메뉴 건너뛰기




Volumn 5, Issue FEB, 2014, Pages

Clinical perspectives and fundamental aspects of local cardiovascular and renal renin-angiotensin systems

Author keywords

Arteries and kidney; Heart; Local renin angiotensin systems

Indexed keywords

ALDOSTERONE; ANGIOTENSIN 1 RECEPTOR; ANGIOTENSIN 2 RECEPTOR; ANGIOTENSIN CONVERTING ENZYME 2; ANGIOTENSIN I; ANGIOTENSIN II; ANGIOTENSIN II [3-8]; ANGIOTENSIN III; ANGIOTENSIN RECEPTOR ANTAGONIST; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; NITRIC OXIDE; PHOSPHATIDYLINOSITOL 3 KINASE; PRORENIN RECEPTOR; TRANSFORMING GROWTH FACTOR BETA;

EID: 84901038638     PISSN: None     EISSN: 16642392     Source Type: Journal    
DOI: 10.3389/fendo.2014.00016     Document Type: Review
Times cited : (43)

References (122)
  • 1
    • 84901065708 scopus 로고    scopus 로고
    • Hypertensive heart diseases: time for new paradigms
    • New York: Springer
    • Frohlich ED, Re RN, editors. Hypertensive heart diseases: time for new paradigms. In: The Local Cardiac Renin Angiotensin System. New York: Springer (2006). p. 1-5.
    • (2006) The Local Cardiac Renin Angiotensin System , pp. 1-5
    • Frohlich, E.D.1    Re, R.N.2
  • 2
    • 84890489207 scopus 로고    scopus 로고
    • Are local renin angiotensin systems the focal points for understanding salt sensitivity in hypertension?
    • 2nd ed. New York: Springer
    • Frohlich ED, Re RN, editors. Are local renin angiotensin systems the focal points for understanding salt sensitivity in hypertension? In: The Local Cardiac Renin-Angiotensin-Aldosterone System. 2nd ed. New York: Springer (2009). p. 1-6.
    • (2009) The Local Cardiac Renin-Angiotensin-Aldosterone System , pp. 1-6
    • Frohlich, E.D.1    Re, R.N.2
  • 3
    • 78650176624 scopus 로고    scopus 로고
    • Clinical import of the local renin angiotensin aldosterone systems
    • New York: Humana Press
    • De Mello WC, Frohlich ED, editors. Clinical import of the local renin angiotensin aldosterone systems. In: Renin Angiotensin System and Cardiovascular Disease. New York: Humana Press (2009). p. 7-14.
    • (2009) Renin Angiotensin System and Cardiovascular Disease , pp. 7-14
    • De Mello, W.C.1    Frohlich, E.D.2
  • 4
    • 43449134667 scopus 로고    scopus 로고
    • Update on tissue renin-angiotensin systems
    • doi: 10.1007/s00109-008-0336-0
    • Bader M, Ganten D. Update on tissue renin-angiotensin systems. J Mol Med (Berl) (2008) 86(6):615-21. doi: 10.1007/s00109-008-0336-0.
    • (2008) J Mol Med (Berl) , vol.86 , Issue.6 , pp. 615-621
    • Bader, M.1    Ganten, D.2
  • 5
    • 0035843893 scopus 로고    scopus 로고
    • Cardiac angiotensin II formation in the clinical course of heart failure and its relationship with left ventricular function
    • doi:10.1161/hh0901.089882
    • Serneri GGN, Boddi M, Cecioni I, Vanni S, Coppo M, Papa ML, et al. Cardiac angiotensin II formation in the clinical course of heart failure and its relationship with left ventricular function. Circ Res (2001) 88:961-8. doi:10.1161/hh0901.089882.
    • (2001) Circ Res , vol.88 , pp. 961-968
    • Serneri, G.G.N.1    Boddi, M.2    Cecioni, I.3    Vanni, S.4    Coppo, M.5    Papa, M.L.6
  • 6
    • 84901010885 scopus 로고    scopus 로고
    • Local renin angiotensin systems in the cardiovascular system
    • De Mello WC, Frohlich ED, editors. New York: Humana Press
    • Re RN. Local renin angiotensin systems in the cardiovascular system. In: De Mello WC, Frohlich ED, editors. Renin Angiotensin System and Cardiovascular Disease. New York: Humana Press (2009). p. 25-34.
    • (2009) Renin Angiotensin System and Cardiovascular Disease , pp. 25-34
    • Re, R.N.1
  • 7
    • 83055171601 scopus 로고    scopus 로고
    • Intracrine function from angiotensin to stem cells
    • Frohlich ED, Re RN, editors. New York: Humana Press
    • Re RN, Cook JL. Intracrine function from angiotensin to stem cells. In: Frohlich ED, Re RN, editors. The Local Cardiac Renin Angiotensin System. New York: Humana Press (2009). p. 91-100.
    • (2009) The Local Cardiac Renin Angiotensin System , pp. 91-100
    • Re, R.N.1    Cook, J.L.2
  • 8
    • 17044370781 scopus 로고    scopus 로고
    • Working outside the system: an update on unconventional behavior of the renin angiotensin system components
    • doi:10.1016/j.biocel.2005.01.012
    • Kurdi M, De Mello WC, Booz GW. Working outside the system: an update on unconventional behavior of the renin angiotensin system components. Int J Biochem Cell Biol (2005) 37:1357-67. doi:10.1016/j.biocel.2005.01.012.
    • (2005) Int J Biochem Cell Biol , vol.37 , pp. 1357-1367
    • Kurdi, M.1    De Mello, W.C.2    Booz, G.W.3
  • 9
    • 0017196706 scopus 로고
    • Pumping ability of the hypertrophying left ventricle of the spontaneously hypertensive rat
    • doi:10.1161/01.RES.38.5.423
    • Pfeffer MA, Pfeffer JM, Frohlich ED. Pumping ability of the hypertrophying left ventricle of the spontaneously hypertensive rat. Circ Res (1976) 38:423-9. doi:10.1161/01.RES.38.5.423.
    • (1976) Circ Res , vol.38 , pp. 423-429
    • Pfeffer, M.A.1    Pfeffer, J.M.2    Frohlich, E.D.3
  • 10
    • 0021968215 scopus 로고
    • Influence of chronic captopril therapy on the infracted left ventricle of the rat
    • doi:10.1161/01.RES.57.1.84
    • Pfeffer MA, Pfeffer JM, Braunwald E. Influence of chronic captopril therapy on the infracted left ventricle of the rat. Circ Res (1985) 57:84-95. doi:10.1161/01.RES.57.1.84.
    • (1985) Circ Res , vol.57 , pp. 84-95
    • Pfeffer, M.A.1    Pfeffer, J.M.2    Braunwald, E.3
  • 11
    • 0040437788 scopus 로고
    • Regression of left ventricular hypertrophy and prevention of left ventricular dysfunction by captopril in the spontaneously hypertensive rat
    • doi:10.1073/pnas.79.10.3310
    • Pfeffer JM, Pfeffer MA, Mirsky I, Braunwald E. Regression of left ventricular hypertrophy and prevention of left ventricular dysfunction by captopril in the spontaneously hypertensive rat. Proc Natl Acad Sci U S A (1982) 79:3310-4. doi:10.1073/pnas.79.10.3310.
    • (1982) Proc Natl Acad Sci U S A , vol.79 , pp. 3310-3314
    • Pfeffer, J.M.1    Pfeffer, M.A.2    Mirsky, I.3    Braunwald, E.4
  • 12
    • 0026786643 scopus 로고
    • Effect of captopril on mortality and morbidity in patients with left ventricular dysfunction after myocardial infarction. Results of the survival and ventricular enlargement trial.
    • doi:10.1056/NEJM199209033271001
    • Pfeffer MA, Braunwald E, Moye' LA, Basta L, Brown EJ Jr, Cuddy TE, et al. Effect of captopril on mortality and morbidity in patients with left ventricular dysfunction after myocardial infarction. Results of the survival and ventricular enlargement trial. N Engl J Med (1992) 327:669-77. doi:10.1056/NEJM199209033271001.
    • (1992) N Engl J Med , vol.327 , pp. 669-677
    • Pfeffer, M.A.1    Braunwald, E.2    Moye', L.A.3    Basta, L.4    Brown Jr., E.J.5    Cuddy, T.E.6
  • 13
    • 33751167230 scopus 로고    scopus 로고
    • Improvements in clinical outcomes with the use of angiotensin-converting enzyme inhibitors: cross-fertilization between clinical and basic investigation
    • doi:10.1152/ajpheart.00647.2006
    • Pfeffer MA, Frohlich ED. Improvements in clinical outcomes with the use of angiotensin-converting enzyme inhibitors: cross-fertilization between clinical and basic investigation. Am J Physiol Heart Circ Physiol (2006) 291:H2021-5. doi:10.1152/ajpheart.00647.2006.
    • (2006) Am J Physiol Heart Circ Physiol , vol.291
    • Pfeffer, M.A.1    Frohlich, E.D.2
  • 14
    • 10244250457 scopus 로고    scopus 로고
    • Evidence for the existence of a functional cardiac renin-angiotensin system in humans
    • doi:10.1161/01.CIR.94.8.1886
    • Neri Serneri GG, Boddi M, Coppo M, Chechi T, Zarone N, Martelli M, et al. Evidence for the existence of a functional cardiac renin-angiotensin system in humans. Circulation (1996) 94:1886-95. doi:10.1161/01.CIR.94.8.1886.
    • (1996) Circulation , vol.94 , pp. 1886-1895
    • Neri Serneri, G.G.1    Boddi, M.2    Coppo, M.3    Chechi, T.4    Zarone, N.5    Martelli, M.6
  • 15
    • 0014200585 scopus 로고
    • Effects of treatment on morbidity in hypertension. Results in patients with diastolic blood pressures averaging 115 through 129 mm Hg.
