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Volumn 27, Issue 6, 2012, Pages 615-621

A critique of methods to measure cytotoxicity in mammalian cell genotoxicity assays

Author keywords

[No Author keywords available]

Indexed keywords

2,4 DIAMINOTOLUENE; 2,4 DINITROPHENOL; 4 NITROQUINOLINE 1 OXIDE; ARSENITE SODIUM; CYTOTOXIC AGENT; DOXORUBICIN; HYCANTHONE; LIPOCORTIN 5; MITOMYCIN C; PROPIDIUM IODIDE;

EID: 84868538327     PISSN: 02678357     EISSN: 14643804     Source Type: Journal    
DOI: 10.1093/mutage/ges045     Document Type: Review
Times cited : (33)

References (34)
  • 1
    • 0026062312 scopus 로고
    • International Commission for Protection Against Environmental Mutagens and Carcinogens. Genotoxicity under extreme culture conditions. A report from ICPEMC Task Group 9
    • Scott, D., Galloway, S. M., Marshall, R. R., Ishidate, M. Jr, Brusick, D., Ashby, J. and Myhr, B. C. (1991) International Commission for Protection Against Environmental Mutagens and Carcinogens. Genotoxicity under extreme culture conditions. A report from ICPEMC Task Group 9. Mutat. Res., 257, 147-204.
    • (1991) Mutat. Res. , vol.257 , pp. 147-204
    • Scott, D.1    Galloway, S.M.2    Marshall, R.R.3    Ishidate, Jr.M.4    Brusick, D.5    Ashby, J.6    Myhr, B.C.7
  • 2
    • 0026718955 scopus 로고
    • Chromosomal aberration tests in vitro: Problems with protocol design and interpretation of results
    • Kirkland, D. J. (1981) Chromosomal aberration tests in vitro: problems with protocol design and interpretation of results. Mutagenesis, 7, 95-106.
    • (1981) Mutagenesis , vol.7 , pp. 95-106
    • Kirkland, D.J.1
  • 3
    • 0034032414 scopus 로고    scopus 로고
    • Cytotoxicity and chromosome aberrations in vitro: Experience in industry and the case for an upper limit on toxicity in the aberration assay
    • Galloway, S. M. (2000) Cytotoxicity and chromosome aberrations in vitro: experience in industry and the case for an upper limit on toxicity in the aberration assay. Environ. Mol. Mutagen., 35, 191-201.
    • (2000) Environ. Mol. Mutagen. , vol.35 , pp. 191-201
    • Galloway, S.M.1
  • 4
    • 0003488241 scopus 로고    scopus 로고
    • OECD No 473 In Vitro Mammalian Chromosome Aberration Test. Organisation for Economic Cooperation and Development, Paris
    • OECD (1997) Guideline for the Testing of Chemicals. No. 473. In Vitro Mammalian Chromosome Aberration Test. Organisation for Economic Cooperation and Development, Paris. http://www.oecd-ilibrary.org/environment/test-no-473-in- vitro-mammalian-chromosome-aberrat ion-test-9789264071261-en
    • (1997) Guideline for the Testing of Chemicals
  • 5
    • 0003488241 scopus 로고    scopus 로고
    • OECD In Vitro Mammalian Cell Gene Mutation Test. Organisation for Economic Cooperation and Development, Paris
    • OECD (1997) Guideline for the Testing of Chemicals. No. 476. In Vitro Mammalian Cell Gene Mutation Test. Organisation for Economic Cooperation and Development, Paris. http://www.oecd-ilibrary.org/environment/test-no-476-in- vitro-mammalian-cell-gene-mutation-test-9789264071322-en
    • (1997) Guideline for the Testing of Chemicals. No 476
  • 6
    • 84868140055 scopus 로고    scopus 로고
    • OECD In Vitro Mammalian Cell Micronucleus Test. Organisation for Economic Cooperation and Development, Paris
    • OECD (2010) Guideline for the Testing of Chemicals. No. 487. In Vitro Mammalian Cell Micronucleus Test. Organisation for Economic Cooperation and Development, Paris. http://www.oecd-ilibrary.org/environment/test-no-487-in- vitro-mammalian-cell-micronucleus-test-9789264091016-en
    • (2010) Guideline for the Testing of Chemicals. No 487
  • 9
    • 0019484137 scopus 로고
    • The use of Chinese hamster ovary cells to quantify specific locus mutation and to determine mutagenicity of chemicals. A report of the gene-tox program
    • Hsie, A. W., Casciano, D. A., Couch, D. B., Krahn, D. F., O'Neill, J. P. and Whitfield, B. L. (1981) The use of Chinese hamster ovary cells to quantify specific locus mutation and to determine mutagenicity of chemicals. A report of the gene-tox program. Mutat. Res., 86, 193-214.
