메뉴 건너뛰기




Volumn 107, Issue 36, 2010, Pages 15810-15815

The apical-basal cell polarity determinant Crumbs regulates Hippo signaling in Drosophila

Author keywords

Cell proliferation; Imaginal discs; Organ size control; Tumor suppressor

Indexed keywords

ADAPTOR PROTEIN; CRUMBS PROTEIN; MEMBRANE PROTEIN; MERLIN; UNCLASSIFIED DRUG; CRUMBS PROTEIN, DROSOPHILA; DROSOPHILA PROTEIN; HPO PROTEIN, DROSOPHILA; PROTEIN SERINE THREONINE KINASE; SIGNAL PEPTIDE;

EID: 77957676987     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1004060107     Document Type: Article
Times cited : (256)

References (45)
  • 1
    • 0035674837 scopus 로고    scopus 로고
    • Epithelial cell polarity and cell junctions in Drosophila
    • DOI 10.1146/annurev.genet.35.102401.091415
    • Tepass U, Tanentzapf G, Ward R, Fehon R (2001) Epithelial cell polarity and cell junctions in Drosophila. Annu Rev Genet 35:747-784. (Pubitemid 34032991)
    • (2001) Annual Review of Genetics , vol.35 , pp. 747-784
    • Tepass, U.1    Tanentzapf, G.2
  • 2
    • 34447102014 scopus 로고    scopus 로고
    • Polarity regulators and the control of epithelial architecture, cell migration, and tumorigenesis
    • Dow LE, Humbert PO (2007) Polarity regulators and the control of epithelial architecture, cell migration, and tumorigenesis. Int Rev Cytol 262:253-302.
    • (2007) Int Rev Cytol , vol.262 , pp. 253-302
    • Dow, L.E.1    Humbert, P.O.2
  • 4
    • 56749170093 scopus 로고    scopus 로고
    • Control of tumourigenesis by the Scribble/Dlg/Lgl polarity module
    • Humbert PO, et al. (2008) Control of tumourigenesis by the Scribble/Dlg/Lgl polarity module. Oncogene 27:6888-6907.
    • (2008) Oncogene , vol.27 , pp. 6888-6907
    • Humbert, P.O.1
  • 5
    • 33845478597 scopus 로고    scopus 로고
    • Regulation of imaginal disc growth by tumor-suppressor genes in Drosophila
    • Hariharan IK, Bilder D (2006) Regulation of imaginal disc growth by tumor-suppressor genes in Drosophila. Annu Rev Genet 40:335-361.
    • (2006) Annu Rev Genet , vol.40 , pp. 335-361
    • Hariharan, I.K.1    Bilder, D.2
  • 6
    • 28544438939 scopus 로고    scopus 로고
    • Endocytic control of epithelial polarity and proliferation in Drosophila
    • Lu H, Bilder D (2005) Endocytic control of epithelial polarity and proliferation in Drosophila. Nat Cell Biol 7:1232-1239.
    • (2005) Nat Cell Biol , vol.7 , pp. 1232-1239
    • Lu, H.1    Bilder, D.2
  • 7
    • 4143119015 scopus 로고    scopus 로고
    • DaPKC-dependent phosphorylation of Crumbs is required for epithelial cell polarity in Drosophila
    • DOI 10.1083/jcb.200311031
    • Sotillos S, Díaz-Meco MT, Caminero E, Moscat J, Campuzano S (2004) DaPKC-dependent phosphorylation of Crumbs is required for epithelial cell polarity in Drosophila. J Cell Biol 166:549-557. (Pubitemid 39097174)
    • (2004) Journal of Cell Biology , vol.166 , Issue.4 , pp. 549-557
    • Sotillos, S.1    Diaz-Meco, M.T.2    Caminero, E.3    Moscat, J.4    Campuzano, S.5
  • 8
    • 27644568520 scopus 로고    scopus 로고
    • The Drosophila tumor suppressor vps25 prevents nonautonomous overproliferation by regulating notch trafficking
    • Vaccari T, Bilder D (2005) The Drosophila tumor suppressor vps25 prevents nonautonomous overproliferation by regulating notch trafficking. Dev Cell 9:687-698.
