-
1
-
-
73949115305
-
The metabolic syndrome
-
Eckel RH, Alberti KG, Grundy SM, Zimmet PZ: The metabolic syndrome. Lancet 2010, 375:181-183.
-
(2010)
Lancet
, vol.375
, pp. 181-183
-
-
Eckel, R.H.1
Alberti, K.G.2
Grundy, S.M.3
Zimmet, P.Z.4
-
2
-
-
70350245011
-
Harmonizing the metabolic syndrome: A joint interim statement of the International Diabetes Federation Task Force on Epidemiology and Prevention; National Heart, Lung, and Blood Institute; American Heart Association; World Heart Federation; International Atherosclerosis Society; and International Association for the Study of Obesity
-
This paper is of particular interest, as it describes the new diagnostic criteria for the metabolic syndrome
-
Alberti KG, Eckel RH, Grundy SM, et al.: Harmonizing the metabolic syndrome: a joint interim statement of the International Diabetes Federation Task Force on Epidemiology and Prevention; National Heart, Lung, and Blood Institute; American Heart Association; World Heart Federation; International Atherosclerosis Society; and International Association for the Study of Obesity. Circulation 2009, 120:1640-1645. This paper is of particular interest, as it describes the new diagnostic criteria for the metabolic syndrome.
-
(2009)
Circulation
, vol.120
, pp. 1640-1645
-
-
Alberti, K.G.1
Eckel, R.H.2
Grundy, S.M.3
-
3
-
-
0037021505
-
The metabolic syndrome and total and cardiovascular disease mortality in middle-aged men
-
DOI 10.1001/jama.288.21.2709
-
Lakka HM, Laaksonen DE, Lakka TA, et al.: The metabolic syndrome and total and cardiovascular disease mortality in middle-aged men. JAMA 2002, 288:2709-2716. (Pubitemid 35403784)
-
(2002)
Journal of the American Medical Association
, vol.288
, Issue.21
, pp. 2709-2716
-
-
Lakka, H.-M.1
Laaksonen, D.E.2
Lakka, T.A.3
Niskanen, L.K.4
Kumpusalo, E.5
Tuomilehto, J.6
Salonen, J.T.7
-
4
-
-
77957198071
-
The metabolic syndrome and cardiovascular risk: A systematic review and meta-analysis
-
This recent meta-analysis described the high cardiovascular risk associated with the metabolic syndrome, using the definition of the National Cholesterol Education Program
-
Motillo S, Filion KB, Genest J, et al.: The metabolic syndrome and cardiovascular risk: a systematic review and meta-analysis. J Am Coll Cardiol 2010, 56:1113-1132. This recent meta-analysis described the high cardiovascular risk associated with the metabolic syndrome, using the definition of the National Cholesterol Education Program.
-
(2010)
J Am Coll Cardiol
, vol.56
, pp. 1113-1132
-
-
Motillo, S.1
Filion, K.B.2
Genest, J.3
-
5
-
-
77951879058
-
Aldosterone: Effects on the kidney and cardiovascular system
-
Briet M, Schiffrin EL: Aldosterone: effects on the kidney and cardiovascular system. Nat.Rev.Nephrol. 2010, 6:261-273.
-
(2010)
Nat.Rev.Nephrol.
, vol.6
, pp. 261-273
-
-
Briet, M.1
Schiffrin, E.L.2
-
6
-
-
34548207763
-
Multimarker approach to evaluate the incidence of the metabolic syndrome and longitudinal changes in metabolic risk factors: The Framingham Offspring Study
-
DOI 10.1161/CIRCULATIONAHA.107.708537
-
Ingelsson E, Pencina MJ, Tofler GH, et al.: Multimarker approach to evaluate the incidence of the metabolic syndrome and longitudinal changes in metabolic risk factors: the Framingham Offspring Study. Circulation 2007, 116:984-992. (Pubitemid 47329563)
-
(2007)
Circulation
, vol.116
, Issue.9
, pp. 984-992
-
-
Ingelsson, E.1
Pencina, M.J.2
Tofler, G.H.3
Benjamin, E.J.4
Lanier, K.J.5
Jacques, P.F.6
Fox, C.S.7
Meigs, J.B.8
Levy, D.9
Larson, M.G.10
Selhub, J.11
D'Agostino Sr., R.B.12
Wang, T.J.13
Vasan, R.S.14
-
7
-
-
0021751231
-
Atrial natriuretic factor inhibits the stimulation of aldosterone secretion by angiotensin II, ACTH and potassium in vitro and angiotensin II-induced steroidogenesis in vivo
-
Chartier L, Schiffrin E, Thibault G, et al.: Atrial natriuretic factor inhibits the stimulation of aldosterone secretion by angiotensin II, ACTH and potassium in vitro and angiotensin II-induced steroidogenesis in vivo. Endocrinology 1984, 115:2026-2028.
-
(1984)
Endocrinology
, vol.115
, pp. 2026-2028
-
-
Chartier, L.1
Schiffrin, E.2
Thibault, G.3
-
8
-
-
77955407190
-
Analysis of insulin sensitivity in adipose tissue of patients with primary aldosteronism
-
This study is the first one to test insulin sensitivity in adipose tissue obtained from patients with primary aldosteronism and controls. The authors did not demonstrate insulin resistance in vitro after aldosterone administration in primary adipocyte cell culture
-
Urbanet R, Pilon C, Calcagno A, et al.: Analysis of insulin sensitivity in adipose tissue of patients with primary aldosteronism. J Clin Endocrinol Metab 2010, 95:4037-4042. This study is the first one to test insulin sensitivity in adipose tissue obtained from patients with primary aldosteronism and controls. The authors did not demonstrate insulin resistance in vitro after aldosterone administration in primary adipocyte cell culture.