    • (1981) Mutat. Res. , vol.86 , pp. 193-214
    • Hsie, A.W.1    Casciano, D.A.2    Couch, D.B.3    Krahn, D.F.4    O'Neill, J.P.5    Whitfield, B.L.6
  • 10
    • 0019812701 scopus 로고
    • Mutagenesis by chemical agents in V79 Chinese hamster cells: A review and analysis of the literature. A report of the Gene-Tox Program
    • Bradley, M. O., Bhuyan, B., Francis, M. C., Langenbach, R., Peterson, A. and Huberman, E. (1981) Mutagenesis by chemical agents in V79 Chinese hamster cells: a review and analysis of the literature. A report of the Gene-Tox Program. Mutat. Res., 87, 81-142.
    • (1981) Mutat. Res. , vol.87 , pp. 81-142
    • Bradley, M.O.1    Bhuyan, B.2    Francis, M.C.3    Langenbach, R.4    Peterson, A.5    Huberman, E.6
  • 11
    • 0021015467 scopus 로고
    • A comparison of the agar cloning and microtitration techniques for assaying cell survival and mutation frequency in L5178Y mouse lymphoma cells
    • Cole, J., Arlett, C. F., Green, M. H., Lowe, J. and Muriel, W. (1983) A comparison of the agar cloning and microtitration techniques for assaying cell survival and mutation frequency in L5178Y mouse lymphoma cells. Mutat. Res., 111, 371-386.
    • (1983) Mutat. Res. , vol.111 , pp. 371-386
    • Cole, J.1    Arlett, C.F.2    Green, M.H.3    Lowe, J.4    Muriel, W.5
  • 12
    • 0016423549 scopus 로고
    • Laboratory procedure for assessing specific locus mutations at the TK locus in cultured L5178Y mouse lymphoma cells
    • Clive, D. and Spector, J. F. (1975) Laboratory procedure for assessing specific locus mutations at the TK locus in cultured L5178Y mouse lymphoma cells. Mutat. Res., 31, 17-29.
    • (1975) Mutat. Res. , vol.31 , pp. 17-29
    • Clive, D.1    Spector, J.F.2
  • 13
    • 0036934462 scopus 로고    scopus 로고
    • Mouse lymphoma thymidine kinase gene mutation assay: Follow-up International Workshop on Genotoxicity Test Procedures, New Orleans, Louisiana, April 2000
    • Moore, M. M., Honma, M., Clements, J., et al. (2002) Mouse lymphoma thymidine kinase gene mutation assay: follow-up International Workshop on Genotoxicity Test Procedures, New Orleans, Louisiana, April 2000. Environ. Mol. Mutagen., 40, 292-299.
    • (2002) Environ. Mol. Mutagen. , vol.40 , pp. 292-299
    • Moore, M.M.1    Honma, M.2    Clements, J.3
  • 14
    • 0842309805 scopus 로고    scopus 로고
    • Population doubling: A simple and more accurate estimation of cell growth suppression in the in vitro assay for chromosomal aberrations that reduces irrelevant positive results
    • Greenwood, S. K., Hill, R. B., Sun, J. T., Armstrong, M. J., Johnson, T. E., Gara, J. P. and Galloway, S. M. (2004) Population doubling: a simple and more accurate estimation of cell growth suppression in the in vitro assay for chromosomal aberrations that reduces irrelevant positive results. Environ. Mol. Mutagen., 43, 36-44.
