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Volumn 30, Issue 7, 2009, Pages 1260-1268

DNA double-strand break repair activities in mammary epithelial cells - Influence of endogenous p53 variants

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN P53;

EID: 67650150998     PISSN: 01433334     EISSN: 14602180     Source Type: Journal    
DOI: 10.1093/carcin/bgp117     Document Type: Article
Times cited : (30)

References (51)
  • 1
    • 33745115304 scopus 로고    scopus 로고
    • p53 and breast cancer, an update
    • Lacroix,N. et al. (2006) p53 and breast cancer, an update. Endocr. Relat. Cancer, 13, 293-325.
    • (2006) Endocr. Relat. Cancer , vol.13 , pp. 293-325
    • Lacroix, N.1
  • 2
    • 33846850422 scopus 로고    scopus 로고
    • Ten genes for inherited breast cancer
    • Walsh,T. et al. (2007) Ten genes for inherited breast cancer. Cancer Cell, 11, 103-105.
    • (2007) Cancer Cell , vol.11 , pp. 103-105
    • Walsh, T.1
  • 3
    • 33847271255 scopus 로고    scopus 로고
    • Links between DNA double strand break repair and breast cancer: Accumulating evidence from both familial and nonfamilial cases
    • Ralhan,R. et al. (2007) Links between DNA double strand break repair and breast cancer: Accumulating evidence from both familial and nonfamilial cases. Cancer Lett., 248, 1-17.
    • (2007) Cancer Lett , vol.248 , pp. 1-17
    • Ralhan, R.1
  • 4
    • 0025633582 scopus 로고
    • Germ line p53 mutations in a familial syndrome of breast cancer, sarcomas, and other neoplasms
    • Malkin,D. et al. (1990) Germ line p53 mutations in a familial syndrome of breast cancer, sarcomas, and other neoplasms. Science, 250, 1233-1238.
    • (1990) Science , vol.250 , pp. 1233-1238
    • Malkin, D.1
  • 5
    • 0037689113 scopus 로고    scopus 로고
    • Comparison of p53 mutational status with mRNA and protein expression in a panel of 24 human breast carcinoma cell lines
    • Concin,N. et al. (2003) Comparison of p53 mutational status with mRNA and protein expression in a panel of 24 human breast carcinoma cell lines. Breast Cancer Res. Treat., 79, 37-46.
    • (2003) Breast Cancer Res. Treat , vol.79 , pp. 37-46
    • Concin, N.1
  • 6
    • 33746714410 scopus 로고    scopus 로고
    • Thirteen new p53 gene mutants identified among 41 human breast cancer cell lines
    • Wasielewski,M. et al. (2006) Thirteen new p53 gene mutants identified among 41 human breast cancer cell lines. Breast Cancer Res. Treat., 99, 97-101.
    • (2006) Breast Cancer Res. Treat , vol.99 , pp. 97-101
    • Wasielewski, M.1
  • 7
    • 37549020704 scopus 로고    scopus 로고
    • Recurrent gross mutations of the PTEN tumor suppressor gene in breast cancers with deficient DSB repair
    • Saal,L.H. et al. (2008) Recurrent gross mutations of the PTEN tumor suppressor gene in breast cancers with deficient DSB repair. Nat. Genet., 40, 102-107.
    • (2008) Nat. Genet , vol.40 , pp. 102-107
    • Saal, L.H.1
  • 8
    • 0035858984 scopus 로고    scopus 로고
    • p53 mutants can often transactivate promoters containing a p21 but not Bax or PIG3 responsive elements
    • Campomenosi,P. et al. (2001) p53 mutants can often transactivate promoters containing a p21 but not Bax or PIG3 responsive elements. Oncogene, 20, 3573-3579.
    • (2001) Oncogene , vol.20 , pp. 3573-3579
    • Campomenosi, P.1
  • 9
    • 0027284915 scopus 로고
    • p53-catalyzed annealing of complementary single-stranded nucleic acids
    • Oberosler,P. et al. (1993) p53-catalyzed annealing of complementary single-stranded nucleic acids. EMBO J., 12, 2389-2396.
    • (1993) EMBO J , vol.12 , pp. 2389-2396
    • Oberosler, P.1
  • 10
    • 0027982948 scopus 로고
    • p53 binds single-stranded DNA ends and catalyzes DNA renaturation and strand transfer
    • Bakalkin,G. et al. (1994) p53 binds single-stranded DNA ends and catalyzes DNA renaturation and strand transfer. Proc. Natl Acad. Sci. USA, 91, 413-417.
