Heart failure: How important is cellular sequestration? the role of the renin-angiotensin-aldosterone system

Journal of Molecular and Cellular Cardiology

Volumn 37, Issue 2, 2004, Pages 431-438

  De Mello, Walmor C ^a  

^a UNIVERSITY OF PUERTO RICO   (Puerto Rico)

Author keywords

Cell coupling; Cellular sequestration; Fibroblasts; Fibrosis; Heart failure; Renin angiotensin aldosterone

Indexed keywords

ALDOSTERONE; ANGIOTENSIN; ANGIOTENSIN 1 RECEPTOR ANTAGONIST; BASIC FIBROBLAST GROWTH FACTOR; CONNEXIN 43; CYCLIC AMP; CYTOKINE; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; ENALAPRILAT; ENDOTHELIN; EPIDERMAL GROWTH FACTOR; ISOPRENALINE; LOSARTAN; PLATELET DERIVED GROWTH FACTOR; RENIN; RETINOID; VERAPAMIL; ZAPRINAST;

ADRENERGIC SYSTEM; CELL COMMUNICATION; CELL ISOLATION; CELL MEMBRANE; CELL STRUCTURE; CELL SYNCHRONIZATION; CONGESTIVE HEART FAILURE; DISEASE COURSE; DOWN REGULATION; HAMSTER; HEART ARRHYTHMIA; HEART FAILURE; HEART FUNCTION; HEART MUSCLE CONTRACTILITY; HEART MUSCLE FIBROSIS; HEART VENTRICLE HYPERTROPHY; HUMAN; HYPERPOLARIZATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM; REVIEW;

ALDOSTERONE; ANGIOTENSIN II; ANGIOTENSIN-CONVERTING ENZYME INHIBITORS; ANIMALS; ARRHYTHMIA; CARDIAC OUTPUT, LOW; CELL COMMUNICATION; FIBROBLASTS; FIBROSIS; HUMANS; RENIN-ANGIOTENSIN SYSTEM; SIGNAL TRANSDUCTION; SYMPATHETIC NERVOUS SYSTEM;

EID: 3242707692     PISSN: 00222828     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.yjmcc.2004.05.007     Document Type: Review

References (96)