    • (2004) Environ. Mol. Mutagen. , vol.43 , pp. 36-44
    • Greenwood, S.K.1    Hill, R.B.2    Sun, J.T.3    Armstrong, M.J.4    Johnson, T.E.5    Gara, J.P.6    Galloway, S.M.7
  • 15
    • 0035122936 scopus 로고    scopus 로고
    • Automatic analysis of slides processed in the Comet assay
    • Frieauff, W., Hartmann, A. and Suter, W. (2001) Automatic analysis of slides processed in the Comet assay. Mutagenesis, 16, 133-137.
    • (2001) Mutagenesis , vol.16 , pp. 133-137
    • Frieauff, W.1    Hartmann, A.2    Suter, W.3
  • 16
    • 77249135763 scopus 로고    scopus 로고
    • Coupling cytotoxicity bio-markers with DNA damage assessment in TK6 human lymphoblast cells
    • Shi, J., Springer, S. and Escobar, P. (2010) Coupling cytotoxicity bio-markers with DNA damage assessment in TK6 human lymphoblast cells. Mutat. Res., 696, 167-178.
    • (2010) Mutat. Res. , vol.696 , pp. 167-178
    • Shi, J.1    Springer, S.2    Escobar, P.3
  • 19
    • 0035682461 scopus 로고    scopus 로고
    • Increased efficiency of gamma-irradiated versus mitomycin C-treated feeder cells for the expansion of normal human cells in long-term cultures
    • Roy, A., Krzykwa, E., Lemieux, R. and Néron, S. (2001) Increased efficiency of gamma-irradiated versus mitomycin C-treated feeder cells for the expansion of normal human cells in long-term cultures. J. Hematother. Stem Cell Res., 10, 873-880.
    • (2001) J. Hematother. Stem Cell Res. , vol.10 , pp. 873-880
    • Roy, A.1    Krzykwa, E.2    Lemieux, R.3    Néron, S.4
  • 20
    • 0017234880 scopus 로고
    • Comparison of different methods of determining cell viability after exposure to cytotoxic compounds
    • Bhuyan, B. K., Loughman, B. E., Fraser, T. J. and Day, K. J. (1976) Comparison of different methods of determining cell viability after exposure to cytotoxic compounds. Exp. Cell. Res., 97, 275-280.
    • (1976) Exp. Cell. Res. , vol.97 , pp. 275-280
    • Bhuyan, B.K.1    Loughman, B.E.2    Fraser, T.J.3    Day, K.J.4
  • 21
    • 0026800513 scopus 로고
    • A quantitative assessment of the cytotoxicity associated with chromosomal aberration detection in Chinese hamster ovary cells
    • Armstrong, M. J., Bean, C. L. and Galloway, S. M. (1992) A quantitative assessment of the cytotoxicity associated with chromosomal aberration detection in Chinese hamster ovary cells. Mutat. Res., 265, 45-60.
    • (1992) Mutat. Res. , vol.265 , pp. 45-60
    • Armstrong, M.J.1    Bean, C.L.2    Galloway, S.M.3
  • 22
    • 10044285837 scopus 로고    scopus 로고
    • Dead or dying: The importance of time in cytotoxicity assays using arsenite as an example
    • Komissarova, E. V., Saha, S. K. and Rossman, T. G. (2005) Dead or dying: the importance of time in cytotoxicity assays using arsenite as an example. Toxicol. Appl. Pharmacol., 202, 99-107.