-
(2010)
J Clin Endocrinol Metab
, vol.95
, pp. 4037-4042
-
-
Urbanet, R.1
Pilon, C.2
Calcagno, A.3
-
9
-
-
59849118673
-
Reconsidering the roles of the mineralocorticoid receptor
-
This review raises the important question of the role of glucocorticoids acting through MR activation
-
Funder JW: Reconsidering the roles of the mineralocorticoid receptor. Hypertension 2009, 53:286-290. This review raises the important question of the role of glucocorticoids acting through MR activation.
-
(2009)
Hypertension
, vol.53
, pp. 286-290
-
-
Funder, J.W.1
-
10
-
-
0023761690
-
Localisation of 11 beta-hydroxysteroid dehydrogenase - Tissue specific protector of the mineralocorticoid receptor
-
Edwards CR, Stewart PM, Burt D, et al.: Localisation of 11 beta-hydroxysteroid dehydrogenase - tissue specific protector of the mineralocorticoid receptor. Lancet 1988, 2:986-989.
-
(1988)
Lancet
, vol.2
, pp. 986-989
-
-
Edwards, C.R.1
Stewart, P.M.2
Burt, D.3
-
11
-
-
77956478909
-
Expression of genes related to glucocorticoid action in human subcutaneous and omental adipose tissue
-
Veilleux A, Laberge PY, Morency J, et al.: Expression of genes related to glucocorticoid action in human subcutaneous and omental adipose tissue. J Steroid Biochem Mol Biol 2010, 122:28-34.
-
(2010)
J Steroid Biochem Mol Biol
, vol.122
, pp. 28-34
-
-
Veilleux, A.1
Laberge, P.Y.2
Morency, J.3
-
12
-
-
0030444810
-
Exclusion of corticosterone from epithelial mineralocorticoid receptors is insufficient for selectivity of aldosterone action: In vivo binding studies
-
DOI 10.1210/en.137.12.5264
-
Funder J, Myles K: Exclusion of corticosterone from epithelial mineralocorticoid receptors is insufficient for selectivity of aldosterone action: in vivo binding studies. Endocrinology 1996, 137:5264-5268. (Pubitemid 26423083)
-
(1996)
Endocrinology
, vol.137
, Issue.12
, pp. 5264-5268
-
-
Funder, J.1
Myles, K.2
-
13
-
-
78049265267
-
Aldosterone: A cardiovascular risk factor?
-
Funder JW, Reincke M: Aldosterone: a cardiovascular risk factor? Biochim Biophys Acta 2010, 1802:1188-1192.
-
(2010)
Biochim Biophys Acta
, vol.1802
, pp. 1188-1192
-
-
Funder, J.W.1
Reincke, M.2
-
14
-
-
0019424146
-
The effect of weight reduction on blood pressure, plasma renin activity, and plasma aldosterone levels in obese patients
-
Tuck ML, Sowers J, Dornfeld L, et al.: The effect of weight reduction on blood pressure, plasma renin activity, and plasma aldosterone levels in obese patients. N Engl J Med 1981, 304:930-933. (Pubitemid 11101080)
-
(1981)
New England Journal of Medicine
, vol.304
, Issue.16
, pp. 930-933
-
-
Tuck, M.L.1
Sowers, J.2
Dornfeld, L.3
-
15
-
-
47549088476
-
Body mass index predicts plasma aldosterone concentrations in overweight-obese primary hypertensive patients
-
DOI 10.1210/jc.2008-0251
-
Rossi GP, Belfiore A, Bernini G, et al.: Body mass index predicts plasma aldosterone concentrations in overweight-obese primary hypertensive patients. J Clin Endocrinol Metab 2008, 93:2566-2571. (Pubitemid 352008521)
-
(2008)
Journal of Clinical Endocrinology and Metabolism
, vol.93
, Issue.7
, pp. 2566-2571
-
-
Rossi, G.P.1
Belfiore, A.2
Bernini, G.3
Fabris, B.4
Caridi, G.5
Ferri, C.6
Giacchetti, G.7
Letizia, C.8
Maccario, M.9
Mannelli, M.10
Palumbo, G.11
Patalano, A.12
Rizzoni, D.13
Rossi, E.14
Pessina, A.C.15
Mantero, F.16
-
16
-
-
35948958973
-
Body mass index predicts aldosterone production in normotensive adults on a high-salt diet
-
DOI 10.1210/jc.2007-1088
-
Bentley-Lewis R, Adler GK, Perlstein T, et al.: Body mass index predicts aldosterone production in normotensive adults on a high-salt diet. J Clin Endocrinol Metab 2007, 92:4472-4475. (Pubitemid 350074772)
-
(2007)
Journal of Clinical Endocrinology and Metabolism
, vol.92
, Issue.11
, pp. 4472-4475
-
-
Bentley-Lewis, R.1
Adler, G.K.2
Perlstein, T.3
Seely, E.W.4
Hopkins, P.N.5
Williams, G.H.6
Garg, R.7
-
17
-
-
0033158374
-
Visceral obesity and insulin resistance are associated with plasma aldosterone levels in women
-
Goodfriend TL, Kelley DE, Goodpaster BH, Winters SJ: Visceral obesity and insulin resistance are associated with plasma aldosterone levels in women. Obes Res 1999, 7:355-362. (Pubitemid 129710596)
-
(1999)
Obesity Research
, vol.7
, Issue.4
, pp. 355-362
-
-
Goodfriend, T.L.1
Kelley, D.E.2
Goodpaster, B.H.3
Winters, S.J.4
-
18
-
-
14644395574
-
Weight loss and the renin-angiotensin-aldosterone system
-
DOI 10.1161/01.HYP.0000154361.47683.d3
-
Engeli S, Bohnke J, Gorzelniak K, et al.: Weight loss and the renin-angiotensin-aldosterone system. Hypertension 2005, 45:356-362. (Pubitemid 40315803)
-
(2005)
Hypertension
, vol.45
, Issue.3
, pp. 356-362
-
-
Engeli, S.1
Bohnke, J.2
Gorzelniak, K.3
Janke, J.4
Schling, P.5
Bader, M.6
Luft, F.C.7
Sharma, A.M.8
-
19
-
-
0036563232
-
Hormonal regulation of the human adipose-tissue renin-angiotensin system: Relationship to obesity and hypertension
-
DOI 10.1097/00004872-200205000-00032
-
Gorzelniak K, Engeli S, Janke J, et al.: Hormonal regulation of the human adipose-tissue renin-angiotensin system: relationship to obesity and hypertension. J Hypertens 2002, 20:965-973. (Pubitemid 34913678)
-
(2002)
Journal of Hypertension
, vol.20
, Issue.5
, pp. 965-973
-
-
Gorzelniak, K.1
Engeli, S.2
Janke, J.3
Luft, F.C.4
Sharma, A.M.5
-
20
-
-
0026506195
-
In vitro effects of insulin on aldosterone production in rat zona glomerulosa cells
-
Petrasek D, Jensen G, Tuck M, Stern N: In vitro effects of insulin on aldosterone production in rat zona glomerulosa cells. Life Sci 1992, 50:1781-1787.