1. Seta Y., Schank K., Bozhurt B., Oral H., Mann D.L. Basic mechanisms in heart failure: the cytokine hypothesis. J Card Fail. 2:1996;243-249
2. Schwartz K., Chassagne C., Boheler K.R. The molecular biology of heart failure. J Am Cell Cardiol. 22:(4 Suppl A):1993;A30-A33
3. Kirschenbaum L.A. Stresses of the failing heart. J Mol Cell Cardiol. 35:2003;1017-1019
4. Afzal N., Dhalla N.S. Differential changes in left and right ventricular SR calcium transport in congestive heart failure. Am J Physiol. 262:1992;H868-H874
5. Hill M.F., Singal P.K. Antioxidant and oxidative stress changes during heart failure subsequent to myocardial infarction in rats. Am J Pathol. 148:1996;291-300
6. Wencker D., Chandra M., Nguyen K., Miao W., Garantziotis S., Factor S.M., et al. A mechanistic role for the cardiac myocyte apoptosis in heart failure. J Clin Invest. 111:2003;1497-1504
7. Morgan M.E., Baker K.M. Cardiac hypertrophy: mechanical, neural and endocrine dependence. Circulation. 83:1991;23-25
8. Weismand H.F., Weinfeldt M.L. Toward an understanding of the molecular basis of cardiomyopathies. J Am Cell Cardiol. 10:1987;1135-1138
9. Wrogemann K., Nylen E.G. Mitochondrial calcium overloading in cardiomyopathic hamsters. J Mol Cell Cardiol. 10:1978;185-195
10. Jasmin G., Proschek L. Calcium and myocardial cell injury. An appraisal in the cardiomyopathic hamster. Can J Physiol Pharmacol. 62:1984;891-900
11. i and contractility in nonfailing and failing human myocardium. Circulation. 106:2002;447-453
12. Pacifico A., Henry P.D. Structural pathways and prevention of heart failure and sudden death. J Cardiovasc Electrophysiol. 14:2003;764-775
13. Armoundas A.A., Wu R., Juang G., Marban E., Tomaseli G.F. Electrical and structural remodeling of the failing ventricle. Pharmacol Ther. 92:2003;213-230
14. De Mello W.C. Renin angiotensin system and cell communication in the failing heart. Hypertension. 27:1996;1267-1272
15. Severs N.J. Pathophysiology of gap junctions in heart disease. J Cardiac Electrophysiol. 5:1994;462-475
16. Severs N.J. Gap junctions and connexin expression in human heart disease. De Mello W.C., Janse M. Heart cell coupling and impulse propagation in health and disease. 2002;321-334 Kluwer Academic Publishers, Boston
17. Cherry R., De Mello W.C. Confocal microscopy and intercellular communication in failing cardiomyopathic heart. FASEB J. 1996 April 14;. [abstract 2275]
18. Malsev V.A., Sabbath H.N., Undrovinas A.I. Down-regulation of sodium-current in chronic heart failure: effect of long-term therapy with carvedilol. Cell Mol Life Sci. 59:2001;1561-1568
19. Feldman A.M., Rowena G.T., Kessler P.D., Weisman H.F., Schulman S.P., Blumenthal R.S., et al. Diminished beta-adrenergic receptor responsiveness and cardiac dilation in heart of cardiomyopathic Syrian hamsters are associated with abnormality of G stimulatory protein. Circulation. 81:1990;1341-1352
20. Bohm M., Giershick P., Jacobs K.H., Pieske B., Schnabel P., Ungerer M., et al. Increase in Gi in human heart with dilated but not ischemic cardiomyopathy. Circulation. 82:1990;1249-1265
21. De Mello W.C. Impaired regulation of cell communication by beta-adrenergic receptor activation in the failing heart. Hypertension. 27:1996;265-268
22. Imanaga I., Hirosawa N., Lin H., Sakamoto Y., Matsumura T., Mayama K. Phosphorylation of connexin 43 and regulation of cardiac gap junction. De Mello W.C., Janse M. Heart cell coupling and impulse propagation in health and disease. 2002;184-205 Kluwer Academic Publishers, Boston
23. De Mello W.C. Interaction of cAMP and calcium in the control of electrical coupling of heart fibers. Biochem Biophys Acta. 888:1986;91-99
24. Xiao R.P. Beta-adrenergic signaling in the heart: dual coupling of the beta adrenergic receptor to G(s) and G(i) proteins. Sci STKE. 104:2001;RE15
25. De Mello W.C. Cardiac arrhythmias; the possible role of the renin angiotensin system. J Mol Med. 79:2001;103-108
26. De Mello W.C. Cell coupling and impulse propagation in the failing heart: the possible role of the renin angiotensin system. De Mello W.C., Janse M. Heart cell coupling and impulse propagation in health and disease. 2002;283-320 Kluwer Academic Publishers, Boston
