Cytosolic (pro)renin and the matter of intracellular renin actions

Frontiers in Bioscience - Scholar

Volumn 5 S, Issue 1, 2013, Pages 198-205

  Peters, Jorg ^a  

^a UNIVERSITY OF GREIFSWALD   (Germany)

Author keywords

Angiotensin; Cytoplasmatic renin; Intracellular renin angiotensin system; Prorenin; Renin; Review; Secretory renin

Indexed keywords

ALDOSTERONE; ANGIOTENSIN II; CYTOSOLIC RENIN; LACTATE DEHYDROGENASE; PRORENIN; RENIN; SECRETORY PROTEIN; UNCLASSIFIED DRUG;

ALDOSTERONE RELEASE; AMINO TERMINAL SEQUENCE; CELL NUCLEUS; CELL VACUOLE; CYTOSOL; ENDOPLASMIC RETICULUM; ENZYME ACTIVITY; EXON; GENE OVEREXPRESSION; HEART MUSCLE ISCHEMIA; HEART MUSCLE NECROSIS; MITOCHONDRIAL ENERGY TRANSFER; MITOCHONDRION; NONHUMAN; OXIDATIVE PHOSPHORYLATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN TRANSPORT; REGULATORY MECHANISM; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM; REVIEW; RIBOSOME; RNA TRANSLATION; SIGNAL TRANSDUCTION; UPREGULATION; ANIMAL; HUMAN; METABOLISM; PHYSIOLOGY;

ANIMALS; CYTOSOL; HUMANS; RENIN; RENIN-ANGIOTENSIN SYSTEM;

EID: 84883729395     PISSN: 19450516     EISSN: 19450524     Source Type: Journal    
DOI: 10.2741/s366     Document Type: Review

References (40)

