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Volumn 5, Issue APR, 2014, Pages

T cell responses to viral infections - opportunities for peptide vaccination

Author keywords

Acute; Chronic; DC; Infection; Peptides; Vaccination; Virus

Indexed keywords

ANTIGEN; CYTOKINE; GAG PROTEIN; GAMMA INTERFERON; IMMUNOLOGICAL ADJUVANT; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; PEPTIDE VACCINE; TOLL LIKE RECEPTOR; TUMOR NECROSIS FACTOR ALPHA; VIRUS VACCINE;

EID: 84900867914     PISSN: None     EISSN: 16643224     Source Type: Journal    
DOI: 10.3389/fimmu.2014.00171     Document Type: Review
Times cited : (170)

References (117)
  • 2
    • 0023772685 scopus 로고
    • Herpes simplex virus infection of the human sensory neuron. An electron microscopy study
    • doi: 10.1007/BF01314654
    • Lycke E, Hamark B, Johansson M, Krotochwil A, Lycke J, Svennerholm B. Herpes simplex virus infection of the human sensory neuron. An electron microscopy study. Arch Virol (1988) 101:87-104. doi: 10.1007/BF01314654.
    • (1988) Arch Virol , vol.101 , pp. 87-104
    • Lycke, E.1    Hamark, B.2    Johansson, M.3    Krotochwil, A.4    Lycke, J.5    Svennerholm, B.6
  • 3
    • 84900839871 scopus 로고    scopus 로고
    • WHO. Influenza Factsheet
    • WHO. Influenza Factsheet. (2009). Available from: http://www.who.int/mediacentre/factsheets/fs211/en/index.html.
    • (2009)
  • 5
    • 49749222804 scopus 로고
    • Virus particles in cultured lymphoblasts from Burkitt's lymphoma
    • doi:10.1016/S0140-6736(64)91524-7
    • Epstein MA, Achong BG, Barr YM. Virus particles in cultured lymphoblasts from Burkitt's lymphoma. Lancet (1964) 1:702-3. doi:10.1016/S0140-6736(64)91524-7.
    • (1964) Lancet , vol.1 , pp. 702-703
    • Epstein, M.A.1    Achong, B.G.2    Barr, Y.M.3
  • 9
    • 84870166070 scopus 로고    scopus 로고
    • Immune response to viruses: cell-mediated immunity
    • Mahy BWJ, van Regenmortel MHV, editors. Birmingham, AL: Elsevier
    • Zajac AJ. Immune response to viruses: cell-mediated immunity. In: Mahy BWJ, van Regenmortel MHV, editors. Encyclopedia of Virology. Birmingham, AL: Elsevier (2008). p. 70-7.
    • (2008) Encyclopedia of Virology , pp. 70-77
    • Zajac, A.J.1
  • 10
    • 65649117727 scopus 로고    scopus 로고
    • The role of CD4 T cell help for CD8 CTL activation
    • doi:10.1016/j.bbrc.2009.04.134
    • Zhang S, Zhang H, Zhao J. The role of CD4 T cell help for CD8 CTL activation. Biochem Biophys Res Commun (2009) 384:405-8. doi:10.1016/j.bbrc.2009.04.134.
    • (2009) Biochem Biophys Res Commun , vol.384 , pp. 405-408
    • Zhang, S.1    Zhang, H.2    Zhao, J.3
  • 13
    • 84856511137 scopus 로고    scopus 로고
    • +) T cells during cytomegalovirus infection
    • doi:10.1007/s12026-011-8251-9
    • +) T cells during cytomegalovirus infection. Immunol Res (2011) 51:195-204. doi:10.1007/s12026-011-8251-9.
    • (2011) Immunol Res , vol.51 , pp. 195-204
    • Snyder, C.M.1
  • 14
    • 84859423387 scopus 로고    scopus 로고
    • Measles virus, immune control, and persistence
    • doi:10.1111/j.1574-6976.2012.00330.x
    • Griffin DE, Lin WH, Pan CH. Measles virus, immune control, and persistence. FEMS Microbiol Rev (2012) 36:649-62. doi:10.1111/j.1574-6976.2012.00330.x.
    • (2012) FEMS Microbiol Rev , vol.36 , pp. 649-662
    • Griffin, D.E.1    Lin, W.H.2    Pan, C.H.3
  • 16
    • 33847670199 scopus 로고    scopus 로고
    • NS1 protein of influenza A virus inhibits the function of intracytoplasmic pathogen sensor, RIG-I
    • doi:10.1165/rcmb.2006-0283RC
    • Guo Z, Chen LM, Zeng H, Gomez JA, Plowden J, Fujita T, et al. NS1 protein of influenza A virus inhibits the function of intracytoplasmic pathogen sensor, RIG-I. Am J Respir Cell Mol Biol (2007) 36:263-9. doi:10.1165/rcmb.2006-0283RC.
    • (2007) Am J Respir Cell Mol Biol , vol.36 , pp. 263-269
    • Guo, Z.1    Chen, L.M.2    Zeng, H.3    Gomez, J.A.4    Plowden, J.5    Fujita, T.6
  • 17
    • 64049090424 scopus 로고    scopus 로고
    • Human respiratory syncytial virus nonstructural protein NS2 antagonizes the activation of beta interferon transcription by interacting with RIG-I
    • doi:10.1128/JVI.02434-08
    • Ling Z, Tran KC, Teng MN. Human respiratory syncytial virus nonstructural protein NS2 antagonizes the activation of beta interferon transcription by interacting with RIG-I. J Virol (2009) 83:3734-42. doi:10.1128/JVI.02434-08.
