Evaluation of the genotoxic activity of paclitaxel by the in vitro micronucleus test in combination with fluorescent in situ hybridization of a DNA centromeric probe and the alkaline single cell gel electrophoresis technique (comet assay) in human T-lymphocytes

Environmental and Molecular Mutagenesis

Volumn 34, Issue 4, 1999, Pages 269-278

  Digue, L ^a   Orsiere T ^a   De Meo M ^a   Mattei M G ^b   Depetris, D ^b   Duffaud, F ^a,c   Favre, R ^c   Botta, Alain ^a  

^a AIX MARSEILLE UNIVERSITY   (France)

^b INSERM   (France)

^c TIMONE HOSPITAL   (France)

Author keywords

CBMN; Comet assay; FISH; Genotoxicity; Lymphocyte; Paclitaxel

Indexed keywords

PACLITAXEL;

ARTICLE; CELL CULTURE; COMET ASSAY; DNA DAMAGE; DNA PROBE; FLUORESCENCE IN SITU HYBRIDIZATION; GENOTOXICITY; HUMAN; HUMAN CELL; MICRONUCLEUS TEST; TOXICITY TESTING;

ADULT; AGED; ANTINEOPLASTIC AGENTS, PHYTOGENIC; CENTROMERE; COMET ASSAY; DIMETHYL SULFOXIDE; DNA PROBES; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; HUMANS; IN SITU HYBRIDIZATION, FLUORESCENCE; MICRONUCLEUS TESTS; MIDDLE AGED; PACLITAXEL; T-LYMPHOCYTES;

EID: 0342470418     PISSN: 08936692     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1098-2280(1999)34:4<269::AID-EM7>3.0.CO;2-D     Document Type: Article

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