-
1
-
-
14644427890
-
Local and systemic insulin resistance resulting from hepatic activation of IKK-[beta] and NF-[kappa]B
-
Cai D, Yuan M, Frantz DF, Melendez PA, Hansen L, et al. (2005) Local and systemic insulin resistance resulting from hepatic activation of IKK-[beta] and NF-[kappa]B. Nat Med 11: 183-190.
-
(2005)
Nat Med
, vol.11
, pp. 183-190
-
-
Cai, D.1
Yuan, M.2
Frantz, D.F.3
Melendez, P.A.4
Hansen, L.5
-
2
-
-
33845866857
-
Inflammation and metabolic disorders
-
Hotamisligil GS (2006) Inflammation and metabolic disorders. Nature 444: 860-867.
-
(2006)
Nature
, vol.444
, pp. 860-867
-
-
Hotamisligil, G.S.1
-
3
-
-
0027459878
-
Adipose expression of tumor necrosis factor-alpha: Direct role in obesity-linked insulin resistance
-
Hotamisligil GS, Shargill NS, Spiegelman BM (1993) Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance. Science 259: 87-91.
-
(1993)
Science
, vol.259
, pp. 87-91
-
-
Hotamisligil, G.S.1
Shargill, N.S.2
Spiegelman, B.M.3
-
4
-
-
51549120560
-
Fat Talks, Liver and Muscle Listen
-
Olefsky JM (2008) Fat Talks, Liver and Muscle Listen. Cell 134: 914-916.
-
(2008)
Cell
, vol.134
, pp. 914-916
-
-
Olefsky, J.M.1
-
6
-
-
79955038882
-
Fatty acid-induced NLRP3-ASC inflammasome activation interferes with insulin signaling
-
Wen H, Gris D, Lei Y, Jha S, Zhang L, et al. (2011) Fatty acid-induced NLRP3-ASC inflammasome activation interferes with insulin signaling. Nat Immunol 12: 408-415.
-
(2011)
Nat Immunol
, vol.12
, pp. 408-415
-
-
Wen, H.1
Gris, D.2
Lei, Y.3
Jha, S.4
Zhang, L.5
-
7
-
-
33750584214
-
TLR4 links innate immunity and fatty acid-induced insulin resistance
-
Shi H, Kokoeva MV, Inouye K, Tzameli I, Yin H, et al. (2006) TLR4 links innate immunity and fatty acid-induced insulin resistance. J Clin Invest.
-
(2006)
J Clin Invest
-
-
Shi, H.1
Kokoeva, M.V.2
Inouye, K.3
Tzameli, I.4
Yin, H.5
-
8
-
-
75749108288
-
Double-Stranded RNA-Dependent Protein Kinase Links Pathogen Sensing with Stress and Metabolic Homeostasis
-
Nakamura T, Furuhashi M, Li P, Cao H, Tuncman G, et al. (2010) Double-Stranded RNA-Dependent Protein Kinase Links Pathogen Sensing with Stress and Metabolic Homeostasis. Cell 140: 338-348.
-
(2010)
Cell
, vol.140
, pp. 338-348
-
-
Nakamura, T.1
Furuhashi, M.2
Li, P.3
Cao, H.4
Tuncman, G.5
-
9
-
-
84864657351
-
Fetuin-A acts as an endogenous ligand of TLR4 to promote lipid-induced insulin resistance
-
Pal D, Dasgupta S, Kundu R, Maitra S, Das G, et al. (2012) Fetuin-A acts as an endogenous ligand of TLR4 to promote lipid-induced insulin resistance. Nat Med 18: 1279-1285.
-
(2012)
Nat Med
, vol.18
, pp. 1279-1285
-
-
Pal, D.1
Dasgupta, S.2
Kundu, R.3
Maitra, S.4
Das, G.5
-
10
-
-
34347399563
-
Metabolic Endotoxemia Initiates Obesity and Insulin Resistance
-
Cani PD, Amar J, Iglesias MA, Poggi M, Knauf C, et al. (2007) Metabolic Endotoxemia Initiates Obesity and Insulin Resistance. Diabetes 56: 1761-1772.