    • (1994) Proc. Natl Acad. Sci. USA , vol.91 , pp. 413-417
    • Bakalkin, G.1
  • 11
    • 0029013273 scopus 로고
    • p53 and its 14 kDa C-terminal domain recognize primary DNA damage in the form of insertion/deletion mismatches
    • Lee,S. et al. (1995) p53 and its 14 kDa C-terminal domain recognize primary DNA damage in the form of insertion/deletion mismatches. Cell, 81, 1013-1020.
    • (1995) Cell , vol.81 , pp. 1013-1020
    • Lee, S.1
  • 12
    • 0030985675 scopus 로고    scopus 로고
    • Human p53 binds Holliday junctions strongly and facilitates their cleavage
    • Lee,S. et al. (1997) Human p53 binds Holliday junctions strongly and facilitates their cleavage. J. Biol. Chem., 272, 7532-7539.
    • (1997) J. Biol. Chem , vol.272 , pp. 7532-7539
    • Lee, S.1
  • 13
    • 0031865231 scopus 로고    scopus 로고
    • Specific mismatch recognition in heteroduplex intermediates by p53 suggests a role in fidelity control of homologous recombination
    • Dudenhöffer,C. et al. (1998) Specific mismatch recognition in heteroduplex intermediates by p53 suggests a role in fidelity control of homologous recombination. Mol. Cell. Biol., 18, 5332-5342.
    • (1998) Mol. Cell. Biol , vol.18 , pp. 5332-5342
    • Dudenhöffer, C.1
  • 14
    • 0030604728 scopus 로고    scopus 로고
    • p53 Protein exhibits 3′-to-5′ exonuclease activity
    • Mummenbrauer,T. et al. (1996) p53 Protein exhibits 3′-to-5′ exonuclease activity. Cell, 85, 1089-1099.
    • (1996) Cell , vol.85 , pp. 1089-1099
    • Mummenbrauer, T.1
  • 15
    • 0034648693 scopus 로고    scopus 로고
    • Role of heteroduplex joints in the functional interactions between human Rad51 and wild-type p53
    • Süsse,S. et al. (2000) Role of heteroduplex joints in the functional interactions between human Rad51 and wild-type p53. Oncogene, 19, 4500-4512.
    • (2000) Oncogene , vol.19 , pp. 4500-4512
    • Süsse, S.1
  • 16
    • 0034612585 scopus 로고    scopus 로고
    • Substrate specificity of the p53-associated 3′-5′ exonuclease
    • Skalski,V. et al. (2000) Substrate specificity of the p53-associated 3′-5′ exonuclease. Oncogene, 19, 3321-3329.
    • (2000) Oncogene , vol.19 , pp. 3321-3329
    • Skalski, V.1
  • 17
    • 0029969418 scopus 로고    scopus 로고
    • p53 is linked directly to homologous recombination processes via Rad51/RecA protein interaction
    • Stürzbecher,H.W. et al. (1996) p53 is linked directly to homologous recombination processes via Rad51/RecA protein interaction. EMBO J., 15, 1992-2002.
    • (1996) EMBO J , vol.15 , pp. 1992-2002
    • Stürzbecher, H.W.1
  • 18
    • 0030883593 scopus 로고    scopus 로고
    • Interaction of p53 with the human Rad51 protein
    • Buchhop,S. et al. (1997) Interaction of p53 with the human Rad51 protein. Nucleic Acids Res., 25, 3868-3874.
    • (1997) Nucleic Acids Res , vol.25 , pp. 3868-3874
    • Buchhop, S.1
  • 19
    • 0037416149 scopus 로고    scopus 로고
    • BLM helicase-dependent transport of p53 to sites of stalled DNA replication forks modulates homologous recombination
    • Sengupta,S. et al. (2003) BLM helicase-dependent transport of p53 to sites of stalled DNA replication forks modulates homologous recombination. EMBO J., 22, 1210-1222.
    • (2003) EMBO J , vol.22 , pp. 1210-1222
    • Sengupta, S.1
  • 20
    • 0038519801 scopus 로고    scopus 로고
    • p53 interacts with hRAD51 and hRAD54, and directly modulates homologous recombination
    • Linke,S.P. et al. (2003) p53 interacts with hRAD51 and hRAD54, and directly modulates homologous recombination. Cancer Res., 63 2596-2605.