-
(1992)
Life Sci
, vol.50
, pp. 1781-1787
-
-
Petrasek, D.1
Jensen, G.2
Tuck, M.3
Stern, N.4
-
21
-
-
34548419736
-
Insulin resistance and hyperinsulinemia are related to plasma aldosterone levels in hypertensive patients
-
DOI 10.2337/dc07-0525
-
Colussi G, Catena C, Lapenna R, et al.: Insulin resistance and hyperinsulinemia are related to plasma aldosterone levels in hypertensive patients. Diabetes Care 2007, 30:2349-2354. (Pubitemid 47359046)
-
(2007)
Diabetes Care
, vol.30
, Issue.9
, pp. 2349-2354
-
-
Colussi, G.1
Catena, C.2
Lapenna, R.3
Nadalini, E.4
Chiuch, A.5
Sechi, L.A.6
-
22
-
-
0028912629
-
Relationships among plasma aldosterone, high-density lipoprotein cholesterol, and insulin in humans
-
Goodfriend TL, Egan B, Stepniakowski K, Ball DL: Relationships among plasma aldosterone, high-density lipoprotein cholesterol, and insulin in humans. Hypertension 1995, 25:30-36.
-
(1995)
Hypertension
, vol.25
, pp. 30-36
-
-
Goodfriend, T.L.1
Egan, B.2
Stepniakowski, K.3
Ball, D.L.4
-
23
-
-
43249106771
-
A novel adipokine CTRP1 stimulates aldosterone production
-
This paper provides one of the explanations for the link between obesity and aldosterone synthesis. The authors demonstrated that C1q TNF-related protein (CTRP)1, an adipokine, stimulates the synthesis of aldosterone by cells from the human adrenal cortical cell line H295R
-
Jeon JH, Kim KY, Kim JH, et al.: A novel adipokine CTRP1 stimulates aldosterone production. FASEB J 2008, 22:1502-1511. This paper provides one of the explanations for the link between obesity and aldosterone synthesis. The authors demonstrated that C1q TNF-related protein (CTRP)1, an adipokine, stimulates the synthesis of aldosterone by cells from the human adrenal cortical cell line H295R.
-
(2008)
FASEB J
, vol.22
, pp. 1502-1511
-
-
Jeon, J.H.1
Kim, K.Y.2
Kim, J.H.3
-
24
-
-
0036942824
-
Oxidized products of linoleic acid stimulate adrenal steroidogenesis
-
DOI 10.1081/ERC-120016804
-
Goodfriend TL, Ball DL, Raff H, et al.: Oxidized products of linoleic acid stimulate adrenal steroidogenesis. Endocr Res 2002, 28:325-330. (Pubitemid 36042482)
-
(2002)
Endocrine Research
, vol.28
, Issue.4
, pp. 325-330
-
-
Goodfriend, T.L.1
Ball, D.L.2
Raff, H.3
Bruder, E.D.4
Gardner, H.W.5
Spiteller, G.6
-
25
-
-
0842333052
-
Epoxy-Keto Derivative of Linoleic Acid Stimulates Aldosterone Secretion
-
DOI 10.1161/01.HYP.0000113294.06704.64
-
Goodfriend TL, Ball DL, Egan BM, et al.: Epoxy-keto derivative of linoleic acid stimulates aldosterone secretion. Hypertension 2004, 43:358-363. (Pubitemid 38174139)
-
(2004)
Hypertension
, vol.43
, Issue.2 II
, pp. 358-363
-
-
Goodfriend, T.L.1
Ball, D.L.2
Egan, B.M.3
Campbell, W.B.4
Nithipatikom, K.5
-
26
-
-
10744220710
-
Human adipocytes secrete mineralocorticoid-releasing factors
-
DOI 10.1073/pnas.2336140100
-
Ehrhart-Bornstein M, Lamounier-Zepter V, Schraven A, et al.: Human adipocytes secrete mineralocorticoid-releasing factors. Proc Natl Acad Sci U S A 2003, 100:14211-14216. (Pubitemid 37499216)
-
(2003)
Proceedings of the National Academy of Sciences of the United States of America
, vol.100
, Issue.SUPPL. 2
, pp. 14211-14216
-
-
Ehrhart-Bornstein, M.1
Lamounier-Zepter, V.2
Schraven, A.3
Langenbach, J.4
Willenberg, H.S.5
Barthel, A.6
Hauner, H.7
McCann, S.M.8
Scherbaum, W.A.9
Bornstein, S.R.10
-
28
-
-
34347406538
-
Pivotal role of the mineralocorticoid receptor in corticosteroid-induced adipogenesis
-
DOI 10.1096/fj.06-7970com
-
Caprio M, Feve B, Claes A, et al.: Pivotal role of the mineralocorticoid receptor in corticosteroid-induced adipogenesis. FASEB J 2007, 21:2185-2194. (Pubitemid 47026453)
-
(2007)
FASEB Journal
, vol.21
, Issue.9
, pp. 2185-2194
-
-
Caprio, M.1
Feve, B.2
Claes, A.3
Viengchareun, S.4
Lombes, M.5
Zennaro, M.-C.6
-
29
-
-
19044393872
-
Adipose tissue, inflammation, and cardiovascular disease
-
Berg AH, Scherer PE: Adipose tissue, inflammation, and cardiovascular disease. Circ Res 2005, 96:939-949.