-
(2007)
Diabetes
, vol.56
, pp. 1761-1772
-
-
Cani, P.D.1
Amar, J.2
Iglesias, M.A.3
Poggi, M.4
Knauf, C.5
-
11
-
-
84857058546
-
Immuno-microbiota cross and talk: The new paradigm of metabolic diseases
-
Burcelin R, Garidou L, Pomié C (2012) Immuno-microbiota cross and talk: The new paradigm of metabolic diseases. Seminars in Immunology 24: 67-74.
-
(2012)
Seminars in Immunology
, vol.24
, pp. 67-74
-
-
Burcelin, R.1
Garidou, L.2
Pomié, C.3
-
12
-
-
82455171885
-
Involvement of tissue bacteria in the onset of diabetes in humans: Evidence for a concept
-
Amar J, Serino M, Lange C, Chabo C, Iacovoni J, et al. (2011) Involvement of tissue bacteria in the onset of diabetes in humans: evidence for a concept. Diabetologia 54: 3055-3061.
-
(2011)
Diabetologia
, vol.54
, pp. 3055-3061
-
-
Amar, J.1
Serino, M.2
Lange, C.3
Chabo, C.4
Iacovoni, J.5
-
13
-
-
43549107065
-
Energy intake is associated with endotoxemia in apparently healthy men
-
Amar J, Burcelin R, Ruidavets JB, Cani PD, Fauvel J, et al. (2008) Energy intake is associated with endotoxemia in apparently healthy men. The American Journal of Clinical Nutrition 87: 1219-1223.
-
(2008)
The American Journal of Clinical Nutrition
, vol.87
, pp. 1219-1223
-
-
Amar, J.1
Burcelin, R.2
Ruidavets, J.B.3
Cani, P.D.4
Fauvel, J.5
-
14
-
-
48249125862
-
Changes in Gut Microbiota Control Metabolic Endotoxemia-Induced Inflammation in High-Fat Diet-Induced Obesity and Diabetes in Mice
-
Cani PD, Bibiloni R, Knauf C, Waget A, Neyrinck AM, et al. (2008) Changes in Gut Microbiota Control Metabolic Endotoxemia-Induced Inflammation in High-Fat Diet-Induced Obesity and Diabetes in Mice. Diabetes 57: 1470-1481.
-
(2008)
Diabetes
, vol.57
, pp. 1470-1481
-
-
Cani, P.D.1
Bibiloni, R.2
Knauf, C.3
Waget, A.4
Neyrinck, A.M.5
-
15
-
-
80052278497
-
Intestinal mucosal adherence and translocation of commensal bacteria at the early onset of type 2 diabetes: Molecular mechanisms and probiotic treatment
-
Amar J, Chabo C, Waget A, Klopp P, Vachoux C, et al. (2011) Intestinal mucosal adherence and translocation of commensal bacteria at the early onset of type 2 diabetes: molecular mechanisms and probiotic treatment. EMBO Molecular Medicine 3: 559-572.
-
(2011)
EMBO Molecular Medicine
, vol.3
, pp. 559-572
-
-
Amar, J.1
Chabo, C.2
Waget, A.3
Klopp, P.4
Vachoux, C.5
-
16
-
-
65249099918
-
Changes in gut microbiota control inflammation in obese mice through a mechanism involving GLP-2-driven improvement of gut permeability
-
Cani PD, Possemiers S, Van de Wiele T, Guiot Y, Everard A, et al. (2009) Changes in gut microbiota control inflammation in obese mice through a mechanism involving GLP-2-driven improvement of gut permeability. Gut 58: 1091-1103.
-
(2009)
Gut
, vol.58
, pp. 1091-1103
-
-
Cani, P.D.1
Possemiers, S.2
Van De Wiele, T.3
Guiot, Y.4
Everard, A.5
-
17
-
-
76249120134
-
Recognition of peptidoglycan from the microbiota by Nod1 enhances systemic innate immunity
-
Clarke TB, Davis KM, Lysenko ES, Zhou AY, Yu Y, et al. (2010) Recognition of peptidoglycan from the microbiota by Nod1 enhances systemic innate immunity. Nat Med 16: 228-231.