    • Veterans Administration Cooperative Study Group on Antihypertensive Agents. doi:10.1001/jama.202.11.1028
    • Veterans Administration Cooperative Study Group on Antihypertensive Agents. Effects of treatment on morbidity in hypertension. Results in patients with diastolic blood pressures averaging 115 through 129 mm Hg. JAMA (1967) 202:1028-34. doi:10.1001/jama.202.11.1028.
    • (1967) JAMA , vol.202 , pp. 1028-1034
  • 16
    • 0014952910 scopus 로고
    • Effects of treatment on morbidity in hypertension. II. Results in patients with diastolic blood pressure averaging 90 through 114 mm Hg.
    • Veterans Administration Cooperative Study Group on Antihypertensive Agents. doi:10.1001/jama.213.7.1143
    • Veterans Administration Cooperative Study Group on Antihypertensive Agents. Effects of treatment on morbidity in hypertension. II. Results in patients with diastolic blood pressure averaging 90 through 114 mm Hg. JAMA (1970) 213:1143-52. doi:10.1001/jama.213.7.1143.
    • (1970) JAMA , vol.213 , pp. 1143-1152
  • 17
    • 72949132104 scopus 로고
    • Factors of risk in the development of coronary heart disease-six year follow-up experience. The Framingham Study.
    • doi:10.7326/0003-4819-55-1-33
    • Kannel WB, Dawber TR, Kagan A, Revotskie N, Stokes J. Factors of risk in the development of coronary heart disease-six year follow-up experience. The Framingham Study. Ann Intern Med (1961) 55:33-60. doi:10.7326/0003-4819-55-1-33.
    • (1961) Ann Intern Med , vol.55 , pp. 33-60
    • Kannel, W.B.1    Dawber, T.R.2    Kagan, A.3    Revotskie, N.4    Stokes, J.5
  • 18
    • 0032729878 scopus 로고    scopus 로고
    • Risk mechanisms in hypertensive heart disease
    • doi:10.1161/01.HYP.34.4.782
    • Frohlich ED. Risk mechanisms in hypertensive heart disease. Hypertension (1999) 34:782-9. doi:10.1161/01.HYP.34.4.782.
    • (1999) Hypertension , vol.34 , pp. 782-789
    • Frohlich, E.D.1
  • 19
    • 0025729459 scopus 로고
    • Cardioreparative effects of lisinopril in rats with genetic hypertension and left ventricular hypertrophy
    • doi:10.1161/01.CIR.83.5.1771
    • Brilla CG, Janicki JS, Weber KT. Cardioreparative effects of lisinopril in rats with genetic hypertension and left ventricular hypertrophy. Circulation (1991) 83:1771-9. doi:10.1161/01.CIR.83.5.1771.
    • (1991) Circulation , vol.83 , pp. 1771-1779
    • Brilla, C.G.1    Janicki, J.S.2    Weber, K.T.3
  • 20
    • 0037188574 scopus 로고    scopus 로고
    • Losartan-dependent regression of myocardial fibrosis is associated with reduction of left ventricular chamber stiffness in hypertensive patients
    • doi:10.1161/01.CIR.0000017264.66561.3D
    • Diez J, Querejata R, Lopez B, Gonzalez A, Larman M, Martinez-Ubago JL. Losartan-dependent regression of myocardial fibrosis is associated with reduction of left ventricular chamber stiffness in hypertensive patients. Circulation (2002) 105:2512-7. doi:10.1161/01.CIR.0000017264.66561.3D.
    • (2002) Circulation , vol.105 , pp. 2512-2517
    • Diez, J.1    Querejata, R.2    Lopez, B.3    Gonzalez, A.4    Larman, M.5    Martinez-Ubago, J.L.6
  • 21
    • 65449182814 scopus 로고    scopus 로고
    • Towards a new paradigm about hypertensive heart disease. Hypertensive diseases: current challenges, new concepts and management.
    • doi:10.1016/j.mcna.2009.02.002
    • Diez J. Towards a new paradigm about hypertensive heart disease. Hypertensive diseases: current challenges, new concepts and management. Med Clin North Am (2009) 93:637-45. doi:10.1016/j.mcna.2009.02.002.
    • (2009) Med Clin North Am , vol.93 , pp. 637-645
    • Diez, J.1
  • 22
    • 73849127738 scopus 로고    scopus 로고
    • A translational approach to hypertensive heart disease
    • doi:10.1161/HYPERTENSIONAHA.109.141887
    • Diez J, Frohlich ED. A translational approach to hypertensive heart disease. Hypertension (2010) 55:1-8. doi:10.1161/HYPERTENSIONAHA.109.141887.
    • (2010) Hypertension , vol.55 , pp. 1-8
    • Diez, J.1    Frohlich, E.D.2
  • 23
    • 33845210475 scopus 로고    scopus 로고
    • Angiotensin II causes hypertension and cardiac hypertrophy through its receptors in the kidney
    • doi:10.1073/pnas.0605545103
    • Crowley SD, Gurley SB, Herrera MJ, Ruiz P, Griffiths R, Kumar AP, et al. Angiotensin II causes hypertension and cardiac hypertrophy through its receptors in the kidney. Proc Natl Acad Sci U S A (2006) 103(47):17985-90. doi:10.1073/pnas.0605545103.
    • (2006) Proc Natl Acad Sci U S A , vol.103 , Issue.47 , pp. 17985-17990
    • Crowley, S.D.1    Gurley, S.B.2    Herrera, M.J.3    Ruiz, P.4    Griffiths, R.5    Kumar, A.P.6
  • 24
    • 84949179683 scopus 로고    scopus 로고
    • Salt and multiorgan damage in hypertension. Vascular stiffening and cardiorenal structural dysfunction responses
    • Safar ME, O'Rourke MF, Frohlich ED, editors. London: Springer-Verlag. (in press).
    • Frohlich ED. Salt and multiorgan damage in hypertension. Vascular stiffening and cardiorenal structural dysfunction responses. In: Safar ME, O'Rourke MF, Frohlich ED, editors. Pulse Pressure and Cardiovascular Stiffness. London: Springer-Verlag (2014) (in press).
    • (2014) Pulse Pressure and Cardiovascular Stiffness
    • Frohlich, E.D.1
  • 25
    • 34250832808 scopus 로고    scopus 로고
    • The salt conundrum: a hypothesis
    • doi:10.1161/HYPERTENSIONAHA.107.088328
    • Frohlich ED. The salt conundrum: a hypothesis. Hypertension (2007) 50:161-6. doi:10.1161/HYPERTENSIONAHA.107.088328.
    • (2007) Hypertension , vol.50 , pp. 161-166
    • Frohlich, E.D.1
  • 26
    • 80055022673 scopus 로고    scopus 로고
    • Sodium and its multiorgan targets
    • doi:10.1161/CIRCULATIONAHA.111.029371
    • Frohlich ED, Susic D. Sodium and its multiorgan targets. Circulation (2011) 124:1882-5. doi:10.1161/CIRCULATIONAHA.111.029371.
    • (2011) Circulation , vol.124 , pp. 1882-1885
    • Frohlich, E.D.1    Susic, D.2
  • 27
    • 79953060193 scopus 로고    scopus 로고
    • The importance of population-wide sodium reduction as a means to prevent cardiovascular disease and stroke: a call to action from the American Heart Association
    • doi:10.1161/CIR.0b013e31820d0793
    • Appel LJ, Frohlich ED, Hall JE, Pearson TA, Sacco RL, Seals DR, et al. The importance of population-wide sodium reduction as a means to prevent cardiovascular disease and stroke: a call to action from the American Heart Association. Circulation (2011) 123:1138-43. doi:10.1161/CIR.0b013e31820d0793.
    • (2011) Circulation , vol.123 , pp. 1138-1143
    • Appel, L.J.1    Frohlich, E.D.2    Hall, J.E.3    Pearson, T.A.4    Sacco, R.L.5    Seals, D.R.6
  • 28
    • 84870949675 scopus 로고    scopus 로고
    • Sodium, blood pressure, and cardiovascular disease: further evidence supporting the American Heart Association sodium reduction recommendations
    • doi:10.1161/CIR.0b013e318279acbf
    • Whelton PK, Appel LJ, Sacco RJ, Anderson CAM, Antman EM, Campbell N, et al. Sodium, blood pressure, and cardiovascular disease: further evidence supporting the American Heart Association sodium reduction recommendations. Circulation (2012) 126:2880-9. doi:10.1161/CIR.0b013e318279acbf.
    • (2012) Circulation , vol.126 , pp. 2880-2889
    • Whelton, P.K.1    Appel, L.J.2    Sacco, R.J.3    Anderson, C.A.M.4    Antman, E.M.5    Campbell, N.6
  • 29
    • 84879378546 scopus 로고    scopus 로고
    • Salt in health and disease-a delicate balance
    • doi:10.1056/NEJMra1212606
    • Kotchen TA, Cowley AW Jr, Frohlich ED. Salt in health and disease-a delicate balance. N Engl J Med (2013) 368:1229-37. doi:10.1056/NEJMra1212606.
    • (2013) N Engl J Med , vol.368 , pp. 1229-1237
    • Kotchen, T.A.1    Cowley Jr., A.W.2    Frohlich, E.D.3
  • 30
    • 0027517659 scopus 로고
    • The effect of angiotensin-converting-enzyme inhibition on diabetic nephropathy. The Collaborative Study Group.
    • doi:10.1056/NEJM199311113292004
    • Lewis EJ, Hunsicker LG, Bain RP, Rolude RD. The effect of angiotensin-converting-enzyme inhibition on diabetic nephropathy. The Collaborative Study Group. N Engl J Med (1993) 320:1456-62. doi:10.1056/NEJM199311113292004.