    • (2003) Cancer Res , vol.63 , pp. 2596-2605
    • Linke, S.P.1
  • 21
    • 10944230682 scopus 로고    scopus 로고
    • The interaction of p53 with replication protein A mediates suppression of homologous recombination
    • Romanova,L.Y. et al. (2004) The interaction of p53 with replication protein A mediates suppression of homologous recombination. Oncogene, 23, 9025-9033.
    • (2004) Oncogene , vol.23 , pp. 9025-9033
    • Romanova, L.Y.1
  • 22
    • 0032478085 scopus 로고    scopus 로고
    • BRCA1 regulates p53-dependent gene expression
    • Ouchi,T. et al. (1998) BRCA1 regulates p53-dependent gene expression. Proc. Natl Acad. Sci. USA, 95, 2302-2306.
    • (1998) Proc. Natl Acad. Sci. USA , vol.95 , pp. 2302-2306
    • Ouchi, T.1
  • 23
    • 0032473879 scopus 로고    scopus 로고
    • BRCA1 physically associates with p53 and stimulates its transcriptional activity
    • Zhang,H. et al. (1998) BRCA1 physically associates with p53 and stimulates its transcriptional activity. Oncogene, 16, 1713-1721.
    • (1998) Oncogene , vol.16 , pp. 1713-1721
    • Zhang, H.1
  • 24
    • 0032506021 scopus 로고    scopus 로고
    • The BRCA2 gene product functionally interacts with p53 and Rad51
    • Marmorstein,L.Y. et al. (1998) The BRCA2 gene product functionally interacts with p53 and Rad51. Proc. Natl Acad. Sci. USA, 95, 13869-13874.
    • (1998) Proc. Natl Acad. Sci. USA , vol.95 , pp. 13869-13874
    • Marmorstein, L.Y.1
  • 25
    • 0842332845 scopus 로고    scopus 로고
    • p53 inhibits strand exchange and replication fork regression promoted by human Rad51
    • Yoon,D. et al. (2004) p53 inhibits strand exchange and replication fork regression promoted by human Rad51. J. Mol. Biol., 336, 639-654.
    • (2004) J. Mol. Biol , vol.336 , pp. 639-654
    • Yoon, D.1
  • 26
    • 2442477786 scopus 로고    scopus 로고
    • p53's double life: Transactivation-independent repression of homologous recombination
    • Bertrand,P. et al. (2004) p53's double life: transactivation-independent repression of homologous recombination. Trends Genet., 20, 235-243.
    • (2004) Trends Genet , vol.20 , pp. 235-243
    • Bertrand, P.1
  • 27
    • 11244344381 scopus 로고    scopus 로고
    • p53: Traffic cop at the crossroads of DNA repair and recombination
    • Sengupta,S. et al. (2005) p53: Traffic cop at the crossroads of DNA repair and recombination. Nat. Rev. Mol. Cell Biol., 6, 44-55.
    • (2005) Nat. Rev. Mol. Cell Biol , vol.6 , pp. 44-55
    • Sengupta, S.1
  • 28
    • 33644927601 scopus 로고    scopus 로고
    • p53 in recombination and repair
    • Gatz,S.A. et al. (2006) p53 in recombination and repair. Cell Death Differ., 13, 1003-1016.
    • (2006) Cell Death Differ , vol.13 , pp. 1003-1016
    • Gatz, S.A.1
  • 29
    • 0036337997 scopus 로고    scopus 로고
    • DNA substrate dependence of p53-mediated regulation of double-strand break repair
    • Akyüz,N. et al. (2002) DNA substrate dependence of p53-mediated regulation of double-strand break repair. Mol. Cell. Biol., 22 6306-6317.
    • (2002) Mol. Cell. Biol , vol.22 , pp. 6306-6317
    • Akyüz, N.1
  • 30
    • 14944342130 scopus 로고    scopus 로고
    • Nonhomologous end-joining of site-specific but not of radiation-induced DNA double-strand breaks is reduced in the presence of wild-type p53
    • Dahm-Daphi,J. et al. (2005) Nonhomologous end-joining of site-specific but not of radiation-induced DNA double-strand breaks is reduced in the presence of wild-type p53. Oncogene, 24, 1663-1672.
    • (2005) Oncogene , vol.24 , pp. 1663-1672
    • Dahm-Daphi, J.1
  • 31
    • 13544267789 scopus 로고    scopus 로고
    • Discriminatory suppression of homologous recombination by p53
    • Yun,S. et al. (2004) Discriminatory suppression of homologous recombination by p53. Nucleic Acids Res., 32, 6479-6489.