    • (2005) Toxicol. Appl. Pharmacol. , vol.202 , pp. 99-107
    • Komissarova, E.V.1    Saha, S.K.2    Rossman, T.G.3
  • 23
    • 2342510973 scopus 로고    scopus 로고
    • Use of multiple assay endpoints to investigate the effects of incubation time, dose of toxin, and plating density in cell-based cytotoxicity assays
    • Riss, T. L. and Moravec, R. A. (2004) Use of multiple assay endpoints to investigate the effects of incubation time, dose of toxin, and plating density in cell-based cytotoxicity assays. Assay Drug. Dev. Technol., 2, 51-62.
    • (2004) Assay Drug. Dev. Technol. , vol.2 , pp. 51-62
    • Riss, T.L.1    Moravec, R.A.2
  • 24
    • 0030580936 scopus 로고    scopus 로고
    • Revalidation of the in vitro alkaline elution/rat hepatocyte assay for DNA damage: Improved criteria for assessment of cytotoxicity and genotoxicity and results for 81 compounds
    • Storer, R. D., McKelvey, T. W., Kraynak, A. R., Elia, M. C., Barnum, J. E., Harmon, L. S., Nichols, W. W. and DeLuca, J. G. (1996) Revalidation of the in vitro alkaline elution/rat hepatocyte assay for DNA damage: improved criteria for assessment of cytotoxicity and genotoxicity and results for 81 compounds. Mutat. Res., 368, 59-101.
    • (1996) Mutat. Res. , vol.368 , pp. 59-101
    • Storer, R.D.1    McKelvey, T.W.2    Kraynak, A.R.3    Elia, M.C.4    Barnum, J.E.5    Harmon, L.S.6    Nichols, W.W.7    Deluca, J.G.8
  • 25
    • 0027191506 scopus 로고
    • Cytotoxicity as measured by trypan blue as a potentially confounding variable in the in vitro alkaline elution/rat hepatocyte assay
    • Elia, M. C., Storer, R. D., Harmon, L. S., Kraynak, A. R., McKelvey, T. W., Hertzog, P. R., Keenan, K. P., DeLuca, J. G. and Nichols, W. W. (1993) Cytotoxicity as measured by trypan blue as a potentially confounding variable in the in vitro alkaline elution/rat hepatocyte assay. Mutat. Res., 291, 193-205.
    • (1993) Mutat. Res. , vol.291 , pp. 193-205
    • Elia, M.C.1    Storer, R.D.2    Harmon, L.S.3    Kraynak, A.R.4    McKelvey, T.W.5    Hertzog, P.R.6    Keenan, K.P.7    Deluca, J.G.8    Nichols, W.W.9
  • 26
    • 34547659877 scopus 로고    scopus 로고
    • Cytotoxicity in cultured mammalian cells is a function of the method used to estimate it
    • Fellows, M. D. and O'Donovan, M. R. (2007) Cytotoxicity in cultured mammalian cells is a function of the method used to estimate it. Mutagenesis, 22, 275-280.
    • (2007) Mutagenesis , vol.22 , pp. 275-280
    • Fellows, M.D.1    O'Donovan, M.R.2
  • 27
    • 0028980552 scopus 로고
    • Extended-term cultures of human T-lymphocytes: A practical alternative to primary human lymphocytes for use in genotoxicity testing
    • O'Donovan, M. R., Freemantle, M. R., Hull, G., Bell, D. A., Arlett, C. F. and Cole, J. (1995) Extended-term cultures of human T-lymphocytes: a practical alternative to primary human lymphocytes for use in genotoxicity testing. Mutagenesis, 10, 189-201.
    • (1995) Mutagenesis , vol.10 , pp. 189-201
    • O'Donovan, M.R.1    Freemantle, M.R.2    Hull, G.3    Bell, D.A.4    Arlett, C.F.5    Cole, J.6
  • 28
    • 77958081677 scopus 로고    scopus 로고
    • Evaluation of different cytotoxic and cytostatic measures for the in vitro micronucleus test (MNVit): Introduction to the collaborative trial
    • Kirkland, D. (2010) Evaluation of different cytotoxic and cytostatic measures for the in vitro micronucleus test (MNVit): introduction to the collaborative trial. Mutat. Res., 702, 135-138.