    • (1993) N Engl J Med , vol.320 , pp. 1456-1462
    • Lewis, E.J.1    Hunsicker, L.G.2    Bain, R.P.3    Rolude, R.D.4
  • 31
    • 0035922441 scopus 로고    scopus 로고
    • Effects of losartan on renal and cardiovascular outcomes in patients with type 2 diabetes and nephropathy
    • doi:10.1056/NEJMoa011161
    • Brenner BM, Cooper ME, de Zeeuw D, Keane WF, Mitch WE, Parving HH, et al. Effects of losartan on renal and cardiovascular outcomes in patients with type 2 diabetes and nephropathy. N Engl J Med (2001) 345:861-9. doi:10.1056/NEJMoa011161.
    • (2001) N Engl J Med , vol.345 , pp. 861-869
    • Brenner, B.M.1    Cooper, M.E.2    de Zeeuw, D.3    Keane, W.F.4    Mitch, W.E.5    Parving, H.H.6
  • 32
    • 79952769061 scopus 로고    scopus 로고
    • Salt-induced renal injury in SHRs is mediated by AT1 receptor activation
    • doi:10.1097/HJH.0b013e3283440683
    • Susic D, Frohlich ED, Kobori H, Shao W, Seth D, Navar LG. Salt-induced renal injury in SHRs is mediated by AT1 receptor activation. J Hypertens (2011) 29:17-26. doi:10.1097/HJH.0b013e3283440683.
    • (2011) J Hypertens , vol.29 , pp. 17-26
    • Susic, D.1    Frohlich, E.D.2    Kobori, H.3    Shao, W.4    Seth, D.5    Navar, L.G.6
  • 33
    • 0038460302 scopus 로고    scopus 로고
    • The seventh report of the joint national committee on prevention, detection, evaluation, and treatment of high blood pressure: the JNC 7 report
    • doi:10.1001/jama.289.19.2560
    • Chobanian AV, Bakris GL, Black HR, Cushman WC, Green LA, Izzo JL Jr, et al. The seventh report of the joint national committee on prevention, detection, evaluation, and treatment of high blood pressure: the JNC 7 report. JAMA (2003) 289:2560-72. doi:10.1001/jama.289.19.2560.
    • (2003) JAMA , vol.289 , pp. 2560-2572
    • Chobanian, A.V.1    Bakris, G.L.2    Black, H.R.3    Cushman, W.C.4    Green, L.A.5    Izzo Jr., J.L.6
  • 34
    • 84901010887 scopus 로고    scopus 로고
    • Cellular oxidative stress, aging and the local RAS
    • Frohlich ED, Re RN, editors. New York: Humana Press
    • Ferder LF. Cellular oxidative stress, aging and the local RAS. In: Frohlich ED, Re RN, editors. The Local Cardiac Renin-Angiotensin-Aldosterone System. New York: Humana Press (2006). p. 201-17.
    • (2006) The Local Cardiac Renin-Angiotensin-Aldosterone System , pp. 201-217
    • Ferder, L.F.1
  • 35
    • 0028313957 scopus 로고
    • Is an intracellular renin angiotensin system involved in the control of cell communication in heart?
    • doi:10.1097/00005344-199404000-00018
    • De Mello WC. Is an intracellular renin angiotensin system involved in the control of cell communication in heart? J Cardiovasc Pharmacol (1994) 23:640-6. doi:10.1097/00005344-199404000-00018.
    • (1994) J Cardiovasc Pharmacol , vol.23 , pp. 640-646
    • De Mello, W.C.1
  • 36
    • 0343627693 scopus 로고    scopus 로고
    • Angiotensin II and the heart-on the intracrine renin 431 angiotensin system
    • doi:10.1161/01.HYP.35.6.1183
    • De Mello WC, Danser AHJ. Angiotensin II and the heart-on the intracrine renin 431 angiotensin system. Hypertension (2000) 35:1183-8. doi:10.1161/01.HYP.35.6.1183.
    • (2000) Hypertension , vol.35 , pp. 1183-1188
    • De Mello, W.C.1    Danser, A.H.J.2
  • 37
    • 0032407402 scopus 로고    scopus 로고
    • Intracellular angiotensin II regulates the inward calcium current in cardiac myocytes
    • doi:10.1161/01.HYP.32.6.976
    • De Mello WC. Intracellular angiotensin II regulates the inward calcium current in cardiac myocytes. Hypertension (1998) 32:076-82. doi:10.1161/01.HYP.32.6.976.
    • (1998) Hypertension , vol.32 , pp. 076-082
    • De Mello, W.C.1
  • 38
    • 39149092333 scopus 로고    scopus 로고
    • The basis of an intracrine physiology
    • doi:10.1177/0091270007312155
    • Re RN, Cook JL. The basis of an intracrine physiology. J Clin Pharmacol (2008) 48:344-50. doi:10.1177/0091270007312155.
    • (2008) J Clin Pharmacol , vol.48 , pp. 344-350
    • Re, R.N.1    Cook, J.L.2
  • 39
    • 39149119226 scopus 로고    scopus 로고
    • The intracellular renin angiotensin system: implications in cardiovascular remodeling
    • doi:10.1097/MNH.0b013e3282f521a8
    • Kumar R, Singh VP, Baker KM. The intracellular renin angiotensin system: implications in cardiovascular remodeling. Curr Opin Nephrol Hypertens (2008) 17:168-73. doi:10.1097/MNH.0b013e3282f521a8.
    • (2008) Curr Opin Nephrol Hypertens , vol.17 , pp. 168-173
    • Kumar, R.1    Singh, V.P.2    Baker, K.M.3
  • 40
    • 0035965208 scopus 로고    scopus 로고
    • Controlled hypertension, a transgenic toggle switch reveals differential mechanisms underlying vascular disease
    • doi:10.1074/jbc. M103296200
    • Kantachuvesiri S, Fleming S, Peters J, Peters B, Brooker G, Lammie AG, et al. Controlled hypertension, a transgenic toggle switch reveals differential mechanisms underlying vascular disease. J Biol Chem (2001) 276:36727-33. doi:10.1074/jbc. M103296200.
    • (2001) J Biol Chem , vol.276 , pp. 36727-36733
    • Kantachuvesiri, S.1    Fleming, S.2    Peters, J.3    Peters, B.4    Brooker, G.5    Lammie, A.G.6
  • 41
    • 0036851785 scopus 로고    scopus 로고
    • Role of the local renin-angiotensin system in cardiac damage: a minireview focussing on transgenic animal models
    • doi:10.1006/jmcc.2002.2077
    • Bader M. Role of the local renin-angiotensin system in cardiac damage: a minireview focussing on transgenic animal models. J Mol Cell Cardiol (2002) 34:1455-62. doi:10.1006/jmcc.2002.2077.
    • (2002) J Mol Cell Cardiol , vol.34 , pp. 1455-1462
    • Bader, M.1
  • 42
    • 0028229413 scopus 로고
    • Cardiac renin and angiotensins. Uptake from plasma versus in situ synthesis.
    • doi:10.1161/01.HYP.24.1.37
    • Danser AH, van Kats JP, Admiraal PJ, Derkx FH, Lamers JM, Verdouw PD, et al. Cardiac renin and angiotensins. Uptake from plasma versus in situ synthesis. Hypertension (1994) 24(1):37-48. doi:10.1161/01.HYP.24.1.37.
    • (1994) Hypertension , vol.24 , Issue.1 , pp. 37-48
    • Danser, A.H.1    van Kats, J.P.2    Admiraal, P.J.3    Derkx, F.H.4    Lamers, J.M.5    Verdouw, P.D.6
  • 44
    • 84858228729 scopus 로고    scopus 로고
    • G protein-coupled receptor signalling in the cardiac nuclear membrane: evidence and possible roles in physiological and pathophysiological function
    • doi:10.1113/jphysiol.2011.222794
    • Tadevosyan A, Vaniotis G, Allen BG, Hébert TE, Nattel S. G protein-coupled receptor signalling in the cardiac nuclear membrane: evidence and possible roles in physiological and pathophysiological function. J Physiol (2012) 590(Pt 6):1313-30. doi:10.1113/jphysiol.2011.222794.
    • (2012) J Physiol , vol.590 , Issue.PART 6 , pp. 1313-1330
    • Tadevosyan, A.1    Vaniotis, G.2    Allen, B.G.3    Hébert, T.E.4    Nattel, S.5
  • 45
    • 33646076471 scopus 로고    scopus 로고
    • Nuclear accumulation of the AT1 receptor in a rat vascular cell line: effects upon signal transduction and cellular proliferation
    • doi:10.1016/j.yjmcc.2005.11.014
    • Cook JL, Mills SJ, Naquin R, Alam J, Re RN. Nuclear accumulation of the AT1 receptor in a rat vascular cell line: effects upon signal transduction and cellular proliferation. J Mol Cell Cardiol (2006) 40:696-707. doi:10.1016/j.yjmcc.2005.11.014.
    • (2006) J Mol Cell Cardiol , vol.40 , pp. 696-707
    • Cook, J.L.1    Mills, S.J.2    Naquin, R.3    Alam, J.4    Re, R.N.5
  • 46
    • 41949119685 scopus 로고    scopus 로고
    • Intracellular ANG II directly induces in vitro transcription of TGF-beta1, MCP-1, and NHE-3 mRNAs in isolated rat renal cortical nuclei via activation of nuclear AT1a receptors
    • doi:10.1152/ajpcell.00432.2007
    • Li XC, Zhuo JL. Intracellular ANG II directly induces in vitro transcription of TGF-beta1, MCP-1, and NHE-3 mRNAs in isolated rat renal cortical nuclei via activation of nuclear AT1a receptors. Am J Physiol Renal Physiol (2008) 294:C1034-45. doi:10.1152/ajpcell.00432.2007.