27. De Mello W.C., Cherry R., Manivannan S. Electrophysiologic and morphologic abnormalities in the failing heart; effect of enalapril on the electrical properties. J Cardiac Fail. 3:1997;53-62
28. Dzau V.J. Implications of local angiotensin production in cardiovascular physiology and pharmacology. Am J Cardiol. 59:(Suppl A):1987;A59-65
29. Lindpaintner K., Jin M.W., Niedrmaier N., Wilhelm M.J., Ganten D. Cardiac angiotensinogen and its local activation in the isolated perfused beating heart. Circ Res. 67:1990;564-573
30. De Mello W.C., Danser A.H.J. Angiotensin II and the heart. On the intracrine renin angiotensin system. Hypertension. 35:2000;1183-1188
31. Lee Y.A., Liang C.S., Lee H.A., Lindpaintner K. Local stress, not systemic factors regulate gene expression of cardiac renin angiotensin system in vivo: a comprehensive study of all its components in the dog. Proc Natl Acad Sci USA. 93:1996;11035-11040
32. Asano K., Dutcher D., Port J., et al. Selective downregulation of the angiotensin II AT1-receptor subtype in the failing human ventricular myocardium. Circulation. 95:1997;1193-1200
33. Haywood G.A., Gullestad L., Katsuya T., et al. AT1 and AT2 angiotensin receptor gene expression in the human heart failure. Circulation. 95:1997;1201-1206
34. Studer R., Reinecke H., Muller B., et al. Increased angiotensin-1 converting enzyme gene expression in the failing human heart. J Clin Invest. 94:1994;301-310
35. De Mello W.C., Altieri P. The role of the renin angiotensin system in the control of cell communication in the heart; effects of angiotensin II and enalapril. J Cardiovasc Pharmacol. 20:1992;643-651
36. Hunter T. Tyrosine phosphorylation: past, present and future. Biochem Soc Trans Hopkin Medal Lec. 24:1996;307-327
37. Atikinson M.M., Menko A.S., Johnson R.G., Shepard R., Sheridan J.D. Rapid and reversible reduction of junctional permeability in cells infected with a temperature-sensitive mutant of avian sarcome virus. J Cell Biol. 91:1981;573-578
38. Zhou L., Kasperek E.M., Nicholson B.J. Dissection of the molecular basis of Pp60-src induced gating of connexin43 gap junctions. J Cell Biol. 144:1999;1033-1045
39. Toyofuku T., Yabuki M., Otsu K., Kusaya T., Tada M., Hori M. Functional role of c-src in gap junctions of the cardiomyopathic hamster heart. Circ Res. 85:1999;672-681
40. Haendeler J., Berk B. Tyrosine phosphorylation is involved in Ang II-mediated signal transduction. Reg Pept. 95:2000;1-7
41. Trosko J.E., Chia-Chang C.C., Madhukaar B.V., Oh S.Y. Chemical, oncogene and growth. Regulator modulation of extracellular, intracellular and intercellular communication. De Mello W.C. Intercellular communication. 1990;111-126 CRC Press, Boca Raton
42. Warn-Cramer B.J., Cotrell G.T., Burt J.M., Lau A.F. Regulation of connexin 43 gap junctional communication by mitogen-activated protein kinase. J Biol Chem. 273:1998;9188-9196
43. Dostal D.E. The cardiac renin-angiotensin system: novel signaling mechanisms related to cardiac growth and function. Reg Pept. 91:2000;1-11
44. Wilgenbus K.K., Kirkpatrik C.J., Kmechem R., Willecke K., Traub O. Expression of Cx26, Cx32 and Cx43 gap junction proteins in normal and neoplastic human tissues. Int J Cancer. 51:1992;522-529
45. Ruch R.J. The role of gap junction intercellular communication in neoplasia. Ann Clin Lab Sci. 24:1994;216-231
46. Katz S.A., Opsahl J.A., Lunzer M.M., Forbis L.M., Hirsch A.T. Effect of bilateral nephrectomy on active renin, angiotensinogen, and renin glycoforms in plasma and myocardium. Hypertension. 30:1997;259-266
47. Danser A.H.J., van Katz J.P., Admiraal P.J.J., Derbx F.H.M., Lamers J.M.J., Verdouw P.D., et al. Schalekamp MADH cardiac renin and angiotensins. Uptake from plasma versus in situ synthesis. Hypertension. 24:1994;37-48
48. Peters J., Farrenkopf R., Clausmeyer S., Zimmer J., Kantachuverisi S., Sharp M.G., et al. Functional significance of prorenin internalization in the rat heart. Circ Res. 90:2002;1135-1141
49. Clausmeyer S., Reinecke A., Farrenkoft R., et al. Tissue-specific expression of a rat renin transcript lacking the coding sequence for the prefragment and its stimulation by myocardial infarction. Endocrinology. 141:2000;2963-2970