    • (2005) Dev Cell , vol.9 , pp. 687-698
    • Vaccari, T.1    Bilder, D.2
  • 9
    • 0025285657 scopus 로고
    • Crumbs encodes an EGF-like protein expressed on apical membranes of Drosophila epithelial cells and required for organization of epithelia
    • Tepass U, Theres C, Knust E (1990) crumbs encodes an EGF-like protein expressed on apical membranes of Drosophila epithelial cells and required for organization of epithelia. Cell 61:787-799. (Pubitemid 120035109)
    • (1990) Cell , vol.61 , Issue.5 , pp. 787-799
    • Tepass, U.1    Theres, C.2    Knust, E.3
  • 10
    • 0033953429 scopus 로고    scopus 로고
    • A conserved motif in Crumbs is required for E-cadherin localisation and zonula adherens formation in Drosophila
    • Klebes A, Knust E (2000) A conserved motif in Crumbs is required for E-cadherin localisation and zonula adherens formation in Drosophila. Curr Biol 10:76-85.
    • (2000) Curr Biol , vol.10 , pp. 76-85
    • Klebes, A.1    Knust, E.2
  • 11
    • 33847206401 scopus 로고    scopus 로고
    • The Salvador-Warts-Hippo pathway - An emerging tumour-suppressor network
    • DOI 10.1038/nrc2070, PII NRC2070
    • Harvey K, Tapon N (2007) The Salvador-Warts-Hippo pathway - An emerging tumoursuppressor network. Nat Rev Cancer 7:182-191. (Pubitemid 46310494)
    • (2007) Nature Reviews Cancer , vol.7 , Issue.3 , pp. 182-191
    • Harvey, K.1    Tapon, N.2
  • 12
    • 48749118705 scopus 로고    scopus 로고
    • The Fat and Warts signaling pathways: New insights into their regulation, mechanism and conservation
    • Reddy BV, Irvine KD (2008) The Fat and Warts signaling pathways: New insights into their regulation, mechanism and conservation. Development 135:2827-2838.
    • (2008) Development , vol.135 , pp. 2827-2838
    • Reddy, B.V.1    Irvine, K.D.2
  • 13
    • 34247191134 scopus 로고    scopus 로고
    • Hippo signaling in organ size control
    • Pan D (2007) Hippo signaling in organ size control. Genes Dev 21:886-897.
    • (2007) Genes Dev , vol.21 , pp. 886-897
    • Pan, D.1
  • 14
    • 70549083563 scopus 로고    scopus 로고
    • Herding Hippos: Regulating growth in flies and man
    • Badouel C, Garg A, McNeill H (2009) Herding Hippos: Regulating growth in flies and man. Curr Opin Cell Biol 21:837-843.
    • (2009) Curr Opin Cell Biol , vol.21 , pp. 837-843
    • Badouel, C.1    Garg, A.2    McNeill, H.3
  • 15
    • 54449090287 scopus 로고    scopus 로고
    • Boundaries of Dachsous Cadherin activity modulate the Hippo signaling pathway to induce cell proliferation
    • Willecke M, Hamaratoglu F, Sansores-Garcia L, Tao C, Halder G (2008) Boundaries of Dachsous Cadherin activity modulate the Hippo signaling pathway to induce cell proliferation. Proc Natl Acad Sci USA 105:14897-14902.
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 14897-14902
    • Willecke, M.1    Hamaratoglu, F.2    Sansores-Garcia, L.3    Tao, C.4    Halder, G.5
  • 16
    • 76249109900 scopus 로고    scopus 로고
    • Kibra functions as a tumor suppressor protein that regulates Hippo signaling in conjunction with Merlin and Expanded
    • Yu J, et al. (2010) Kibra functions as a tumor suppressor protein that regulates Hippo signaling in conjunction with Merlin and Expanded. Dev Cell 18:288-299.
    • (2010) Dev Cell , vol.18 , pp. 288-299
    • Yu, J.1
  • 18
    • 76249093838 scopus 로고    scopus 로고
    • Kibra is a regulator of the Salvador/Warts/Hippo signaling network
    • Genevet A, Wehr MC, Brain R, Thompson BJ, Tapon N (2010) Kibra is a regulator of the Salvador/Warts/Hippo signaling network. Dev Cell 18:300-308.
    • (2010) Dev Cell , vol.18 , pp. 300-308
    • Genevet, A.1    Wehr, M.C.2    Brain, R.3    Thompson, B.J.4    Tapon, N.5
  • 19
    • 30344445706 scopus 로고    scopus 로고
    • The tumour-suppressor genes NF2/Merlin and Expanded act through Hippo signalling to regulate cell proliferation and apoptosis
    • Hamaratoglu F, et al. (2006) The tumour-suppressor genes NF2/Merlin and Expanded act through Hippo signalling to regulate cell proliferation and apoptosis. Nat Cell Biol 8:27-36.