    • (2008) Am J Physiol Renal Physiol , vol.294
    • Li, X.C.1    Zhuo, J.L.2
  • 47
    • 0015219676 scopus 로고
    • Angiotensin II: rapid localization in nuclei of smooth and cardiac muscle
    • doi:10.1126/science.172.3988.1138
    • Robertson AL Jr, Khairallah PA. Angiotensin II: rapid localization in nuclei of smooth and cardiac muscle. Science (1971) 172:1138-9. doi:10.1126/science.172.3988.1138.
    • (1971) Science , vol.172 , pp. 1138-1139
    • Robertson Jr., A.L.1    Khairallah, P.A.2
  • 48
    • 33646838387 scopus 로고    scopus 로고
    • Intracellular Ang II induces cytosolic Ca2+ mobilization by stimulating intracellular AT1 receptors in proximal tubule cells
    • doi:10.1152/ajprenal.00269.2005
    • Zhuo JL, Li XC, Garvin JL, Navar LG, Carretero OA. Intracellular Ang II induces cytosolic Ca2+ mobilization by stimulating intracellular AT1 receptors in proximal tubule cells. Am J Physiol Renal Physiol (2006) 290:F1382-90. doi:10.1152/ajprenal.00269.2005.
    • (2006) Am J Physiol Renal Physiol , vol.290
    • Zhuo, J.L.1    Li, X.C.2    Garvin, J.L.3    Navar, L.G.4    Carretero, O.A.5
  • 50
    • 0035074165 scopus 로고    scopus 로고
    • Tissue renin-angiotensin systems: new insights from experimental animal models in hypertension research
    • doi:10.1007/s001090100210
    • Bader M, Peters J, Baltatu O, Müller DN, Luft FC, Ganten D. Tissue renin-angiotensin systems: new insights from experimental animal models in hypertension research. J Mol Med (Berl) (2001) 79(2-3):76-102. doi:10.1007/s001090100210.
    • (2001) J Mol Med (Berl) , vol.79 , Issue.2-3 , pp. 76-102
    • Bader, M.1    Peters, J.2    Baltatu, O.3    Müller, D.N.4    Luft, F.C.5    Ganten, D.6
  • 51
    • 34249326592 scopus 로고    scopus 로고
    • Is angiotensin II a direct mediator of left ventricular hypertrophy?
    • doi:10.1161/HYPERTENSIONAHA.106.075085
    • Reudelhuber TL, Bernstein KE, Delafontaine P. Is angiotensin II a direct mediator of left ventricular hypertrophy? Hypertension (2007) 49:1196-201. doi:10.1161/HYPERTENSIONAHA.106.075085.
    • (2007) Hypertension , vol.49 , pp. 1196-1201
    • Reudelhuber, T.L.1    Bernstein, K.E.2    Delafontaine, P.3
  • 52
    • 0031811360 scopus 로고    scopus 로고
    • Blood pressure-independent cardiac hypertrophy induced by locally activated renin angiotensin system
    • doi:10.1161/01.HYP.31.6.1324
    • Mazzolai L, Nussberger J, Aubert JF, Brunner DB, Gabbiani G, Brunner HR, et al. Blood pressure-independent cardiac hypertrophy induced by locally activated renin angiotensin system. Hypertension (1998) 31:1324-30. doi:10.1161/01.HYP.31.6.1324.
    • (1998) Hypertension , vol.31 , pp. 1324-1330
    • Mazzolai, L.1    Nussberger, J.2    Aubert, J.F.3    Brunner, D.B.4    Gabbiani, G.5    Brunner, H.R.6
  • 53
    • 23244440907 scopus 로고    scopus 로고
    • Angiotensin II-mediated phenotypic cardiomyocyte remodeling leads to age-dependent cardiac dysfunction and failure
    • doi:10.1161/01.HYP.0000173069.53699.d9
    • Domenighetti AA, Wang Q, Egger M, Richards SM, Pedrazzini T, Delbridge LM. Angiotensin II-mediated phenotypic cardiomyocyte remodeling leads to age-dependent cardiac dysfunction and failure. Hypertension (2005) 46:426-32. doi:10.1161/01.HYP.0000173069.53699.d9.
    • (2005) Hypertension , vol.46 , pp. 426-432
    • Domenighetti, A.A.1    Wang, Q.2    Egger, M.3    Richards, S.M.4    Pedrazzini, T.5    Delbridge, L.M.6
  • 54
    • 78249242127 scopus 로고    scopus 로고
    • Local angiotensin II aggravates cardiac remodeling in hypertension
    • doi:10.1152/ajpheart.00538.2010
    • Xu J, Carretero OA, Liao TD, Peng H, Shesely EG, Xu J, et al. Local angiotensin II aggravates cardiac remodeling in hypertension. Am J Physiol Heart Circ Physiol (2010) 299(5):H1328-38. doi:10.1152/ajpheart.00538.2010.
    • (2010) Am J Physiol Heart Circ Physiol , vol.299 , Issue.5
    • Xu, J.1    Carretero, O.A.2    Liao, T.D.3    Peng, H.4    Shesely, E.G.5    Xu, J.6
  • 55
    • 0344528550 scopus 로고    scopus 로고
    • An alternative transcript of the rat renin gene can result in a truncated prorenin that is transported into adrenal mitochondria
    • doi:10.1161/01.RES.84.3.337
    • Clausmeyer S, Sturebecher R, Peters J. An alternative transcript of the rat renin gene can result in a truncated prorenin that is transported into adrenal mitochondria. Circ Res (1999) 84:337-44. doi:10.1161/01.RES.84.3.337.
    • (1999) Circ Res , vol.84 , pp. 337-344
    • Clausmeyer, S.1    Sturebecher, R.2    Peters, J.3
  • 56
    • 84883729395 scopus 로고    scopus 로고
    • Cytosolic (pro)renin and the matter of intracellular renin actions
    • doi:10.2741/S366
    • Peters J. Cytosolic (pro)renin and the matter of intracellular renin actions. Front Biosci (Schol Ed) (2013) 5:198-205. doi:10.2741/S366.
    • (2013) Front Biosci (Schol Ed) , vol.5 , pp. 198-205
    • Peters, J.1
  • 57
    • 84859434135 scopus 로고    scopus 로고
    • Local renin-angiotensin systems in the adrenal gland
    • doi:10.1016/j.peptides.2012.01.023
    • Peters J. Local renin-angiotensin systems in the adrenal gland. Peptides (2012) 34(2):427-32. doi:10.1016/j.peptides.2012.01.023.
    • (2012) Peptides , vol.34 , Issue.2 , pp. 427-432
    • Peters, J.1
  • 58
    • 0029054506 scopus 로고
    • Influence of intracellular renin on heart cell communication
    • doi:10.1161/01.HYP.25.6.1172
    • De Mello WC. Influence of intracellular renin on heart cell communication. Hypertension (1995) 25:1172-7. doi:10.1161/01.HYP.25.6.1172.
    • (1995) Hypertension , vol.25 , pp. 1172-1177
    • De Mello, W.C.1
  • 59
    • 84873470711 scopus 로고    scopus 로고
    • Intracellular renin alters the electrical properties of the intact heart ventricle of adult Sprague Dawley rats
    • doi:10.1016/j.regpep.2012.12.015
    • De Mello WC. Intracellular renin alters the electrical properties of the intact heart ventricle of adult Sprague Dawley rats. Regul Pept (2013) 181:45-9. doi:10.1016/j.regpep.2012.12.015.
    • (2013) Regul Pept , vol.181 , pp. 45-49
    • De Mello, W.C.1
  • 60
    • 0035068120 scopus 로고    scopus 로고
    • Cardiac arrhythmias: the possible role of the renin angiotensin system
    • doi:10.1007/s001090100195
    • De Mello WC. Cardiac arrhythmias: the possible role of the renin angiotensin system. J Mol Med (2001) 79:103-8. doi:10.1007/s001090100195.
    • (2001) J Mol Med , vol.79 , pp. 103-108
    • De Mello, W.C.1
  • 61
    • 3242707692 scopus 로고    scopus 로고
    • Heart failure: how important is cellular sequestration?. The role of the renin-angiotensin-aldosterone system.
    • doi:10.1016/j.yjmcc.2004.05.007
    • De Mello WC. Heart failure: how important is cellular sequestration? The role of the renin-angiotensin-aldosterone system. J Mol Cell Cardiol (2004) 37:431-8. doi:10.1016/j.yjmcc.2004.05.007.
    • (2004) J Mol Cell Cardiol , vol.37 , pp. 431-438
    • De Mello, W.C.1
  • 62
    • 33845608395 scopus 로고    scopus 로고
    • A novel signal transduction cascade involving direct physical interaction of the renin/prorenin receptor with the transcription factor promyelocytic zinc finger protein
    • doi:10.1161/01.RES.0000251700.00994.0d
    • Schefe JH, Menk M, Reinemund J, Effertz K, Hobbs RM, PandolfiPP, et al. A novel signal transduction cascade involving direct physical interaction of the renin/prorenin receptor with the transcription factor promyelocytic zinc finger protein. Circ Res (2006) 99:1355-66. doi:10.1161/01.RES.0000251700.00994.0d.
    • (2006) Circ Res , vol.99 , pp. 1355-1366
    • Schefe, J.H.1    Menk, M.2    Reinemund, J.3    Effertz, K.4    Hobbs, R.M.5    Pandolfi, P.P.6
  • 63
    • 33845628410 scopus 로고    scopus 로고
    • On the pathophysiological implications of an intracellular renin receptor
    • doi:10.1161/01.RES.0000253141.65450.fc
    • De Mello WC. On the pathophysiological implications of an intracellular renin receptor. Circ Res (2006) 99:1285-6. doi:10.1161/01.RES.0000253141.65450.fc.
    • (2006) Circ Res , vol.99 , pp. 1285-1286
    • De Mello, W.C.1
  • 64
    • 84886099600 scopus 로고    scopus 로고
    • Nonclassical renin-angiotensin system and renal function
    • doi:10.1002/cphy.c120002
    • Chappell MC. Nonclassical renin-angiotensin system and renal function. Compr Physiol (2012) 2:2733-52. doi:10.1002/cphy.c120002.