    • (2004) Nucleic Acids Res , vol.32 , pp. 6479-6489
    • Yun, S.1
  • 32
    • 0037104045 scopus 로고    scopus 로고
    • Absence of major defects in non-homologous DNA end joining in human breast cancer cell lines
    • Mérel,P. et al. (2002) Absence of major defects in non-homologous DNA end joining in human breast cancer cell lines. Oncogene, 21, 5654-5659.
    • (2002) Oncogene , vol.21 , pp. 5654-5659
    • Mérel, P.1
  • 33
    • 46049108550 scopus 로고    scopus 로고
    • A sensitive test for the detection of specific DSB repair defects in primary cells from breast cancer specimens
    • Keimling,M. et al. (2008) A sensitive test for the detection of specific DSB repair defects in primary cells from breast cancer specimens. Int. J. Cancer, 123, 730-736.
    • (2008) Int. J. Cancer , vol.123 , pp. 730-736
    • Keimling, M.1
  • 34
    • 52649098072 scopus 로고    scopus 로고
    • Dissecting the role of p53 phosphorylation in homologous recombination provides new clues for gain-of-function mutants
    • Restle,A. et al. (2008) Dissecting the role of p53 phosphorylation in homologous recombination provides new clues for gain-of-function mutants. Nucleic Acids Res., 36, 5362-5375.
    • (2008) Nucleic Acids Res , vol.36 , pp. 5362-5375
    • Restle, A.1
  • 35
    • 0021742268 scopus 로고
    • The minimum amount of homology required for homologous recombination in mammalian cells
    • Rubnitz,J. et al. (1984) The minimum amount of homology required for homologous recombination in mammalian cells. Mol. Cell. Biol., 4, 2253-2258.
    • (1984) Mol. Cell. Biol , vol.4 , pp. 2253-2258
    • Rubnitz, J.1
  • 36
    • 58149145579 scopus 로고    scopus 로고
    • Human MutL-complexes monitor homologous recombination independently of mismatch repair
    • Siehler,S.Y. et al. (2009) Human MutL-complexes monitor homologous recombination independently of mismatch repair. DNA Repair (Amst.) 8, 242-252.
    • (2009) DNA Repair (Amst.) , vol.8 , pp. 242-252
    • Siehler, S.Y.1
  • 37
    • 0037134020 scopus 로고    scopus 로고
    • A system for stable expression of short interfering RNAs in mammalian cells
    • Brummelkamp,T.R. et al. (2002) A system for stable expression of short interfering RNAs in mammalian cells. Science, 296, 550-553.
    • (2002) Science , vol.296 , pp. 550-553
    • Brummelkamp, T.R.1
  • 38
    • 21744432851 scopus 로고    scopus 로고
    • Differences in the association of p53 phosphorylated on serine 15 and key enzymes of homologous recombination
    • Restle,A. et al. (2005) Differences in the association of p53 phosphorylated on serine 15 and key enzymes of homologous recombination. Oncogene, 24, 4380-4387.
    • (2005) Oncogene , vol.24 , pp. 4380-4387
    • Restle, A.1
  • 39
    • 33645814188 scopus 로고    scopus 로고
    • p53 modulates homologous recombination by transcriptional regulation of the Rad51 gene
    • Arias-Lopez,C. et al. (2006) p53 modulates homologous recombination by transcriptional regulation of the Rad51 gene. EMBO Rep., 7, 219-224.
    • (2006) EMBO Rep , vol.7 , pp. 219-224
    • Arias-Lopez, C.1
  • 40
    • 0042632901 scopus 로고    scopus 로고
    • Pathways of DNA double-strand break repair during the mammalian cell cycle
    • Rothkamm,K. et al. (2003) Pathways of DNA double-strand break repair during the mammalian cell cycle. Mol. Cell. Biol., 23 5706-5715.
    • (2003) Mol. Cell. Biol , vol.23 , pp. 5706-5715
    • Rothkamm, K.1
  • 41
    • 6344234817 scopus 로고    scopus 로고
    • Genetic steps of mammalian homologous repair with distinct mutagenic consequences
    • Stark,J. M. et al. (2004) Genetic steps of mammalian homologous repair with distinct mutagenic consequences. Mol. Cell. Biol., 24, 9305-9316.
