-
1
-
-
1542322900
-
Why Target Apoptosis in Cancer Treatment?
-
Kasibhatla S, Tseng B, (2003) Why Target Apoptosis in Cancer Treatment? Mol Cancer Ther 2: 573-580.
-
(2003)
Mol Cancer Ther
, vol.2
, pp. 573-580
-
-
Kasibhatla, S.1
Tseng, B.2
-
4
-
-
0038075338
-
Decision making by p53: life, death and cancer
-
Oren M, (2003) Decision making by p53: life, death and cancer. Cell Death Differ 10: 431-442.
-
(2003)
Cell Death Differ
, vol.10
, pp. 431-442
-
-
Oren, M.1
-
5
-
-
65349103899
-
Blinded by the light: the growing complexity of p53
-
Vousden KH, Prives C, (2009) Blinded by the light: the growing complexity of p53. Cell 137: 413-431.
-
(2009)
Cell
, vol.137
, pp. 413-431
-
-
Vousden, K.H.1
Prives, C.2
-
6
-
-
0028292480
-
Identification of a p53-dependent negative response element in the bcl-2 gene
-
Miyashita T, Harigai M, Hanada M, Reed JC, (1994) Identification of a p53-dependent negative response element in the bcl-2 gene. Cancer Res 54: 3131-3135.
-
(1994)
Cancer Res
, vol.54
, pp. 3131-3135
-
-
Miyashita, T.1
Harigai, M.2
Hanada, M.3
Reed, J.C.4
-
7
-
-
0035890849
-
A minimal Bcl-x promoter is activated by Brn-3a and repressed by p53
-
Sugars KL, Budhram-Mahadeo V, Packham G, Latchman DS, (2001) A minimal Bcl-x promoter is activated by Brn-3a and repressed by p53. Nucleic Acids Res 29: 4530-4540.
-
(2001)
Nucleic Acids Res
, vol.29
, pp. 4530-4540
-
-
Sugars, K.L.1
Budhram-Mahadeo, V.2
Packham, G.3
Latchman, D.S.4
-
8
-
-
0036479115
-
Transcriptional repression of the anti apoptotic survivin gene by wild type p53
-
Hoffman WH, Biade S, Zilfou JT, Chen J, Murphy M, (2002) Transcriptional repression of the anti apoptotic survivin gene by wild type p53. J Biol Chem 277: 3247-3257.
-
(2002)
J Biol Chem
, vol.277
, pp. 3247-3257
-
-
Hoffman, W.H.1
Biade, S.2
Zilfou, J.T.3
Chen, J.4
Murphy, M.5
-
9
-
-
0034602188
-
Role of BAX in the apoptotic response to anticancer agents
-
Zhang L, Yu J, Park BH, Kinzler KW, Vogelstein B, (2000) Role of BAX in the apoptotic response to anticancer agents. Science 290: 989-992.
-
(2000)
Science
, vol.290
, pp. 989-992
-
-
Zhang, L.1
Yu, J.2
Park, B.H.3
Kinzler, K.W.4
Vogelstein, B.5
-
10
-
-
51049086207
-
Oligomerization of BAK by p53 utilizes conserved residues of the p53 DNA binding domain
-
Pietsch EC, Perchiniak E, Canutescu AA, Wang G, Dunbrack RL, et al. (2008) Oligomerization of BAK by p53 utilizes conserved residues of the p53 DNA binding domain. J Biol Chem 283: 21294-21304.
-
(2008)
J Biol Chem
, vol.283
, pp. 21294-21304
-
-
Pietsch, E.C.1
Perchiniak, E.2
Canutescu, A.A.3
Wang, G.4
Dunbrack, R.L.5
-
11
-
-
0034640281
-
Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis
-
Oda E, Ohki R, Murasawa H, Nemoto J, Shibue T, et al. (2000) Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis. Science 288: 1053-1058.
-
(2000)
Science
, vol.288
, pp. 1053-1058
-
-
Oda, E.1
Ohki, R.2
Murasawa, H.3
Nemoto, J.4
Shibue, T.5
-
13
-
-
0037085380
-
Rapid kinetics of tBid-induced cytochrome c and Smac/DIABLO release and mitochondrial depolarization
-
Madesh M, Antonsson B, Srinivasula SM, Alnemri ES, Hajnóczky G, (2002) Rapid kinetics of tBid-induced cytochrome c and Smac/DIABLO release and mitochondrial depolarization. J Biol Chem 277: 5651-9.