    • (2012) Compr Physiol , vol.2 , pp. 2733-2752
    • Chappell, M.C.1
  • 65
    • 84872617624 scopus 로고    scopus 로고
    • Angiotensin converting enzyme 2, angiotensin (1-7) and Mas: new players of the renin angiotensin system
    • doi:10.1530/JOE-12-0341
    • Santos RAS, Ferreira AJ, Braga TV, Bader M. Angiotensin converting enzyme 2, angiotensin (1-7) and Mas: new players of the renin angiotensin system. J Endocrinol (2013) 216:R1-17. doi:10.1530/JOE-12-0341.
    • (2013) J Endocrinol , vol.216
    • Santos, R.A.S.1    Ferreira, A.J.2    Braga, T.V.3    Bader, M.4
  • 66
    • 0037667643 scopus 로고    scopus 로고
    • Newly recognized components of the renin-angiotensin system: potential roles in cardiovascular and renal regulation
    • doi:10.1210/er.2003-0001
    • Carey RM, Siragy HM. Newly recognized components of the renin-angiotensin system: potential roles in cardiovascular and renal regulation. Endocr Rev (2003) 24(3):261-71. doi:10.1210/er.2003-0001.
    • (2003) Endocr Rev , vol.24 , Issue.3 , pp. 261-271
    • Carey, R.M.1    Siragy, H.M.2
  • 67
    • 0035966085 scopus 로고    scopus 로고
    • Evidence that the angiotensin IV (AT(4)) receptor is the enzyme insulin regulate aminopeptidase
    • doi:10.1074/jbc. C100512200
    • Albiston AL, McDowall SG, Matsacos D, Sim P, Clune E, Mustafa T, et al. Evidence that the angiotensin IV (AT(4)) receptor is the enzyme insulin regulate aminopeptidase. J Biol Chem (2001) 276(52):48623-6. doi:10.1074/jbc. C100512200.
    • (2001) J Biol Chem , vol.276 , Issue.52 , pp. 48623-48626
    • Albiston, A.L.1    McDowall, S.G.2    Matsacos, D.3    Sim, P.4    Clune, E.5    Mustafa, T.6
  • 68
    • 0031989144 scopus 로고    scopus 로고
    • Angiotensin IV AT4-receptor system in the rat kidney
    • Handa RK, Krebs LT, Harding JW, Handa SE. Angiotensin IV AT4-receptor system in the rat kidney. Am J Physiol (1998) 274(2 Pt 2):F290-9.
    • (1998) Am J Physiol , vol.274 , Issue.2 PART 2
    • Handa, R.K.1    Krebs, L.T.2    Harding, J.W.3    Handa, S.E.4
  • 69
    • 0037478671 scopus 로고    scopus 로고
    • Angiotensin-(1-7) is an endogenous ligand for the G protein-coupled receptor Mas
    • doi:10.1073/pnas.1432869100
    • Santos RA, Simoes e Silva AC, Maric C, Silva DM, Machado RP, de Buhr I, et al. Angiotensin-(1-7) is an endogenous ligand for the G protein-coupled receptor Mas. Proc Natl Acad Sci U S A (2003) 100(14):8258-63. doi:10.1073/pnas.1432869100.
    • (2003) Proc Natl Acad Sci U S A , vol.100 , Issue.14 , pp. 8258-8263
    • Santos, R.A.1    Simoes e Silva, A.C.2    Maric, C.3    Silva, D.M.4    Machado, R.P.5    de Buhr, I.6
  • 70
    • 84873033171 scopus 로고    scopus 로고
    • ACE2, angiotensin-(1-7), and Mas: the other side of the coin
    • doi:10.1007/s00424-012-1120-0
    • Bader M. ACE2, angiotensin-(1-7), and Mas: the other side of the coin. Pflugers Arch (2013) 465(1):79-85. doi:10.1007/s00424-012-1120-0.
    • (2013) Pflugers Arch , vol.465 , Issue.1 , pp. 79-85
    • Bader, M.1
  • 71
    • 33846996406 scopus 로고    scopus 로고
    • The (pro)renin receptor: pathophysiological roles in cardiovascular and renal pathology
    • doi:10.1097/MNH.0b013e328040bfab
    • Nguyen G. The (pro)renin receptor: pathophysiological roles in cardiovascular and renal pathology. Curr Opin Nephrol Hypertens (2007) 16(2):129-33. doi:10.1097/MNH.0b013e328040bfab.
    • (2007) Curr Opin Nephrol Hypertens , vol.16 , Issue.2 , pp. 129-133
    • Nguyen, G.1
  • 72
    • 58149216360 scopus 로고    scopus 로고
    • (Pro)renin receptors: are they biologically relevant?
    • doi:10.1097/MNH.0b013e3283196aaf
    • Danser AH. (Pro)renin receptors: are they biologically relevant? Curr Opin Nephrol Hypertens (2009) 18(1):74-8. doi:10.1097/MNH.0b013e3283196aaf.
    • (2009) Curr Opin Nephrol Hypertens , vol.18 , Issue.1 , pp. 74-78
    • Danser, A.H.1
  • 73
    • 33750147612 scopus 로고    scopus 로고
    • Isolation and identification of proangiotensin-12, apossible component of the renin angiotensin system
    • doi:10.1016/j.bbrc.2006.09.146
    • Nagata S, Kato J, Sasaki K, Minamino N, Eto T, Kitamura K. Isolation and identification of proangiotensin-12, apossible component of the renin angiotensin system. Biochem Biophys Res Commun (2006) 350:1026-31. doi:10.1016/j.bbrc.2006.09.146.
    • (2006) Biochem Biophys Res Commun , vol.350 , pp. 1026-1031
    • Nagata, S.1    Kato, J.2    Sasaki, K.3    Minamino, N.4    Eto, T.5    Kitamura, K.6
  • 74
    • 77951257899 scopus 로고    scopus 로고
    • Plasma and tissue levels of proangiotensin-12 and components of the renin angiotensin system(RAS) following low or high salt-feeding in rats
    • doi:10.1016/j.peptides.2010.02.008
    • Nagata S, Kato J, Kuwasako K, Kitamura K. Plasma and tissue levels of proangiotensin-12 and components of the renin angiotensin system(RAS) following low or high salt-feeding in rats. Peptides (2010) 31:889-92. doi:10.1016/j.peptides.2010.02.008.
    • (2010) Peptides , vol.31 , pp. 889-892
    • Nagata, S.1    Kato, J.2    Kuwasako, K.3    Kitamura, K.4
  • 75
    • 83255175529 scopus 로고    scopus 로고
    • Chymase-dependent generation of angiotensin II from angiotensin-(1-12) in human atrial tissue
    • doi:10.1371/journal.pone.0028501
    • Ahmad S, Simmons T, Varagic J, Moniwa N, Chappell MC, Ferrario CM. Chymase-dependent generation of angiotensin II from angiotensin-(1-12) in human atrial tissue. PLoS One (2011) 6:e28501. doi:10.1371/journal.pone.0028501.
    • (2011) PLoS One , vol.6
    • Ahmad, S.1    Simmons, T.2    Varagic, J.3    Moniwa, N.4    Chappell, M.C.5    Ferrario, C.M.6
  • 76
    • 84891403514 scopus 로고    scopus 로고
    • An evolving story of angiotensin-II-forming pathways in rodents and humans
    • doi:10.1042/CS20130400
    • Ferrario CM, Ahmad S, Nagata S, Simington SW, Varagic J, Kon N, et al. An evolving story of angiotensin-II-forming pathways in rodents and humans. Clin Sci (Lond) (2014) 126(7):461-9. doi:10.1042/CS20130400.
    • (2014) Clin Sci (Lond) , vol.126 , Issue.7 , pp. 461-469
    • Ferrario, C.M.1    Ahmad, S.2    Nagata, S.3    Simington, S.W.4    Varagic, J.5    Kon, N.6
  • 77
    • 84876407858 scopus 로고    scopus 로고
    • Discovery and characterization of alamandine: a novel component of the renin-angiotensin system
    • doi:10.1161/CIRCRESAHA.113.301077
    • Lautner RQ, Villela DC, Fraga-Silva RA, Silva N, Verano-Braga T, Costa-Fraga F, et al. Discovery and characterization of alamandine: a novel component of the renin-angiotensin system. Circ Res (2013) 112:1104-11. doi:10.1161/CIRCRESAHA.113.301077.
    • (2013) Circ Res , vol.112 , pp. 1104-1111
    • Lautner, R.Q.1    Villela, D.C.2    Fraga-Silva, R.A.3    Silva, N.4    Verano-Braga, T.5    Costa-Fraga, F.6
  • 78
    • 58149375072 scopus 로고    scopus 로고
    • Angiotensin II type 2 receptor stimulation: a novel option of therapeutic interference with the renin-angiotensin system in myocardial infarction?
    • doi:10.1161/CIRCULATIONAHA.108.784868
    • Kaschina E, Grzesiak A, Li J, Foryst-Ludwig A, Timm M, Rompe F, et al. Angiotensin II type 2 receptor stimulation: a novel option of therapeutic interference with the renin-angiotensin system in myocardial infarction? Circulation (2008) 118:2523-32. doi:10.1161/CIRCULATIONAHA.108.784868.
    • (2008) Circulation , vol.118 , pp. 2523-2532
    • Kaschina, E.1    Grzesiak, A.2    Li, J.3    Foryst-Ludwig, A.4    Timm, M.5    Rompe, F.6
  • 79
    • 0035902572 scopus 로고    scopus 로고
    • Angiotensin II type 2 receptor is essential for left ventricular hypertrophy and cardiac fibrosis in chronic angiotensin II-induced hypertension
    • doi:10.1161/01.CIR.104.3.346
    • Ichihara S, Senbonmatsu T, Price E Jr, Ichiki T, Gaffney FA, Inagami T. Angiotensin II type 2 receptor is essential for left ventricular hypertrophy and cardiac fibrosis in chronic angiotensin II-induced hypertension. Circulation (2001) 104:346-51. doi:10.1161/01.CIR.104.3.346.
