Chymase-dependent generation of angiotensin II from angiotensin-(1-12) in human atrial tissue

PLoS ONE

Volumn 6, Issue 12, 2011, Pages

  Ahmad, Sarfaraz ^a   Simmons, Tony ^a   Varagic, Jasmina ^a   Moniwa, Norihito ^a   Chappell, Mark C ^a   Ferrario, Carlos M ^a  

^a WAKE FOREST SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOTENSIN (1-12); ANGIOTENSIN DERIVATIVE; CHYMASE; UNCLASSIFIED DRUG; ANGIOTENSIN II; DIPEPTIDYL CARBOXYPEPTIDASE;

ADULT; AGED; ARTICLE; BIOTINYLATION; CELL MEMBRANE; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; HEART MUSCLE CELL; HOMEOSTASIS; HUMAN; HUMAN TISSUE; HYDROLYSIS; IMMUNOCYTOCHEMISTRY; IMMUNOLOCALIZATION; IMMUNOREACTIVITY; MALE; PROTEIN CLEAVAGE; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN METABOLISM; PROTEIN PURIFICATION; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM; ANIMAL; CYTOLOGY; ENZYMOLOGY; GENE EXPRESSION REGULATION; HEART ATRIUM; METABOLISM; MIDDLE AGED; PATHOLOGY; PROTEIN TRANSPORT; RAT;

AGED; AGED, 80 AND OVER; ANGIOTENSIN II; ANIMALS; CHYMASES; FEMALE; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HEART ATRIA; HUMANS; MALE; MIDDLE AGED; MYOCYTES, CARDIAC; PEPTIDYL-DIPEPTIDASE A; PROTEIN TRANSPORT; RATS;

EID: 83255175529     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0028501     Document Type: Article

References (54)

