Epidermal growth factor receptor inhibitor ameliorates excessive astrogliosis and improves the regeneration microenvironment and functional recovery in adult rats following spinal cord injury

Journal of Neuroinflammation

Volumn 11, Issue , 2014, Pages

  Li, Zai Wang ^a   Li, Ji Jun ^b   Wang, Lan ^c   Zhang, Jian Ping ^a   Wu, Jing Jing ^a   Mao, Xu Qiang ^a   Shi, Guo Feng ^a   Wang, Qian ^b   Wang, Feng ^a   Zou, Jian ^a,d  

^a WUXI PEOPLE S HOSPITAL AFFILIATED TO NANJING MEDICAL UNIVERSITY   (China)

^b SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

^c Wuxi 9th People s Hospital Affiliated to Suzhou Medical College of Soochow University   (China)

^d Wuxi Clinical Science Research Institute   (China)

Author keywords

Astrogliosis; Epidermal growth factor receptor; Regeneration microenvironment; Spinal cord injury

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR; EPIDERMAL GROWTH FACTOR RECEPTOR KINASE INHIBITOR; GLIAL FIBRILLARY ACIDIC PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 1BETA; N [4 (3 BROMOANILINO) 6 QUINAZOLINYL]ACRYLAMIDE; PROTEOCHONDROITIN SULFATE; TUMOR NECROSIS FACTOR ALPHA; BROXURIDINE; CYCLOOXYGENASE 2; MYELIN; PD168393; QUINAZOLINE DERIVATIVE;

ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASTROCYTOSIS; CELL ACTIVATION; CELL LEVEL; CELL PROLIFERATION; CELL REGENERATION; CELL SURVIVAL; CELL VOLUME; CONTROLLED STUDY; CYTOKINE RELEASE; DRUG EFFICACY; DRUG MECHANISM; DRUG POTENCY; DRUG RESPONSE; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; IMMUNOFLUORESCENCE TEST; IN VITRO STUDY; IN VIVO STUDY; MOLECULAR DYNAMICS; NONHUMAN; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; QUANTITATIVE ANALYSIS; RAT; SIGNAL TRANSDUCTION; SPINAL CORD INJURY; WESTERN BLOTTING; ASTROCYTE; BLADDER FUNCTION; CELL DAMAGE; CELL LOSS; CONVALESCENCE; CORRELATION ANALYSIS; CULTURE MEDIUM; DEMYELINATION; FUNCTIONAL STATUS; HINDLIMB; IMMUNOFLUORESCENCE; INHIBITION KINETICS; MICROENVIRONMENT; MOTOR PERFORMANCE; NERVE CELL; NERVE FIBER REGENERATION; NEWBORN; RESIDUAL URINE; ANIMAL; ANTAGONISTS AND INHIBITORS; CELL CULTURE; COMPLICATION; DISEASE MODEL; DRUG EFFECTS; EXPLORATORY BEHAVIOR; GLIOSIS; KIDNEY DISEASES; METABOLISM; PHOSPHORYLATION; PHYSIOLOGY; REGENERATION; SPRAGUE DAWLEY RAT;

ANIMALS; ANIMALS, NEWBORN; ASTROCYTES; CELLS, CULTURED; DISEASE MODELS, ANIMAL; EXPLORATORY BEHAVIOR; FEMALE; GLIAL FIBRILLARY ACIDIC PROTEIN; GLIOSIS; KIDNEY DISEASES; PHOSPHORYLATION; QUINAZOLINES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, EPIDERMAL GROWTH FACTOR; RECOVERY OF FUNCTION; REGENERATION; SPINAL CORD INJURIES;

EID: 84901271301     PISSN: None     EISSN: 17422094     Source Type: Journal    
DOI: 10.1186/1742-2094-11-71     Document Type: Article

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