Fluorescence-based recombination assay for sensitive and specific detection of genotoxic carcinogens in human cells

Archives of Toxicology

Volumn 88, Issue 5, 2014, Pages 1141-1159

  Ireno, Ivanildce C ^a   Baumann, Cindy ^a   Stöber, Regina ^b   Hengstler, Jan G ^b   Wiesmüller, Lisa ^a  

^a UNIVERSITY OF ULM   (Germany)

^b LEIBNIZ RESEARCH CENTRE FOR WORKING ENVIRONMENT AND HUMAN FACTORS   (Germany)

Author keywords

Genotoxic carcinogen; Human cells; Metabolic activation; p53; Primary hepatocytes; Specificity

Indexed keywords

CARCINOGEN; CYCLOPHOSPHAMIDE; ENHANCED GREEN FLUORESCENT PROTEIN; GREEN FLUORESCENT PROTEIN; MUTAGENIC AGENT; RECOMBINANT PROTEIN;

ARTICLE; CELL CLONE; CHROMOSOME ABERRATION; CONTROLLED STUDY; DNA RECOMBINATION; ELECTROPORATION; FLUORESCENCE ANALYSIS; FLUORESCENCE BASED RECOMBINATION ASSAY; GENOTOXICITY; HUMAN; HUMAN CELL; LIVER CELL CULTURE; LYMPHATIC LEUKEMIA; MAMMAL CELL; METABOLIC ACTIVATION; MUTATION; PRIORITY JOURNAL; SENSITIVITY AND SPECIFICITY; TRANSIENT TRANSFECTION; CELL LINE; DNA DAMAGE; DRUG EFFECTS; FLUORESCENCE; GENETIC RECOMBINATION; GENETICS; MUTAGEN TESTING; PROCEDURES;

CARCINOGENS; CELL LINE; CYCLOPHOSPHAMIDE; DNA DAMAGE; FLUORESCENCE; GREEN FLUORESCENT PROTEINS; HUMANS; MUTAGENICITY TESTS; MUTAGENS; RECOMBINANT PROTEINS; RECOMBINATION, GENETIC; SENSITIVITY AND SPECIFICITY;

EID: 84901300409     PISSN: 03405761     EISSN: 14320738     Source Type: Journal    
DOI: 10.1007/s00204-014-1229-3     Document Type: Article

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