natl Acad Sci USA 101:2-3.
35. A receptors. Pharmacol Ther 116:20-34.
36. A receptors. Eur J Neurosci 29:1177-1187.
37. Hodge CW, Chappelle AM, Samson HH (1995) GABAergic transmission in the nucleus accumbens is involved in the termination of ethanol self-administration in rats. Alcohol Clin Exp Res 19:1486-1493.
38. Hodge CW, Nannini MA, Olive MF, Kelley SP, Mehmert KK (2001) Allopregnanolone and pentobarbital infused into the nucleus accumbens substitute for the discriminative stimulus effects of ethanol. Alcohol Clin Exp Res 25:1441-1447.
39. A receptor. J Med Chem 40:61-72.
40. A receptor antagonism in the extended amygdala decreases ethanol self-administration in rats. Eur J Pharmacol 283:151-159.
41. Janak PH, Gill TM (2003) Comparison of the effects of allopregnanolone with direct GABAergic agonists on ethanol self-administration with and without concurrently available sucrose. Alcohol 30:1-7.
42. Janak PH, Redfern JE, Samson HH (1998) The reinforcing effects of ethanol are altered by the endogenous neurosteroid, allopregnanolone. Alcohol Clin Exp Res 22:1106-1112.
43. A receptors containing α5 subunits in the CA1 and CA3 hippocampal fields regulate ethanol-motivated behaviors: an extended ethanol reward circuitry. J Neurosci 21:2166-2177.
44. A receptors in the acute and chronic effects of ethanol: a decade of progress. Psychopharmacology (Berl) 205:529-564.
45. A receptor function. Trends Pharmacol Sci 16:295-303.
46. Martin-Garcia E, Darbra S, Pallares M (2007) Intrahippocampal allopregnanolone decreases voluntary chronic alcohol consumption in non-selected rats. Prog Neuropsychopharmacol Biol Psychiatry 31:823-831.
47. A receptors in the rat brain. Brain Res 1165:15-20.
48. Mihalek RM, Banerjee PK, Korpi ER, Quinlan JJ, Firestone LL, Mi ZP, Lagenaur C, Tretter V, Sieghart W, Anagnostaras SG, Sage JR, Fanselow MS, Guidotti A, Spigelman I, Li Z, DeLorey TM, Olsen RW, Homanics GE (1999) Attenuated sensitivity to neuroactive steroids in γ-aminobutyrate type A receptor delta subunit knockout mice. Proc Natl Acad Sci USA 96:12905-12910.
49. A receptors. Trends Neurosci 27:569-575.
50. Moore EM, Serio KM, Goldfarb KJ, Stepanovska S, Linsenbardt DN, Boehm SL II (2007) GABAergic modulation of binge-like ethanol intake in C57BL/6J mice. Pharmacol Biochem Behav 88:105-113.
51. Nie H, Janak PH (2003) Comparison of reinstatement of ethanol- and sucrose-seeking by conditioned stimuli and priming injections of allopregnanolone after extinction in rats. Psychopharmacology (Berl) 168:222-228.
52. A receptors to synaptic and extrasynaptic membranes of cerebellar granule cells. J Neurosci 18:1693-1703.
53. A receptor subtypes: the "one glass of wine" receptors. Alcohol 41:201-209.
54. O'Malley SS, Krishnan-Sarin S, Farren C, Sinha R, Kreek MJ (2002) Naltrexone decreases craving and alcohol self-administration in alcohol-dependent subjects and activates the hypothalamo-pituitary-adrenocortical axis. Psychopharmacology (Berl) 160:19-29.
55. Petry NM (1997) Benzodiazepine-GABA modulation of concurrent ethanol and sucrose reinforcement in the rat. Exp Clin Psychopharmacol 5:183-194.
56. A receptors: immunocytochemical distribution of 13 subunits in the adult rat brain. Neuroscience 101:815-850.
57. Reddy DS, Rogawski MA (2000) Chronic treatment with the neuroactive steroid ganaxolone in the rat induces anticonvulsant tolerance to diazepam but not to itself. J Pharmacol Exp Ther 295:1241-1248.
58. A receptors in the nucleus accumbens mediate moderate intake of alcohol. J Neurosci 29:543-549.
59. Ryabinin AE, Galvan-Rosas A, Bachtell RK, Risinger FO (2003) High alcohol/sucrose consumption during dark circadian phase in C57BL/6J mice: involvement of hippocampus, lateral septum and urocortin-positive cells of the Edinger-Westphal nucleus. Psychopharmacology (Berl) 165:296-305.
60. Samson HH, Chappell A (2001) Muscimol injected into the medial prefrontal cortex of the rat alters ethanol self-administration. Physiol Behav 74:581-587.
61. A receptor activity in rat hippocampus. J Neurosci 24:6521-6530.
62. Sinnott RS, Phillips TJ, Finn DA (2002) Alteration of voluntary ethanol and saccharin consumption by the neurosteroid allopregnanolone in mice. Psychopharmacology (Berl) 162:438-447.
63. A receptors. Proc Natl Acad Sci USA 100:14439-14444.
64. A receptors are a target for alcohol. Nat Neurosci 5:721-722.
65. 3δγ-aminobutyric acid type A receptors at low concentrations known to affect humans. Proc Natl Acad Sci USA 100:15218-15223.