Characterization of EGFR and ErbB2 expression in atopic dermatitis patients

Archives of Dermatological Research

Volumn 304, Issue 10, 2012, Pages 773-780

  Sääf, Annika ^a   Pivarcsi, Andor ^a   Winge, Mårten C G ^a,b   Wahlgren, Carl Fredrik ^b   Homey, Bernhard ^c   Nordenskjöld, Magnus ^a   Tengvall Linder, Maria ^a   Bradley, Maria ^a,b  

^a KAROLINSKA INSTITUTE   (Sweden)

^b KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^c UNIVERSITY HOSPITAL DÜSSELDORF   (Germany)

Author keywords

Atopic dermatitis; CCL26; DNA microarray; EGFR; ErbB2; Keratinocytes

Indexed keywords

EOTAXIN 3; EPIDERMAL GROWTH FACTOR RECEPTOR; EPIDERMAL GROWTH FACTOR RECEPTOR 2; INTERLEUKIN 4;

ADULT; ARTICLE; ATOPIC DERMATITIS; CELL DIFFERENTIATION; CELL PROLIFERATION; CLINICAL ARTICLE; CONTROLLED STUDY; EGRF GENE; EPIDERMIS; ERBB2 GENE; FEMALE; GENE FUNCTION; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IMMUNOPATHOGENESIS; IN VITRO STUDY; INFLAMMATION; KERATINOCYTE; MALE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SKIN; TH2 CELL; TRANSCRIPTION REGULATION;

ADOLESCENT; ADULT; CELL DIFFERENTIATION; CELL LINE; CHEMOKINES, CC; DERMATITIS, ATOPIC; FEMALE; HUMANS; INFLAMMATION MEDIATORS; INTERLEUKIN-4; KERATINOCYTES; MALE; MIDDLE AGED; QUINAZOLINES; RECEPTOR, EPIDERMAL GROWTH FACTOR; RECEPTOR, ERBB-2; SKIN; TH2 CELLS; TRANSCRIPTION, GENETIC; YOUNG ADULT;

EID: 84871246274     PISSN: 03403696     EISSN: 1432069X     Source Type: Journal    
DOI: 10.1007/s00403-012-1242-4     Document Type: Article

References (20)

1. Belso N, Szell M et al (2008) Differential expression of D-type cyclins in HaCaT keratinocytes and in psoriasis. J Invest Dermatol 128(3):634-642 (Pubitemid 351252661)
2. Bianchini D, Jayanth A et al (2008) Epidermal growth factor receptor inhibitor-related skin toxicity: mechanisms, treatment, and its potential role as a predictive marker. Clin Colorectal Cancer 7(1):33-43 (Pubitemid 351252449)
3. Bieber T (2008) Atopic dermatitis. N Engl J Med 358(14):1483-1494
4. Gebhardt F, Zanker KS et al (1999) Modulation of epidermal growth factor receptor gene transcription by a polymorphic dinucleotide repeat in intron 1. J Biol Chem 274(19):13176-13180
5. Huang CL, Yang CH et al (2009) EGFR intron 1 dinucleotide repeat polymorphism is associated with the occurrence of skin rash with gefitinib treatment. Lung Cancer 64(3):346-351
6. Jost M, Kari C et al (2000) The EGF receptor - an essential regulator of multiple epidermal functions. Eur J Dermatol 10(7):505-510
7. Kagami S, Kakinuma T et al (2003) Significant elevation of serum levels of eotaxin-3/CCL26, but not of eotaxin-2/CCL24, in patients with atopic dermatitis: serum eotaxin-3/CCL26 levels reflect the disease activity of atopic dermatitis. Clin Exp Immunol 134(2):309-313 (Pubitemid 37372284)
8. Ma F, Sun T et al (2009) Polymorphisms of EGFR predict clinical outcome in advanced non-small-cell lung cancer patients treated with Gefitinib. Lung Cancer 66(1):114-119
9. Mascia F, Cataisson C et al (2009) EGFR regulates the expression of keratinocyte-derived granulocyte/macrophage colonystimulating factor in vitro and in vivo. J Invest Dermatol 130(3):682-693
10. Mascia F, Mariani V et al (2003) Blockade of the EGF receptor induces a deranged chemokine expression in keratinocytes leading to enhanced skin inflammation. Am J Pathol 163(1):303-312 (Pubitemid 36759615)
11. Nanney LB, Magid M et al (1984) Comparison of epidermal growth factor binding and receptor distribution in normal human epidermis and epidermal appendages. J Invest Dermatol 83(5):385-393 (Pubitemid 14024387)
12. Nanney LB, Stoscheck CM et al (1986) Altered [125I] epidermal growth factor binding and receptor distribution in psoriasis. J Invest Dermatol 86(3):260-265 (Pubitemid 16124159)
13. Owczarek W, Paplinska M et al (2010) Analysis of eotaxin 1/CCL11, eotaxin 2/CCL24 and eotaxin 3/CCL26 expression in lesional and non-lesional skin of patients with atopic dermatitis. Cytokine 50(2):181-185
14. Pastore S, Mascia F et al (2008) The epidermal growth factor receptor system in skin repair and inflammation. J Invest Dermatol 128(6):1365-1374 (Pubitemid 351693180)
15. Pivarcsi A, Szell M et al (2001) Serum factors regulate the expression of the proliferation-related genes alpha5 integrin and keratin 1, but not keratin 10, in HaCaT keratinocytes. Arch Dermatol Res 293(4):206-213 (Pubitemid 32391427)
16. Pullman H (1978) The pathogenesis of psoriasis. Autoradiographic in vitro studies on cell proliferation in psoriasis vulgaris and other normal and hyperproliferative states of epidermal and dermal human cells. Fortschr Med 96(25):1335-1338
17. Sipples R (2006) Common side effects of anti-EGFR therapy: acneform rash. Semin Oncol Nurs 22(1 Suppl 1):28-34 (Pubitemid 43564198)
18. Sääf AM, Tengvall-Linder M et al (2008) Global expression profiling in atopic eczema reveals reciprocal expression of inflammatory and lipid genes. PLoS ONE 3(12):e4017
19. Williams HC, Burney PG et al (1994) The UK working party's diagnostic criteria for atopic dermatitis. III Independent hospital validation. Br J Dermatol 131(3):406-416 (Pubitemid 24290228)
20. Yarden Y (2001) The EGFR family and its ligands in human cancer. Signalling mechanisms and therapeutic opportunities. Eur J Cancer 37(Suppl 4):S3-S8 (Pubitemid 32938123)