1. Ferrario CM, (2010) New physiological concepts of the renin-angiotensin system from the investigation of precursors and products of angiotensin I metabolism. Hypertension 55: 445-452.
2. Paul M, Poyan MA, Kreutz R, (2006) Physiology of local renin-angiotensin systems. Physiol Rev 86: 747-803.
3. Nagata S, Kato J, Sasaki K, Minamino N, Eto T, et al. (2006) Isolation and identification of proangiotensin-12, a possible component of the renin-angiotensin system. Biochem Biophys Res Commun 350: 1026-1031.
4. Prosser HC, Forster ME, Richards AM, Pemberton CJ, (2009) Cardiac chymase converts rat proAngiotensin-12 (PA12) to angiotensin II: effects of PA12 upon cardiac haemodynamics. Cardiovasc Res 82: 40-50.
5. Prosser HC, Richards AM, Forster ME, Pemberton CJ, (2010) Regional vascular response to ProAngiotensin-12 (PA12) through the rat arterial system. Peptides 31: 1540-1545.
6. Arakawa H, Chitravanshi VC, Sapru HN, (2011) The hypothalamic arcuate nucleus: a new site of cardiovascular action of angiotensin-(1-12) and angiotensin II. Am J Physiol Heart Circ Physiol 300: H951-H960.
7. Arnold AC, Isa K, Shaltout HA, Nautiyal M, Ferrario CM, et al. (2010) Angiotensin-(1-12) requires angiotensin converting enzyme and AT1 receptors for cardiovascular actions within the solitary tract nucleus. Am J Physiol Heart Circ Physiol 299: H763-H771.
8. Chitravanshi VC, Sapru HN, (2011) Cardiovascular responses elicited by a new endogenous angiotensin in the nucleus tractus solitarius of the rat. Am J Physiol Heart Circ Physiol 300: H230-H240.
9. Isa K, Garcia-Espinosa MA, Arnold AC, Pirro NT, Tommasi EN, et al. (2009) Chronic immunoneutralization of brain angiotensin-(1-12) lowers blood pressure in transgenic (mRen2)27 hypertensive rats. Am J Physiol Regul Integr Comp Physiol 297: R111-R115.
10. Jessup JA, Trask AJ, Chappell MC, Nagata S, Kato J, et al. (2008) Localization of the novel angiotensin peptide, angiotensin-(1-12), in heart and kidney of hypertensive and normotensive rats. Am J Physiol Heart Circ Physiol 294: H2614-H2618.
11. Ferrario CM, Varagic J, Habibi J, Nagata S, Kato J, et al. (2009) Differential regulation of angiotensin-(1-12) in plasma and cardiac tissue in response to bilateral nephrectomy. Am J Physiol Heart Circ Physiol 296: H1184-H1192.
12. Trask AJ, Jessup JA, Chappell MC, Ferrario CM, (2008) Angiotensin-(1-12) is an alternate substrate for angiotensin peptide production in the heart. Am J Physiol Heart Circ Physiol 294: H2242-H2247.
13. Ahmad S, Varagic J, Westwood BM, Chappell MC, Ferrario CM, (2011) Uptake and metabolism of the novel peptide angiotensin-(1-12) by neonatal cardiac myocytes. PLoS One 6: e15759.
14. Bujak-Gizycka B, Olszanecki R, Suski M, Madek J, Stachowicz A, et al. (2010) Angiotensinogen metabolism in rat aorta: robust formation of proangiotensin-12. J Physiol Pharmacol 61: 679-682.
15. Varagic J, Trask AJ, Jessup JA, Chappell MC, Ferrario CM, (2008) New angiotensins. J Mol Med (Berl) 86: 663-671.
16. Maeda Y, Inoguchi T, Takei R, Sawada F, Sasaki S, et al. (2010) Inhibition of chymase protects against diabetes-induced oxidative stress and renal dysfunction in hamsters. Am J Physiol Renal Physiol 299: F1328-F1338.
17. Ferrario CM, Varagic J, (2010) The ANG-(1-7)/ACE2/mas axis in the regulation of nephron function. Am J Physiol Renal Physiol 298: F1297-F1305.
18. Welches WR, Brosnihan KB, Ferrario CM, (1993) A comparison of the properties and enzymatic activities of three angiotensin processing enzymes: angiotensin converting enzyme, prolyl endopeptidase and neutral endopeptidase 24.11. Life Sci 52: 1461-1480.
19. Batlle M, Roig E, Perez-Villa F, Lario S, Cejudo-Martin P, et al. (2006) Increased expression of the renin-angiotensin system and mast cell density but not of angiotensin-converting enzyme II in late stages of human heart failure. J Heart Lung Transplant 25: 1117-1125.
20. Chen PM, Leng XG, Fan LL, Ma J, Wang YF, et al. (2005) Changes of chymase, angiotensin converting enzyme and angiotensin II type 1 receptor expressions in the hamster heart during the development of heart failure. Chin Med J (Engl) 118: 1886-1892.
21. Dell'Italia LJ, Meng QC, Balcells E, Straeter-Knowlen IM, Hankes GH, et al. (1995) Increased ACE and chymase-like activity in cardiac tissue of dogs with chronic mitral regurgitation. Am J Physiol 269: H2065-H2073.
22. Dell'Italia LJ, Husain A, (2002) Dissecting the role of chymase in angiotensin II formation and heart and blood vessel diseases. Curr Opin Cardiol 17: 374-379.
23. Huang XR, Chen WY, Truong LD, Lan HY, (2003) Chymase is upregulated in diabetic nephropathy: implications for an alternative pathway of angiotensin II-mediated diabetic renal and vascular disease. J Am Soc Nephrol 14: 1738-1747.
24. Urata H, Kinoshita A, Misono KS, Bumpus FM, Husain A, (1990) Identification of a highly specific chymase as the major angiotensin II-forming enzyme in the human heart. J Biol Chem 265: 22348-22357.
25. Urata H, Healy B, Stewart RW, Bumpus FM, Husain A, (1990) Angiotensin II-forming pathways in normal and failing human hearts. Circ Res 66: 883-890.
26. Urata H, Boehm KD, Philip A, Kinoshita A, Gabrovsek J, et al. (1993) Cellular localization and regional distribution of an angiotensin II-forming chymase in the heart. J Clin Invest 91: 1269-1281.
27. Wei CC, Hase N, Inoue Y, Bradley EW, Yahiro E, et al. (2010) Mast cell chymase limits the cardiac efficacy of Ang I-converting enzyme inhibitor therapy in rodents. J Clin Invest 120: 1229-1239.