    • (2001) Circulation , vol.104 , pp. 346-351
    • Ichihara, S.1    Senbonmatsu, T.2    Price Jr., E.3    Ichiki, T.4    Gaffney, F.A.5    Inagami, T.6
  • 80
    • 0035923630 scopus 로고    scopus 로고
    • Vascular hypertrophy and increased P70S6 kinase in mice lacking the angiotensin II AT2 receptor
    • doi:10.1161/hc4601.099401
    • Brede M, Hadamek K, Meinel L, Wiesmann F, Peters J, Engelhardt S, et al. Vascular hypertrophy and increased P70S6 kinase in mice lacking the angiotensin II AT2 receptor. Circulation (2001) 104:2602-7. doi:10.1161/hc4601.099401.
    • (2001) Circulation , vol.104 , pp. 2602-2607
    • Brede, M.1    Hadamek, K.2    Meinel, L.3    Wiesmann, F.4    Peters, J.5    Engelhardt, S.6
  • 81
    • 84857050578 scopus 로고    scopus 로고
    • AT2 receptor receptor agonists: hypertension and beyond
    • doi:10.1097/MNH.0b013e328350261b
    • Steckelings UM, Paulis L, Namsolleck P, Unger T. AT2 receptor receptor agonists: hypertension and beyond. Curr Opin Nephrol Hypertens (2012) 21:142-6. doi:10.1097/MNH.0b013e328350261b.
    • (2012) Curr Opin Nephrol Hypertens , vol.21 , pp. 142-146
    • Steckelings, U.M.1    Paulis, L.2    Namsolleck, P.3    Unger, T.4
  • 82
    • 84883331559 scopus 로고    scopus 로고
    • Agonists of MAS oncogene and angiotensin II type 2 receptors attenuate cardiopulmonary disease in rats with neonatal hyperoxia-induced lung injury
    • doi:10.1152/ajplung.00360.2012
    • Wagenaar GT, Laghmani elH, Fidder M, Sengers RM, de Visser YP, de Vries L, et al. Agonists of MAS oncogene and angiotensin II type 2 receptors attenuate cardiopulmonary disease in rats with neonatal hyperoxia-induced lung injury. Am J Physiol Lung Cell Mol Physiol (2013) 305(5):L341-51. doi:10.1152/ajplung.00360.2012.
    • (2013) Am J Physiol Lung Cell Mol Physiol , vol.305 , Issue.5
    • Wagenaar, G.T.1    Laghmani el, H.2    Fidder, M.3    Sengers, R.M.4    de Visser, Y.P.5    de Vries, L.6
  • 83
    • 84888375977 scopus 로고    scopus 로고
    • Chronic AT2 receptor activation increases renal ACE2 activity, attenuates AT1 receptor function and blood pressure in obese Zucker rats
    • doi:10.1038/ki.2013.193
    • Ali Q, Wu Y, Hussain T. Chronic AT2 receptor activation increases renal ACE2 activity, attenuates AT1 receptor function and blood pressure in obese Zucker rats. Kidney Int (2013) 84(5):931-9. doi:10.1038/ki.2013.193.
    • (2013) Kidney Int , vol.84 , Issue.5 , pp. 931-939
    • Ali, Q.1    Wu, Y.2    Hussain, T.3
  • 84
    • 84870239177 scopus 로고    scopus 로고
    • Adipocyte deficiency of angiotensinogen prevents obesity-induced hypertension in male mice
    • doi:10.1161/HYPERTENSIONAHA.112.192690
    • Yiannikouris F, Gupte M, Putnam K, Thatcher S, Charnigo R, Rateri DL. Adipocyte deficiency of angiotensinogen prevents obesity-induced hypertension in male mice. Hypertension (2012) 60:1524-30. doi:10.1161/HYPERTENSIONAHA.112.192690.
    • (2012) Hypertension , vol.60 , pp. 1524-1530
    • Yiannikouris, F.1    Gupte, M.2    Putnam, K.3    Thatcher, S.4    Charnigo, R.5    Rateri, D.L.6
  • 85
    • 0036903352 scopus 로고    scopus 로고
    • Regulation of myocardial fibrillar collagen by angiotensin II. A role in hypertensive heart disease?
    • doi:10.1006/jmcc.2002.2081
    • González A, López R, Querejeta R, Díez J. Regulation of myocardial fibrillar collagen by angiotensin II. A role in hypertensive heart disease? J Mol Cell Cardiol (2002) 34:1585-93. doi:10.1006/jmcc.2002.2081.
    • (2002) J Mol Cell Cardiol , vol.34 , pp. 1585-1593
    • González, A.1    López, R.2    Querejeta, R.3    Díez, J.4
  • 86
    • 84894417555 scopus 로고    scopus 로고
    • Angiotensin type 2 receptor stimulation ameliorates left ventricular fibrosis and dysfunction via regulation of tissue inhibitor of matrix metalloproteinase 1/matrix metalloproteinase 9 axis and transforming growth factor β1 in the rat heart)
    • doi:10.1161/HYPERTENSIONAHA.113.02522
    • Lauer D, Slavic S, Sommerfeld M, Thöne-Reineke C, Sharkovska Y, Hallberg A, et al. Angiotensin type 2 receptor stimulation ameliorates left ventricular fibrosis and dysfunction via regulation of tissue inhibitor of matrix metalloproteinase 1/matrix metalloproteinase 9 axis and transforming growth factor β1 in the rat heart). Hypertension (2014) 63:e60-7. doi:10.1161/HYPERTENSIONAHA.113.02522.
    • (2014) Hypertension , vol.63
    • Lauer, D.1    Slavic, S.2    Sommerfeld, M.3    Thöne-Reineke, C.4    Sharkovska, Y.5    Hallberg, A.6
  • 87
    • 0032079560 scopus 로고    scopus 로고
    • Identification and characterization of a novel 9.2-kDa membrane sector-associated protein of vacuolar proton-ATPase from chromaffin granules
    • doi:10.1074/jbc.273.18.10939
    • Ludwig J, Kerscher S, Brandt U, Pfeiffer K, Getlawi F, Apps DK, et al. Identification and characterization of a novel 9.2-kDa membrane sector-associated protein of vacuolar proton-ATPase from chromaffin granules. J Biol Chem (1998) 273(18):10939-47. doi:10.1074/jbc.273.18.10939.
    • (1998) J Biol Chem , vol.273 , Issue.18 , pp. 10939-10947
    • Ludwig, J.1    Kerscher, S.2    Brandt, U.3    Pfeiffer, K.4    Getlawi, F.5    Apps, D.K.6
  • 88
    • 84901003560 scopus 로고    scopus 로고
    • Autophagy and the (pro)renin receptor
    • doi:10.3389/fendo.2013.00155
    • Binger K, Muller DN. Autophagy and the (pro)renin receptor. Front Cell Endocrinol (2013) 4:155. doi:10.3389/fendo.2013.00155.
    • (2013) Front Cell Endocrinol , vol.4 , pp. 155
    • Binger, K.1    Muller, D.N.2
  • 89
    • 77954762963 scopus 로고    scopus 로고
    • The (pro)renin receptor/ATP6AP2 is essential for vacuolar H+-ATAase asymmetry in murine cardiomyocytes
    • doi:10.1161/CIRCRESAHA.110.224667
    • Kinouchi K, Ichihara A, Sano M, Sun-Wada GH, Wada Y, Kurauchi-Mito A, et al. The (pro)renin receptor/ATP6AP2 is essential for vacuolar H+-ATAase asymmetry in murine cardiomyocytes. Circ Res (2010) 107:30-4. doi:10.1161/CIRCRESAHA.110.224667.
    • (2010) Circ Res , vol.107 , pp. 30-34
    • Kinouchi, K.1    Ichihara, A.2    Sano, M.3    Sun-Wada, G.H.4    Wada, Y.5    Kurauchi-Mito, A.6
  • 90
    • 0035650575 scopus 로고    scopus 로고
    • Adipose angiotensinogen is involved in adipose tissue growth and blood pressure regulation
    • doi:10.1096/fj.01-0457fje
    • Massiéra F, Bloch-Faure M, Ceiler D, Murakami K, Fukamizu A, Gasc JM, et al. Adipose angiotensinogen is involved in adipose tissue growth and blood pressure regulation. FASEB J (2001) 15(14):2727-9. doi:10.1096/fj.01-0457fje.
    • (2001) FASEB J , vol.15 , Issue.14 , pp. 2727-2729
    • Massiéra, F.1    Bloch-Faure, M.2    Ceiler, D.3    Murakami, K.4    Fukamizu, A.5    Gasc, J.M.6
  • 91
    • 56549084712 scopus 로고    scopus 로고
    • Eplerenone inhibits the intracrine and extracellular actions of angiotensin II on the inward calcium current in the failing heart. On the presence of an intracrine renin angiotensin aldosterone system.
    • doi:10.1016/j.regpep.2008.06.003
    • De Mello WC, Gerena Y. Eplerenone inhibits the intracrine and extracellular actions of angiotensin II on the inward calcium current in the failing heart. On the presence of an intracrine renin angiotensin aldosterone system. Regul Pept (2008) 151(1-3):54-60. doi:10.1016/j.regpep.2008.06.003.
    • (2008) Regul Pept , vol.151 , Issue.1-3 , pp. 54-60
    • De Mello, W.C.1    Gerena, Y.2
  • 92
    • 78049486063 scopus 로고    scopus 로고
    • Systemic versus local renin angiotensin systems. An overview
    • De Mello WC, Frohlich ED, editors. New York: Humana Press
    • De Mello WC, Re RN. Systemic versus local renin angiotensin systems. An overview. In: De Mello WC, Frohlich ED, editors. Renin Angiotensin System and Cardiovascular Disease. New York: Humana Press (2009). p. 1-5.