-
(2005)
Circ Res
, vol.96
, pp. 939-949
-
-
Berg, A.H.1
Scherer, P.E.2
-
30
-
-
77956573023
-
Plasma procalcitonin is associated with obesity, insulin resistance, and the metabolic syndrome
-
Abbasi A, Corpeleijn E, Postmus D, et al.: Plasma procalcitonin is associated with obesity, insulin resistance, and the metabolic syndrome. J Clin Endocrinol Metab 2010, 95:E26-E31.
-
(2010)
J Clin Endocrinol Metab
, vol.95
-
-
Abbasi, A.1
Corpeleijn, E.2
Postmus, D.3
-
31
-
-
44049097881
-
Mineralocorticoid receptor blockade reverses obesity-related changes in expression of adiponectin, peroxisome proliferator-activated receptor-gamma, and proinflammatory adipokines
-
Guo C, Ricchiuti V, Lian BQ, et al.: Mineralocorticoid receptor blockade reverses obesity-related changes in expression of adiponectin, peroxisome proliferator-activated receptor-gamma, and proinflammatory adipokines. Circulation 2008, 117:2253-2261.
-
(2008)
Circulation
, vol.117
, pp. 2253-2261
-
-
Guo, C.1
Ricchiuti, V.2
Lian, B.Q.3
-
32
-
-
70449718904
-
Blockade of mineralocorticoid receptor reverses adipocyte dysfunction and insulin resistance in obese mice
-
Hirata A, Maeda N, Hiuge A, et al.: Blockade of mineralocorticoid receptor reverses adipocyte dysfunction and insulin resistance in obese mice. Cardiovasc Res 2009, 84:164-172.
-
(2009)
Cardiovasc Res
, vol.84
, pp. 164-172
-
-
Hirata, A.1
Maeda, N.2
Hiuge, A.3
-
33
-
-
33744954417
-
Aldosterone blockade attenuates urinary monocyte chemoattractant protein-1 and oxidative stress in patients with type 2 diabetes complicated by diabetic nephropathy
-
DOI 10.1210/jc.2005-1718
-
Takebayashi K, Matsumoto S, Aso Y, Inukai T: Aldosterone blockade attenuates urinary monocyte chemoattractant protein-1 and oxidative stress in patients with type 2 diabetes complicated by diabetic nephropathy. J Clin Endocrinol Metab 2006, 91:2214-2217. (Pubitemid 43855008)
-
(2006)
Journal of Clinical Endocrinology and Metabolism
, vol.91
, Issue.6
, pp. 2214-2217
-
-
Takebayashi, K.1
Matsumoto, S.2
Aso, Y.3
Inukai, T.4
-
34
-
-
38549140081
-
Selective mineralocorticoid receptor blocker eplerenone reduces resistance artery stiffness in hypertensive patients
-
This clinical study involving hypertensive patients demonstrated the beneficial effect of eplerenone, an MR blocker, on inflammation and resistance artery stiffness
-
Savoia C, Touyz RM, Amiri F, Schiffrin EL: Selective mineralocorticoid receptor blocker eplerenone reduces resistance artery stiffness in hypertensive patients. Hypertension 2008, 51:432-439. This clinical study involving hypertensive patients demonstrated the beneficial effect of eplerenone, an MR blocker, on inflammation and resistance artery stiffness.
-
(2008)
Hypertension
, vol.51
, pp. 432-439
-
-
Savoia, C.1
Touyz, R.M.2
Amiri, F.3
Schiffrin, E.L.4
-
35
-
-
0013850828
-
Hypertension, the potassium ion and impaired carbohydrate tolerance
-
Conn JW: Hypertension, the potassium ion and impaired carbohydrate tolerance. N Engl J Med 1965, 273:1135-1143.
