Regulation of NF-κB Activation through a Novel PI-3K-Independent and PKA/Akt-Dependent Pathway in Human Umbilical Vein Endothelial Cells

PLoS ONE

Volumn 7, Issue 10, 2012, Pages

  Balwani, Sakshi ^a   Chaudhuri, Rituparna ^a   Nandi, Debkumar ^b   Jaisankar, Parasuraman ^b   Agrawal, Anurag ^a   Ghosh, Balaram ^a  

^a CSIR INSTITUTE OF GENOMICS AND INTEGRATIVE BIOLOGY   (India)

^b INDIAN INSTITUTE OF CHEMICAL BIOLOGY   (India)

Author keywords

[No Author keywords available]

Indexed keywords

2 METHYL PYRAN 4 ONE 3 O BETA DEXTRO 2',3',4',6' TETRA O ACETYL GLUCOPYRANOSIDE; CYCLIC AMP DEPENDENT PROTEIN KINASE; I KAPPA B KINASE BETA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; NATURAL PRODUCT; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; SERINE; THREONINE; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; WORTMANNIN;

AMINO ACID COMPOSITION; ARTICLE; CONTROLLED STUDY; CYTOKINE RESPONSE; DRUG MECHANISM; DRUG STRUCTURE; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME MECHANISM; ENZYME PHOSPHORYLATION; ENZYME REGULATION; HUMAN; HUMAN CELL; PHARMACOLOGICAL BLOCKING; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; UMBILICAL VEIN ENDOTHELIAL CELL;

CELLS, CULTURED; CYCLIC AMP-DEPENDENT PROTEIN KINASES; HUMANS; NF-KAPPA B; PHOSPHATIDYLINOSITOL 3-KINASES; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; TUMOR NECROSIS FACTOR-ALPHA;

TETRA;

EID: 84867159338     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0046528     Document Type: Article

References (46)