-
(2002)
J Biol Chem
, vol.277
, pp. 5651-5659
-
-
Madesh, M.1
Antonsson, B.2
Srinivasula, S.M.3
Alnemri, E.S.4
Hajnóczky, G.5
-
14
-
-
84855281811
-
Natural Products: Promising Resources For Cancer Drug Discovery
-
Mondal S, Bandyopadhyay S, Ghosh MK, Mukhopadhyay S, Roy S, et al. (2012) Natural Products: Promising Resources For Cancer Drug Discovery. Anticancer Agents Med Chem 12: 49-75.
-
(2012)
Anticancer Agents Med Chem
, vol.12
, pp. 49-75
-
-
Mondal, S.1
Bandyopadhyay, S.2
Ghosh, M.K.3
Mukhopadhyay, S.4
Roy, S.5
-
15
-
-
0030052102
-
Studies on the immunomodulatory effects of Ashwagandha
-
Ziauddin M, Phansalkar N, Patki P, Diwanay S, Patwardhan B, (1996) Studies on the immunomodulatory effects of Ashwagandha. J Ethnopharmacol 50: 69-76.
-
(1996)
J Ethnopharmacol
, vol.50
, pp. 69-76
-
-
Ziauddin, M.1
Phansalkar, N.2
Patki, P.3
Diwanay, S.4
Patwardhan, B.5
-
16
-
-
0032788630
-
Studies on immunomodulatory activity of Withania somnifera (Ashwagandha) extracts in experimental immune inflammation
-
Agarwal R, Diwanay S, Patki P, Patwardhan B, (1999) Studies on immunomodulatory activity of Withania somnifera (Ashwagandha) extracts in experimental immune inflammation. J Ethnopharmacol 67: 27-35.
-
(1999)
J Ethnopharmacol
, vol.67
, pp. 27-35
-
-
Agarwal, R.1
Diwanay, S.2
Patki, P.3
Patwardhan, B.4
-
17
-
-
33947632348
-
Protective effect of Withania somnifera root powder in relation to lipid peroxidation, antioxidant status, glycoproteins and bone collagen on adjuvant-induced arthritis in rats
-
Rasool M, Varalakshmi P, (2007) Protective effect of Withania somnifera root powder in relation to lipid peroxidation, antioxidant status, glycoproteins and bone collagen on adjuvant-induced arthritis in rats. Fundam Clin Pharmacol 21: 157-164.
-
(2007)
Fundam Clin Pharmacol
, vol.21
, pp. 157-164
-
-
Rasool, M.1
Varalakshmi, P.2
-
18
-
-
0142217513
-
Growth inhibition of human tumor cell lines by withanolides from Withania somnifera leaves
-
Jayaprakasam B, Zhang Y, Seeram NP, Nair MG, (2003) Growth inhibition of human tumor cell lines by withanolides from Withania somnifera leaves. Life Sci 74: 125-132.
-
(2003)
Life Sci
, vol.74
, pp. 125-132
-
-
Jayaprakasam, B.1
Zhang, Y.2
Seeram, N.P.3
Nair, M.G.4
-
19
-
-
0037458381
-
Induction of nitric oxide synthase expression by Withania somnifera in macrophages
-
Iuvone T, Esposito G, Capasso F, Izzo AA, (2003) Induction of nitric oxide synthase expression by Withania somnifera in macrophages. Life Sci 72: 1617-1625.
-
(2003)
Life Sci
, vol.72
, pp. 1617-1625
-
-
Iuvone, T.1
Esposito, G.2
Capasso, F.3
Izzo, A.A.4
-
20
-
-
77956469863
-
Withanolide D induces apoptosis in leukemia by targeting the activation of neutral sphingomyelinase-ceramide cascade mediated by synergistic activation of c-Jun N-terminal kinase and p38 mitogen-activated protein kinase
-
Mondal S, Mandal C, Sangwan R, Chandra S, Mandal C, (2010) Withanolide D induces apoptosis in leukemia by targeting the activation of neutral sphingomyelinase-ceramide cascade mediated by synergistic activation of c-Jun N-terminal kinase and p38 mitogen-activated protein kinase. Mol Can 9: 239.
-
(2010)
Mol Can
, vol.9
, pp. 239
-
-
Mondal, S.1
Mandal, C.2
Sangwan, R.3
Chandra, S.4
Mandal, C.5
-
21
-
-
0033967393
-
The role of p53-target genes in human cancer
-
Tokino T, Nakamura Y, (2000) The role of p53-target genes in human cancer. Crit Rev Oncol Hematol 33: 1-6.
