MENA is a transcriptional target of the Wnt/beta-catenin pathway

PLoS ONE

Volumn 7, Issue 5, 2012, Pages

  Najafov, Ayaz ^a,b   Şeker, Tuncay ^a   Even, Ipek ^a   Hoxhaj, Gerta ^a   Selvi, Osman ^a   Özel, Duygu Esen ^c   Koman, Ahmet ^a   Birgül Iyison, Necla ^a  

^a BOGAZICI UNIVERSITY   (Turkey)

^b UNIVERSITY OF DUNDEE   (United Kingdom)

^c DEPARTMENT OF PLANT SYSTEMS BIOLOGY   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

BETA CATENIN; GLYCOGEN SYNTHASE KINASE 3BETA; LITHIUM CHLORIDE; MESSENGER RNA; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR TCF4; UNCLASSIFIED DRUG; WNT PROTEIN; WNT1 PROTEIN; WNT3A PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BINDING SITE; CONTROLLED STUDY; DROSOPHILA MELANOGASTER; ENZYME INHIBITION; EYE CANCER; GENE; GENE TARGETING; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; MENA GENE; METASTASIS; MOUSE; NONHUMAN; PROMOTER REGION; PROTEIN DNA INTERACTION; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; TUMOR GROWTH; UPREGULATION;

ANIMALS; BASIC HELIX-LOOP-HELIX LEUCINE ZIPPER TRANSCRIPTION FACTORS; BETA CATENIN; BINDING SITES; CELL LINE, TRANSFORMED; CHROMATIN IMMUNOPRECIPITATION; DNA-BINDING PROTEINS; DROSOPHILA; GLYCOGEN SYNTHASE KINASE 3; HEK293 CELLS; HUMANS; LIGANDS; LUCIFERASES; MICE; MICE, INBRED C57BL; MICROFILAMENT PROTEINS; PROMOTER REGIONS, GENETIC; RNA, MESSENGER; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC; TRANSCRIPTIONAL ACTIVATION; UP-REGULATION; WNT PROTEINS;

DROSOPHILA MELANOGASTER; MAMMALIA;

EID: 84861207252     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0037013     Document Type: Article

References (44)