-
(1965)
N Engl J Med
, vol.273
, pp. 1135-1143
-
-
Conn, J.W.1
-
36
-
-
32544448025
-
Prevalence and characteristics of the metabolic syndrome in primary aldosteronism
-
DOI 10.1210/jc.2005-1733
-
Fallo F, Veglio F, Bertello C, et al.: Prevalence and characteristics of the metabolic syndrome in primary aldosteronism. J Clin Endocrinol Metab 2006, 91:454-459. (Pubitemid 43236909)
-
(2006)
Journal of Clinical Endocrinology and Metabolism
, vol.91
, Issue.2
, pp. 454-459
-
-
Fallo, F.1
Veglio, F.2
Bertello, C.3
Sonino, N.4
Della, M.P.5
Ermani, M.6
Rabbia, F.7
Federspil, G.8
Mulatero, P.9
-
37
-
-
33748752420
-
Insulin sensitivity in patients with primary aldosteronism: A follow-up study
-
DOI 10.1210/jc.2006-0736
-
Catena C, Lapenna R, Baroselli S, et al.: Insulin sensitivity in patients with primary aldosteronism: a follow-up study. J Clin Endocrinol Metab 2006, 91:3457-3463. (Pubitemid 44402119)
-
(2006)
Journal of Clinical Endocrinology and Metabolism
, vol.91
, Issue.9
, pp. 3457-3463
-
-
Catena, C.1
Lapenna, R.2
Baroselli, S.3
Nadalini, E.4
Colussi, G.5
Novello, M.6
Favret, G.7
Melis, A.8
Cavarape, A.9
Sechi, L.A.10
-
38
-
-
72049094255
-
Aldosterone status associated with insulin resistance in patients with heart failure - Data from the ALOFT study
-
Freel EM, Tsorlalis IK, Lewsey JD, et al.: Aldosterone status associated with insulin resistance in patients with heart failure - data from the ALOFT study. Heart 2009, 95:1920-1924.
-
(2009)
Heart
, vol.95
, pp. 1920-1924
-
-
Freel, E.M.1
Tsorlalis, I.K.2
Lewsey, J.D.3
-
39
-
-
77951649148
-
Aldosterone production and insulin resistance in healthy adults
-
Garg R, Hurwitz S, Williams GH, et al.: Aldosterone production and insulin resistance in healthy adults. J Clin Endocrinol Metab 2010, 95:1986-1990.
-
(2010)
J Clin Endocrinol Metab
, vol.95
, pp. 1986-1990
-
-
Garg, R.1
Hurwitz, S.2
Williams, G.H.3
-
40
-
-
0035818572
-
Genetic variation in aldosterone synthase predicts plasma glucose levels
-
DOI 10.1073/pnas.221467098
-
Ranade K, Wu KD, Risch N, et al.: Genetic variation in aldosterone synthase predicts plasma glucose levels. Proc Natl Acad Sci U S A 2001, 98:13219-13224. (Pubitemid 33051343)
-
(2001)
Proceedings of the National Academy of Sciences of the United States of America
, vol.98
, Issue.23
, pp. 13219-13224
-
-
Ranade, K.1
Wu, K.D.2
Risch, N.3
Olivier, M.4
Pei, D.5
Hsiao, C.-F.6
Chuang, L.-M.7
Ho, L.-T.8
Jorgenson, E.9
Pesich, R.10
Chen, Y.-D.I.11
Dzau, V.12
Lin, A.13
Olshen, R.A.14
Curb, D.15
Cox, D.R.16
Botstein, D.17
-
41
-
-
23144456873
-
Aldosterone inhibits uncoupling protein-1, induces insulin resistance, and stimulates proinflammatory adipokines in adipocytes
-
DOI 10.1055/s-2005-870240
-
Kraus D, Jager J, Meier B, et al.: Aldosterone inhibits uncoupling protein-1, induces insulin resistance, and stimulates proinflammatory adipokines in adipocytes. Horm Metab Res 2005, 37:455-459. (Pubitemid 41081228)
-
(2005)
Hormone and Metabolic Research
, vol.37
, Issue.7
, pp. 455-459
-
-
Kraus, D.1
Jager, J.2
Meier, B.3
Fasshauer, M.4
Klein, J.5
-
42
-
-
50349092814
-
Low-dose spironolactone reduces reactive oxygen species generation and improves insulin-stimulated glucose transport in skeletal muscle in the TG(mRen2)27 rat
-
Lastra G, Whaley-Connell A, Manrique C, et al.: Low-dose spironolactone reduces reactive oxygen species generation and improves insulin-stimulated glucose transport in skeletal muscle in the TG(mRen2)27 rat. Am J Physiol Endocrinol Metab 2008, 295:E110-E116.
-
(2008)
Am J Physiol Endocrinol Metab
, vol.295
-
-
Lastra, G.1
Whaley-Connell, A.2
Manrique, C.3
-
43
-
-
63849107748
-
Aldosterone inhibits insulin-induced glucose uptake by degradation of insulin receptor substrate (IRS) 1 and IRS2 via a reactive oxygen species-mediated pathway in 3 T3-L1 adipocytes
-
Wada T, Ohshima S, Fujisawa E, et al.: Aldosterone inhibits insulin-induced glucose uptake by degradation of insulin receptor substrate (IRS) 1 and IRS2 via a reactive oxygen species-mediated pathway in 3 T3-L1 adipocytes. Endocrinology 2009, 150:1662-1669.