28. Akasu M, Urata H, Kinoshita A, Sasaguri M, Ideishi M, et al. (1998) Differences in tissue angiotensin II-forming pathways by species and organs in vitro. Hypertension 32: 514-520.
29. Balcells E, Meng QC, Johnson WH Jr, Oparil S, Dell'Italia LJ, (1997) Angiotensin II formation from ACE and chymase in human and animal hearts: methods and species considerations. Am J Physiol 273: H1769-H1774.
30. Becari C, Teixeira FR, Oliveira EB, Salgado MC, (2011) Angiotensin-converting enzyme inhibition augments the expression of rat elastase-2, an angiotensin II-forming enzyme. Am J Physiol Heart Circ Physiol 301: H565-H570.
31. Urata H, Kinoshita A, Perez DM, Misono KS, Bumpus FM, et al. (1991) Cloning of the gene and cDNA for human heart chymase. J Biol Chem 266: 17173-17179.
32. Kinoshita A, Urata H, Bumpus FM, Husain A, (1991) Multiple determinants for the high substrate specificity of an angiotensin II-forming chymase from the human heart. J Biol Chem 266: 19192-19197.
33. Fleming I, (2006) Signaling by the angiotensin-converting enzyme. Circ Res 98: 887-896.
34. Kielty CM, Lees M, Shuttleworth CA, Woolley D, (1993) Catabolism of intact type VI collagen microfibrils: susceptibility to degradation by serine proteinases. Biochem Biophys Res Commun 191: 1230-1236.
35. Lee M, Calabresi L, Chiesa G, Franceschini G, Kovanen PT, (2002) Mast cell chymase degrades apoE and apoA-II in apoA-I-knockout mouse plasma and reduces its ability to promote cellular cholesterol efflux. Arterioscler Thromb Vasc Biol 22: 1475-1481.
36. Tchougounova E, Pejler G, (2001) Regulation of extravascular coagulation and fibrinolysis by heparin-dependent mast cell chymase. FASEB J 15: 2763-2765.
37. Tchougounova E, Pejler G, Abrink M, (2003) The chymase, mouse mast cell protease 4, constitutes the major chymotrypsin-like activity in peritoneum and ear tissue. A role for mouse mast cell protease 4 in thrombin regulation and fibronectin turnover. J Exp Med 198: 423-431.
38. Fukami H, Okunishi H, Miyazaki M, (1998) Chymase: its pathophysiological roles and inhibitors. Curr Pharm Des 4: 439-453.
39. Inoue N, Muramatsu M, Jin D, Takai S, Hayashi T, et al. (2009) Effects of chymase inhibitor on angiotensin II-induced abdominal aortic aneurysm development in apolipoprotein E-deficient mice. Atherosclerosis 204: 359-364.
40. Kanemitsu H, Takai S, Tsuneyoshi H, Yoshikawa E, Nishina T, et al. (2008) Chronic chymase inhibition preserves cardiac function after left ventricular repair in rats. Eur J Cardiothorac Surg 33: 25-31.
41. Komeda K, Jin D, Takai S, Hayashi M, Takeshita A, et al. (2008) Significance of chymase-dependent angiotensin II formation in the progression of human liver fibrosis. Hepatol Res 38: 501-510.
42. Miyazaki M, Takai S, (2006) Tissue angiotensin II generating system by angiotensin-converting enzyme and chymase. J Pharmacol Sci 100: 391-397.
43. Takai S, Shiota N, Sakaguchi M, Muraguchi H, Matsumura E, et al. (1997) Characterization of chymase from human vascular tissues. Clin Chim Acta 265: 13-20.
44. Takai S, Jin D, Sakaguchi M, Miyazaki M, (1999) Chymase-dependent angiotensin II formation in human vascular tissue. Circulation 100: 654-658.
45. Takai S, Jin D, Miyazaki M, (2010) New approaches to blockade of the renin-angiotensin-aldosterone system: chymase as an important target to prevent organ damage. J Pharmacol Sci 113: 301-309.
46. Miyazaki M, Takai S, Jin D, Muramatsu M, (2006) Pathological roles of angiotensin II produced by mast cell chymase and the effects of chymase inhibition in animal models. Pharmacol Ther 112: 668-676.
47. Nakajima K, Powers JC, Ashe BM, Zimmerman M, (1979) Mapping the extended substrate binding site of cathepsin G and human leukocyte elastase. Studies with peptide substrates related to the alpha 1-protease inhibitor reactive site. J Biol Chem 254: 4027-4032.
48. Skeggs LT, Levine M, Lentz KE, Kahn JR, Dorer FE, (1977) New developments in our knowledge of the chemistry of renin. Fed Proc 36: 1755-1759.
49. Dorer FE, Kahn JR, Lentz KE, Levine M, Skeggs LT, (1975) Formation of angiotensin II from tetradecapeptide renin substrate by angiotensin-converting enzyme. Biochem Pharmacol 24: 1137-1139.
50. Dell'Italia LJ, Rocic P, Lucchesi PA, (2002) Use of angiotensin-converting enzyme inhibitors in patients with diabetes and coronary artery disease. Curr Probl Cardiol 27: 6-36.
51. Calkins H, Brugada J, Packer DL, Cappato R, Chen SA, et al. (2007) HRS/EHRA/ECAS expert Consensus Statement on catheter and surgical ablation of atrial fibrillation: recommendations for parsonnel, policy, procedures and follow-up. A report of the Heart Rhythm Society (HRS)Task Force on catheter and surgical ablation of atrial fibrillation. Heart Rhythm 4: 816-861.
52. Gwathmey TM, Shaltout HA, Pendergrass KD, Pirro NT, Figueroa JP, et al. (2009) Nuclear angiotensin II type 2 (AT2) receptors are functionally linked to nitric oxide production. Am J Physiol Renal Physiol 296: F1484-F1493.
53. Shaltout HA, Westwood BM, Averill DB, Ferrario CM, Figueroa JP, et al. (2007) Angiotensin metabolism in renal proximal tubules, urine, and serum of sheep: evidence for ACE2-dependent processing of angiotensin II. Am J Physiol Renal Physiol 292: F82-F91.
54. Cohen JA, Lindsey SH, Pirro NT, Brosnihan KB, Gallagher PE, et al. (2010) Influence of estrogen depletion and salt loading on renal angiotensinogen expression in the mRen(2).Lewis strain. Am J Physiol Renal Physiol 299: F35-F42.