    • (2004) Mol. Cell. Biol , vol.24 , pp. 9305-9316
    • Stark, J.M.1
  • 42
    • 85047697866 scopus 로고    scopus 로고
    • A single mutated BRCA1 allele leads to impaired fidelity of double strand break end-joining
    • Baldeyron,C. et al. (2002) A single mutated BRCA1 allele leads to impaired fidelity of double strand break end-joining. Oncogene, 21, 1401-1410.
    • (2002) Oncogene , vol.21 , pp. 1401-1410
    • Baldeyron, C.1
  • 43
    • 0033578066 scopus 로고    scopus 로고
    • Mutant p53 proteins stimulate spontaneous and radiation-induced intrachromosomal homologous recombination independently of the alteration of the transactivation activity and of the G1 checkpoint
    • Saintipy,Y. et al. (1999) Mutant p53 proteins stimulate spontaneous and radiation-induced intrachromosomal homologous recombination independently of the alteration of the transactivation activity and of the G1 checkpoint. Oncogene, 18, 3553-3563.
    • (1999) Oncogene , vol.18 , pp. 3553-3563
    • Saintipy, Y.1
  • 44
    • 0034955777 scopus 로고    scopus 로고
    • Reduced expression of the BRCA1 gene and increased chromosomal instability in MCF-7 cell line
    • Kachhap,S.K. et al. (2001) Reduced expression of the BRCA1 gene and increased chromosomal instability in MCF-7 cell line. Cell Biol. Int., 25, 547-551.
    • (2001) Cell Biol. Int , vol.25 , pp. 547-551
    • Kachhap, S.K.1
  • 45
    • 44149124776 scopus 로고    scopus 로고
    • Chaperone-dependent stabilization and degradation of p53 mutants
    • Müller,P. et al. (2008) Chaperone-dependent stabilization and degradation of p53 mutants. Oncogene, 27, 3371-3383.
    • (2008) Oncogene , vol.27 , pp. 3371-3383
    • Müller, P.1
  • 46
    • 0036253156 scopus 로고    scopus 로고
    • Effect of wild-type, S15D and R175H p53 proteins on DNA end joining in vitro: Potential mechanism of DNA double-strand break repair modulation
    • Okorokov,A.L. et al. (2002) Effect of wild-type, S15D and R175H p53 proteins on DNA end joining in vitro: Potential mechanism of DNA double-strand break repair modulation. Carcinogenesis, 23 549-557.
    • (2002) Carcinogenesis , vol.23 , pp. 549-557
    • Okorokov, A.L.1
  • 47
    • 0033554592 scopus 로고    scopus 로고
    • Dissociation of the recombination control and the sequence-specific transactivation function of p53
    • Dudenhöffer,C. et al. (1999) Dissociation of the recombination control and the sequence-specific transactivation function of p53. Oncogene, 18, 5773-5784.
    • (1999) Oncogene , vol.18 , pp. 5773-5784
    • Dudenhöffer, C.1
  • 48
    • 0033973807 scopus 로고    scopus 로고
    • Function, oligomerization, and conformation of tumor-associated p53 proteins with mutated C-terminus
    • Atz,J. et al. (2000) Function, oligomerization, and conformation of tumor-associated p53 proteins with mutated C-terminus. J. Cell. Biochem., 76, 572-584.
    • (2000) J. Cell. Biochem , vol.76 , pp. 572-584
    • Atz, J.1
  • 49
    • 33845999615 scopus 로고    scopus 로고
    • Essential role for nuclear PTEN in maintaining chromosomal integrity
    • Shen,W.H. et al. (2007) Essential role for nuclear PTEN in maintaining chromosomal integrity. Cell, 128, 157-170.
    • (2007) Cell , vol.128 , pp. 157-170
    • Shen, W.H.1
  • 50
    • 65949105079 scopus 로고    scopus 로고
    • High incidence of protein-truncating TP53 mutations in BRICA1-related breast cancer
    • Holstege,H. et al. (2009) High incidence of protein-truncating TP53 mutations in BRICA1-related breast cancer. Cancer Res., 69 3625-3633.
    • (2009) Cancer Res , vol.69 , pp. 3625-3633
    • Holstege, H.1
  • 51
    • 0037469359 scopus 로고    scopus 로고
    • Activities of wildtype and mutant p53 in suppression of homologous recombination as measured by a retroviral vector system
    • Lu,X. et al. (2003) Activities of wildtype and mutant p53 in suppression of homologous recombination as measured by a retroviral vector system. Mutat. Res., 522, 69-83.
    • (2003) Mutat. Res , vol.522 , pp. 69-83
    • Lu, X.1


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