-
(2010)
Nat Med
, vol.16
, pp. 228-231
-
-
Clarke, T.B.1
Davis, K.M.2
Lysenko, E.S.3
Zhou, A.Y.4
Yu, Y.5
-
18
-
-
2542466966
-
Innate immune recognition of microbes through Nod1 and Nod2: Implications for disease
-
Carneiro LAM, Travassos LH, Philpott DJ (2004) Innate immune recognition of microbes through Nod1 and Nod2: implications for disease. Microbes and Infection 6: 609-616.
-
(2004)
Microbes and Infection
, vol.6
, pp. 609-616
-
-
Carneiro, L.A.M.1
Travassos, L.H.2
Philpott, D.J.3
-
19
-
-
38549167992
-
Nod-like proteins in inflammation and disease
-
Carneiro L, Magalhaes J, Tattoli I, Philpott D, Travassos L (2008) Nod-like proteins in inflammation and disease. The Journal of Pathology 214: 136-148.
-
(2008)
The Journal of Pathology
, vol.214
, pp. 136-148
-
-
Carneiro, L.1
Magalhaes, J.2
Tattoli, I.3
Philpott, D.4
Travassos, L.5
-
20
-
-
80052901762
-
NOD1 Activators Link Innate Immunity to Insulin Resistance
-
Schertzer JD, Tamrakar AK, Magalhães JG, Pereira S, Bilan PJ, et al. (2011) NOD1 Activators Link Innate Immunity to Insulin Resistance. Diabetes 60: 2206-2215.
-
(2011)
Diabetes
, vol.60
, pp. 2206-2215
-
-
Schertzer, J.D.1
Tamrakar, A.K.2
Magalhães, J.G.3
Pereira, S.4
Bilan, P.J.5
-
22
-
-
80053259945
-
NOD1 activation induces proinflammatory gene expression and insulin resistance in 3T3-L1 adipocytes
-
Zhao L, Hu P, Zhou Y, Purohit J, Hwang D (2011) NOD1 activation induces proinflammatory gene expression and insulin resistance in 3T3-L1 adipocytes. American Journal of Physiology - Endocrinology And Metabolism 301: E587-E598.
-
(2011)
American Journal of Physiology - Endocrinology and Metabolism
, vol.301
-
-
Zhao, L.1
Hu, P.2
Zhou, Y.3
Purohit, J.4
Hwang, D.5
-
23
-
-
78649817454
-
NOD2 Activation Induces Muscle Cell-Autonomous Innate Immune Responses and Insulin Resistance
-
Tamrakar AK, Schertzer JD, Chiu TT, Foley KP, Bilan PJ, et al. (2010) NOD2 Activation Induces Muscle Cell-Autonomous Innate Immune Responses and Insulin Resistance. Endocrinology 151: 5624-5637.
-
(2010)
Endocrinology
, vol.151
, pp. 5624-5637
-
-
Tamrakar, A.K.1
Schertzer, J.D.2
Chiu, T.T.3
Foley, K.P.4
Bilan, P.J.5
-
24
-
-
0029948212
-
Mechanism of free fatty acid-induced insulin resistance in humans
-
Roden M, Price TB, Perseghin G, Petersen KF, Rothman DL, et al. (1996) Mechanism of free fatty acid-induced insulin resistance in humans. The Journal of Clinical Investigation 97: 2859-2865.
-
(1996)
The Journal of Clinical Investigation
, vol.97
, pp. 2859-2865
-
-
Roden, M.1
Price, T.B.2
Perseghin, G.3
Petersen, K.F.4
Rothman, D.L.5
-
26
-
-
29044447292
-
Free Fatty Acids Produce Insulin Resistance and Activate the Proinflammatory Nuclear Factor-κB Pathway in Rat Liver
-
Boden G, She P, Mozzoli M, Cheung P, Gumireddy K, et al. (2005) Free Fatty Acids Produce Insulin Resistance and Activate the Proinflammatory Nuclear Factor-κB Pathway in Rat Liver. Diabetes 54: 3458-3465.