1. Baldwin AS, (2001) The transcription factor NF-κB and human disease. J Clin Invest 107: 3.
2. Springer T, (1994) Traffic signals for lymphocyte recirculation and leukocyte emigration: The multistep paradigm. Cell 76: 301-314.
3. Siebenlist D, Franzuso O, Brown R, (1994) Structure, regulation and function of NF-κB. Ann Rev Cell Biol 10: 405.
4. Ghosh S, May MJ, Kopp EB, (1998) NF-κB and Rel proteins: evolutionarily conserved mediators of immune responses. Annu Rev Immunol 16: 225.
5. Zhu L, Fukuda S, Cordis G, Das DK, Maulik N, (2001) Anti-apoptotic protein survivin plays a significant role in tubular morphogenesis of human coronary arteriolar endothelial cells by hypoxic preconditioning. FEBS Lett 508: 369-374.
6. Hinz M, Krappmann D, Eichten A, Heder A, Scheidereit C, et al. (1999) NF-kappaB function in growth control: regulation of cyclin D1 expression and G0/G1-to-S-phase transition. Mol Cell Biol 19: 2690.
7. Chen ZJ, Parent L, Maniatis T, (1996) Site-specific phosphorylation of IκBα by a novel ubiquitination-dependent protein kinase activity. Cell 84: 853.
8. Zandi E, Rothwarf DM, Delhase M, Hayakawa M, Karin M, (1997) The IkappaB kinase complex (IKK) contains two kinase subunits, IKKalpha and IKKbeta, necessary for IkappaB phosphorylation and NF-kappaB activation. Cell 91: 243-52.
9. Rothwarf DM, Zandi E, Natoli G, Karin M, (1998) IKK-gamma is an essential regulatory subunit of the IkappaB kinase complex. Nature 395: 297-300.
10. Ozes ON, Mayo LD, Gustin JA, Pfeffer SR, Pfeffer LM, et al. (1999) NF-kappaB activation by tumour necrosis factor requires the Akt serine-threonine kinase. Nature 401: 82-85.
11. Yang SK, Wang YC, Chao CC, Chuang YJ, Lan CY, et al. (2010) Dynamic cross-talk analysis among TNF-R, TLR-4 and IL-1R signalings in TNFα-induced inflammatory responses. BMC Medical Genomics 3: 1-19.
12. Blonska M, Shambharkar PB, Kobayashi M, Zhang D, Sakurai H, et al. (2005) TAK1 is recruited to the tumor necrosis factor-alpha (TNF-alpha) receptor 1 complex in a receptor-interacting protein (RIP)-dependent manner and cooperates with MEKK3 leading to NF-kappaB activation. J Biol Chem 280: 43056-43063.
13. Alpert D, Schwenger P, Han J, Vilcek J, (1999) Cell stress and MKK6b-mediated p38 MAP kinase activation inhibit tumor necrosis factor-induced IkappaB phosphorylation and NF-kappaB activation. J Biol Chem 274: 22176-22183.
14. Kang JS, Yoon YD, Han MH, Han SB, Lee K, et al. (2006) Glabridin Suppresses Intercellular Adhesion Molecule-1Expression in Tumor Necrosis Factor-α-stimulated Human Umbilical Vein Endothelial Cells by Blocking Sphingosine Kinase Pathway: Implications of Akt, Extracellular Signal-Regulated Kinase, and Nuclear Factor-κB/Rel Signaling Pathways. Mol Pharmacol 69: 941-949.
15. Gustin JA, Ozes ON, Akca H, Pincheira R, Mayo LD, et al. (2004) Cell type-specific expression of the IκBα kinases determines the significance of phosphatidylinositol 3-kinase/Akt signaling to NF-κB activation. J Biol Chem 279: 1615-1620.
16. Burow ME, Weldon CB, Melnik LI, Duong BN, Collins-Burow BM, et al. (2000) PI-3K/AKT regulation of NF-kappaB signaling events in suppression of TNF-induced apoptosis. Biochem Biophys Res Commun 271: 342-345.
17. Meng F, D'Mello SR, (2003) NF-kappaB stimulates Akt phosphorylation and gene expression by distinct signaling mechanisms. Biochimica et Biophysica Acta 1630: 35-40.
18. Secchiero P, Gonelli A, Carnevale E, Milani D, Pandolfi A, et al. (2003) TRAIL Promotes the Survival and Proliferation of Primary Human Vascular Endothelial Cells by Activating the Akt and ERK Pathways. Circulation 107: 2250-2256.
19. Hermann C, Assmus B, Urbich C, Zeiher AM, Dimmeler S, (2000) Insulin-Mediated Stimulation of Protein Kinase Akt: A Potent Survival Signaling Cascade for Endothelial Cells. ArteriosclerThromb Vasc Biol 20: 402-409.
20. Gonzalez-Robayna IJ, Falender AE, Ochsner S, Firestone GL, Richards JS, (2000) Follicle-Stimulating hormone (FSH) stimulates phosphorylation and activation of protein kinase B (PKB/Akt) and serum and glucocorticoid-lnduced kinase (Sgk): evidence for A kinase-independent signaling by FSH in granulosa cells. Mol Endocrinol 14: 1283-1300.
21. Filippa N, Sable CL, Filloux C, Hemmings B, Van Obberghen E, (1999) Mechanism of protein kinase B activation by cyclic AMP-dependent protein kinase. Mol Cell Biol 19: 4989-5000.
22. Forti FL, Armelin HA, (2000) ACTH inhibits A Ras-dependent anti-apoptotic and mitogenic pathway in mouse Y1 adrenocortical cells. Endocr Res 26: 911-914.
23. Kim S, Jee K, Kim D, Koh H, Chung J, (2001) Cyclic AMP inhibits Akt activity by blocking the membrane localization of PDK1. J Biol Chem 276: 12864-12870.