    • (2009) J Virol , vol.83 , pp. 3734-3742
    • Ling, Z.1    Tran, K.C.2    Teng, M.N.3
  • 18
    • 0027971622 scopus 로고
    • + cytotoxic T-cell responses during chronic viral infection
    • + cytotoxic T-cell responses during chronic viral infection. J Virol (1994) 68:8056-63.
    • (1994) J Virol , vol.68 , pp. 8056-8063
    • Matloubian, M.1    Concepcion, R.J.2    Ahmed, R.3
  • 19
    • 84887473368 scopus 로고    scopus 로고
    • Cellular immune correlates of protection against symptomatic pandemic influenza
    • doi:10.1038/nm.3350
    • Sridhar S, Begom S, Bermingham A, Hoschler K, Adamson W, Carman W, et al. Cellular immune correlates of protection against symptomatic pandemic influenza. Nat Med (2013) 19:1305-12. doi:10.1038/nm.3350.
    • (2013) Nat Med , vol.19 , pp. 1305-1312
    • Sridhar, S.1    Begom, S.2    Bermingham, A.3    Hoschler, K.4    Adamson, W.5    Carman, W.6
  • 21
    • 0029820873 scopus 로고    scopus 로고
    • Immunopathogenesis of HIV infection
    • doi:10.1146/annurev.micro.50.1.825
    • Pantaleo G, Fauci AS. Immunopathogenesis of HIV infection. Annu Rev Microbiol (1996) 50:825-54. doi:10.1146/annurev.micro.50.1.825.
    • (1996) Annu Rev Microbiol , vol.50 , pp. 825-854
    • Pantaleo, G.1    Fauci, A.S.2
  • 22
    • 0030831656 scopus 로고    scopus 로고
    • Cytotoxic-T-cell responses, viral load, and disease progression in early human immunodeficiency virus type 1 infection
    • doi:10.1056/NEJM199710303371803
    • Musey L, Hughes J, Schacker T, Shea T, Corey L, McElrath MJ. Cytotoxic-T-cell responses, viral load, and disease progression in early human immunodeficiency virus type 1 infection. N Engl J Med (1997) 337:1267-74. doi:10.1056/NEJM199710303371803.
    • (1997) N Engl J Med , vol.337 , pp. 1267-1274
    • Musey, L.1    Hughes, J.2    Schacker, T.3    Shea, T.4    Corey, L.5    McElrath, M.J.6
  • 23
    • 84857751302 scopus 로고    scopus 로고
    • HIV-specific cytolytic CD4 T cell responses during acute HIV infection predict disease outcome
    • doi:10.1126/scitranslmed.3003165
    • Soghoian DZ, Jessen H, Flanders M, Sierra-Davidson K, Cutler S, Pertel T, et al. HIV-specific cytolytic CD4 T cell responses during acute HIV infection predict disease outcome. Sci Transl Med (2012) 4:123ra125. doi:10.1126/scitranslmed.3003165.
    • (2012) Sci Transl Med , vol.4
    • Soghoian, D.Z.1    Jessen, H.2    Flanders, M.3    Sierra-Davidson, K.4    Cutler, S.5    Pertel, T.6
  • 24
    • 0028950823 scopus 로고
    • Kinetics of Gag-specific cytotoxic T lymphocyte responses during the clinical course of HIV-1 infection: a longitudinal analysis of rapid progressors and long-term asymptomatics
    • doi:10.1084/jem.181.4.1365
    • Klein MR, Van Baalen CA, Holwerda AM, Kerkhof Garde SR, Bende RJ, Keet IP, et al. Kinetics of Gag-specific cytotoxic T lymphocyte responses during the clinical course of HIV-1 infection: a longitudinal analysis of rapid progressors and long-term asymptomatics. J Exp Med (1995) 181:1365-72. doi:10.1084/jem.181.4.1365.
    • (1995) J Exp Med , vol.181 , pp. 1365-1372
    • Klein, M.R.1    Van Baalen, C.A.2    Holwerda, A.M.3    Kerkhof Garde, S.R.4    Bende, R.J.5    Keet, I.P.6
  • 25
    • 0029116868 scopus 로고
    • High levels of anti-human immunodeficiency virus type 1 (HIV-1) memory cytotoxic T-lymphocyte activity and low viral load are associated with lack of disease in HIV-1-infected long-term nonprogressors
    • Rinaldo C, Huang XL, Fan ZF, Ding M, Beltz L, Logar A, et al. High levels of anti-human immunodeficiency virus type 1 (HIV-1) memory cytotoxic T-lymphocyte activity and low viral load are associated with lack of disease in HIV-1-infected long-term nonprogressors. J Virol (1995) 69:5838-42.
    • (1995) J Virol , vol.69 , pp. 5838-5842
    • Rinaldo, C.1    Huang, X.L.2    Fan, Z.F.3    Ding, M.4    Beltz, L.5    Logar, A.6
  • 26
    • 0030665003 scopus 로고    scopus 로고
    • Co-evolution of human immunodeficiency virus and cytotoxic T-lymphocyte responses
    • doi:10.1111/j.1600-065X.1997.tb01004.x
    • Goulder P, Price D, Nowak M, Rowland-Jones S, Phillips R, McMichael A. Co-evolution of human immunodeficiency virus and cytotoxic T-lymphocyte responses. Immunol Rev (1997) 159:17-29. doi:10.1111/j.1600-065X.1997.tb01004.x.
    • (1997) Immunol Rev , vol.159 , pp. 17-29
    • Goulder, P.1    Price, D.2    Nowak, M.3    Rowland-Jones, S.4    Phillips, R.5    McMichael, A.6
  • 28
    • 40049094957 scopus 로고    scopus 로고
    • Genetic and immunologic heterogeneity among persons who control HIV infection in the absence of therapy
    • doi:10.1086/526786
    • Pereyra F, Addo MM, Kaufmann DE, Liu Y, Miura T, Rathod A, et al. Genetic and immunologic heterogeneity among persons who control HIV infection in the absence of therapy. J Infect Dis (2008) 197:563-71. doi:10.1086/526786.
