Oncogenic programmes and Notch activity: An 'organized crime'?

Seminars in Cell and Developmental Biology

Volumn 28, Issue , 2014, Pages 78-85

  Dominguez, Maria ^a  

^a INSTITUTO DE NEUROCIENCIAS   (Spain)

Author keywords

Cancer; Drosophila; Notch

Indexed keywords

CYTOKINE; JANUS KINASE; NOTCH RECEPTOR; PROTEIN; SONIC HEDGEHOG PROTEIN; STAT PROTEIN; UNCLASSIFIED DRUG; UPD PROTEIN;

ACETYLATION; ANGIOGENESIS; APOPTOSIS; CANCER TEST; CARBOXY TERMINAL SEQUENCE; CARCINOGENESIS; CARCINOGENICITY; CELL INVASION; CELL MIGRATION; CELL PROLIFERATION; CELL SURVIVAL; CONTACT INHIBITION; DISTANT METASTASIS; DROSOPHILA MELANOGASTER; ENDOCYTOSIS; EPIGENETICS; GENE EXPRESSION; GENE MUTATION; GENE SILENCING; GENETIC REGULATION; GOLGI COMPLEX; GROWTH REGULATION; HUMAN; IMAGINAL DISC; LIGAND BINDING; LYSOSOME; METASTASIS; NEOVASCULARIZATION (PATHOLOGY); NONHUMAN; ONCOGENE; ORGAN GROWTH; PROTEIN FUNCTION; REVIEW; SIGNAL TRANSDUCTION; STEREOTYPY; TIGHT JUNCTION; TISSUE GROWTH; TUMOR CELL; TUMOR GENE; TUMOR INVASION; TUMOR SUPPRESSOR GENE; ANIMAL; GENETICS; HEDGEHOG; METABOLISM; MUTATION; NEOPLASM; PHYSIOLOGY;

ANIMALIA; DROSOPHILA MELANOGASTER;

ANIMALS; HEDGEHOGS; HUMANS; MUTATION; NEOPLASMS; RECEPTORS, NOTCH; SIGNAL TRANSDUCTION;

EID: 84901286739     PISSN: 10849521     EISSN: 10963634     Source Type: Journal    
DOI: 10.1016/j.semcdb.2014.04.012     Document Type: Review

References (65)