50. van Kesteren C.A.M., Saris J.J., Dekkers F.H.M., Lamers J.M.J., Saxena P.R., Schalekamp M.A.D.H., et al. Cultured neonatal rat cardiac myocytes and fibroblasts do not synthesize renin or angiotensinogen: evidence for stretch-induced cardiomyocyte hypertrophy independent of angiotensin II. Cardiovasc Res. 43:1999;148-156
51. De Mello W.C. Is an intracellular renin angiotensin system involved in the control of cell communication in heart? J Cardiovasc Pharmacol. 23:1994;640-646
52. De Mello W.C. Influence of intracellular renin on heart cell communication. Hypertension. 25:1995;1172-1177
53. De Mello W.C., Re R.N. Is an intracrine renin angiotensin system involved in the control of cardiovascular function? Pawan K., Sigal I., Dixon M.C., Lorrie A., Kirshenbaum, Dhalla S. Cardiac remodeling and failure. 2003;365-375 Kluwer Academic Publishers, Boston
54. Cook J.L., Zhung Z., Re R.N. In vitro evidence for an intracellular site of angiotensin action. Circ Res. 89:2001;1138-1146
55. Filipenu C.M., Henning R.H., de Zeeuw D., Nelemans A. Intracellular angiotensin II and cell growth of vascular smooth muscle cells. Br J Pharmacol. 132:2001;1590-1596
56. 2+ channels in arterial myocytes. Hypertension. 39:2002;474-478
57. Admiraal P.J.J., Danser A.H.J., Jong M.S., Pieterman H., Derbx F.H.M., Schalekamp M.A.D.H. Regional angiotensin II production in essential hypertension and renal artery stenosis. Hypertension. 21:1993;173-184
58. Baker K.M., Campanile M.P., Trachte G.J., Peach M.J. Identification and characterization of the rabbit angiotensin II myocardial receptor. Circ Res. 54:1984;286-293
59. Sen I., Rajasekaran A.K. Angiotensin II-binding protein in adult and neonatal rat heart. J Mol Cell Cardiol. 23:1991;563-572
60. Re R.N., LaBiche R.A., Bryan S.E. Nuclear-hormone mediated changes in chromatin solubility. Biochem Biophys Res Commun. 110:1983;61-68
61. Fu M.L., Schulze W., Wallukat G., Elies R., Eftekhari P., Hjalmarson A., et al. Immunochemical localization of angiotensin II receptor (AT1) in the heart with anti-peptide antibody showing a positive chronotropic effect. Receptor Channel. 6:1998;99-111
62. Kato A., Sugiura N., Hagiwara H., Hirose S. Cloning, amino acid sequence and tissue distribution of porcine thimet oligopeptidase. A comparison with soluble angiotensin-binding protein. Eur J Biochem. 221:1994;159-165
63. Yamada H., Fabris B., Allen A.M., Jackson C.I., Mendelsohn A.O. Localization of angiotensin converting enzyme in rat heart. Circ Res. 68:1991;141-149
64. De Mello W.C., Crespo M.J. Correlation between changes in morphology, electrical properties and angiotensin converting enzyme activity in the failing heart. Eur J Pharmacol. 378:1999;187-194
65. De Mello W.C. Further studies on the effect of intracellular angiotensins on heart cell communication: on the role of endogenous angiotensin II. Reg Pept. 115:2003;31-36
66. Soubrier F., Alhenc-Gelas F., Hubert C., Allegrini J., John M., Tregar G., et al. Two putative active centers in human angiotensin I-converting enzyme revealed by molecular cloning. Proc Natl Acad Sci USA. 85:1988;9386-9390
67. Kohlstedt K., Brandes R.P., Muller-Estern W., Busse R., Fleming I. Angiotensin converting enzyme is involved in outside-in signaling in endothelial cells. Circ Res. 94:2004;60-67
68. De Mello W.C. Angiotensin converting enzyme and the arrhythmogenic action of angiotensin I. Cardiac cell membrane as a site of angiotensin I conversion. Reg Pept. 121:2004;73-78
69. De Mello W.C., Crespo M.J., Altieri P.I. Effect of enalapril on intracellular resistance and conduction velocity in rat ventricular muscle. J Cardiovasc Pharmacol. 22:1993;259-263
70. De Mello W.C. Electrical activity of the heart and angiotensin converting enzyme inhibitors; on the hyperpolarizing action of enalapril. J Human Hypertens. 16:(Suppl 1):2002;S89-S92
71. Booz G.W., Baker K.M. Molecular signaling mechanisms controlling growth and function of cardiac fibroblasts. Cardiovasc Res. 30:1995;537-543
72. Lijnen P.J., Petrov V.V., Fagard R.H. Angiotensin II-induced stimulation of collagen secretion and production in cardiac fibroblasts is mediated via angiotensin II subtype 1 receptors. Renin Angioten Aldosteron Syst. 2:2001;117-122
73. Ivanciw D., Rehm M., Porst M., Goppelt-Struebe M. Induction of connective tissue growth factor by angiotensin II: integration of signaling pathways. Arterioscler Thromb Vasc Biol. 23:2003;1782-1787