    • (2008) J Infect Dis , vol.197 , pp. 563-571
    • Pereyra, F.1    Addo, M.M.2    Kaufmann, D.E.3    Liu, Y.4    Miura, T.5    Rathod, A.6
  • 29
    • 84876413860 scopus 로고    scopus 로고
    • HIV escape mutations occur preferentially at HLA-binding sites of CD8 T-cell epitopes
    • doi:10.1097/QAD.0b013e32835e1616
    • Bronke C, Almeida CA, McKinnon E, Roberts SG, Keane NM, Chopra A, et al. HIV escape mutations occur preferentially at HLA-binding sites of CD8 T-cell epitopes. AIDS (2013) 27:899-905. doi:10.1097/QAD.0b013e32835e1616.
    • (2013) AIDS , vol.27 , pp. 899-905
    • Bronke, C.1    Almeida, C.A.2    McKinnon, E.3    Roberts, S.G.4    Keane, N.M.5    Chopra, A.6
  • 31
    • 0025287307 scopus 로고
    • Antiviral cytotoxic T cell response induced by in vivo priming with a free synthetic peptide
    • doi:10.1084/jem.171.5.1815
    • Aichele P, Hengartner H, Zinkernagel RM, Schulz M. Antiviral cytotoxic T cell response induced by in vivo priming with a free synthetic peptide. J Exp Med (1990) 171:1815-20. doi:10.1084/jem.171.5.1815.
    • (1990) J Exp Med , vol.171 , pp. 1815-1820
    • Aichele, P.1    Hengartner, H.2    Zinkernagel, R.M.3    Schulz, M.4
  • 32
    • 0026057983 scopus 로고
    • Protection against lethal Sendai virus infection by in vivo priming of virus-specific cytotoxic T lymphocytes with a free synthetic peptide
    • doi:10.1073/pnas.88.6.2283
    • Kast WM, Roux L, Curren J, Blom HJ, Voordouw AC, Meloen RH, et al. Protection against lethal Sendai virus infection by in vivo priming of virus-specific cytotoxic T lymphocytes with a free synthetic peptide. Proc Natl Acad Sci U S A (1991) 88:2283-7. doi:10.1073/pnas.88.6.2283.
    • (1991) Proc Natl Acad Sci U S A , vol.88 , pp. 2283-2287
    • Kast, W.M.1    Roux, L.2    Curren, J.3    Blom, H.J.4    Voordouw, A.C.5    Meloen, R.H.6
  • 33
    • 0026034957 scopus 로고
    • Peptide-induced antiviral protection by cytotoxic T cells
    • doi:10.1073/pnas.88.3.991
    • Schulz M, Zinkernagel RM, Hengartner H. Peptide-induced antiviral protection by cytotoxic T cells. Proc Natl Acad Sci U S A (1991) 88:991-3. doi:10.1073/pnas.88.3.991.
    • (1991) Proc Natl Acad Sci U S A , vol.88 , pp. 991-993
    • Schulz, M.1    Zinkernagel, R.M.2    Hengartner, H.3
  • 34
    • 0029798058 scopus 로고    scopus 로고
    • Peptide vaccination can lead to enhanced tumor growth through specific T-cell tolerance induction
    • doi:10.1073/pnas.93.15.7855
    • Toes RE, Offringa R, Blom RJ, Melief CJ, Kast WM. Peptide vaccination can lead to enhanced tumor growth through specific T-cell tolerance induction. Proc Natl Acad Sci U S A (1996) 93:7855-60. doi:10.1073/pnas.93.15.7855.
    • (1996) Proc Natl Acad Sci U S A , vol.93 , pp. 7855-7860
    • Toes, R.E.1    Offringa, R.2    Blom, R.J.3    Melief, C.J.4    Kast, W.M.5
  • 35
    • 0032080385 scopus 로고    scopus 로고
    • Enhancement of tumor outgrowth through CTL tolerization after peptide vaccination is avoided by peptide presentation on dendritic cells
    • Toes RE, Van Der Voort EI, Schoenberger SP, Drijfhout JW, Van Bloois L, Storm G, et al. Enhancement of tumor outgrowth through CTL tolerization after peptide vaccination is avoided by peptide presentation on dendritic cells. J Immunol (1998) 160:4449-56.
    • (1998) J Immunol , vol.160 , pp. 4449-4456
    • Toes, R.E.1    Van Der Voort, E.I.2    Schoenberger, S.P.3    Drijfhout, J.W.4    Van Bloois, L.5    Storm, G.6
  • 36
    • 44849109375 scopus 로고    scopus 로고
    • Superior induction of anti-tumor CTL immunity by extended peptide vaccines involves prolonged, DC-focused antigen presentation
    • doi:10.1002/eji.200737995
    • Bijker MS, Van Den Eeden SJ, Franken KL, Melief CJ, Van Der Burg SH, Offringa R. Superior induction of anti-tumor CTL immunity by extended peptide vaccines involves prolonged, DC-focused antigen presentation. Eur J Immunol (2008) 38:1033-42. doi:10.1002/eji.200737995.
    • (2008) Eur J Immunol , vol.38 , pp. 1033-1042
    • Bijker, M.S.1    Van Den Eeden, S.J.2    Franken, K.L.3    Melief, C.J.4    Van Der Burg, S.H.5    Offringa, R.6
  • 37
    • 38449106129 scopus 로고    scopus 로고
    • + CTL priming by exact peptide epitopes in incomplete Freund's adjuvant induces a vanishing CTL response, whereas long peptides induce sustained CTL reactivity
    • + CTL priming by exact peptide epitopes in incomplete Freund's adjuvant induces a vanishing CTL response, whereas long peptides induce sustained CTL reactivity. J Immunol (2007) 179:5033-40.