1. Hori K., Sen A., Artavanis-Tsakonas S. Notch signaling at a glance. J Cell Sci 2013, 126:2135-2140.
2. Kopan R., Ilagan M.X.G. The canonical Notch signaling pathway: unfolding the activation mechanism. Cell 2009, 137:216-233.
3. Andersson E.R., Sandberg R., Lendahl U. Notch signaling: simplicity in design, versatility in function. Development 2011, 138:3593-3612.
4. Miele L., Espinoza I., Pochampally, Watabe, Xing F. Notch signaling: targeting cancer stem cells and epithelial-to-mesenchymal transition. Ott 2013, 1249.
5. Palomero T., Sulis M.L., Cortina M., Real P.J., Barnes K., Ciofani M., et al. Mutational loss of PTEN induces resistance to NOTCH1 inhibition in T-cell leukemia. Nat Med 2007, 13:1203-1210.
6. Ntziachristos P., Tsirigos A., Van Vlierberghe P., Nedjic J., Trimarchi T., Flaherty M.S., et al. Genetic inactivation of the polycomb repressive complex 2 in T cell acute lymphoblastic leukemia. Nat Med 2012, 18:298-301.
7. Pallavi S.K., Ho D.M., Hicks C., Miele L., Artavanis-Tsakonas S. Notch and Mef2 synergize to promote proliferation and metastasis through JNK signal activation in Drosophila. EMBO J 2012, 31:2895-2907.
8. Vallejo D.M., Caparros E., Dominguez M. Targeting Notch signalling by the conserved miR-8/200 microRNA family in development and cancer cells. EMBO J 2011, 30:756-769.
9. Roti G., Carlton A., Ross K.N., Markstein M., Pajcini K., Su A.H., et al. Complementary genomic screens identify SERCA as a therapeutic target in NOTCH1 mutated cancer. Cancer Cell 2013, 23:390-405.
10. Wong C.C., Martincorena I., Rust A.G., Rashid M., Alifrangis C., et al. Inactivating CUX1 mutations promotes tumorigenesis. Nat Genet 2014, 46:33-38.
11. Irvine K.D., Rauskolb C. Boundaries in development: formation and function. Annu Rev Cell Dev Biol 2001, 17:189-214.
12. Vaccari T., Bilder D. At the crossroads of polarity, proliferation and apoptosis: the use of Drosophila to unravel the multifaceted role of endocytosis in tumor suppression. Mol Oncol 2009, 1-12.
13. Djiane A., Krejčí A., Feder B., Fexova S., Millen K., Bray S.J. Dissecting the mechanisms of Notch induced hyperplasia. EMBO J 2012, 32:60-71.
14. Roignant J.-Y., Treisman J.E. Pattern formation in the Drosophila eye disc. Int J Dev Biol 2009, 53:795-804.
15. Pecot C.V., Rupalmoole R., Yang D., Akbani R., Ivan C., et al. Tumour angiogenesis regulation by the miR200 family. Nat Commun 2013, 4:2427.
16. Brabletz S., Bajdak K., Meidhof S., Burk U., Niedermann G., Firat E., et al. The ZEB1/miR-200 feedback loop controls Notch signalling in cancer cells. EMBO J 2011, 1-13.
17. Thomas, David Strutt, Rabaptin-5 Rabex-5 are neoplastic tumour suppressor genes that interact to modulate Rab5 dynamics in Drosophila melanogaster. Dev Biol 2014, 385(January (1)):107-121.
18. Klein T. The tumour suppressor gene l(2)giant discs is required to restrict the activity of Notch to the dorsoventral boundary during Drosophila wing development. Dev Biol 2003, 255:313-333.
19. Childress J.L., Acar M., Tao C., Halder G. Lethal giant discs, a novel C2-domain protein, restricts Notch activation during endocytosis. Curr Biol 2006, 16:2228-2233.
20. Jaekel R., Klein T. The Drosophila Notch inhibitor and tumor suppressor gene lethal (2) giant discs encodes a conserved regulator of endosomal trafficking. Dev Cell 2006, 11:655-669.
21. Graves H.K., Woodfield S.E., Yang C.C., Halder G., Bergmann A. Notch signaling activates yorkie non-cell autonomously in Drosophila. PLoS ONE 2012, 7:e37615.
22. Thompson B.J., Mathieu J., Sung H.H., Loeser E., Rorth P., Cohen S.M. Tumor suppressor properties of the ESCRT-II complex component Vps25 in Drosophila. Dev Cell 2005, 9:711-720.
23. Moberg K.H., Schelble S., Burdick S.K., Hariharan I.K. Mutations in erupted, the Drosophila ortholog of mammalian tumor susceptibility gene 101, elicit non-cell-autonomous overgrowth. Dev Cell 2005, 9:699-710.