    • (2009) Renin Angiotensin System and Cardiovascular Disease , pp. 1-5
    • De Mello, W.C.1    Re, R.N.2
  • 93
    • 0037370644 scopus 로고    scopus 로고
    • The implication of intracrine hormone action for physiology and medicine
    • doi:10.1152/ajpheart.00935.2002
    • Re RN. The implication of intracrine hormone action for physiology and medicine. Am J Physiol Heart Circ Physiol (2003) 284:H751-7. doi:10.1152/ajpheart.00935.2002.
    • (2003) Am J Physiol Heart Circ Physiol , vol.284
    • Re, R.N.1
  • 94
    • 84876688248 scopus 로고    scopus 로고
    • Intracellular angiotensin II increases the total potassium current and the resting potential of arterial myocytes from vascular resistance vessels of the rat. Physiological and pathological implications.
    • doi:10.1016/j.jash.2013.02.003
    • De Mello WC. Intracellular angiotensin II increases the total potassium current and the resting potential of arterial myocytes from vascular resistance vessels of the rat. Physiological and pathological implications. J Am Soc Hypertens (2013) 7(3):192-7. doi:10.1016/j.jash.2013.02.003.
    • (2013) J Am Soc Hypertens , vol.7 , Issue.3 , pp. 192-197
    • De Mello, W.C.1
  • 95
    • 0029108913 scopus 로고
    • Physiological roles and properties of potassium channels in arterial smooth muscle
    • Nelson MT, Quayle JM. Physiological roles and properties of potassium channels in arterial smooth muscle. Am J Physiol (1995) 268(4 Pt 1):C799-822.
    • (1995) Am J Physiol , vol.268 , Issue.4 PART 1
    • Nelson, M.T.1    Quayle, J.M.2
  • 96
    • 84869129079 scopus 로고    scopus 로고
    • Subcellular characteristics of functional intracellular renin-angiotensin systems
    • doi:10.1016/j.peptides.2012.09.016
    • Abadir PM, Walston JD, Carey RM. Subcellular characteristics of functional intracellular renin-angiotensin systems. Peptides (2012) 38(2):437-45. doi:10.1016/j.peptides.2012.09.016.
    • (2012) Peptides , vol.38 , Issue.2 , pp. 437-445
    • Abadir, P.M.1    Walston, J.D.2    Carey, R.M.3
  • 98
    • 78650173023 scopus 로고    scopus 로고
    • Novel aspects of angiotensin II action in the heart. Implications to myocardial ischemia and heart failure.
    • doi:10.1016/j.regpep.2010.10.003
    • De Mello WC. Novel aspects of angiotensin II action in the heart. Implications to myocardial ischemia and heart failure. Regul Pept (2011) 166(1-3):9-14. doi:10.1016/j.regpep.2010.10.003.
    • (2011) Regul Pept , vol.166 , Issue.1-3 , pp. 9-14
    • De Mello, W.C.1
  • 100
    • 34547988015 scopus 로고    scopus 로고
    • Beneficial versus harmful effects of Angiotensin (1-7) on impulse propagation and cardiac arrhythmias in the failing heart
    • doi:10.3317/jraas.2007.015
    • De Mello WC, Ferrario CM, Jessup JA. Beneficial versus harmful effects of Angiotensin (1-7) on impulse propagation and cardiac arrhythmias in the failing heart. J Renin Angiotensin Aldosterone Syst (2007) 8:74-80. doi:10.3317/jraas.2007.015.
    • (2007) J Renin Angiotensin Aldosterone Syst , vol.8 , pp. 74-80
    • De Mello, W.C.1    Ferrario, C.M.2    Jessup, J.A.3
  • 101
    • 14844345007 scopus 로고    scopus 로고
    • Angiotensin (1-7) re-establishes impulse conduction in cardiac muscle during ischaemia-reperfusion. The role of the sodium pump.
    • doi:10.3317/jraas.2004.041
    • De Mello WC. Angiotensin (1-7) re-establishes impulse conduction in cardiac muscle during ischaemia-reperfusion. The role of the sodium pump. J Renin Angiotensin Aldosterone Syst (2004) 5(4):203-8. doi:10.3317/jraas.2004.041.
    • (2004) J Renin Angiotensin Aldosterone Syst , vol.5 , Issue.4 , pp. 203-208
    • De Mello, W.C.1
  • 102
    • 84874075137 scopus 로고    scopus 로고
    • Aliskiren, at low doses, reduces the electrical remodeling in the heart of the TGR(mRen2)27 rat independently of blood pressure
    • doi:10.1177/1470320312463832
    • De Mello W, Rivera M, Rabell A, Gerena Y. Aliskiren, at low doses, reduces the electrical remodeling in the heart of the TGR(mRen2)27 rat independently of blood pressure. J Renin Angiotensin Aldosterone Syst (2013) 14(1):23-33. doi:10.1177/1470320312463832.
    • (2013) J Renin Angiotensin Aldosterone Syst , vol.14 , Issue.1 , pp. 23-33
    • De Mello, W.1    Rivera, M.2    Rabell, A.3    Gerena, Y.4
  • 103
    • 2942751868 scopus 로고    scopus 로고
    • Mechanical stress activates angiotensin II type 1 receptor without the involvement of angiotensin II
    • doi:10.1038/ncb1137
    • Zou Y, Akazawa H, Qin Y, Sano M, Takano H, Minamino T, et al. Mechanical stress activates angiotensin II type 1 receptor without the involvement of angiotensin II. Nat Cell Biol (2004) 6:499-506. doi:10.1038/ncb1137.
    • (2004) Nat Cell Biol , vol.6 , pp. 499-506
    • Zou, Y.1    Akazawa, H.2    Qin, Y.3    Sano, M.4    Takano, H.5    Minamino, T.6
  • 104
    • 84870464616 scopus 로고    scopus 로고
    • Mechanical stretch reduces the effect of angiotensin II on potassium current in cardiac ventricular cells of adult Sprague Dawley rats. On the role of AT1 receptors as mechanosensors.
    • doi:10.1016/j.jash.2012.08.006
    • De Mello WC. Mechanical stretch reduces the effect of angiotensin II on potassium current in cardiac ventricular cells of adult Sprague Dawley rats. On the role of AT1 receptors as mechanosensors. J Am Soc Hypertens (2012) 6(6):369-74. doi:10.1016/j.jash.2012.08.006.
    • (2012) J Am Soc Hypertens , vol.6 , Issue.6 , pp. 369-374
    • De Mello, W.C.1
  • 105
    • 0038053724 scopus 로고    scopus 로고
    • A novel angiotensin converting enzyme related carboxypeptidase (ACE2) converts angiotensin I to angiotensin (1-9)
    • doi:10.1161/01.RES.87.5.e1
    • Donoghue M, Hsieh F, Baronas E, Godbout K, Gosselin M, Stagliano N, et al. A novel angiotensin converting enzyme related carboxypeptidase (ACE2) converts angiotensin I to angiotensin (1-9). Circ Res (2000) 87:E1-9. doi:10.1161/01.RES.87.5.e1.
    • (2000) Circ Res , vol.87
    • Donoghue, M.1    Hsieh, F.2    Baronas, E.3    Godbout, K.4    Gosselin, M.5    Stagliano, N.6
  • 106
    • 0034721906 scopus 로고    scopus 로고
    • A human homolog of angiotensin-converting enzyme. Cloning and functional expression as a captopril-insensitive carboxypeptidase.
    • doi:10.1074/jbc. M002615200
    • Tipnis SR, Hooper NM, Hyde R, Karran E, Christie G, Turner AJ. A human homolog of angiotensin-converting enzyme. Cloning and functional expression as a captopril-insensitive carboxypeptidase. J Biol Chem (2000) 275:33238-43. doi:10.1074/jbc. M002615200.
    • (2000) J Biol Chem , vol.275 , pp. 33238-33243
    • Tipnis, S.R.1    Hooper, N.M.2    Hyde, R.3    Karran, E.4    Christie, G.5    Turner, A.J.6
  • 107
    • 0037142101 scopus 로고    scopus 로고
    • Angiotensin-converting enzyme 2 is an essential regulator of heart function
    • doi:10.1038/nature00786
    • Crackower MA, Sarao R, Oudit GY, Yagil C, Kozieradzki I, Scanga SE, et al. Angiotensin-converting enzyme 2 is an essential regulator of heart function. Nature (2002) 417(6891):822-8. doi:10.1038/nature00786.
    • (2002) Nature , vol.417 , Issue.6891 , pp. 822-828
    • Crackower, M.A.1    Sarao, R.2    Oudit, G.Y.3    Yagil, C.4    Kozieradzki, I.5    Scanga, S.E.6
  • 108
    • 28144445338 scopus 로고    scopus 로고
    • Advances in biochemical and functional roles of angiotensin-converting enzyme 2 and angiotensin-(1-7) in regulation of cardiovascular function
    • doi:10.1152/ajpheart.00618.2005
    • Ferrario CM, Trask AJ, Jessup JA. Advances in biochemical and functional roles of angiotensin-converting enzyme 2 and angiotensin-(1-7) in regulation of cardiovascular function. Am J Physiol Heart Circ Physiol (2005) 289:H2281-90. doi:10.1152/ajpheart.00618.2005.