74. Shivakumar K., Dostal D.E., Boheler K., Baker K.M., Lakkatta E.G. Differential response of cardiac fibroblasts from young adult and senescent rats to ANG II. Am J Physiol Heart Circ Physiol. 284:2003;H1454-H1459
75. Sarkar S., Vellaichamy E., Young D., Sen S. Influence of cytokines and growth factors in Ang II-mediated collagen upregulation by fibroblasts in rats: role of myocytes. Am J Physiol Heart Circ Physiol. 287:2004;107-117
76. Doble B.W., Chen Y., Bosc D.G., Litchfield D.W., Kardami E. Fibroblast growth factor-2 decreases metabolic coupling and stimulates phosphorylation as well as masking of connexin43 epitopes in cardiac myocytes. Circ Res. 79:1996;647-658
77. Bonvalet J.P., Alfaidy N., Farman N., Lombes M. Aldosterone intracellular receptors in human heart. Eur Heart J. 16:(Suppl N):1995;92-97
78. De Mello W.C. Aldosterone modulates the effect of angiotensin II on the electrical properties of adult rat heart. J Cardiovasc Pharmacol. 40:2002;90-95
79. Silvestre J.S., Heymans C., Oubenaissa A., et al. Activation of cardiac aldosterone production in rat myocardial infarction. Circulation. 99:1999;2694-2701
80. Takeda Y., Takashi Y., Masashi D., et al. Cardiac aldosterone production in genetic hypertensive rats. Hypertension. 36:2000;495-500
81. Delcayre C., Swynghedauw B. Molecular mechanisms of myocardial remodeling. The role of aldosterone. J Mol Cell Cardiol. 34:2002;1577-1584
82. Horisberger J.D., Rossier B.C. Aldosterone regulation of gene transcription leading to control of ion transport. Hypertension. 19:1992;221-227
83. Mizuno Y., Yoshimura M., Yasue H., et al. Aldosterone production is activated in failing ventricle in humans. Circulation. 103:2001;72-77
84. De Mello W.C. Intracellular angiotensin II regulates the inward calcium current in cardiac myocytes. Hypertension. 32:1998;976-982
85. Kang P.M., Nakousi A., Simpson T., Scheuer J., Buttrick P.M. Role of endogenous renin angiotensin system in c-fos activation and PKC-epsilon translocation in adult rat hearts. Am J Physiol. 270:1996;H2177-H2183
86. Malhotra R., Sadoshima J., Broscius F.C., Izumo S. Mechanical stretch and angiotensin II differentially upregulated the renin angiotensin system in cardiac myocytes in vitro. Circ Res. 85:1999;137-146
87. Tamura K., Umemura S., Nyui N., Hibi K., Ishigami T., Kihara M., et al. Activation of angiotensinogen gene in cardiac myocytes by angiotensin II and mechanical stretch. Am J Physiol. 44:1998;R1-R9
88. Guo Y., Mascareno E., Siddiqui M.A. Distinct components of Janus kinase/signal transducer and activation of transcription signaling pathway mediate the regulation of systemic and tissue localized renin angiotensin system. Mol Endocrinol. 18:2004;1033-1041
89. Donoghue M., Hsieh F., Baronas E., et al. A novel angiotensin-converting enzyme related carboxypeptidase (ACE2) converts angiotensin 1 to angiotensin 1-9. Circ Res. 87:2000;E1-E9
90. Tipnis S.R., Hooper N.M., Hyde R., et al. A human homolog of angiotensin converting enzyme. Cloning and functional expression as a captopril-insensitive carboxypeptidase. J Biol Chem. 275:2000;33238-33243
91. Zisman L.S., Keller R.S., Weaver B., et al. Increased angiotensin (1-7) forming activity in failing human heart ventricles: evidence for upregulation of the angiotensin converting enzyme homolog (ACE2). Circulation. 108:2003;1707-1712
92. Zisman L.S. ACE2: its role in the counter regulatory response to heart failure. De Mello W.C. Renin-angiotensin and the heart. 2004;119-132 John Wiley and Sons, London
93. Harmer D., Gilbert M., Borman R., Clark K.L. Quantitative mRNA expression profiling of ACE2, a novel homologue of angiotensin converting enzyme. FEBS Lett. 532:2002;107-110
94. Ferrario C., Chappel M., Tallant E.K., et al. Counterregulatory actions of angiotensin (1-7). Hypertension. 30:1997;535-541
95. Ferreira A.J., Santos R.A., Almeida A.P. Angiotensin 1-7: cardioprotective effect in myocardial ischemia/reperfusion. Hypertension. 38:2001;665-668
96. Donohue M., Wakimoto H., Maguire C.T., Acton S., Hales P., Stagliano N., et al. Heart block, ventricular tachycardia, and sudden death in ACE2 transgenic mice with downregulated connexins. J Mol Cell Cardiol. 35:2003;1043-1053