    • (2007) J Immunol , vol.179 , pp. 5033-5040
    • Bijker, M.S.1    Van Den Eeden, S.J.2    Franken, K.L.3    Melief, C.J.4    Offringa, R.5    Van Der Burg, S.H.6
  • 38
    • 34247849183 scopus 로고    scopus 로고
    • Effector and memory CTL differentiation
    • doi:10.1146/annurev.immunol.25.022106.141548
    • Williams MA, Bevan MJ. Effector and memory CTL differentiation. Annu Rev Immunol (2007) 25:171-92. doi:10.1146/annurev.immunol.25.022106.141548.
    • (2007) Annu Rev Immunol , vol.25 , pp. 171-192
    • Williams, M.A.1    Bevan, M.J.2
  • 41
    • 82255174297 scopus 로고    scopus 로고
    • Universal peptide vaccines-optimal peptide vaccine design based on viral sequence conservation
    • doi:10.1016/j.vaccine.2011.07.132
    • Toussaint NC, Maman Y, Kohlbacher O, Louzoun Y. Universal peptide vaccines-optimal peptide vaccine design based on viral sequence conservation. Vaccine (2011) 29:8745-53. doi:10.1016/j.vaccine.2011.07.132.
    • (2011) Vaccine , vol.29 , pp. 8745-8753
    • Toussaint, N.C.1    Maman, Y.2    Kohlbacher, O.3    Louzoun, Y.4
  • 42
    • 84880301028 scopus 로고    scopus 로고
    • Current progress in development of hepatitis C virus vaccines
    • doi:10.1038/nm.3183
    • Liang TJ. Current progress in development of hepatitis C virus vaccines. Nat Med (2013) 19:869-78. doi:10.1038/nm.3183.
    • (2013) Nat Med , vol.19 , pp. 869-878
    • Liang, T.J.1
  • 47
    • 84893112391 scopus 로고    scopus 로고
    • Advances in the study of HLA-restricted epitope vaccines
    • Zhao L, Zhang M, Cong H. Advances in the study of HLA-restricted epitope vaccines. Hum Vaccin Immunother (2013) 9:2566-77.
    • (2013) Hum Vaccin Immunother , vol.9 , pp. 2566-2577
    • Zhao, L.1    Zhang, M.2    Cong, H.3
  • 48
    • 37349030106 scopus 로고    scopus 로고
    • An unanticipated lack of consensus cytotoxic T lymphocyte epitopes in HIV-1 databases: the contribution of prediction programs
    • doi:10.1097/QAD.0b013e3282f15622
    • Schellens IM, Kesmir C, Miedema F, Van Baarle D, Borghans JA. An unanticipated lack of consensus cytotoxic T lymphocyte epitopes in HIV-1 databases: the contribution of prediction programs. AIDS (2008) 22:33-7. doi:10.1097/QAD.0b013e3282f15622.
    • (2008) AIDS , vol.22 , pp. 33-37
    • Schellens, I.M.1    Kesmir, C.2    Miedema, F.3    Van Baarle, D.4    Borghans, J.A.5
  • 49
    • 80051924477 scopus 로고    scopus 로고
    • + T cell responses to influenza A infection and vaccination in HLA-A2.1 transgenic mice
    • doi:10.4049/jimmunol.1100664
    • + T cell responses to influenza A infection and vaccination in HLA-A2.1 transgenic mice. J Immunol (2011) 187:1895-902. doi:10.4049/jimmunol.1100664.
    • (2011) J Immunol , vol.187 , pp. 1895-1902
    • Tan, A.C.1    La Gruta, N.L.2    Zeng, W.3    Jackson, D.C.4
  • 50
    • 0027973079 scopus 로고
    • The relationship between class I binding affinity and immunogenicity of potential cytotoxic T cell epitopes
    • Sette A, Vitiello A, Reherman B, Fowler P, Nayersina R, Kast WM, et al. The relationship between class I binding affinity and immunogenicity of potential cytotoxic T cell epitopes. J Immunol (1994) 153:5586-92.
    • (1994) J Immunol , vol.153 , pp. 5586-5592
    • Sette, A.1    Vitiello, A.2    Reherman, B.3    Fowler, P.4    Nayersina, R.5    Kast, W.M.6
  • 51
    • 0035751961 scopus 로고    scopus 로고
    • Strategies for designing and optimizing new generation vaccines
    • doi:10.1038/35105075
    • Berzofsky JA, Ahlers JD, Belyakov IM. Strategies for designing and optimizing new generation vaccines. Nat Rev Immunol (2001) 1:209-19. doi:10.1038/35105075.
    • (2001) Nat Rev Immunol , vol.1 , pp. 209-219
    • Berzofsky, J.A.1    Ahlers, J.D.2    Belyakov, I.M.3
  • 52
    • 84887938115 scopus 로고    scopus 로고
    • A peptide's perspective on antigen presentation to the immune system
    • doi:10.1038/nchembio.1391
    • Neefjes J, Ovaa H. A peptide's perspective on antigen presentation to the immune system. Nat Chem Biol (2013) 9:769-75. doi:10.1038/nchembio.1391.
    • (2013) Nat Chem Biol , vol.9 , pp. 769-775
    • Neefjes, J.1    Ovaa, H.2
  • 55
    • 84885723472 scopus 로고    scopus 로고
    • Dendritic cells process synthetic long peptides better than whole protein, improving antigen presentation and T-cell activation
    • doi:10.1002/eji.201343324
    • Rosalia RA, Quakkelaar ED, Redeker A, Khan S, Camps M, Drijfhout JW, et al. Dendritic cells process synthetic long peptides better than whole protein, improving antigen presentation and T-cell activation. Eur J Immunol (2013) 43:2554-65. doi:10.1002/eji.201343324.