-
(2000)
Crit Rev Oncol Hematol
, vol.33
, pp. 1-6
-
-
Tokino, T.1
Nakamura, Y.2
-
22
-
-
0031037897
-
The release of cytochrome c from mitochondria: a primary site for Bcl-2 regulation of apoptosis
-
Kluck RM, Wetzel EB, Green DR, Newmeyer DD, (1997) The release of cytochrome c from mitochondria: a primary site for Bcl-2 regulation of apoptosis. Science 275: 1132-6.
-
(1997)
Science
, vol.275
, pp. 1132-1136
-
-
Kluck, R.M.1
Wetzel, E.B.2
Green, D.R.3
Newmeyer, D.D.4
-
23
-
-
66349101019
-
Execution of superoxide-induced cell death by the proapoptotic Bcl-2-related proteins Bid and Bak
-
Madesh M, Zong WX, Hawkins BJ, Ramasamy S, Venkatachalam T, et al. (2009) Execution of superoxide-induced cell death by the proapoptotic Bcl-2-related proteins Bid and Bak. Mol Cell Biol 29: 3099-112.
-
(2009)
Mol Cell Biol
, vol.29
, pp. 3099-3112
-
-
Madesh, M.1
Zong, W.X.2
Hawkins, B.J.3
Ramasamy, S.4
Venkatachalam, T.5
-
25
-
-
0031743648
-
p53 activates the CD95 (APO-1/Fas) gene in response to DNA damage by anticancer drugs
-
Müller M, Wilder S, Bannasch D, Israeli D, Lehlbach K, et al. (1998) p53 activates the CD95 (APO-1/Fas) gene in response to DNA damage by anticancer drugs. J Exp Med 188: 2033-2045.
-
(1998)
J Exp Med
, vol.188
, pp. 2033-2045
-
-
Müller, M.1
Wilder, S.2
Bannasch, D.3
Israeli, D.4
Lehlbach, K.5
-
26
-
-
0031253977
-
KILLER/DR5 is a DNA damage-inducible p53-regulated death receptor gene
-
Wu GS, Burns TF, McDonald ER 3rd, Jiang W, Meng R, et al. (1997) KILLER/DR5 is a DNA damage-inducible p53-regulated death receptor gene. Nat Genet 17: 141-143.
-
(1997)
Nat Genet
, vol.17
, pp. 141-143
-
-
Wu, G.S.1
Burns, T.F.2
McDonald III, E.R.3
Jiang, W.4
Meng, R.5
-
27
-
-
2342553892
-
Mitochondrial p53 activates Bak and causes disruption of a Bak-Mcl1 complex
-
Leu JI, Dumont P, Hafey M, Murphy ME, George DL, (2004) Mitochondrial p53 activates Bak and causes disruption of a Bak-Mcl1 complex. Nat Cell Biol 6: 443-50.
-
(2004)
Nat Cell Biol
, vol.6
, pp. 443-450
-
-
Leu, J.I.1
Dumont, P.2
Hafey, M.3
Murphy, M.E.4
George, D.L.5
-
28
-
-
0032555697
-
Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis
-
Li H, Zhu H, Xu CJ, Yuan J, (1998) Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis. Cell 94: 491-501.
-
(1998)
Cell
, vol.94
, pp. 491-501
-
-
Li, H.1
Zhu, H.2
Xu, C.J.3
Yuan, J.4
-
29
-
-
0242319666
-
Apoptosis - the p53 network
-
Haupt S, Berger M, Goldberg Z, Haupt Y, (2003) Apoptosis - the p53 network. J Cell Sci 116: 4077-85.
-
(2003)
J Cell Sci
, vol.116
, pp. 4077-4085
-
-
Haupt, S.1
Berger, M.2
Goldberg, Z.3
Haupt, Y.4
-
30
-
-
0028927607
-
The Fas death factor
-
Nagata S, Golstein P, (1995) The Fas death factor. Science 267: 1449-1456.
-
(1995)
Science
, vol.267
, pp. 1449-1456
-
-
Nagata, S.1
Golstein, P.2
-
31
-
-
0034163385
-
CD95 (Fas/APO-1) and p53 signal apoptosis independently in diverse cell types
-
O'Connor L, Harris AW, Strasser A, (2000) CD95 (Fas/APO-1) and p53 signal apoptosis independently in diverse cell types. Cancer Res 60: 1217-1220.
-
(2000)
Cancer Res
, vol.60
, pp. 1217-1220
-
-
O'Connor, L.1
Harris, A.W.2
Strasser, A.3
-
32
-
-
0035957653
-
Proapoptotic BAX and BAK: a requisite gateway to mitochondrial dysfunction and death
-
Wei MC, Zong WX, Cheng EH, Lindsten T, Panoutsakopoulou V, et al. (2001) Proapoptotic BAX and BAK: a requisite gateway to mitochondrial dysfunction and death. Science 292: 727-30.