-
(2005)
Diabetes
, vol.54
, pp. 3458-3465
-
-
Boden, G.1
She, P.2
Mozzoli, M.3
Cheung, P.4
Gumireddy, K.5
-
27
-
-
65549131061
-
Bacterial Endotoxin Stimulates Adipose Lipolysis via Toll-Like Receptor 4 and Extracellular Signal-regulated Kinase Pathway
-
Zu L, He J, Jiang H, Xu C, Pu S, et al. (2009) Bacterial Endotoxin Stimulates Adipose Lipolysis via Toll-Like Receptor 4 and Extracellular Signal-regulated Kinase Pathway. Journal of Biological Chemistry 284: 5915-5926.
-
(2009)
Journal of Biological Chemistry
, vol.284
, pp. 5915-5926
-
-
Zu, L.1
He, J.2
Jiang, H.3
Xu, C.4
Pu, S.5
-
28
-
-
0041568670
-
TNF-α induction of lipolysis is mediated through activation of the extracellular signal related kinase pathway in 3T3-L1 adipocytes
-
Souza SC, Palmer HJ, Kang Y-H, Yamamoto MT, Muliro KV, et al. (2003) TNF-α induction of lipolysis is mediated through activation of the extracellular signal related kinase pathway in 3T3-L1 adipocytes. Journal of Cellular Biochemistry 89: 1077-1086.
-
(2003)
Journal of Cellular Biochemistry
, vol.89
, pp. 1077-1086
-
-
Souza, S.C.1
Palmer, H.J.2
Kang, Y.-H.3
Yamamoto, M.T.4
Muliro, K.V.5
-
29
-
-
29044440372
-
Signalling mechanisms regulating lipolysis
-
Carmen G-Y, Víctor S-M (2006) Signalling mechanisms regulating lipolysis. Cellular Signalling 18: 401-408.
-
(2006)
Cellular Signalling
, vol.18
, pp. 401-408
-
-
Carmen, G.-Y.1
Víctor, S.-M.2
-
30
-
-
28544434876
-
Murine Nod1 but not its human orthologue mediates innate immune detection of tracheal cytotoxin
-
Magalhaes JG, Philpott DJ, Nahori M-A, Jehanno M, Fritz J, et al. (2005) Murine Nod1 but not its human orthologue mediates innate immune detection of tracheal cytotoxin. EMBO Rep 6: 1201-1207.
-
(2005)
EMBO Rep
, vol.6
, pp. 1201-1207
-
-
Magalhaes, J.G.1
Philpott, D.J.2
Nahori, M.-A.3
Jehanno, M.4
Fritz, J.5
-
31
-
-
79960965328
-
Discovery and Characterization of 2-Aminobenzimidazole Derivatives as Selective NOD1 Inhibitors
-
Correa Ricardo G, Khan Pasha M, Askari N, Zhai D, Gerlic M, et al. (2011) Discovery and Characterization of 2-Aminobenzimidazole Derivatives as Selective NOD1 Inhibitors. Chemistry & Biology 18: 825-832.
-
(2011)
Chemistry & Biology
, vol.18
, pp. 825-832
-
-
Correa Ricardo, G.1
Khan Pasha, M.2
Askari, N.3
Zhai, D.4
Gerlic, M.5
-
32
-
-
84881019813
-
Identification of Benzimidazole Diamides as Selective Inhibitors of the Nucleotide-Binding Oligomerization Domain 2 (NOD2) Signaling Pathway
-
Rickard DJ, Sehon CA, Kasparcova V, Kallal LA, Zeng X, et al. (2013) Identification of Benzimidazole Diamides as Selective Inhibitors of the Nucleotide-Binding Oligomerization Domain 2 (NOD2) Signaling Pathway. PLoS ONE 8: e69619.
