Innate immune recognition of microbes through Nod1 and Nod2: Implications for disease

Microbes and Infection

Volumn 6, Issue 6, 2004, Pages 609-616

  Carneiro, Leticia A M ^a   Travassos, Leonardo H ^a   Philpott, Dana J ^b  

^a STATE UNIVERSITY OF RIO DE JANEIRO   (Brazil)

^b INSTITUT PASTEUR   (France)

Author keywords

Innate immunity; Nod1; Nod2; Peptidoglycan; Toll like receptors

Indexed keywords

CELL PROTEIN; CELL RECEPTOR; NUCLEOTIDE BINDING OLIGOMERIZATION PROTEIN 1; NUCLEOTIDE BINDING OLIGOMERIZATION PROTEIN 2; PEPTIDOGLYCAN; TOLL LIKE RECEPTOR; UNCLASSIFIED DRUG;

ANTIGEN RECOGNITION; APOPTOSIS; BACTERIAL INFECTION; CHRONIC INFLAMMATION; GENE MUTATION; GENETIC CODE; HOST PATHOGEN INTERACTION; HUMAN; IMMUNE RESPONSE; INFECTION RESISTANCE; INFECTION SENSITIVITY; INFLAMMATION; INFLAMMATORY DISEASE; MEDIATOR; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; REVIEW; SIGNAL TRANSDUCTION;

BACTERIA (MICROORGANISMS);

EID: 2542466966     PISSN: 12864579     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.micinf.2004.01.012     Document Type: Short Survey

References (39)