    • (2005) Am J Physiol Heart Circ Physiol , vol.289
    • Ferrario, C.M.1    Trask, A.J.2    Jessup, J.A.3
  • 109
    • 0141988865 scopus 로고    scopus 로고
    • Increased angiotensin (1-7) forming activity in failing human heart ventricles: evidence for upregulation of the angiotensin converting enzyme homolog, ACE2
    • doi:10.1161/01.CIR.0000094734.67990.99
    • Zisman LS, Keller RS, Weaver B, Lin Q, Speth R, Bristow MR, et al. Increased angiotensin (1-7) forming activity in failing human heart ventricles: evidence for upregulation of the angiotensin converting enzyme homolog, ACE2. Circulation (2003) 108:1707-12. doi:10.1161/01.CIR.0000094734.67990.99.
    • (2003) Circulation , vol.108 , pp. 1707-1712
    • Zisman, L.S.1    Keller, R.S.2    Weaver, B.3    Lin, Q.4    Speth, R.5    Bristow, M.R.6
  • 110
    • 73349125736 scopus 로고    scopus 로고
    • Cell swelling, impulse conduction, and cardiac arrhythmias in the failing heart. Opposite effects of angiotensin II and angiotensin (1-7) on cell volume regulation.
    • doi:10.1007/s11010-009-0135-0
    • De Mello WC. Cell swelling, impulse conduction, and cardiac arrhythmias in the failing heart. Opposite effects of angiotensin II and angiotensin (1-7) on cell volume regulation. Mol Cell Biochem (2009) 330(1-2):211-7. doi:10.1007/s11010-009-0135-0.
    • (2009) Mol Cell Biochem , vol.330 , Issue.1-2 , pp. 211-217
    • De Mello, W.C.1
  • 111
    • 70350457666 scopus 로고    scopus 로고
    • Loss of angiotensin-converting enzyme 2 accelerates maladaptive left ventricular remodeling in response to myocardial infarction
    • doi:10.1161/CIRCHEARTFAILURE.108.840124
    • Kassiri Z, Zhong J, Guo D, Basu R, Wang X, Liu PP, et al. Loss of angiotensin-converting enzyme 2 accelerates maladaptive left ventricular remodeling in response to myocardial infarction. Circ Heart Fail (2009) 2:446-55. doi:10.1161/CIRCHEARTFAILURE.108.840124.
    • (2009) Circ Heart Fail , vol.2 , pp. 446-455
    • Kassiri, Z.1    Zhong, J.2    Guo, D.3    Basu, R.4    Wang, X.5    Liu, P.P.6
  • 112
    • 33644866153 scopus 로고    scopus 로고
    • Expression and localization of N-domain ANG I-converting enzymes in mesangial cells in culture from spontaneously hypertensive rats
    • doi:10.1152/ajprenal.00110.2005
    • Camargo de Andrade MC, Di Marco GS, de Paulo CI, Mortara RA, Sabatini RA, Pesquero JB, et al. Expression and localization of N-domain ANG I-converting enzymes in mesangial cells in culture from spontaneously hypertensive rats. Am J Physiol Renal Physiol (2006) 290:F364-F375. doi:10.1152/ajprenal.00110.2005.
    • (2006) Am J Physiol Renal Physiol , vol.290
    • Camargo de Andrade, M.C.1    Di Marco, G.S.2    de Paulo, C.I.3    Mortara, R.A.4    Sabatini, R.A.5    Pesquero, J.B.6
  • 113
    • 5044220674 scopus 로고    scopus 로고
    • Evidence against a major role for angiotensin converting enzyme-related carboxypeptidase (ACE2) in angiotensin peptide metabolism in the human coronary circulation
    • doi:10.1097/00004872-200410000-00020
    • Campbell DJ, Zeitz CJ, Esler MD, Horowitz JD. Evidence against a major role for angiotensin converting enzyme-related carboxypeptidase (ACE2) in angiotensin peptide metabolism in the human coronary circulation. J Hypertens (2004) 22:1971-6. doi:10.1097/00004872-200410000-00020.
    • (2004) J Hypertens , vol.22 , pp. 1971-1976
    • Campbell, D.J.1    Zeitz, C.J.2    Esler, M.D.3    Horowitz, J.D.4
  • 114
    • 84862561605 scopus 로고    scopus 로고
    • Angiotensin-(1-7) in kidney disease: a review of the controversies
    • doi:10.1042/CS20120111
    • Zimmerman D, Burns KD. Angiotensin-(1-7) in kidney disease: a review of the controversies. Clin Sci (2012) 123:333-46. doi:10.1042/CS20120111.
    • (2012) Clin Sci , vol.123 , pp. 333-346
    • Zimmerman, D.1    Burns, K.D.2
  • 115
    • 0034727695 scopus 로고    scopus 로고
    • Limitation of excessive extracellular matrix turnover may contribute to survival benefit of spironolactone therapy in patients with congestive heart failure: insights from the randomized aldactone evaluation study (RALES)
    • on behalf of RALES Investigators. doi:10.1161/01.CIR.102.22.2700
    • Zannad F, Alla F, Dousset B, Perez A, Pitt B; on behalf of RALES Investigators. Limitation of excessive extracellular matrix turnover may contribute to survival benefit of spironolactone therapy in patients with congestive heart failure: insights from the randomized aldactone evaluation study (RALES). Circulation (2000) 102(22):2700-6. doi:10.1161/01.CIR.102.22.2700.
    • (2000) Circulation , vol.102 , Issue.22 , pp. 2700-2706
    • Zannad, F.1    Alla, F.2    Dousset, B.3    Perez, A.4    Pitt, B.5
  • 116
    • 0035830440 scopus 로고    scopus 로고
    • Aldosterone production is activated in the failing ventricle in humans
    • doi:10.1161/01.CIR.103.1.72
    • Mizuno Y, Yoshimura M, Yasue H, Sakamoto T, Ogawa H, Kugiyama K, et al. Aldosterone production is activated in the failing ventricle in humans. Circulation (2001) 103:72-7. doi:10.1161/01.CIR.103.1.72.
    • (2001) Circulation , vol.103 , pp. 72-77
    • Mizuno, Y.1    Yoshimura, M.2    Yasue, H.3    Sakamoto, T.4    Ogawa, H.5    Kugiyama, K.6
  • 117
    • 84856339877 scopus 로고    scopus 로고
    • Aldosterone, mineralocorticoid receptor, and heart failure
    • doi:10.1016/j.mce.2011.06.038
    • Messaoudi S, Azibani F, Delcayre C, Jaisser F. Aldosterone, mineralocorticoid receptor, and heart failure. Mol Cell Endocrinol (2012) 350(2):266-72. doi:10.1016/j.mce.2011.06.038.
    • (2012) Mol Cell Endocrinol , vol.350 , Issue.2 , pp. 266-272
    • Messaoudi, S.1    Azibani, F.2    Delcayre, C.3    Jaisser, F.4
  • 118
    • 84873027749 scopus 로고    scopus 로고
    • Mineralocorticoid receptor-mediated vascular insulin resistance: an early contributor to diabetes-related vascular disease?
    • doi:10.2337/db12-0905
    • Bender SB, McGraw AP, Jaffe IZ, Sowers JR. Mineralocorticoid receptor-mediated vascular insulin resistance: an early contributor to diabetes-related vascular disease? Diabetes (2013) 62(2):313-9. doi:10.2337/db12-0905.
    • (2013) Diabetes , vol.62 , Issue.2 , pp. 313-319
    • Bender, S.B.1    McGraw, A.P.2    Jaffe, I.Z.3    Sowers, J.R.4
  • 119
    • 84898005689 scopus 로고    scopus 로고
    • The role of tissue renin-angiotensin-aldosterone system in the development of endothelial dysfunction and arterial stiffness
    • doi:10.3389/fendo.2013.00161
    • Aroor AR, Demarco VG, Jia G, Sun Z, Nistala R, Meininger GA, et al. The role of tissue renin-angiotensin-aldosterone system in the development of endothelial dysfunction and arterial stiffness. Front Endocrinol (Lausanne) (2013) 4:161. doi:10.3389/fendo.2013.00161.
    • (2013) Front Endocrinol (Lausanne) , vol.4 , pp. 161
    • Aroor, A.R.1    Demarco, V.G.2    Jia, G.3    Sun, Z.4    Nistala, R.5    Meininger, G.A.6
  • 120
    • 34548850880 scopus 로고    scopus 로고
    • Aldosterone suppresses insulin signaling via the downregulation of insulin receptor substrate-1 in vascular smooth muscle cells
    • doi:10.1161/HYPERTENSIONAHA.107.093955
    • Hitomi H, Kiyomoto H, Nishiyama A, Hara T, Moriwaki K, Kaifu K, et al. Aldosterone suppresses insulin signaling via the downregulation of insulin receptor substrate-1 in vascular smooth muscle cells. Hypertension (2007) 50:750-5. doi:10.1161/HYPERTENSIONAHA.107.093955.
    • (2007) Hypertension , vol.50 , pp. 750-755
    • Hitomi, H.1    Kiyomoto, H.2    Nishiyama, A.3    Hara, T.4    Moriwaki, K.5    Kaifu, K.6
  • 121
    • 79955974994 scopus 로고    scopus 로고
    • The role of aldosterone in the metabolic syndrome
    • doi:10.1007/s11906-011-0182-2
    • Briet M, Schiffrin EL. The role of aldosterone in the metabolic syndrome. Curr Hypertens Rep (2011) 13:163-72. doi:10.1007/s11906-011-0182-2.
    • (2011) Curr Hypertens Rep , vol.13 , pp. 163-172
    • Briet, M.1    Schiffrin, E.L.2
  • 122
    • 84950318825 scopus 로고    scopus 로고
    • Spironolactone enhances the beneficial effect of aliskiren on cardiac structural and electrical remodeling in TGR(mRen2)27 rats
    • doi:10.1177/1470320313497818
    • De Mello WC. Spironolactone enhances the beneficial effect of aliskiren on cardiac structural and electrical remodeling in TGR(mRen2)27 rats. J Renin Angiotensin Aldosterone (2013). doi:10.1177/1470320313497818.
    • (2013) J Renin Angiotensin Aldosterone
    • De Mello, W.C.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.