-
(2013)
PLoS ONE
, vol.8
-
-
Rickard, D.J.1
Sehon, C.A.2
Kasparcova, V.3
Kallal, L.A.4
Zeng, X.5
-
33
-
-
80054772017
-
Identification of Inhibitors of NOD1-Induced Nuclear Factor-κB Activation
-
Khan PM, Correa RG, Divlianska DB, Peddibhotla S, Sessions EH, et al. (2011) Identification of Inhibitors of NOD1-Induced Nuclear Factor-κB Activation. ACS Medicinal Chemistry Letters 2: 780-785.
-
(2011)
ACS Medicinal Chemistry Letters
, vol.2
, pp. 780-785
-
-
Khan, P.M.1
Correa, R.G.2
Divlianska, D.B.3
Peddibhotla, S.4
Sessions, E.H.5
-
34
-
-
85027958029
-
Peptidoglycan recognition proteins: Modulators of the microbiome and inflammation
-
Royet J, Gupta D, Dziarski R (2011) Peptidoglycan recognition proteins: modulators of the microbiome and inflammation. Nat Rev Immunol 11: 837-851.
-
(2011)
Nat Rev Immunol
, vol.11
, pp. 837-851
-
-
Royet, J.1
Gupta, D.2
Dziarski, R.3
-
36
-
-
79957962932
-
Non-apoptotic role of BID in inflammation and innate immunity
-
Yeretssian G, Correa RG, Doiron K, Fitzgerald P, Dillon CP, et al. (2011) Non-apoptotic role of BID in inflammation and innate immunity. Nature 474: 96-99.
-
(2011)
Nature
, vol.474
, pp. 96-99
-
-
Yeretssian, G.1
Correa, R.G.2
Doiron, K.3
Fitzgerald, P.4
Dillon, C.P.5
-
37
-
-
0034306450
-
Specificity and mechanism of action of some commonly used protein kinase inhibitors
-
Davies SP, Reddy H, Caivano M, Cohen P (2000) Specificity and mechanism of action of some commonly used protein kinase inhibitors. Biochem J 351: 95-105.
-
(2000)
Biochem J
, vol.351
, pp. 95-105
-
-
Davies, S.P.1
Reddy, H.2
Caivano, M.3
Cohen, P.4
-
38
-
-
0030991201
-
The Transcriptional Activity of NF-κB Is Regulated by the IκB-Associated PKAc Subunit through a Cyclic AMP-Independent Mechanism
-
Zhong H, SuYang H, Erdjument-Bromage H, Tempst P, Ghosh S (1997) The Transcriptional Activity of NF-κB Is Regulated by the IκB-Associated PKAc Subunit through a Cyclic AMP-Independent Mechanism. Cell 89: 413-424.
-
(1997)
Cell
, vol.89
, pp. 413-424
-
-
Zhong, H.1
SuYang, H.2
Erdjument-Bromage, H.3
Tempst, P.4
Ghosh, S.5
-
39
-
-
84867159338
-
Regulation of NF-κB Activation through a Novel PI-3K-Independent and PKA/Akt-Dependent Pathway in Human Umbilical Vein Endothelial Cells
-
Balwani S, Chaudhuri R, Nandi D, Jaisankar P, Agrawal A, et al. (2012) Regulation of NF-κB Activation through a Novel PI-3K-Independent and PKA/Akt-Dependent Pathway in Human Umbilical Vein Endothelial Cells. PLoS ONE 7: e46528.
-
(2012)
PLoS ONE
, vol.7
-
-
Balwani, S.1
Chaudhuri, R.2
Nandi, D.3
Jaisankar, P.4
Agrawal, A.5
-
40
-
-
84855997854
-
Both inflammatory and classical lipolytic pathways are involved in lipopolysaccharide-induced lipolysis in human adipocytes
-
Grisouard J, Bouillet E, Timper K, Radimerski T, Dembinski K, et al. (2012) Both inflammatory and classical lipolytic pathways are involved in lipopolysaccharide-induced lipolysis in human adipocytes. Innate Immunity 18: 25-34.