    • (2006) Nat Cell Biol , vol.8 , pp. 27-36
    • Hamaratoglu, F.1
  • 20
    • 42049120338 scopus 로고    scopus 로고
    • The TEAD/TEF family of transcription factor Scalloped mediates Hippo signaling in organ size control
    • Zhang L, et al. (2008) The TEAD/TEF family of transcription factor Scalloped mediates Hippo signaling in organ size control. Dev Cell 14:377-387.
    • (2008) Dev Cell , vol.14 , pp. 377-387
    • Zhang, L.1
  • 21
    • 33749125438 scopus 로고    scopus 로고
    • Delineation of a Fat tumor suppressor pathway
    • Cho E, et al. (2006) Delineation of a Fat tumor suppressor pathway. Nat Genet 38: 1142-1150.
    • (2006) Nat Genet , vol.38 , pp. 1142-1150
    • Cho, E.1
  • 22
    • 76449098074 scopus 로고    scopus 로고
    • Crumbs is required to achieve proper organ size control during Drosophila head development
    • Richardson EC, Pichaud F (2010) Crumbs is required to achieve proper organ size control during Drosophila head development. Development 137:641-650.
    • (2010) Development , vol.137 , pp. 641-650
    • Richardson, E.C.1    Pichaud, F.2
  • 23
    • 0141616617 scopus 로고    scopus 로고
    • Hippo promotes proliferation arrest and apoptosis in the Salvador/Warts pathway
    • DOI 10.1038/ncb1050
    • Udan RS, Kango-Singh M, Nolo R, Tao C, Halder G (2003) Hippo promotes proliferation arrest and apoptosis in the Salvador/Warts pathway. Nat Cell Biol 5: 914-920. (Pubitemid 37220698)
    • (2003) Nature Cell Biology , vol.5 , Issue.10 , pp. 914-920
    • Udan, R.S.1    Kango-Singh, M.2    Nolo, R.3    Tao, C.4    Halder, G.5
  • 24
    • 33750614445 scopus 로고    scopus 로고
    • The fat cadherin acts through the hippo tumor-suppressor pathway to regulate tissue size
    • Willecke M, et al. (2006) The fat cadherin acts through the hippo tumor-suppressor pathway to regulate tissue size. Curr Biol 16:2090-2100.
    • (2006) Curr Biol , vol.16 , pp. 2090-2100
    • Willecke, M.1
  • 25
    • 33750624298 scopus 로고    scopus 로고
    • The tumor-suppressor gene fat controls tissue growth upstream of expanded in the hippo signaling pathway
    • Silva E, Tsatskis Y, Gardano L, Tapon N, McNeill H (2006) The tumor-suppressor gene fat controls tissue growth upstream of expanded in the hippo signaling pathway. Curr Biol 16:2081-2089.
    • (2006) Curr Biol , vol.16 , pp. 2081-2089
    • Silva, E.1    Tsatskis, Y.2    Gardano, L.3    Tapon, N.4    McNeill, H.5
  • 26
    • 33746410714 scopus 로고    scopus 로고
    • Dachs: An unconventional myosin that functions downstream of Fat to regulate growth, affinity and gene expression in Drosophila
    • DOI 10.1242/dev.02427
    • Mao Y, et al. (2006) Dachs: An unconventional myosin that functions downstream of Fat to regulate growth, affinity and gene expression in Drosophila. Development 133:2539-2551. (Pubitemid 44123403)
    • (2006) Development , vol.133 , Issue.13 , pp. 2539-2551
    • Mao, Y.1    Rauskolb, C.2    Cho, E.3    Hu, W.-L.4    Hayter, H.5    Minihan, G.6    Katz, F.N.7    Irvine, K.D.8
  • 27
    • 0035818984 scopus 로고    scopus 로고
    • Drosophila Stardust is a partner of Crumbs in the control of epithelial cell polarity
    • BachmannA, SchneiderM,Theilenberg E,Grawe F, Knust E (2001) Drosophila Stardust is a partner of Crumbs in the control of epithelial cell polarity. Nature 414:638-643.