24. Herz H.M., Chen Z., Scherr H., Lackey M., Bolduc C., Bergmann A. vps25 mosaics display non-autonomous cell survival and overgrowth, and autonomous apoptosis. Development 2006, 133:1871-1880.
25. Vaccari T., Bilder D. The Drosophila tumor suppressor vps25 prevents nonautonomous overproliferation by regulating Notch trafficking. Dev Cell 2005, 9:687-698.
26. Chao J.L. Localized Notch signal acts through eyg and upd to promote global growth in Drosophila eye. Development 2004, 131:3839-3847.
27. Gutierrez-Aviñon F.J., Ferres-Marco D., Dominguez M. The position and function of the Notch-mediated eye growth organizer: the roles of JAK/STAT and four-jointed. EMBO Rep 2009, 10:1051-1058.
28. Dominguez M., Ferres-Marco D., Gutierrez-Aviño F.J., Speicher S.A., Beneyto M. Growth and specification of the eye are controlled independently by Eyegone and Eyeless in Drosophila. Nat Genet 2004, 36:31-39.
29. Ishikawa H.O., Takeuchi H., Haltiwanger R.S., Irvine K.D. Four-jointed is a golgi kinase that phosphorylates a subset of cadherin domains. Science 2008, 321:401-404.
30. Edgar B.A. From cell structure to transcription: hippo forges a new path. Cell 2006, 124(2):267-273.
31. Rock R., Heinrich A.C., Schumacher N., Gessler M. Fjx1: a Notch-inducible secreted ligand with specific binding sites in developing mouse embryos and adult brain. Dev Dyn 2005, 234:602-612.
32. Grzeschik N.A., Parsons L.M., Allott M.L., Harvey K.F., Richardson H.E. Lgl, aPKC, and Crumbs regulate the Salvador/Warts/Hippo pathway through two distinct mechanisms. Curr Biol 2010, 20(7):573-581.
33. Robinson B.S., Huang J., Hong Y., Moberg K.H. Crumbs regulates Salvador/Warts/Hippo signaling in Drosophila via the FERM-domain protein expanded. Curr Biol 2010, 20(7):582-590.
34. Chen C.L., Gajewski K.M., Hamaratoglu F., Bossuyt W., Sansores-Garcia L., Tao C., et al. The apical-basal cell polarity determinant Crumbs regulates Hippo signaling in Drosophila. Proc Natl Acad Sci USA 2010, 107(36):15810-15815.
35. Herranz H., Stamataki E., Feiguin F., Milan M. Self-refinement of Notch activity through the transmembrane protein Crumbs: modulation of gamma-Secretase activity. EMBO Rep 2006, 7:297-302.
36. Maitra S., Kulikauskas R.M., Gavilan H., Fehon R.G. The tumor suppressors Merlin and Expanded function cooperatively to modulate receptor endocytosis and signaling. Curr Biol 2006, 16:702-709.
37. Harvey K.F., Zhang X., Thomas D.M. The Hippo pathway and human cancer. Nat Rev Cancer 2013, 13:246-257. 10.1038/nrc3458.
38. Da Ros V.G., Gutierrez-Perez I., Ferres-Marco D., Dominguez M. Dampening the signals transduced through Hedgehog via microRNA miR-7 facilitates Notch-induced tumorigenesis. PLoS Biol 2013, 115:e1001554.
39. Martinez A.-M., Schuettengruber B., Sakr S., Janic A., Gonzalez C., Cavalli G. Polyhomeotic has a tumor suppressor activity mediated by repression of Notch signaling. Nat Genet 2009, 41:1076-1082.
40. Saj A., Arziman Z., Stempfle D., van Belle W., Sauder U., Horn T., et al. A combined ex vivo and in vivo RNAi screen for notch regulators in Drosophila reveals an extensive Notch interaction network. Dev Cell 2010, 18:862-876.
41. Classen A.-K., Bunker B.D., Harvey K.F., Vaccari T., Bilder D. A tumor suppressor activity of Drosophila Polycomb genes mediated by JAK-STAT signaling. Nat Genet 2009, 41:1150-1155.
42. Feng S., Huang J., Wang J. Loss of the Polycomb group gene polyhomeotic induces non-autonomous cell overproliferation. EMBO Rep 2011, 12:157-163.
43. Liefke R., Oswald F., Alvarado C., Ferres-Marco D., Mittler G., Rodriguez P., et al. Histone demethylase KDM5A is an integral part of the core Notch-RBP-J repressor complex. Genes Dev 2010, 24:590-601.