1. Cadigan KM, Nusse R, (1997) Wnt signaling: a common theme in animal development. Genes Dev 11: 3286-3305.
2. Peifer M, Polakis P, (2000) Wnt signaling in oncogenesis and embryogenesis-a look outside the nucleus. Science 287: 1606-1609.
3. Polakis P, (2000) Genes Dev 14: 1837-1851.
4. Stambolic V, Ruel L, Woodgett JR, (1996) Lithium inhibits glycogen synthase kinase-3 activity and mimics wingless signalling in intact cells. Curr Biol 6: 1664-1668.
5. Behrens J, Jerchow BA, Wurtele M, Grimm J, Asbrand C, et al. (1998) Functional interaction of an axin homolog, conductin, with beta-catenin, APC, and GSK3beta. Science 280: 596-599.
6. Behrens J, Jerchow BA, Wurtele M, Grimm J, Asbrand C, et al. (1998) Functional interaction of an axin homolog, conductin, with beta-catenin, APC, and GSK3beta. Science 280: 596-599.
7. Hart MJ, de los Santos R, Albert IN, Rubinfeld B, Polakis P, (1998) Downregulation of beta-catenin by human Axin and its association with the APC tumor suppressor, beta-catenin and GSK3 beta. Curr Biol 8: 573-581.
8. Lin SY, Xia W, Wang JC, Kwong KY, Spohn B, et al. (2000) Beta-catenin, a novel prognostic marker for breast cancer: its roles in cyclin D1 expression and cancer progression. Proc Natl Acad Sci U S A 97: 4262-4266.
9. Ryo A, Nakamura M, Wulf G, Liou YC, Lu KP, (2001) Pin1 regulates turnover and subcellular localization of beta-catenin by inhibiting its interaction with APC. Nat Cell Biol 3: 793-801.
10. Ugolini F, Charafe-Jauffret E, Bardou VJ, Geneix J, Adelaide J, et al. (2001) WNT pathway and mammary carcinogenesis: loss of expression of candidate tumor suppressor gene SFRP1 in most invasive carcinomas except of the medullary type. Oncogene 20: 5810-5817.
11. Wissmann C, Wild PJ, Kaiser S, Roepcke S, Stoehr R, et al. (2003) WIF1, a component of the Wnt pathway, is down-regulated in prostate, breast, lung, and bladder cancer. J Pathol 201: 204-212.
12. Hoschuetzky H, Aberle H, Kemler R, (1994) Beta-catenin mediates the interaction of the cadherin-catenin complex with epidermal growth factor receptor. J Cell Biol 127: 1375-1380.
13. Shibamoto S, Hayakawa M, Takeuchi K, Hori T, Oku N, et al. (1994) Tyrosine phosphorylation of beta-catenin and plakoglobin enhanced by hepatocyte growth factor and epidermal growth factor in human carcinoma cells. Cell Adhes Commun 1: 295-305.
14. Kanai Y, Ochiai A, Shibata T, Oyama T, Ushijima S, et al. (1995) c-erbB-2 gene product directly associates with beta-catenin and plakoglobin. Biochem Biophys Res Commun 208: 1067-1072.
15. Adam L, Vadlamudi RK, McCrea P, Kumar R, (2001) Tiam1 overexpression potentiates heregulin-induced lymphoid enhancer factor-1/beta-catenin nuclear signaling in breast cancer cells by modulating the intercellular stability. J Biol Chem 276: 28443-28450.
16. Schroeder JA, Adriance MC, McConnell EJ, Thompson MC, Pockaj B, et al. (2002) ErbB-beta-catenin complexes are associated with human infiltrating ductal breast and murine mammary tumor virus (MMTV)-Wnt-1 and MMTV-c-Neu transgenic carcinomas. J Biol Chem 277: 22692-22698.
17. Playford MP, Bicknell D, Bodmer WF, Macaulay VM, (2000) Insulin-like growth factor 1 regulates the location, stability, and transcriptional activity of beta-catenin. Proc Natl Acad Sci U S A 97: 12103-12108.
18. Danilkovitch-Miagkova A, Miagkov A, Skeel A, Nakaigawa N, Zbar B, et al. (2001) Oncogenic mutants of RON and MET receptor tyrosine kinases cause activation of the beta-catenin pathway. Mol Cell Biol 21: 5857-5868.
19. Kim K, Lee KY, (2001) Tyrosine phosphorylation translocates beta-catenin from cell-cell interface to the cytoplasm, but does not significantly enhance the LEF-1-dependent transactivating function. Cell Biol Int 25: 421-427.
20. Arteaga CL, (2002) Overview of epidermal growth factor receptor biology and its role as a therapeutic target in human neoplasia. Semin Oncol 29: 3-9.
21. Normanno N, Bianco C, De Luca A, Maiello MR, Salomon DS, (2003) Target-based agents against ErbB receptors and their ligands: a novel approach to cancer treatment. Endocr Relat Cancer 10: 1-21.