-
(2009)
Endocrinology
, vol.150
, pp. 1662-1669
-
-
Wada, T.1
Ohshima, S.2
Fujisawa, E.3
-
44
-
-
34548850880
-
Aldosterone suppresses insulin signaling via the downregulation of insulin receptor substrate-1 in vascular smooth muscle cells
-
DOI 10.1161/HYPERTENSIONAHA.107.093955
-
Hitomi H, Kiyomoto H, Nishiyama A, et al.: Aldosterone suppresses insulin signaling via the downregulation of insulin receptor substrate-1 in vascular smooth muscle cells. Hypertension 2007, 50:750-755. (Pubitemid 47442741)
-
(2007)
Hypertension
, vol.50
, Issue.4
, pp. 750-755
-
-
Hitomi, H.1
Kiyomoto, H.2
Nishiyama, A.3
Hara, T.4
Moriwaki, K.5
Kaifu, K.6
Ihara, G.7
Fujita, Y.8
Ugawa, T.9
Kohno, M.10
-
45
-
-
2442695641
-
Aldosterone stimulates gene expression of hepatic gluconeogenic enzymes through the glucocorticoid receptor in a manner independent of the protein kinase B cascade
-
DOI 10.1507/endocrj.51.243
-
Yamashita R, Kikuchi T, Mori Y, et al.: Aldosterone stimulates gene expression of hepatic gluconeogenic enzymes through the glucocorticoid receptor in a manner independent of the protein kinase B cascade. Endocr J 2004, 51:243-251. (Pubitemid 38657562)
-
(2004)
Endocrine Journal
, vol.51
, Issue.2
, pp. 243-251
-
-
Yamashita, R.1
Kikuchi, T.2
Mori, Y.3
Aoki, K.4
Kaburagi, Y.5
Yasuda, K.6
Sekihara, H.7
-
46
-
-
77953165944
-
Spironolactone improves glucose and lipid metabolism by ameliorating hepatic steatosis and inflammation and suppressing enhanced gluconeogenesis induced by high-fat and high-fructose diet
-
The authors demonstrated the role of MR activation in hepatic steatosis, inflammation, and oxidative stress in mice receiving a high-fat and high-fructose diet. They also demonstrated that MR activation is implicated in hepatic gluconeogenesis, which could participate in the impairment of glucose metabolism associated with metabolic syndrome
-
Wada T, Kenmochi H, Miyashita Y, et al.: Spironolactone improves glucose and lipid metabolism by ameliorating hepatic steatosis and inflammation and suppressing enhanced gluconeogenesis induced by high-fat and high-fructose diet. Endocrinology 2010, 151:2040-2049. The authors demonstrated the role of MR activation in hepatic steatosis, inflammation, and oxidative stress in mice receiving a high-fat and high-fructose diet. They also demonstrated that MR activation is implicated in hepatic gluconeogenesis, which could participate in the impairment of glucose metabolism associated with metabolic syndrome.
-
(2010)
Endocrinology
, vol.151
, pp. 2040-2049
-
-
Wada, T.1
Kenmochi, H.2
Miyashita, Y.3
-
47
-
-
33748141662
-
Plasma aldosterone is independently associated with the metabolic syndrome
-
DOI 10.1161/01.HYP.0000231338.41548.fc, PII 0000426820060800000016
-
Bochud M, Nussberger J, Bovet P, et al.: Plasma aldosterone is independently associated with the metabolic syndrome. Hypertension 2006, 48:239-245. (Pubitemid 44309818)
-
(2006)
Hypertension
, vol.48
, Issue.2
, pp. 239-245
-
-
Bochud, M.1
Nussberger, J.2
Bovet, P.3
Maillard, M.R.4
Elston, R.C.5
Paccaud, F.6
Shamlaye, C.7
Burnier, M.8
-
48
-
-
21044441652
-
Clinical and genetic correlates of serum aldosterone in the community: The framingham heart study
-
DOI 10.1016/j.amjhyper.2004.12.005, PII S0895706105000063
-
Kathiresan S, Larson MG, Benjamin EJ, et al.: Clinical and genetic correlates of serum aldosterone in the community: the Framingham Heart Study. Am J Hypertens 2005, 18:657-665. (Pubitemid 40692433)
-
(2005)
American Journal of Hypertension
, vol.18
, Issue.5
, pp. 657-665
-
-
Kathiresan, S.1
Larson, M.G.2
Benjamin, E.J.3
Corey, D.4
Murabito, J.M.5
Fox, C.S.6
Wilson, P.W.F.7
Rifai, N.8
Meigs, J.B.9
Ricken, G.10
Lifton, R.P.11
Levy, D.12
Vasan, R.S.13
-
49
-
-
34447136169
-
Beneficial effects of eplerenone versus hydrochlorothiazide on coronary circulatory function in patients with diabetes mellitus
-
DOI 10.1210/jc.2007-0393
-
Joffe HV, Kwong RY, Gerhard-Herman MD, et al.: Beneficial effects of eplerenone versus hydrochlorothiazide on coronary circulatory function in patients with diabetes mellitus. J Clin Endocrinol Metab 2007, 92:2552-2558. (Pubitemid 47037357)
-
(2007)
Journal of Clinical Endocrinology and Metabolism
, vol.92
, Issue.7
, pp. 2552-2558
-
-
Joffe, H.V.1
Kwong, R.Y.2
Gerhard-Herman, M.D.3
Rice, C.4
Feldman, K.5
Adler, G.K.6
-
50
-
-
34548513414
-
The effect of spironolactone on circulating adipocytokines in patients with type 2 diabetes mellitus complicated by diabetic nephropathy
-
DOI 10.1016/j.metabol.2006.07.025, PII S0026049506002836
-
Matsumoto S, Takebayashi K, Aso Y: The effect of spironolactone on circulating adipocytokines in patients with type 2 diabetes mellitus complicated by diabetic nephropathy. Metabolism 2006, 55:1645-1652. (Pubitemid 44827131)
-
(2006)
Metabolism: Clinical and Experimental
, vol.55
, Issue.12
, pp. 1645-1652
-
-
Matsumoto, S.1
Takebayashi, K.2
Aso, Y.3
-
51
-
-
49849106703
-
Salt excess causes left ventricular diastolic dysfunction in rats with metabolic disorder
-
Matsui H, Ando K, Kawarazaki H, et al.: Salt excess causes left ventricular diastolic dysfunction in rats with metabolic disorder. Hypertension 2008, 52:287-294.