44. Herz H.M., Madden L.D., Chen Z., Bolduc C., Buff E., Gupta R., et al. The H3K27me3 demethylase dUTX is a suppressor of Notch- and Rb-dependent tumors in Drosophila. Mol Cell Biol 2010, 30:2485-2497.
45. Ranganathan P., Weaver K.L., Capobianco A.J. Notch signalling in solid tumours: a little bit of everything but not all the time. Nat Rev Cancer 2011, 11:336-351.
46. Ferres-Marco D., Gutierrez-Garcia I., Vallejo D.M., Bolivar J., Gutierrez-Aviño F.J., Dominguez M. Epigenetic silencers and Notch collaborate to promote malignant tumours by Rb silencing. Nature 2006, 439:430-436.
47. Pagliarini R.A. A genetic screen in Drosophila for metastatic behavior. Science 2003, 302:1227-1231.
48. Miles W.O., Dyson N.J., Walker J.A. Modeling tumor invasion and metastasis in Drosophila. Dis Model Mech 2011, 4:753-761.
49. Brumby A.M., Richardson H.E. scribble mutants cooperate with oncogenic Ras or Notch to cause neoplastic overgrowth in Drosophila. EMBO J 2003, 22:5769-5779.
50. Gonzalez C. Drosophila melanogaster: a model and a tool to investigate malignancy and identify new therapeutics. Nat Rev Cancer 2013, 13:172-183.
51. Thiery J.P., Acloque H., Huang R.Y.J., Nieto M.A. Epithelial-mesenchymal transitions in development and disease. Cell 2009, 139:871-890.
52. Shamir E.R., Pappalardo E., Jorgens D.M., Coutinho K., Tsai W.T., Aziz K., et al. Twist1-induced dissemination preserves epithelial identity and requires E-cadherin. J Cell Biol 2014, 204:839-856.
53. Friedl P., Locker J., Sahai E., Segall J.E. Classifying collective cancer cell invasion. Nat Cell Biol 2012, 14:777-783.
54. Leong G.R., Goulding K.R., Amin N., Richardson H.E., Brumby A.M. scribble mutants promote aPKC and JNK-dependent epithelial neoplasia independently of Crumbs. BMC Biol 2009, 7:62.
55. Ohsawa S., Sugimura K., Takino K., Xu T., Miyawaki A., Igaki T. Elimination of oncogenic neighbors by JNK-mediated engulfment in Drosophila. Dev Cell 2011, 20:315-328.
56. Uhlirova M., Bohmann D. JNK- and Fos-regulated Mmp1 expression cooperates with Ras to induce invasive tumors in Drosophila. EMBO J 2006, 25:5294-5304.
57. Beaucher M., Hersperger E., Page-McCaw A., Shearn A. Metastatic ability of Drosophila tumors depends on MMP activity. Dev Biol 2007, 303:625-634.
58. Bossuyt W., De Geest N., Aerts S., Leenaerts I., Marynen P., Hassan B.A. The atonal proneural transcription factor links differentiation and tumor formation in Drosophila. PLoS Biol 2009, 7:e40.
59. Rodahl L.M., Haglund K., Sem-Jacobsen C., Wendler F., Vincent J.P., Lindmo K., et al. Disruption of Vps4 and JNK function in Drosophila causes tumour growth. PLoS ONE 2009, 4:e4354.
60. Zhai Z., Ha N., Papagiannouli F., Hamacher-Brady A., Brady N., Sorge S., et al. Antagonistic regulation of apoptosis and differentiation by the cut transcription factor represents a tumor-suppressing mechanism in Drosophila. PLoS Genet 2012, 8:e1002582.
61. Najafov A., Şeker T., Even I., Hoxhaj G., Selvi O., Özel D.E., et al. MENA is a transcriptional target of the Wnt/beta-catenin pathway. PLoS ONE 2012, 7:e37013.
62. Petzoldt A.G., Gleixner E.M., Fumagalli A., Vaccari T., Simons M. Elevated expression of the V-ATPase C subunit triggers JNK-dependent cell invasion and overgrowth in a Drosophila epithelium. Dis Model Mech 2013, 6:689-700.
63. Hermle T., Guida M.C., Beck S., Helmstädter S., Simons M. Drosophila ATP6AP2/VhaPRR functions both as a novel planar cell polarity core protein and a regulator of endosomal trafficking. EMBO J 2013, 32:245-259.
64. Hori K., Sen A., Kirchhausen T., Artavanis-Tsakonas S. Synergy between the ESCRT-III complex and Deltex defines a ligand-independent Notch signal. J Cell Biol 2011, 195:1005-1015.
65. Schneider M., Troost T., Grawe F., Martinez Arias A., Klein T. Activation of Notch in lgd mutant cells requires the fusion of late endosomes with the lysosome. J Cell Sci 2013, 126:645-656.