    • (2010) Mutat. Res. , vol.702 , pp. 135-138
    • Kirkland, D.1
  • 29
    • 50349083414 scopus 로고    scopus 로고
    • Comparison of different methods for an accurate assessment of cytotoxicity in the in vitro micronucleus test. I. Theoretical aspects
    • Lorge, E., Hayashi, M., Albertini, S. and Kirkland, D. (2008) Comparison of different methods for an accurate assessment of cytotoxicity in the in vitro micronucleus test. I. Theoretical aspects. Mutat. Res., 655, 1-3.
    • (2008) Mutat. Res. , vol.655 , pp. 1-3
    • Lorge, E.1    Hayashi, M.2    Albertini, S.3    Kirkland, D.4
  • 30
    • 79960999090 scopus 로고    scopus 로고
    • Cytotoxicity measurement in in vitro chromosome aberration test and micronucleus test
    • Honma, M. (2011) Cytotoxicity measurement in in vitro chromosome aberration test and micronucleus test. Mutat. Res., 724, 86-87.
    • (2011) Mutat. Res. , vol.724 , pp. 86-87
    • Honma, M.1
  • 31
    • 0018837288 scopus 로고
    • Survey of radiosensitivity in a variety of human cell strains
    • Arlett, C. F. and Harcourt, S. A. (1980) Survey of radiosensitivity in a variety of human cell strains. Cancer Res., 40, 926-932.
    • (1980) Cancer Res. , vol.40 , pp. 926-932
    • Arlett, C.F.1    Harcourt, S.A.2
  • 32
    • 0032711130 scopus 로고    scopus 로고
    • Co-cultivation of CD4+ and CD8+ human T-cells leads to the appearance of CD4 cells expressing CD8 through de novo synthesis of the CD8 alpha-subunit
    • O'Donovan, M. R., Jones, D. R., Robins, R. A., Li, K. F., Shim, H. K., Zheng, Z., Arlett, C. F., Capulas, E. and Cole, J. (1999) Co-cultivation of CD4+ and CD8+ human T-cells leads to the appearance of CD4 cells expressing CD8 through de novo synthesis of the CD8 alpha-subunit. Hum. Immunol., 60, 1018-1027.
    • (1999) Hum. Immunol. , vol.60 , pp. 1018-1027
    • O'Donovan, M.R.1    Jones, D.R.2    Robins, R.A.3    Li, K.F.4    Shim, H.K.5    Zheng, Z.6    Arlett, C.F.7    Capulas, E.8    Cole, J.9
  • 33
    • 84860373682 scopus 로고    scopus 로고
    • Unusual structure-genotoxicity relationship in mouse lymphoma cells observed with a series of kinase inhibitors
    • Fellows, M. D., Luker, T., Cooper, A. and O'Donovan, M. R. (2012) Unusual structure-genotoxicity relationship in mouse lymphoma cells observed with a series of kinase inhibitors. Mutat. Res., 746, 21-28.
    • (2012) Mutat. Res. , vol.746 , pp. 21-28
    • Fellows, M.D.1    Luker, T.2    Cooper, A.3    O'Donovan, M.R.4
  • 34
    • 50349095336 scopus 로고    scopus 로고
    • Comparison of different methods for an accurate assessment of cytotoxic-ity in the in vitro micronucleus test. II. Practical aspects with toxic agents
    • Fellows, M. D., O'Donovan, M. R., Lorge, E. and Kirkland, D. (2008) Comparison of different methods for an accurate assessment of cytotoxic-ity in the in vitro micronucleus test. II. Practical aspects with toxic agents. Mutat. Res., 655, 4-21.
    • (2008) Mutat. Res. , vol.655 , pp. 4-21
    • Fellows, M.D.1    O'Donovan, M.R.2    Lorge, E.3    Kirkland, D.4


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