-
(2008)
Hypertension
, vol.52
, pp. 287-294
-
-
Matsui, H.1
Ando, K.2
Kawarazaki, H.3
-
52
-
-
0037417252
-
Eplerenone, a selective aldosterone blocker, in patients with left ventricular dysfunction after myocardial infarction
-
DOI 10.1056/NEJMoa030207
-
Pitt B, Remme W, Zannad F, et al.: Eplerenone, a selective aldosterone blocker, in patients with left ventricular dysfunction after myocardial infarction. N Engl J Med 2003, 348:1309-1321. (Pubitemid 36384098)
-
(2003)
New England Journal of Medicine
, vol.348
, Issue.14
, pp. 1309-1321
-
-
Pitt, B.1
Remme, W.2
Zannad, F.3
Neaton, J.4
Martinez, F.5
Roniker, B.6
Bittman, R.7
Hurley, S.8
Kleiman, J.9
Gatlin, M.10
-
53
-
-
0033517302
-
The effect of spironolactone on morbidity and mortality in patients with severe heart failure
-
DOI 10.1056/NEJM199909023411001
-
Pitt B, Zannad F, Remme WJ, et al.: The effect of spironolactone on morbidity and mortality in patients with severe heart failure. Randomized Aldactone Evaluation Study Investigators. N Engl J Med 1999, 341:709-717. (Pubitemid 29407370)
-
(1999)
New England Journal of Medicine
, vol.341
, Issue.10
, pp. 709-717
-
-
Pitt, B.1
Zannad, F.2
Remme, W.J.3
Cody, R.4
Castaigne, A.5
Perez, A.6
Palensky, J.7
Wittes, J.8
-
54
-
-
0028290539
-
Mineralocorticoids, hypertension, and cardiac fibrosis
-
Young M, Fullerton M, Dilley R, Funder J: Mineralocorticoids, hypertension, and cardiac fibrosis. J Clin Invest 1994, 93:2578-2583. (Pubitemid 24177174)
-
(1994)
Journal of Clinical Investigation
, vol.93
, Issue.6
, pp. 2578-2583
-
-
Young, M.1
Fullerton, M.2
Dilley, R.3
Funder, J.4
-
55
-
-
0027081410
-
Mineralocorticoid excess, dietary sodium, and myocardial fibrosis
-
Brilla CG, Weber KT: Mineralocorticoid excess, dietary sodium, and myocardial fibrosis. J Lab Clin Med. 1992, 120:893-901. (Pubitemid 23002899)
-
(1992)
Journal of Laboratory and Clinical Medicine
, vol.120
, Issue.6
, pp. 893-901
-
-
Brilla, C.G.1
Weber, K.T.2
-
56
-
-
31744433843
-
Cardioprotective mechanisms of spironolactone associated with the angiotensinconverting enzyme/epidermal growth factor receptor/extracellular signal-regulated kinases, NAD(P)H oxidase/lectin-like oxidized low-density lipoprotein receptor-1, and Rho-kinase pathways in aldosterone/salt-induced hypertensive rats
-
Nakano S, Kobayashi N, Yoshida K, et al.: Cardioprotective mechanisms of spironolactone associated with the angiotensinconverting enzyme/epidermal growth factor receptor/extracellular signal-regulated kinases, NAD(P)H oxidase/lectin-like oxidized low-density lipoprotein receptor-1, and Rho-kinase pathways in aldosterone/salt-induced hypertensive rats. Hypertens Res 2005, 28:925-936.
-
(2005)
Hypertens Res
, vol.28
, pp. 925-936
-
-
Nakano, S.1
Kobayashi, N.2
Yoshida, K.3
-
57
-
-
2542463111
-
Eplerenone prevents salt-induced vascular remodelling and cardiac fibrosis in stroke-prone spontaneously hypertensive rats
-
DOI 10.1161/01.HYP.0000128031.31572.a3
-
Endemann DH, Touyz RM, Iglarz M, et al.: Eplerenone prevents salt-induced vascular remodeling and cardiac fibrosis in stroke-prone spontaneously hypertensive rats. Hypertension 2004, 43:1252-1257. (Pubitemid 38691747)
-
(2004)
Hypertension
, vol.43
, Issue.6
, pp. 1252-1257
-
-
Endemann, D.H.1
Touyz, R.M.2
Iglarz, M.3
Savoia, C.4
Schiffrin, E.L.5
-
58
-
-
0034636125
-
Vascular superoxide production and vasomotor function in hypertension induced by deoxycorticosterone acetate-salt
-
Somers MJ, Mavromatis K, Galis ZS, Harrison DG: Vascular superoxide production and vasomotor function in hypertension induced by deoxycorticosterone acetate-salt. Circulation 2000, 101:1722-1728. (Pubitemid 30196634)
-
(2000)
Circulation
, vol.101
, Issue.14
, pp. 1722-1728
-
-
Somers, M.J.1
Mavromatis, K.2
Galis, Z.S.3
Harrison, D.G.4
-
59
-
-
0035095743
-
Long-term antioxidant administration attenuates mineralocorticoid hypertension and renal inflammatory response
-
Beswick RA, Zhang H, Marable D, et al.: Long-term antioxidant administration attenuates mineralocorticoid hypertension and renal inflammatory response. Hypertension 2001, 37:781-786. (Pubitemid 32199066)
-
(2001)
Hypertension
, vol.37
, Issue.2 II
, pp. 781-786
-
-
Beswick, R.A.1
Zhang, H.2
Marable, D.3
Catravas, J.D.4
Hill, W.D.5
Clinton, W.R.6
-
60
-
-
0036841807
-