    • (2013) Eur J Immunol , vol.43 , pp. 2554-2565
    • Rosalia, R.A.1    Quakkelaar, E.D.2    Redeker, A.3    Khan, S.4    Camps, M.5    Drijfhout, J.W.6
  • 56
    • 77954097759 scopus 로고    scopus 로고
    • Long peptides induce polyfunctional T cells against conserved regions of HIV-1 with superior breadth to single-gene vaccines in macaques
    • doi:10.1002/eji.201040344
    • Rosario M, Bridgeman A, Quakkelaar ED, Quigley MF, Hill BJ, Knudsen ML, et al. Long peptides induce polyfunctional T cells against conserved regions of HIV-1 with superior breadth to single-gene vaccines in macaques. Eur J Immunol (2010) 40:1973-84. doi:10.1002/eji.201040344.
    • (2010) Eur J Immunol , vol.40 , pp. 1973-1984
    • Rosario, M.1    Bridgeman, A.2    Quakkelaar, E.D.3    Quigley, M.F.4    Hill, B.J.5    Knudsen, M.L.6
  • 57
    • 0037213545 scopus 로고    scopus 로고
    • +) T cells mediate viral clearance and disease pathogenesis during acute hepatitis B virus infection
    • doi:10.1128/JVI.77.1.68-76.2003
    • +) T cells mediate viral clearance and disease pathogenesis during acute hepatitis B virus infection. J Virol (2003) 77:68-76. doi:10.1128/JVI.77.1.68-76.2003.
    • (2003) J Virol , vol.77 , pp. 68-76
    • Thimme, R.1    Wieland, S.2    Steiger, C.3    Ghrayeb, J.4    Reimann, K.A.5    Purcell, R.H.6
  • 59
    • 84855396595 scopus 로고    scopus 로고
    • CTL responses of high functional avidity and broad variant cross-reactivity are associated with HIV control
    • doi:10.1371/journal.pone.0029717
    • Mothe B, Llano A, Ibarrondo J, Zamarreno J, Schiaulini M, Miranda C, et al. CTL responses of high functional avidity and broad variant cross-reactivity are associated with HIV control. PLoS One (2012) 7:e29717. doi:10.1371/journal.pone.0029717.
    • (2012) PLoS One , vol.7
    • Mothe, B.1    Llano, A.2    Ibarrondo, J.3    Zamarreno, J.4    Schiaulini, M.5    Miranda, C.6
  • 61
    • 80052202803 scopus 로고    scopus 로고
    • Contribution of cytokines to pathology and protection in virus infection
    • doi:10.1016/j.coviro.2011.05.015
    • Wack A, Openshaw P, O'Garra A. Contribution of cytokines to pathology and protection in virus infection. Curr Opin Virol (2011) 1:184-95. doi:10.1016/j.coviro.2011.05.015.
    • (2011) Curr Opin Virol , vol.1 , pp. 184-195
    • Wack, A.1    Openshaw, P.2    O'Garra, A.3
  • 63
    • 41149096579 scopus 로고    scopus 로고
    • T-cell quality in memory and protection: implications for vaccine design
    • doi:10.1038/nri2274
    • Seder RA, Darrah PA, Roederer M. T-cell quality in memory and protection: implications for vaccine design. Nat Rev Immunol (2008) 8:247-58. doi:10.1038/nri2274.
    • (2008) Nat Rev Immunol , vol.8 , pp. 247-258
    • Seder, R.A.1    Darrah, P.A.2    Roederer, M.3
  • 64
    • 33749511112 scopus 로고    scopus 로고
    • Fatal outcome of human influenza A (H5N1) is associated with high viral load and hypercytokinemia
    • doi:10.1038/nm1477
    • de Jong MD, Simmons CP, Thanh TT, Hien VM, Smith GJ, Chau TN, et al. Fatal outcome of human influenza A (H5N1) is associated with high viral load and hypercytokinemia. Nat Med (2006) 12:1203-7. doi:10.1038/nm1477.
    • (2006) Nat Med , vol.12 , pp. 1203-1207
    • de Jong, M.D.1    Simmons, C.P.2    Thanh, T.T.3    Hien, V.M.4    Smith, G.J.5    Chau, T.N.6
  • 65
    • 77649184739 scopus 로고    scopus 로고
    • The regulation of IL-10 production by immune cells
    • doi:10.1038/nri2711
    • Saraiva M, O'Garra A. The regulation of IL-10 production by immune cells. Nat Rev Immunol (2010) 10:170-81. doi:10.1038/nri2711.
    • (2010) Nat Rev Immunol , vol.10 , pp. 170-181
    • Saraiva, M.1    O'Garra, A.2
  • 66
    • 0034131557 scopus 로고    scopus 로고
    • Abrogation of TGFbeta signaling in T cells leads to spontaneous T cell differentiation and autoimmune disease
    • doi:10.1016/S1074-7613(00)80170-3
    • Gorelik L, Flavell RA. Abrogation of TGFbeta signaling in T cells leads to spontaneous T cell differentiation and autoimmune disease. Immunity (2000) 12:171-81. doi:10.1016/S1074-7613(00)80170-3.
    • (2000) Immunity , vol.12 , pp. 171-181
    • Gorelik, L.1    Flavell, R.A.2
  • 67
    • 0029810790 scopus 로고    scopus 로고
    • Progressive liver injury in chronic hepatitis C infection correlates with increased intrahepatic expression of Th1-associated cytokines
    • doi:10.1002/hep.510240402
    • Napoli J, Bishop GA, McGuinness PH, Painter DM, McCaughan GW. Progressive liver injury in chronic hepatitis C infection correlates with increased intrahepatic expression of Th1-associated cytokines. Hepatology (1996) 24:759-65. doi:10.1002/hep.510240402.