1. Nguyen G., F. Delarue, C. Burckle, L. Bouzhir, T. Giller and J. D. Sraer: Pivotal role of the renin/prorenin receptor in angiotensin II production and cellular responses to renin. J Clin Invest 109(11), 1417-27 (2002)
2. Nguyen G. and A. H. Danser: Prorenin and (pro)renin receptor: a review of available data from in vitro studies and experimental models in rodents. Exp Physiol 93(5), 557-63 (2008)
3. Hackenthal E., M. Paul, D. Ganten and R. Taugner: Morphology, physiology, and molecular biology of renin secretion. Physiol Rev 70(4), 1067-116 (1990)
4. Inagami T., M. Nakamaru, K. N. Pandey, M. Naruse, K. Naruse, K. Misono, T. Okamura and M. Kawamura: Intracellular action of renin, angiotensin production and release. J Hypertens Suppl, 4(4), S11-6 (1986)
5. Rong P., J. L. Berka, D. J. Kelly, D. Alcorn and S. L. Skinner: Renin processing and secretion in adrenal and retina of transgenic (mREN-2)27 rats. Kidney Int 46(6), 1583-7 (1994)
6. Peters J., B. Kranzlin, S. Schaeffer, J. Zimmer, S. Resch, S. Bachmann, N. Gretz and E. Hackenthal: Presence of renin within intramitochondrial dense bodies of the rat adrenal cortex. Am J Physiol 271(3 Pt 1), E439-50 (1996)
7. Clausmeyer S., R. Sturzebecher and J. Peters: An alternative transcript of the rat renin gene can result in a truncated prorenin that is transported into adrenal mitochondria. Circ Res 84(3), 337-44 (1999)
8. Lee-Kirsch M. A., F. Gaudet, M. C. Cardoso and K. Lindpaintner: Distinct renin isoforms generated by tissue-specific transcription initiation and alternative splicing. Circ Res 84(2), 240-6 (1999)
9. Sinn P. L. and C. D. Sigmund: Identification of three human renin mRNA isoforms from alternative tissuespecific transcriptional initiation. Physiol Genomics 3(1), 25-31 (2000)
10. Mercure C., G. Thibault, S. Lussier-Cacan, J. Davignon, E. L. Schiffrin and T. L. Reudelhuber: Molecular analysis of human prorenin prosegment variants in vitro and in vivo. J Biol Chem 270(27), 16355-9 (1995)
11. Wanka H., N. Keßler, J. Ellmer, N. Endlich, B. S. Peters, S. Clausmeyer and J. Peters: Cytosolic renin is targeted to mitochondria and induces apoptosis in H9c2 rat cardiomyoblasts. J Cell Mol Med 13(9A), 2926-37 (2009)
12. Peters J., H. Wanka, B. Peters and S. Hoffmann: A renin transcript lacking exon 1 encodes for a nonsecretory intracellular renin that increases aldosterone production in transgenic rats. J Cell Mol Med 12(4), 1229-37 (2008)
13. Lavoie J. L., X. Liu, R. A. Bianco, T. G. Beltz, A. K. Johnson and C. D. Sigmund: Evidence supporting a functional role for intracellular renin in the brain. Hypertension 47(3), 461-6 (2006)
14. Neupert W. and M. Brunner: The protein import motor of mitochondria. Nat Rev Mol Cell Biol 3(8), 555-65 (2002)
15. Clausmeyer S., A. Reinecke, R. Farrenkopf, T. Unger and J. Peters: Tissue-specific expression of a rat renin transcript lacking the coding sequence for the prefragment and its stimulation by myocardial infarction. Endocrinology 141(8), 2963-70 (2000)
16. Xu D., G. R. Borges, J. L. Grobe, C. J. Pelham, B. Yang and C. D. Sigmund: Preservation of intracellular renin expression is insufficient to compensate for genetic loss of secreted renin. Hypertension 54(6), 1240-7 (2009)
17. Oliverio M. I., H. S. Kim, M. Ito, T. Le, L. Audoly, C. F. Best, S. Hiller, K. Kluckman, N. Maeda, O. Smithies and T. M. Coffman: Reduced growth, abnormal kidney structure, and type 2 (AT2) angiotensin receptor-mediated blood pressure regulation in mice lacking both AT1A and AT1B receptors for angiotensin II. Proc Natl Acad Sci U S A 95(26), 15496-501 (1998)
18. Takahashi N., M. L. Lopez, J. E. Cowhig, Jr., M. A. Taylor, T. Hatada, E. Riggs, G. Lee, R. A. Gomez, H. S. Kim and O. Smithies: Ren1c homozygous null mice are hypotensive and polyuric, but heterozygotes are indistinguishable from wild-Type. J Am Soc Nephrol 16(1), 125-32 (2005)
19. Kim H. S., N. Maeda, G. T. Oh, L. G. Fernandez, R. A. Gomez and O. Smithies: Homeostasis in mice with genetically decreased angiotensinogen is primarily by an increased number of renin-producing cells. J Biol Chem 274(20), 14210-7 (1999)