Aldosterone-induced inflammation in the rat heart: Role of oxidative stress
-
Sun Y, Zhang J, Lu L, et al.: Aldosterone-induced inflammation in the rat heart : role of oxidative stress. Am J Pathol 2002, 161:1773-1781. (Pubitemid 35265535)
-
(2002)
American Journal of Pathology
, vol.161
, Issue.5
, pp. 1773-1781
-
-
Sun, Y.1
Zhang, J.2
Lu, L.3
Chen, S.S.4
Quinn, M.T.5
Weber, K.T.6
-
61
-
-
0035895333
-
A receptor antagonism
-
Ammarguellat F, Larouche I, Schiffrin EL: Myocardial fibrosis in DOCA-salt hypertensive rats: effect of endothelin ET(A) receptor antagonism. Circulation 2001, 103:319-324. (Pubitemid 32095422)
-
(2001)
Circulation
, vol.103
, Issue.2
, pp. 319-324
-
-
Ammarguellat, F.1
Larouche, I.2
Schiffrin, E.L.3
-
62
-
-
0036178760
-
Cardiac and vascular fibrosis and hypertrophy in aldosterone-infused rats: Role of endothelin-1
-
DOI 10.1016/S0895-7061(01)02291-9, PII S0895706101022919
-
Park JB, Schiffrin EL: Cardiac and vascular fibrosis and hypertrophy in aldosterone-infused rats: role of endothelin-1. Am J Hypertens 2002, 15:164-169. (Pubitemid 34161092)
-
(2002)
American Journal of Hypertension
, vol.15
, Issue.2 I
, pp. 164-169
-
-
Park, J.B.1
Schiffrin, E.L.2
-
63
-
-
0038141826
-
Endothelin antagonism on aldosterone-induced oxidative stress and vascular remodeling
-
DOI 10.1161/01.HYP.0000078357.92682.EC
-
Pu Q, Neves MF, Virdis A, et al.: Endothelin antagonism on aldosterone-induced oxidative stress and vascular remodeling. Hypertension 2003, 42:49-55. (Pubitemid 36849598)
-
(2003)
Hypertension
, vol.42
, Issue.1
, pp. 49-55
-
-
Pu, Q.1
Neves, M.F.2
Virdis, A.3
Touyz, R.M.4
Schiffrin, E.L.5
-
65
-
-
12144286297
-
Possible Contributions of Reactive Oxygen Species and Mitogen-Activated Protein Kinase to Renal Injury in Aldosterone/Salt-Induced Hypertensive Rats
-
DOI 10.1161/01.HYP.0000118519.66430.22
-
Nishiyama A, Yao L, Nagai Y, et al.: Possible contributions of reactive oxygen species and mitogen-activated protein kinase to renal injury in aldosterone/salt-induced hypertensive rats. Hypertension 2004, 43:841-848. (Pubitemid 38405598)
-
(2004)
Hypertension
, vol.43
, Issue.4
, pp. 841-848
-
-
Nishiyama, A.1
Yao, L.2
Nagai, Y.3
Miyata, K.4
Yoshizumi, M.5
Kagami, S.6
Kondo, S.7
Kiyomoto, H.8
Shokoji, T.9
Kimura, S.10
Kohno, M.11
Abe, Y.12
-
66
-
-
33846443625
-
Podocyte as the target for aldosterone: Roles of oxidative stress and Sgk1
-
DOI 10.1161/01.HYP.0000255636.11931.a2, PII 0000426820070200000021
-
Shibata S, Nagase M, Yoshida S, et al.: Podocyte as the target for aldosterone: roles of oxidative stress and Sgk1. Hypertension 2007, 49:355-364. (Pubitemid 46143013)
-
(2007)
Hypertension
, vol.49
, Issue.2
, pp. 355-364
-
-
Shibata, S.1
Nagase, M.2
Yoshida, S.3
Kawachi, H.4
Fujita, T.5
-
67
-
-
33845238078
-
Enhanced aldosterone signaling in the early nephropathy of rats with metabolic syndrome: Possible contribution of fat-derived factors
-
Nagase M, Yoshida S, Shibata S, et al.: Enhanced aldosterone signaling in the early nephropathy of rats with metabolic syndrome: possible contribution of fat-derived factors. J.Am.Soc. Nephrol. 2006, 17:3438-3446.
-
(2006)
J.Am.Soc. Nephrol.
, vol.17
, pp. 3438-3446
-
-
Nagase, M.1
Yoshida, S.2
Shibata, S.3
-
68
-
-
2342481268
-
Comparison of renal morphology in the Streptozotocin and the SHR/N-cp models of diabetes
-
DOI 10.1038/labinvest.3700052
-
Gross ML, Ritz E, Schoof A, et al.: Comparison of renal morphology in the Streptozotocin and the SHR/N-cp models of diabetes. Lab Invest 2004, 84:452-464. (Pubitemid 41656473)
-
(2004)
Laboratory Investigation
, vol.84
, Issue.4
, pp. 452-464
-
-
Gross, M.L.1
Ritz, E.2
Schoof, A.3
Adamczak, M.4
Koch, A.5
Tulp, O.6
Parkman, A.7
El-Shakmak, A.8
Szabo, A.9
Amann, K.10
-
69
-
-
35848952953
-
Salt-induced nephropathy in obese spontaneously hypertensive rats via paradoxical activation of the mineralocorticoid receptor: Role of oxidative stress
-
DOI 10.1161/HYPERTENSIONAHA.107.091058
-
Nagase M, Matsui H, Shibata S, et al.: Salt-induced nephropathy in obese spontaneously hypertensive rats via paradoxical activation of the mineralocorticoid receptor: role of oxidative stress. Hypertension 2007, 50:877-883. (Pubitemid 350287529)
-
(2007)
Hypertension
, vol.50
, Issue.5
, pp. 877-883
-
-
Nagase, M.1
Matsui, H.2
Shibata, S.3
Gotoda, T.4
Fujita, T.5
|