    • (1996) Hepatology , vol.24 , pp. 759-765
    • Napoli, J.1    Bishop, G.A.2    McGuinness, P.H.3    Painter, D.M.4    McCaughan, G.W.5
  • 68
    • 84859403357 scopus 로고    scopus 로고
    • Inhibitory receptors on lymphocytes: insights from infections
    • doi:10.4049/jimmunol.1100038
    • Odorizzi PM, Wherry EJ. Inhibitory receptors on lymphocytes: insights from infections. J Immunol (2012) 188:2957-65. doi:10.4049/jimmunol.1100038.
    • (2012) J Immunol , vol.188 , pp. 2957-2965
    • Odorizzi, P.M.1    Wherry, E.J.2
  • 70
    • 0028675323 scopus 로고
    • Development of high potency universal DR-restricted helper epitopes by modification of high affinity DR-blocking peptides
    • doi:10.1016/S1074-7613(94)80017-0
    • Alexander J, Sidney J, Southwood S, Ruppert J, Oseroff C, Maewal A, et al. Development of high potency universal DR-restricted helper epitopes by modification of high affinity DR-blocking peptides. Immunity (1994) 1:751-61. doi:10.1016/S1074-7613(94)80017-0.
    • (1994) Immunity , vol.1 , pp. 751-761
    • Alexander, J.1    Sidney, J.2    Southwood, S.3    Ruppert, J.4    Oseroff, C.5    Maewal, A.6
  • 71
    • 79955098209 scopus 로고    scopus 로고
    • Synthetic peptides containing B- and T-cell epitope of dengue virus-2 E domain III provoked B- and T-cell responses
    • doi:10.1016/j.vaccine.2011.03.002
    • Li S, Peng L, Zhao W, Zhong H, Zhang F, Yan Z, et al. Synthetic peptides containing B- and T-cell epitope of dengue virus-2 E domain III provoked B- and T-cell responses. Vaccine (2011) 29:3695-702. doi:10.1016/j.vaccine.2011.03.002.
    • (2011) Vaccine , vol.29 , pp. 3695-3702
    • Li, S.1    Peng, L.2    Zhao, W.3    Zhong, H.4    Zhang, F.5    Yan, Z.6
  • 72
    • 79951813621 scopus 로고    scopus 로고
    • Recombinant heat shock protein 65 carrying PADRE and HBV epitopes activates dendritic cells and elicits HBV-specific CTL responses
    • doi:10.1016/j.vaccine.2010.12.124
    • Wang H, Su X, Zhang P, Liang J, Wei H, Wan M, et al. Recombinant heat shock protein 65 carrying PADRE and HBV epitopes activates dendritic cells and elicits HBV-specific CTL responses. Vaccine (2011) 29:2328-35. doi:10.1016/j.vaccine.2010.12.124.
    • (2011) Vaccine , vol.29 , pp. 2328-2335
    • Wang, H.1    Su, X.2    Zhang, P.3    Liang, J.4    Wei, H.5    Wan, M.6
  • 73
    • 0024796883 scopus 로고
    • Universally immunogenic T cell epitopes: promiscuous binding to human MHC class II and promiscuous recognition by T cells
    • doi:10.1002/eji.1830191209
    • Panina-Bordignon P, Tan A, Termijtelen A, Demotz S, Corradin G, Lanzavecchia A. Universally immunogenic T cell epitopes: promiscuous binding to human MHC class II and promiscuous recognition by T cells. Eur J Immunol (1989) 19:2237-42. doi:10.1002/eji.1830191209.
    • (1989) Eur J Immunol , vol.19 , pp. 2237-2242
    • Panina-Bordignon, P.1    Tan, A.2    Termijtelen, A.3    Demotz, S.4    Corradin, G.5    Lanzavecchia, A.6
  • 74
    • 84859077427 scopus 로고    scopus 로고
    • Clinical evaluation of safety and immunogenicity of PADRE-cytomegalovirus (CMV) and tetanus-CMV fusion peptide vaccines with or without PF03512676 adjuvant
    • doi:10.1093/infdis/jis107
    • La Rosa C, Longmate J, Lacey SF, Kaltcheva T, Sharan R, Marsano D, et al. Clinical evaluation of safety and immunogenicity of PADRE-cytomegalovirus (CMV) and tetanus-CMV fusion peptide vaccines with or without PF03512676 adjuvant. J Infect Dis (2012) 205:1294-304. doi:10.1093/infdis/jis107.
    • (2012) J Infect Dis , vol.205 , pp. 1294-1304
    • La Rosa, C.1    Longmate, J.2    Lacey, S.F.3    Kaltcheva, T.4    Sharan, R.5    Marsano, D.6
  • 76
    • 0032482474 scopus 로고    scopus 로고
    • T-cell help for cytotoxic T lymphocytes is mediated by CD40-CD40L interactions
    • doi:10.1038/31002
    • Schoenberger SP, Toes RE, Van Der Voort EI, Offringa R, Melief CJ. T-cell help for cytotoxic T lymphocytes is mediated by CD40-CD40L interactions. Nature (1998) 393:480-3. doi:10.1038/31002.
    • (1998) Nature , vol.393 , pp. 480-483
    • Schoenberger, S.P.1    Toes, R.E.2    Van Der Voort, E.I.3    Offringa, R.4    Melief, C.J.5
  • 77
    • 43949163341 scopus 로고
    • Interleukin-12 and its role in the generation of TH1 cells
    • doi:10.1016/0167-5699(93)90230-I
    • Trinchieri G. Interleukin-12 and its role in the generation of TH1 cells. Immunol Today (1993) 14:335-8. doi:10.1016/0167-5699(93)90230-I.