    • (2001) Nature , vol.414 , pp. 638-643
    • Bachmann, A.1    Schneider, M.2    Theilenberg, E.3    Grawe, F.4    Knust, E.5
  • 28
    • 0035819005 scopus 로고    scopus 로고
    • Drosophila Stardust interacts with Crumbs to control polarity of epithelia but not neuroblasts
    • Hong Y, Stronach B, Perrimon N, Jan LY, Jan YN (2001) Drosophila Stardust interacts with Crumbs to control polarity of epithelia but not neuroblasts. Nature 414:634-638.
    • (2001) Nature , vol.414 , pp. 634-638
    • Hong, Y.1    Stronach, B.2    Perrimon, N.3    Jan, L.Y.4    Jan, Y.N.5
  • 29
    • 0037075546 scopus 로고    scopus 로고
    • Drosophila Crumbs is a positional cue in photoreceptor adherens junctions and rhabdomeres
    • DOI 10.1038/nature720
    • Izaddoost S, Nam SC, Bhat MA, Bellen HJ, Choi KW (2002) Drosophila Crumbs is a positional cue in photoreceptor adherens junctions and rhabdomeres. Nature 416: 178-183. (Pubitemid 34246475)
    • (2002) Nature , vol.416 , Issue.6877 , pp. 178-182
    • Izaddoost, S.1    Nam, S.-C.2    Bhat, M.A.3    Bellen, H.J.4    Choi, K.-W.5
  • 30
    • 33747834891 scopus 로고    scopus 로고
    • The FERM protein Yurt is a negative regulatory component of the Crumbs complex that controls epithelial polarity and apical membrane size
    • Laprise P, et al. (2006) The FERM protein Yurt is a negative regulatory component of the Crumbs complex that controls epithelial polarity and apical membrane size. Dev Cell 11:363-374.
    • (2006) Dev Cell , vol.11 , pp. 363-374
    • Laprise, P.1
  • 31
    • 0037009044 scopus 로고    scopus 로고
    • Crumbs interacts with moesin and beta(Heavy)-spectrin in the apical membrane skeleton of Drosophila
    • Médina E, et al. (2002) Crumbs interacts with moesin and beta(Heavy)-spectrin in the apical membrane skeleton of Drosophila. J Cell Biol 158:941-951.
    • (2002) J Cell Biol , vol.158 , pp. 941-951
    • Médina, E.1
  • 32
    • 0034645049 scopus 로고    scopus 로고
    • Apical, lateral, and basal polarization cues contribute to the development of the follicular epithelium during Drosophila oogenesis
    • Tanentzapf G, Smith C, McGlade J, Tepass U (2000) Apical, lateral, and basal polarization cues contribute to the development of the follicular epithelium during Drosophila oogenesis. J Cell Biol 151:891-904.
    • (2000) J Cell Biol , vol.151 , pp. 891-904
    • Tanentzapf, G.1    Smith, C.2    McGlade, J.3    Tepass, U.4
  • 33
    • 38049103263 scopus 로고    scopus 로고
    • Fat and expanded act in parallel to regulate growth through warts
    • Feng Y, Irvine KD (2007) Fat and expanded act in parallel to regulate growth through warts. Proc Natl Acad Sci USA 104:20362-20367.
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 20362-20367
    • Feng, Y.1    Irvine, K.D.2
  • 34
    • 77953738883 scopus 로고    scopus 로고
    • The apical transmembrane protein Crumbs functions as a tumor suppressor that regulates Hippo signaling by binding to Expanded
    • Ling C, et al. (2010) The apical transmembrane protein Crumbs functions as a tumor suppressor that regulates Hippo signaling by binding to Expanded. Proc Natl Acad Sci USA 107:10532-10537.
    • (2010) Proc Natl Acad Sci USA , vol.107 , pp. 10532-10537
    • Ling, C.1
  • 35
    • 77950478873 scopus 로고    scopus 로고
    • Crumbs regulates Salvador/Warts/Hippo signaling in Drosophila via the FERM-domain protein Expanded
    • Robinson BS, Huang J, Hong Y, Moberg KH (2010) Crumbs regulates Salvador/Warts/Hippo signaling in Drosophila via the FERM-domain protein Expanded. Curr Biol 20:582-590.
    • (2010) Curr Biol , vol.20 , pp. 582-590
    • Robinson, B.S.1    Huang, J.2    Hong, Y.3    Moberg, K.H.4
  • 36
    • 61749089153 scopus 로고    scopus 로고
    • The FERM-domain protein Expanded regulates Hippo pathway activity via direct interactions with the transcriptional activator Yorkie
    • Badouel C, et al. (2009) The FERM-domain protein Expanded regulates Hippo pathway activity via direct interactions with the transcriptional activator Yorkie. Dev Cell 16:411-420.
