Losartan-dependent regression of myocardial fibrosis is associated with reduction of left ventricular chamber stiffness in hypertensive patients

Circulation

Volumn 105, Issue 21, 2002, Pages 2512-2517

  Díez, Javier ^a   Querejeta, Ramón ^a   López, Begoña ^a   González, Arantxa ^a   Larman, Mariano ^a   Martínez Ubago, José L ^a  

^a UNIVERSITY OF NAVARRA   (Spain)

Author keywords

Collagen; Hypertension; Myocardium; Peptides

Indexed keywords

COLLAGEN; LOSARTAN;

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CORRELATION FUNCTION; DISEASE SEVERITY; DOPPLER ECHOCARDIOGRAPHY; DRUG EFFECT; ESSENTIAL HYPERTENSION; FEMALE; HEART LEFT VENTRICLE; HEART MUSCLE BIOPSY; HEART MUSCLE FIBROSIS; HEART VENTRICLE SEPTUM; HISTOLOGY; HUMAN; HUMAN TISSUE; MALE; MITRAL VALVE; PRIORITY JOURNAL; RIGIDITY; TREATMENT OUTCOME;

ADULT; AGED; ANTIHYPERTENSIVE AGENTS; BIOLOGICAL MARKERS; BIOPSY; BLOOD PRESSURE; CLUSTER ANALYSIS; COLLAGEN; ECHOCARDIOGRAPHY, DOPPLER; ENDOMYOCARDIAL FIBROSIS; FEMALE; HEART FUNCTION TESTS; HUMANS; HYPERTENSION; LOSARTAN; MALE; MIDDLE AGED; MYOCARDIUM; PEPTIDE FRAGMENTS; PROCOLLAGEN; REFERENCE VALUES; REMISSION INDUCTION; TREATMENT OUTCOME; VENTRICULAR DYSFUNCTION, LEFT;

EID: 0037188574     PISSN: 00097322     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.CIR.0000017264.66561.3D     Document Type: Article

References (32)

1. Clinical aspects of hypertensive myocardial fibrosis
2. Collagen matrix synthesis and degradation in the development and regression of left ventricular hypertrophy
3. Losartan inhibits the posttranscriptional synthesis of collagen type I and reverses left ventricular fibrosis in spontaneously hypertensive rats
4. 1 blockade stimulates extracellular collagen type I degradation and reverses myocardial fibrosis in spontaneously hypertensive rats
5. Usefulness of serum carboxyterminal propeptide of procollagen type I in assessment of the cardioreparative ability of antihypertensive treatment in hypertensive patients
6. Left ventricular diastolic function in hypertension and role of plasma glucose and insulin: Comparison with diabetic heart
7. Cardiac interstitium
8. Relation of transmitral flow velocity patterns to left ventricular diastolic function: New insights from combined hemodynamic and Doppler echocardiographic study
9. Doppler characterization of left ventricular diastolic function in cardiac amyloidosis
10. Left ventricular diastolic function: Comparison of pulsed Doppler echocardiographic and hemodynamic indexes in subjects with and without coronary artery disease
11. Determination of left ventricular chamber stiffness from the time for deceleration of early left ventricular filling
12. Mechanisms of altered patterns of left ventricular filling during the development of congestive heart failure
13. Estimation of left ventricular operating stiffness from Doppler early filling deceleration time in humans
14. Serum carboxy-terminal propeptide of procollagen type I is a marker of myocardial fibrosis in hypertensive heart disease
15. Ethical principles for medical research involving human subjects
16. Relation of transmitral flow velocity patterns to left ventricular dysfunction: New insights from a combined hemodynamic and Doppler echocardiographic study
17. Patterns of left ventricular hypertrophy and geometric remodeling in essential hypertension
18. New Doppler echocardiographic applications for the study of diastolic function
19. Muscle fiber orientation and connective tissue content in the hypertrophied human heart
20. Increased serum concentrations of procollagen peptides in essential hypertension: Relation to cardiac alterations
21. Abnormalities of the extracellular degradation of collagen type I in essential hypertension
22. Biochemical assessment of myocardial fibrosis in hypertensive heart disease
23. Myocardial collagen and left ventricular diastolic function
24. Muscle stiffness determined from canine left ventricular pressure-volume curves
25. Structural basis of ventricular stiffness
26. Left ventricular stiffness during diastole and systole: The influence of changes in volume and inotropic state
27. Impaired diastolic function and coronary reserve in genetic hypertension
28. Lisinopril-mediated regression of myocardial fibrosis in patients with hypertensive heart disease
29. Cardioreparative effects of lisinopril in rats with genetic hypertension and left ventricular hypertrophy
30. Effect of angiotensinconverting enzyme inhibition on myocardial fibrosis and function in hypertrophied and failing myocardium from the spontaneously hypertensive rat
31. Dynamic state of collagen: Pathways of collagen degradation in vivo and their possible role in regulation of collagen mass
32. Congestive heart failure in subjects with normal versus reduced left ventricular ejection fraction: Prevalence and mortality in a population-based cohort