    • (1993) Immunol Today , vol.14 , pp. 335-338
    • Trinchieri, G.1
  • 78
    • 0029812593 scopus 로고    scopus 로고
    • Ligation of CD40 on dendritic cells triggers production of high levels of interleukin-12 and enhances T cell stimulatory capacity: T-T help via APC activation
    • doi:10.1084/jem.184.2.747
    • Cella M, Scheidegger D, Palmer-Lehmann K, Lane P, Lanzavecchia A, Alber G. Ligation of CD40 on dendritic cells triggers production of high levels of interleukin-12 and enhances T cell stimulatory capacity: T-T help via APC activation. J Exp Med (1996) 184:747-52. doi:10.1084/jem.184.2.747.
    • (1996) J Exp Med , vol.184 , pp. 747-752
    • Cella, M.1    Scheidegger, D.2    Palmer-Lehmann, K.3    Lane, P.4    Lanzavecchia, A.5    Alber, G.6
  • 79
    • 79959217462 scopus 로고    scopus 로고
    • A stabilized HIV-1 envelope glycoprotein trimer fused to CD40 ligand targets and activates dendritic cells
    • doi:10.1186/1742-4690-8-48
    • Melchers M, Matthews K, De Vries RP, Eggink D, Van Montfort T, Bontjer I, et al. A stabilized HIV-1 envelope glycoprotein trimer fused to CD40 ligand targets and activates dendritic cells. Retrovirology (2011) 8:48. doi:10.1186/1742-4690-8-48.
    • (2011) Retrovirology , vol.8 , pp. 48
    • Melchers, M.1    Matthews, K.2    De Vries, R.P.3    Eggink, D.4    Van Montfort, T.5    Bontjer, I.6
  • 80
    • 7444271904 scopus 로고    scopus 로고
    • A totally synthetic vaccine of generic structure that targets Toll-like receptor 2 on dendritic cells and promotes antibody or cytotoxic T cell responses
    • doi:10.1073/pnas.0406740101
    • Jackson DC, Lau YF, Le T, Suhrbier A, Deliyannis G, Cheers C, et al. A totally synthetic vaccine of generic structure that targets Toll-like receptor 2 on dendritic cells and promotes antibody or cytotoxic T cell responses. Proc Natl Acad Sci U S A (2004) 101:15440-5. doi:10.1073/pnas.0406740101.
    • (2004) Proc Natl Acad Sci U S A , vol.101 , pp. 15440-15445
    • Jackson, D.C.1    Lau, Y.F.2    Le, T.3    Suhrbier, A.4    Deliyannis, G.5    Cheers, C.6
  • 81
    • 84867624038 scopus 로고    scopus 로고
    • Hepatitis C VLPs delivered to dendritic cells by a TLR2 targeting lipopeptide results in enhanced antibody and cell-mediated responses
    • doi:10.1371/journal.pone.0047492
    • Chua BY, Johnson D, Tan A, Earnest-Silveira L, Sekiya T, Chin R, et al. Hepatitis C VLPs delivered to dendritic cells by a TLR2 targeting lipopeptide results in enhanced antibody and cell-mediated responses. PLoS One (2012) 7:e47492. doi:10.1371/journal.pone.0047492.
    • (2012) PLoS One , vol.7
    • Chua, B.Y.1    Johnson, D.2    Tan, A.3    Earnest-Silveira, L.4    Sekiya, T.5    Chin, R.6
  • 83
    • 84879555935 scopus 로고    scopus 로고
    • Activation, dysfunction and retention of T cells in vaccine sites after injection of incomplete Freund's adjuvant, with or without peptide
    • doi:10.1007/s00262-013-1435-5
    • Salerno EP, Shea SM, Olson WC, Petroni GR, Smolkin ME, McSkimming C, et al. Activation, dysfunction and retention of T cells in vaccine sites after injection of incomplete Freund's adjuvant, with or without peptide. Cancer Immunol Immunother (2013) 62:1149-59. doi:10.1007/s00262-013-1435-5.
    • (2013) Cancer Immunol Immunother , vol.62 , pp. 1149-1159
    • Salerno, E.P.1    Shea, S.M.2    Olson, W.C.3    Petroni, G.R.4    Smolkin, M.E.5    McSkimming, C.6
  • 84
    • 0035451665 scopus 로고    scopus 로고
    • Longevity of antigen presentation and activation status of APC are decisive factors in the balance between CTL immunity versus tolerance
    • den Boer AT, Diehl L, Van Mierlo GJ, Van Der Voort EI, Fransen MF, Krimpenfort P, et al. Longevity of antigen presentation and activation status of APC are decisive factors in the balance between CTL immunity versus tolerance. J Immunol (2001) 167:2522-8.
    • (2001) J Immunol , vol.167 , pp. 2522-2528
    • den Boer, A.T.1    Diehl, L.2    Van Mierlo, G.J.3    Van Der Voort, E.I.4    Fransen, M.F.5    Krimpenfort, P.6
  • 85
    • 84155163017 scopus 로고    scopus 로고
    • The vaccine-site microenvironment induced by injection of incomplete Freund's adjuvant, with or without melanoma peptides
    • doi:10.1097/CJI.0b013e31823731a4
    • Harris RC, Chianese-Bullock KA, Petroni GR, Schaefer JT, Brill LB II, Molhoek KR, et al. The vaccine-site microenvironment induced by injection of incomplete Freund's adjuvant, with or without melanoma peptides. J Immunother (2012) 35:78-88. doi:10.1097/CJI.0b013e31823731a4.