22. Pawlak G, Helfman DM, (2001) Cytoskeletal changes in cell transformation and tumorigenesis. Curr Opin Genet Dev 11: 41-47.
23. Kwiatkowski AV, Gertler FB, Loureiro JJ, (2003) Function and regulation of Ena/VASP proteins. Trends Cell Biol 13: 386-392.
24. Di Modugno F, Bronzi G, Scanlan MJ, Del Bello D, Cascioli S, et al. (2004) Human Mena protein, a serex-defined antigen overexpressed in breast cancer eliciting both humoral and CD8+ T-cell immune response. Int J Cancer 109: 909-918.
25. Kavak E, Najafov A, Ozturk N, Seker T, Cavusoglu K, et al. (2010) Cell Signal 22: 1523-1535.
26. Morin PJ, Sparks AB, Korinek V, Barker N, Clevers H, et al. (1997) Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC. Science 275: 1787-1790.
27. Cha MY, Kim CM, Park YM, Ryu WS, (2004) Hepatitis B virus X protein is essential for the activation of Wnt/beta-catenin signaling in hepatoma cells. Hepatology 39: 1683-1693.
28. Gurzu S, Jung I, Prantner I, Ember I, Pavai Z, et al. (2008) The expression of cytoskeleton regulatory protein Mena in colorectal lesions. Rom J Morphol Embryol 49: 345-349.
29. Toyoda A, Kawana H, Azuhata K, Yu J, Omata A, et al. (2009) Aberrant expression of human ortholog of mammalian enabled (hMena) in human colorectal carcinomas: implications for its role in tumor progression. Int J Oncol 34: 53-60.
30. Tao W, Pennica D, Xu L, Kalejta RF, Levine AJ, (2001) Wrch-1, a novel member of the Rho gene family that is regulated by Wnt-1. Genes Dev 15: 1796-1807.
31. Blair IP, Chetcuti AF, Badenhop RF, Scimone A, Moses MJ, et al. (2006) Positional cloning, association analysis and expression studies provide convergent evidence that the cadherin gene FAT contains a bipolar disorder susceptibility allele. Mol Psychiatry 11: 372-383.
32. Menzies AS, Aszodi A, Williams SE, Pfeifer A, Wehman AM, et al. (2004) Mena and vasodilator-stimulated phosphoprotein are required for multiple actin-dependent processes that shape the vertebrate nervous system. J Neurosci 24: 8029-8038.
33. Lindwall C, Fothergill T, Richards LJ, (2007) Commissure formation in the mammalian forebrain. Curr Opin Neurobiol 17: 3-14.
34. Kahler AK, Djurovic S, Kulle B, Jonsson EG, Agartz I, et al. (2008) Association analysis of schizophrenia on 18 genes involved in neuronal migration: MDGA1 as a new susceptibility gene. Am J Med Genet B Neuropsychiatr Genet 147B: 1089-1100.
35. Katsu T, Ujike H, Nakano T, Tanaka Y, Nomura A, et al. (2003) The human frizzled-3 (FZD3) gene on chromosome 8p21, a receptor gene for Wnt ligands, is associated with the susceptibility to schizophrenia. Neurosci Lett 353: 53-56.
36. Miyaoka T, Seno H, Ishino H, (1999) Increased expression of Wnt-1 in schizophrenic brains. Schizophr Res 38: 1-6.
37. Yang SD, Yu JS, Lee TT, Yang CC, Ni MH, et al. (1995) Dysfunction of protein kinase FA/GSK-3 alpha in lymphocytes of patients with schizophrenic disorder. J Cell Biochem 59: 108-116.
38. Bottomly D, Kyler SL, McWeeney SK, Yochum GS, (2010) Identification of {beta}-catenin binding regions in colon cancer cells using ChIP-Seq. Nucleic Acids Res 38: 5735-45.
39. Nicolas M, Wolfer A, Raj K, Kummer JA, Mill P, et al. (2003) Notch1 functions as a tumor suppressor in mouse skin. Nat Genet 33: 416-421.
40. Reya T, Clevers H, (2005) Wnt signalling in stem cells and cancer. Nature 434: 843-850.
41. Di Modugno F, DeMonte L, Balsamo M, Bronzi G, Nicotra MR, et al. (2007) Molecular cloning of hMena (ENAH) and its splice variant hMena+11a: epidermal growth factor increases their expression and stimulates hMena+11a phosphorylation in breast cancer cell lines. Cancer Res 67: 2657-2665.
42. Pino MS, Balsamo M, Di Modugno F, Mottolese M, Alessio M, et al. (2008) Human Mena+11a isoform serves as a marker of epithelial phenotype and sensitivity to epidermal growth factor receptor inhibition in human pancreatic cancer cell lines. Clin Cancer Res 14: 4943-4950.
43. He TC, Sparks AB, Rago C, Hermeking H, Zawel L, et al. (1998) Identification of c-MYC as a target of the APC pathway. Science 281: 1509-1512.
44. Kim J, Seo J, Lee YS, Kim S, (2005) TFExplorer: integrated analysis database for predicted transcription regulatory elements. Bioinformatics 21: 548-550.