20. Takahashi N., F. Li, K. Hua, J. Deng, C. H. Wang, R. R. Bowers, T. J. Bartness, H. S. Kim and J. B. Harp: Increased energy expenditure, dietary fat wasting, and resistance to diet-induced obesity in mice lacking renin. Cell Metab 6(6), 506-12 (2007)
21. Lochard N., D. W. Silversides, J. P. van Kats, C. Mercure and T. L. Reudelhuber: Brain-specific restoration of angiotensin II corrects renal defects seen in angiotensinogen-deficient mice. J Biol Chem 278(4), 2184-9 (2003)
22. Erdmann B., K. Fuxe and D. Ganten: Subcellular localization of angiotensin II immunoreactivity in the rat cerebellar cortex. Hypertension 28(5), 818-24 (1996)
23. Robertson A. L., Jr. and P. A. Khairallah: Angiotensin II: rapid localization in nuclei of smooth and cardiac muscle. Science 172(988), 1138-9 (1971)
24. Re R. N., D. L. Vizard, J. Brown and S. E. Bryan: Angiotensin II receptors in chromatin fragments generated by micrococcal nuclease. Biochem Biophys Res Commun 119(1), 220-7 (1984)
25. De Mello W. C.: Influence of intracellular renin on heart cell communication. Hypertension 25(6), 1172-7 (1995)
26. Haller H., C. Lindschau, B. Erdmann, P. Quass and F. C. Luft: Effects of intracellular angiotensin II in vascular smooth muscle cells. Circ Res 79(4), 765-72 (1996)
27. De Mello W. C.: Intracellular angiotensin II regulates the inward calcium current in cardiac myocytes. Hypertension 32(6), 976-82 (1998)
28. Eto K., Y. Ohya, Y. Nakamura, I. Abe and M. Iida: Intracellular angiotensin II stimulates voltage-operated Ca(2+) channels in arterial myocytes. Hypertension 39(2 Pt 2), 474-8 (2002)
29. Cook J. L., Z. Zhang and R. N. Re: In vitro evidence for an intracellular site of angiotensin action. Circ Res 89(12), 1138-46 (2001)
30. Cook J. L., R. Re, J. Alam, M. Hart and Z. Zhang: Intracellular angiotensin II fusion protein alters AT1 receptor fusion protein distribution and activates CREB. J Mol Cell Cardiol 36(1), 75-90 (2004)
31. Tadevosyan A., A. Maguy, L. R. Villeneuve, J. Babin, A. Bonnefoy, B. G. Allen and S. Nattel: Nucleardelimited angiotensin receptor-mediated signaling regulates cardiomyocyte gene expression. J Biol Chem 285(29), 22338-49 (2010)
32. Abadir P. M., D. B. Foster, M. Crow, C. A. Cooke, J. J. Rucker, A. Jain, B. J. Smith, T. N. Burks, R. D. Cohn, N. S. Fedarko, R. M. Carey, B. O'Rourke and J. D. Walston: Identification and characterization of a functional mitochondrial angiotensin system. Proc Natl Acad Sci U S A 108(36), 14849-54 (2011)
33. Re R. N. and J. L. Cook: The mitochondrial component of intracrine action. Am J Physiol Heart Circ Physiol 299(3), H577-83 (2010)
34. Takahashi S., T. Ohsawa, R. Miura and Y. Miyake: Purification of high molecular weight (HMW) renin from porcine kidney and direct evidence that the HMW renin is a complex of renin with renin binding protein (RnBP). J Biochem 93(1), 265-74 (1983)
35. Schmitz C., M. Gotthardt, S. Hinderlich, J. R. Leheste, V. Gross, H. Vorum, E. I. Christensen, F. C. Luft, S. Takahashi and T. E. Willnow: Normal blood pressure and plasma renin activity in mice lacking the renin-binding protein, a cellular renin inhibitor. J Biol Chem 275(20), 15357-62 (2000)
36. Tan Q., G. De Benedictis, S. V. Ukraintseva, C. Franceschi, J. W. Vaupel and A. I. Yashin: A centenarian-only approach for assessing gene-gene interaction in human longevity. Eur J Hum Genet 10(2), 119-24 (2002)
37. Peters J.: Secretory and cytosolic (pro)renin in kidney, heart, and adrenal gland. J Mol Med (Berl) 86(6), 711-4 (2008)
38. Peters J., K. Munter, M. Bader, E. Hackenthal, J. J. Mullins and D. Ganten: Increased adrenal renin in transgenic hypertensive rats, TGR(mREN2)27, and its regulation by cAMP, angiotensin II, and calcium. J Clin Invest 91(3), 742-7 (1993)
39. Peters J., N. Obermuller, A. Woyth, B. Peters, C. Maser-Gluth, B. Kranzlin and N. Gretz: Losartan and angiotensin II inhibit aldosterone production in anephric rats via different actions on the intraadrenal renin-Angiotensin system. Endocrinology 140(2), 675-82 (1999)
40. Peters J. and S. Clausmeyer: Intracellular sorting of renin: cell type specific differences and their consequences. J Mol Cell Cardiol 34(12), 1561-8 (2002)