    • (2009) Dev Cell , vol.16 , pp. 411-420
    • Badouel, C.1
  • 37
    • 72649099866 scopus 로고    scopus 로고
    • Mob as tumor suppressor is activated at the cell membrane to control tissue growth and organ size in Drosophila
    • Ho LL, Wei X, Shimizu T, Lai ZC (2010) Mob as tumor suppressor is activated at the cell membrane to control tissue growth and organ size in Drosophila. Dev Biol 337:274-283.
    • (2010) Dev Biol , vol.337 , pp. 274-283
    • Ho, L.L.1    Wei, X.2    Shimizu, T.3    Lai, Z.C.4
  • 38
    • 0029045343 scopus 로고
    • Expression of crumbs confers apical character on plasma membrane domains of ectodermal epithelia of Drosophila
    • Wodarz A, Hinz U, Engelbert M, Knust E (1995) Expression of crumbs confers apical character on plasma membrane domains of ectodermal epithelia of Drosophila. Cell 82:67-76.
    • (1995) Cell , vol.82 , pp. 67-76
    • Wodarz, A.1    Hinz, U.2    Engelbert, M.3    Knust, E.4
  • 39
    • 69649104042 scopus 로고    scopus 로고
    • The Hippo tumor-suppressor pathway regulates apicaldomain size in parallel to tissue growth
    • Hamaratoglu F, et al. (2009) The Hippo tumor-suppressor pathway regulates apicaldomain size in parallel to tissue growth. J Cell Sci 122:2351-2359.
    • (2009) J Cell Sci , vol.122 , pp. 2351-2359
    • Hamaratoglu, F.1
  • 40
    • 69649091710 scopus 로고    scopus 로고
    • The Hippo pathway regulates apical-domain size independently of its growth-control function
    • Genevet A, et al. (2009) The Hippo pathway regulates apical-domain size independently of its growth-control function. J Cell Sci 122:2360-2370.
    • (2009) J Cell Sci , vol.122 , pp. 2360-2370
    • Genevet, A.1
  • 41
    • 0037075580 scopus 로고    scopus 로고
    • Crumbs, the Drosophila homologue of human CRB1/RP12, is essential for photoreceptor morphogenesis
    • DOI 10.1038/nature721
    • Pellikka M, et al. (2002) Crumbs, the Drosophila homologue of human CRB1/RP12, is essential for photoreceptor morphogenesis. Nature 416:143-149. (Pubitemid 34246466)
    • (2002) Nature , vol.416 , Issue.6877 , pp. 143-149
    • Pellikka, M.1    Tanentzapf, G.2    Pinto, M.3    Smith, C.4    McGlade, C.J.5    Ready, D.F.6    Tepass, U.7
  • 42
    • 33645777828 scopus 로고    scopus 로고
    • Self-refinement of Notch activity through the transmembrane protein Crumbs: Modulation of gamma-secretase activity
    • Herranz H, Stamataki E, Feiguin F, Milán M (2006) Self-refinement of Notch activity through the transmembrane protein Crumbs: Modulation of gamma-secretase activity. EMBO Rep 7:297-302.
    • (2006) EMBO Rep , vol.7 , pp. 297-302
    • Herranz, H.1    Stamataki, E.2    Feiguin, F.3    Milán, M.4
  • 43
    • 77951837150 scopus 로고    scopus 로고
    • The Hippo-YAP pathway in organ size control and tumorigenesis: An updated version
    • Zhao B, Li L, Lei Q, Guan KL (2010) The Hippo-YAP pathway in organ size control and tumorigenesis: An updated version. Genes Dev 24:862-874.
    • (2010) Genes Dev , vol.24 , pp. 862-874
    • Zhao, B.1    Li, L.2    Lei, Q.3    Guan, K.L.4
  • 45
    • 49249121662 scopus 로고    scopus 로고
    • Role of the polarity determinant crumbs in suppressing mammalian epithelial tumor progression
    • Karp CM, et al. (2008) Role of the polarity determinant crumbs in suppressing mammalian epithelial tumor progression. Cancer Res 68:4105-4115.
    • (2008) Cancer Res , vol.68 , pp. 4105-4115
    • Karp, C.M.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.