24. Wang L, Liu F, Adamo ML, (2001) Cyclic AMP inhibits extracellular signal-regulated kinase and phosphatidylinositol 3-kinase/Akt pathways by inhibiting Rap1. J Biol Chem 276: 37242-37249.
25. Flood PM, Qian L, Peterson LJ, Zhang F, Shi JS, et al. (2011) Transcriptional Factor NF-κB as a Target for Therapy in Parkinson's Disease. Parkinsons Dis 2011: 216298.
26. Breccia M, Alimena G, (2010) NF-κB as a potential therapeutic target in myelodysplastic syndromes and acute myeloid leukemia. Expert Opin Ther Targets 14: 1157-76.
27. Yu H, Lou JR, Ding WQ, (2010) Clioquinol independently targets NF-kappaB and lysosome pathways in human cancer cells. Anticancer Res 30: 2087-92.
28. Balwani S, Nandi D, Jaisankar P, Ghosh B, (2011) 2-Methyl-pyran-4-one-3-O-β-D-glucopyranoside isolated from leaves of Punica granatum inhibits the TNFα-induced cell adhesion molecules expression by blocking nuclear transcription factor-κB (NF-κB). Biochimie 93: 921-30.
29. Sizemore N, Lerner N, Dombrowski N, Sakurai H, Stark GR, (2002) Distinct Roles of the IκB Kinase α and β Subunits in LiberatingNuclear Factor κB (NF-κB) from IκB and in Phosphorylating the p65Subunit of NF-κB. J Biol Chem 277: 3863-3869.
30. Gratton JP, Morales-Ruiz M, Kureishi Y, Fulton D, Walsh K, et al. (2001) Akt down-regulation of p38 signaling provides a novel mechanism of vascular endothelial growth factor-mediated cytoprotection in endothelial cells. J Biol Chem 276: 30359-65.
31. Attar RM, Caamano J, Carrasco D, Iotsova V, Ishikawa H, et al. (1997) Genetic approaches to study Rel/NF-kB/IkB function in mice. Semin Cancer Biol 8: 93.
32. Takada Y, Kobayashi Y, Aggarwal BB, (2005) Evodiamine Abolishes Constitutive and Inducible NF-κB Activation by Inhibiting IκBα Kinase Activation, thereby Suppressing NF-κB-regulated Antiapoptotic and Metastatic Gene Expression, Up-regulating Apoptosis, and Inhibiting Invasion. J Biol Chem 280: 17203-17212.
33. Mayo MW, Madrid LV, Westerheide SD, Jones DR, Yuan XJ, et al. (2002) PTEN blocks tumor necrosis factor-induced NF-kappa B-dependent transcription by inhibiting the transactivation potential of the p65 subunit. J Biol Chem 277: 11116-11125.
34. Baek YS, Haas S, Hackstein H, Bein G, Hernandez-Santana M, et al. (2009) Identification of novel transcriptional regulators involved in macrophage differentiation and activation in U937 cell. BMC Immunology 10: 10-18.
35. Kermarrec N, Selloum S, Plantefeve G, Chosidow D, Paoletti X, et al. (2005) Regulation of peritoneal and systemic neutrophil-derived tumor necrosis factor-alpha release in patients with severe peritonitis: role of tumor necrosis factor-alpha converting enzyme cleavage. Crit Care Med 33: 1359-64.
36. Lou L, Urbani J, Ribeiro-Neto F, Altschuler DL, (2002) cAMP inhibition of Akt is mediated by activated and phosphorylated Rap1b. J Biol Chem 277: 32799-806.
37. Saito Y, Okamura M, Nakajima S, Hayakawa K, Huang T, et al. (2010) Suppression of nephrin expression by TNF-α via interfering with the cAMP-retinoic acid receptor pathway. AJP- Renal Physiol 298: F1436-F1444.
38. Kopp E, Ghosh S, (1994) Inhibition of NF-kappa B by sodium salicylate and aspirin. Science 265: 956-9.
39. Weber C, Erl W, Pietsch A, Weber PC, (1995) Aspirin inhibits nuclear factor-κB mobilization and monocyte adhesion in stimulated human endothelial cells. Circulation 91: 1914-17.
40. Radomska-Leśniewska DM, Sadowska AM, Van Overveld FJ, Demkow U, Zieliński J, et al. (2006) Influence of N-acetylcysteine on ICAM-1 expression and IL-8 release from endothelial and epithelial cells. J Physiol Pharmacol 57: 325-34.
41. Sakai A, (1996) Diclofenac inhibits endothelial cell adhesion molecule expression induced with lipopolysaccharide. Life Sciences 58: 2377-2387.
42. Strnad J, Burke JR, (2007) IκB kinase inhibitors for treating autoimmune and inflammatory disorders: potential and challenges. Trends Pharmacol Sci 28: 142-148.
43. Vogel AI, Tatchell AR, Furnis BS, Hannaford AJ, Smith WG (1989) Vogel's Textbook of Practical Organic Chemistry 5th Edition: 674.
44. Krohn K, Agocs A, (2007) Total synthesis of dehydro-boscialin glucoside. ARKIVOC V: 46-49.
45. Madan B, Batra S, Ghosh B, (2000) 2′-hydroxychalcone inhibits nuclear factor-kappaB and blocks tumor necrosis factor-alpha- and lipopolysaccharide-induced adhesion of neutrophils to human umbilical vein endothelial cells. Mol Pharmacol 58: 526-534.
46. Mercurio F, Zhu H, Murray BW, Shevchenko A, Bennett BL, et al. (1997) IKK-1 and IKK-2: cytokine-activated IkappaB kinases essential for NF-kappaB activation. Science 278: 860-6.