1. Hinman A.R. Global progress in infectious disease control. Vaccine. 16:1998;1116-1121
2. Basset C., Holton J., O'Mahony R., Roitt I. Innate immunity and pathogen-host interaction. Vaccine. 21:2003;12-23
3. Girardin S.E., Sansonetti P.J., Philpott D.J. Intracellular vs. extracellular recognition of pathogens - common concepts in mammals and flies. Trends Microbiol. 10:2002;1993-1999
4. Lemaitre B., Nicolas E., Michaut L., Reichhart J.M., Hoffman J.M. The dorsoventral regulatory gene cassette spatzle/Toll/cactus controls the potent antifungal response in Drosophila adults. Cell. 86:1996;973-983
5. Medzhitov R. Toll-like receptors and innate immunity. Nat. Rev. Immunol. 1:2001;135-145
6. Akira S., Takeda K., Kaisho T. Toll-like receptors: critical proteins linking innate and acquired immunity. Nat. Immunol. 2:2001;675-680
7. Girardin S.E., Tournebize R., Mavris M., Page A.L., Li X., Stark G.R., Bertin J., DiStefano P.S., Yaniv M., Sansonetti P.J., Philpott D.J. CARD4/Nod1 mediates NF-κB and JNK activation by invasive Shigella flexneri. EMBO Rep. 21:2001;736-742
8. Inohara N., Nunez G. Nods: intracellular proteins involved in inflammation and apoptosis. Nat. Rev. Immunol. 3:2003;371-382
9. Inohara N., Koseki T., Peso L., Hu Y., Yee C., Chen S., Carrio R., Merino J., Liu D., Ni J., Nunez G. Nod1, an Apaf-1-like activator of caspase-9 and nuclear-factor-κB. J. Biol. Chem, 274:1999;14560-14567
10. Inohara N., Koseki T., Lin J., Peso L., Lucas P.C., Chen F.F., Ogura Y., Nunez G. An induced proximity model for NF-κB activation in the Nod1/RICK and RIP signaling pathways. J. Biol. Chem, 275:2000;27823-27831
11. Ogura Y., Inohara N., Benito A., Chen F.C., Yamaoka S., Nunez G. Nod2, a Nod1/Apaf-1 family member that is restricted to monocytes and activates NF-κB. J. Biol. Chem, 276:2001;4812-4818
12. Girardin S.E., Hugot J.P., Sansonetti P.J. Lessons from Nod2 studies: towards a link between Crohn's disease and bacterial sensing. Trends Immunol. 24:2004;652-658
13. Chamaillard M., Girardin S.E., Viala J., Philpott D.J. Nods, Nalps and Naip: intracellular regulators of bacterial-induced inflammation. Cell. Microbiol. 5:2003;581-592
14. Girardin S.E., Boneca I.G., Carneiro L.A.M., Antignac A., Jéhano M., Viala J., Tedin K., Taha M., Labigne A., Zähringer U., Coyle A.J., DiStefano P.S., Bertin J., Sansonetti P.J., Philpott D.J. Nod1 detects a unique muropeptide from Gram-negative bacterial peptidoglycan. Science. 300:2003;1582-1587
15. Chamaillard M., Hashimoto M., Horie Y., Masumoto J., Su Q., Saab L., Ogura Y., Kawasaki A., Fukase K., Kusumoto S., Valvano M., Foster S.J., Mak T.W., Nunez G., Inohara N. An essential role for Nod1 in host recognition of bacterial peptidoglycan containing diaminopimelic acid. Nat. Immunol. 3:2003;702-707
16. Girardin S.E., Boneca I.G., Viala J., Chamaillard M., Labigne A., Thomas G., Philpott D.J., Sansonetti P.J. Nod2 is a general sensor of peptidoglycan through muramyl dipeptide (MDP) detection. J. Biol. Chem. 278:2003;8869-8872
17. Inohara N., Ogura Y., Fontalba A., Gutierrez O., Pons F., Crespo J., Fukase K., Inamura S., Foster S.J., Moran A.P., Fernandez-Luna J.L., Nunez G. Host recognition of bacterial muramyl dipeptide mediated through Nod2. J. Biol. Chem. 278:2003;5509-5512
18. Girardin S.E., Travassos L.H., Hervé M., Blanot D., Boneca I.G., Philpott D.J., Sansonetti P.J., Mengin-Lecreulx D. Peptidoglycan molecular requirements allowing detection by Nod1 and Nod2. J. Biol. Chem. 278:2003;41702-41708
19. Chamaillard M., Philpott D.J., Girardin S.E., Zouali H., Lesage S., Chareyre F., Bui T.H., Giovannini M., Zaehringer U., Penard-Lacronique V., Sansonetti P.J., Hugot J.P., Thomas G. Gene-environment interaction modulated by allelic heterogeneity in inflammatory diseases. Proc. Natl. Acad. Sci. USA. 100:2003;3455-3460
20. Adam A. Modern concepts in immunology. Synthetic Adjuvants. I:1985;1-58 Wiley, New York
21. Nau G.J., Richmond J.F., Schlesinger A., Jennings E.G., Lander E.S., Young R.A. Human macrophage activation programs induced by bacterial pathogens. Proc. Natl. Acad. Sci. USA. 99:2002;1503-1508
22. Heinzelmann M., Polk H.C., Chernobelsky A., Strites T.P., Gordon L.E. Endotoxin and muramyl dipeptide modulate surface receptor expression of human mononuclear cells. Immunopharmacology. 48:2000;117-128
23. Wolfert M.A., Murray T.F., Boons G., Moore J.N. The origin of the synergistic effect of muramyl dipeptide with endotoxin and peptidoglycan. J. Biol. Chem. 277:2002;39179-39186
24. Kobayashi K., Inohara N., Hernandez L.D., Gálan J.E., Nunez G., Janeway C.A., Medzhitov R., Flavell R.A. RICK/Rip2/CARDIAK mediates signalling for receptors of the innate and adaptative immune systems. Nature. 416:2002;194-199
25. Stehlik C., Hayashi H., Pio F., Godzik A., Reed J. CARD6 is a modulator of NF-κB activation by Nod1- and Cardiak-mediated pathways. J. Biol. Chem. 278:2003;31941-31949
26. Kim J.M., Eckman L., Savidge T.C., Lowe D.C., Witthöft T., Kagnoff F. Apoptosis of human intestinal epithelial cells after bacterial invasion. J. Clin. Invest. 102:1998;1815-1823
27. Staskawicz B.J., Ausubel F.M., baker B.J., Ellis J.G., Jones J.D. Molecular genetics of plant disease resistance. Science. 268:1995;661-667
28. Hoffman K., Bucher P., Tschopp J. The CARD domain: a new apoptotic signaling motif. TIBS. 22:1997;155-156
29. Yoo N.J., Park W.S., Kim S.Y., Reed J.C., Son S.G., Lee J.Y., Lee S.H. Nod1, a CARD protein, enhances pro-interleukin-1β processing through the interaction with pro-caspase-1. Biochem. Biophys. Res. Commun. 299:2002;652-658
30. Aliprantis A.O., Yang R.B., Weiss D.S., Godowski P., Zychlinsky A. The apoptotic signaling pathway activated by Toll-like receptor-2. EMBO J. 19:2000;3325-3336
31. Hisamatsu T., Suzuki M., Reinecker H.C., Nadeau W.J., McCormick B.A., Podolsky D.K. CARD15/Nod2 functions as an antibacterial factor in human intestinal epithelial cells. Gastroenterology. 124:2003;654-662
32. Fischer W., Plus J., Buhrdorf R., Gebert B., Odenbreit S., Haas R. Systematic mutagenesis of the Helicobacter pylori cag pathogenecity island: essential genes for CagA translocation in host cells and induction of interleukin-8. Mol. Microbiol. 42:2001;1337-1348
33. Guo L. Regulation of lipid A modifications by Salmonella typhimurium virulence genes phoP-phoQ. Science. 276:1997;250-253
34. Hayashi F., Smith K.D., Ozinsky A., Hawn T.R., Yi E.C., Goodlett D.R., Eng J.K., Akira S., Underhill D.M., Aderem A. The innate immune response to bacterial flagellin is mediated by Toll-like receptor-5. Nature. 410:2001;1099-1103
35. Lucker K.E., Tyler A.N., Marshall G.R., Goldman W.E. Tracheal cytotoxin structural requirements for respiratory epithelial damage in pertussis. Mol. Microbiol. 16:1995;733-738
36. Bartoleschi C., Pardini M.C., Scaringi C., Martino M.C., Pazzani C., Bernardini M.L. Selection of Shigella flexneri candidate virulence genes specifically induced in bacteria resident in host cell cytoplasm. Cell. Microbiol. 4:2002;613-626
37. Lenz L.L., Mohammadi S., Geissler A., Portnoy D.A. SecA2-dependent secretion of autolytic enzymes promotes Listeria monocytogenes pathogenesis. Proc. Natl. Acad. Sci. USA. 100:2003;876-882
38. Akopyants N.S. Analyses of the cap pathogenicity island of Helicobacter pylori. Mol. Microbiol. 28:1998;37-53
39. Philpott D.J., Yamaoka S., Israël A., Sansonetti P.J. Invasive Shigella flexneri activates NF-κB through a lipopolysaccharide-dependent innate intracellular response and leads to IL-8 expression in epithelial cells. J. Immunol. 165:2000;903-914