-
(2012)
Innate Immunity
, vol.18
, pp. 25-34
-
-
Grisouard, J.1
Bouillet, E.2
Timper, K.3
Radimerski, T.4
Dembinski, K.5
-
41
-
-
77951784552
-
NOD1 contributes to mouse host defense against Helicobacter pylori via induction of type I IFN and activation of the ISGF3 signaling pathway
-
Watanabe T, Asano N, Fichtner-Feigl S, Gorelick PL, Tsuji Y, et al. (2010) NOD1 contributes to mouse host defense against Helicobacter pylori via induction of type I IFN and activation of the ISGF3 signaling pathway. The Journal of Clinical Investigation 120: 1645-1662.
-
(2010)
The Journal of Clinical Investigation
, vol.120
, pp. 1645-1662
-
-
Watanabe, T.1
Asano, N.2
Fichtner-Feigl, S.3
Gorelick, P.L.4
Tsuji, Y.5
-
42
-
-
0026733835
-
Cytokines stimulate lipolysis and decrease lipoprotein lipase activity in cultured fat cells by a prostaglandin independent mechanism
-
Hardardottir I, Doerrler W, Feingold KR, Grunfeld C (1992) Cytokines stimulate lipolysis and decrease lipoprotein lipase activity in cultured fat cells by a prostaglandin independent mechanism. Biochem Biophys Res Commun 186: 237-243.
-
(1992)
Biochem Biophys Res Commun
, vol.186
, pp. 237-243
-
-
Hardardottir, I.1
Doerrler, W.2
Feingold, K.R.3
Grunfeld, C.4
-
43
-
-
84894266873
-
Activation of nucleotide oligomerization domain containing protein 1 induces lipolysis through NF-κB and the lipolytic PKA activation in 3T3-L1 adipocytes
-
Purohit JS, Hu P, Chen G, Whelan J, Moustaid-Moussa N, et al. (2013) Activation of nucleotide oligomerization domain containing protein 1 induces lipolysis through NF-κB and the lipolytic PKA activation in 3T3-L1 adipocytes. Biochemistry and Cell Biology 91: 428-434.
-
(2013)
Biochemistry and Cell Biology
, vol.91
, pp. 428-434
-
-
Purohit, J.S.1
Hu, P.2
Chen, G.3
Whelan, J.4
Moustaid-Moussa, N.5
-
44
-
-
84874692963
-
Partial Inhibition of Adipose Tissue Lipolysis Improves Glucose Metabolism and Insulin Sensitivity Without Alteration of Fat Mass
-
Girousse A, Tavernier G, Valle C, Moro C, Mejhert N, et al. (2013) Partial Inhibition of Adipose Tissue Lipolysis Improves Glucose Metabolism and Insulin Sensitivity Without Alteration of Fat Mass. PLoS Biol 11: e1001485.
-
(2013)
PLoS Biol
, vol.11
-
-
Girousse, A.1
Tavernier, G.2
Valle, C.3
Moro, C.4
Mejhert, N.5
-
45
-
-
1242340382
-
Effects of prolonged exercise and recovery on sarcoplasmic reticulum Ca2+ cycling properties in rat muscle homogenates
-
Schertzer JD, Green HJ, Fowles JR, Duhamel TA, Tupling AR (2004) Effects of prolonged exercise and recovery on sarcoplasmic reticulum Ca2+ cycling properties in rat muscle homogenates. Acta Physiologica Scandinavica 180: 195-208.
-
(2004)
Acta Physiologica Scandinavica
, vol.180
, pp. 195-208
-
-
Schertzer, J.D.1
Green, H.J.2
Fowles, J.R.3
Duhamel, T.A.4
Tupling, A.R.5
-
46
-
-
78549272729
-
Whole Body Deletion of AMP-activated Protein Kinase β2 Reduces Muscle AMPK Activity and Exercise Capacity
-
Steinberg GR, O'Neill HM, Dzamko NL, Galic S, Naim T, et al. (2010) Whole Body Deletion of AMP-activated Protein Kinase β2 Reduces Muscle AMPK Activity and Exercise Capacity. Journal of Biological Chemistry 285: 37198-37209.
-
(2010)
Journal of Biological Chemistry
, vol.285
, pp. 37198-37209
-
-
Steinberg, G.R.1
O'Neill, H.M.2
Dzamko, N.L.3
Galic, S.4
Naim, T.5
|