-
(2001)
Science
, vol.292
, pp. 727-730
-
-
Wei, M.C.1
Zong, W.X.2
Cheng, E.H.3
Lindsten, T.4
Panoutsakopoulou, V.5
-
33
-
-
0842278331
-
Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis
-
Chipuk JE, Kuwana T, Bouchier-Hayes L, Droin NM, Newmeyer DD, et al. (2004) Direct activation of Bax by p53 mediates mitochondrial membrane permeabilization and apoptosis. Science 303: 1010-4.
-
(2004)
Science
, vol.303
, pp. 1010-1014
-
-
Chipuk, J.E.1
Kuwana, T.2
Bouchier-Hayes, L.3
Droin, N.M.4
Newmeyer, D.D.5
-
34
-
-
0036729911
-
BAX and BAK mediate p53-independent suppression of tumorigenesis
-
Degenhardt K, Chen G, Lindsten T, White E, (2002) BAX and BAK mediate p53-independent suppression of tumorigenesis. Cancer Cell 2: 193-203.
-
(2002)
Cancer Cell
, vol.2
, pp. 193-203
-
-
Degenhardt, K.1
Chen, G.2
Lindsten, T.3
White, E.4
-
35
-
-
41149136192
-
Analysis of withanolides in root and leaf of Withania somnifera by HPLC with photodiode array and evaporative light scattering detection
-
Chaurasiya ND, Uniyal GC, Lal P, Misra L, Sangwan NS, et al. (2008) Analysis of withanolides in root and leaf of Withania somnifera by HPLC with photodiode array and evaporative light scattering detection. Phytochem Anal 19: 148-54.
-
(2008)
Phytochem Anal
, vol.19
, pp. 148-154
-
-
Chaurasiya, N.D.1
Uniyal, G.C.2
Lal, P.3
Misra, L.4
Sangwan, N.S.5
-
36
-
-
70450224878
-
Apoptotic effects of mahanine on human leukemic cells are mediated through crosstalk between Apo-1/Fas signaling and the Bid protein and via mitochondrial pathways
-
Bhattacharya K, Samanta SK, Tripathi R, Mallick A, Chandra S, et al. (2010) Apoptotic effects of mahanine on human leukemic cells are mediated through crosstalk between Apo-1/Fas signaling and the Bid protein and via mitochondrial pathways. Biochem Pharmacol 79: 361-72.
-
(2010)
Biochem Pharmacol
, vol.79
, pp. 361-372
-
-
Bhattacharya, K.1
Samanta, S.K.2
Tripathi, R.3
Mallick, A.4
Chandra, S.5
-
37
-
-
43049105074
-
To trigger apoptosis, Bak exposes its BH3 domain and homodimerizes via BH3:groove interactions
-
Dewson G, Kratina T, Sim HW, Puthalakath H, Adams JM, et al. (2008) To trigger apoptosis, Bak exposes its BH3 domain and homodimerizes via BH3:groove interactions. Mol Cell 30: 369-80.
-
(2008)
Mol Cell
, vol.30
, pp. 369-380
-
-
Dewson, G.1
Kratina, T.2
Sim, H.W.3
Puthalakath, H.4
Adams, J.M.5
-
38
-
-
73549095984
-
Down regulation of membrane-bound Neu3 constitutes a new potential marker for childhood acute lymphoblastic leukemia and induces apoptosis suppression of neoplastic cells
-
Mandal C, Tringali C, Mondal S, Anastasia L, Chandra S, et al. (2010) Down regulation of membrane-bound Neu3 constitutes a new potential marker for childhood acute lymphoblastic leukemia and induces apoptosis suppression of neoplastic cells. Int J Cancer 126: 337-49.
-
(2010)
Int J Cancer
, vol.126
, pp. 337-349
-
-
Mandal, C.1
Tringali, C.2
Mondal, S.3
Anastasia, L.4
Chandra, S.5
-
39
-
-
56349141560
-
Withaferin A induces apoptosis by activating p38 mitogen-activated protein kinase signaling cascade in leukemic cells of lymphoid and myeloid origin through mitochondrial death cascade
-
Mandal C, Dutta A, Mallick A, Chandra S, Misra L, et al. (2008) Withaferin A induces apoptosis by activating p38 mitogen-activated protein kinase signaling cascade in leukemic cells of lymphoid and myeloid origin through mitochondrial death cascade. Apoptosis 13: 1450-64.
-
(2008)
Apoptosis
, vol.13
, pp. 1450-1464
-
-
Mandal, C.1
Dutta, A.2
Mallick, A.3
Chandra, S.4
Misra, L.5
|