    • (2012) J Immunother , vol.35 , pp. 78-88
    • Harris, R.C.1    Chianese-Bullock, K.A.2    Petroni, G.R.3    Schaefer, J.T.4    Brill II, L.B.5    Molhoek, K.R.6
  • 86
    • 33846090134 scopus 로고    scopus 로고
    • Multiple CD4 and CD8 T-cell activation parameters predict vaccine efficacy in vivo mediated by individual DC-activating agonists
    • doi:10.1016/j.vaccine.2006.10.049
    • Welters MJ, Bijker MS, Van Den Eeden SJ, Franken KL, Melief CJ, Offringa R, et al. Multiple CD4 and CD8 T-cell activation parameters predict vaccine efficacy in vivo mediated by individual DC-activating agonists. Vaccine (2007) 25:1379-89. doi:10.1016/j.vaccine.2006.10.049.
    • (2007) Vaccine , vol.25 , pp. 1379-1389
    • Welters, M.J.1    Bijker, M.S.2    Van Den Eeden, S.J.3    Franken, K.L.4    Melief, C.J.5    Offringa, R.6
  • 88
    • 49949097129 scopus 로고    scopus 로고
    • Phase 1 trial of malaria transmission blocking vaccine candidates Pfs25 and Pvs25 formulated with montanide ISA 51
    • doi:10.1371/journal.pone.0002636
    • Wu Y, Ellis RD, Shaffer D, Fontes E, Malkin EM, Mahanty S, et al. Phase 1 trial of malaria transmission blocking vaccine candidates Pfs25 and Pvs25 formulated with montanide ISA 51. PLoS One (2008) 3:e2636. doi:10.1371/journal.pone.0002636.
    • (2008) PLoS One , vol.3
    • Wu, Y.1    Ellis, R.D.2    Shaffer, D.3    Fontes, E.4    Malkin, E.M.5    Mahanty, S.6
  • 89
    • 77957773809 scopus 로고    scopus 로고
    • Immunization with cocktail of HIV-derived peptides in montanide ISA-51 is immunogenic, but causes sterile abscesses and unacceptable reactogenicity
    • doi:10.1371/journal.pone.0011995
    • Graham BS, McElrath MJ, Keefer MC, Rybczyk K, Berger D, Weinhold KJ, et al. Immunization with cocktail of HIV-derived peptides in montanide ISA-51 is immunogenic, but causes sterile abscesses and unacceptable reactogenicity. PLoS One (2010) 5:e11995. doi:10.1371/journal.pone.0011995.
    • (2010) PLoS One , vol.5
    • Graham, B.S.1    McElrath, M.J.2    Keefer, M.C.3    Rybczyk, K.4    Berger, D.5    Weinhold, K.J.6
  • 90
    • 83055188992 scopus 로고    scopus 로고
    • +) CTL responses with particulate vaccine delivery systems
    • doi:10.1016/j.ejps.2011.08.016
    • +) CTL responses with particulate vaccine delivery systems. Eur J Pharm Sci (2012) 45:482-91. doi:10.1016/j.ejps.2011.08.016.
    • (2012) Eur J Pharm Sci , vol.45 , pp. 482-491
    • Foged, C.1    Hansen, J.2    Agger, E.M.3
  • 91
    • 17444449520 scopus 로고
    • Liposomes as carriers of enzymes or drugs: a new approach to the treatment of storage diseases
    • Gregoriadis G, Ryman BE. Liposomes as carriers of enzymes or drugs: a new approach to the treatment of storage diseases. Biochem J (1971) 124:58.
    • (1971) Biochem J , vol.124 , pp. 58
    • Gregoriadis, G.1    Ryman, B.E.2
  • 92
    • 73949118947 scopus 로고    scopus 로고
    • A CTL-based liposomal vaccine capable of inducing protection against heterosubtypic influenza viruses in HLA-A*0201 transgenic mice
    • doi:10.1016/j.bbrc.2009.12.100
    • Matsui M, Kohyama S, Suda T, Yokoyama S, Mori M, Kobayashi A, et al. A CTL-based liposomal vaccine capable of inducing protection against heterosubtypic influenza viruses in HLA-A*0201 transgenic mice. Biochem Biophys Res Commun (2010) 391:1494-9. doi:10.1016/j.bbrc.2009.12.100.
    • (2010) Biochem Biophys Res Commun , vol.391 , pp. 1494-1499
    • Matsui, M.1    Kohyama, S.2    Suda, T.3    Yokoyama, S.4    Mori, M.5    Kobayashi, A.6
  • 94
    • 0036335685 scopus 로고    scopus 로고
    • Virosomes in vaccine development: induction of cytotoxic T lymphocyte activity with virosome-encapsulated protein antigens
    • doi:10.1081/LPR-120004789
    • Bungener L, Idema J, Ter Veer W, Huckriede A, Daemen T, Wilschut J. Virosomes in vaccine development: induction of cytotoxic T lymphocyte activity with virosome-encapsulated protein antigens. J Liposome Res (2002) 12:155-63. doi:10.1081/LPR-120004789.
    • (2002) J Liposome Res , vol.12 , pp. 155-163
    • Bungener, L.1    Idema, J.2    Ter Veer, W.3    Huckriede, A.4    Daemen, T.5    Wilschut, J.6
  • 95
    • 22544484231 scopus 로고    scopus 로고
    • The virosome concept for influenza vaccines
    • doi:10.1016/j.vaccine.2005.04.026
    • Huckriede A, Bungener L, Stegmann T, Daemen T, Medema J, Palache AM, et al. The virosome concept for influenza vaccines. Vaccine (2005) 23(Suppl 1):S26-38. doi:10.1016/j.vaccine.2005.04.026.
    • (2005) Vaccine , vol.23 , Issue.SUPPL. 1
    • Huckriede, A.1    Bungener, L.2    Stegmann, T.3    Daemen, T.4    Medema, J.5    Palache, A.M.6
  • 96
    • 84860764098 scopus 로고    scopus 로고
    • Immunogenicity and protective capacity of a virosomal respiratory syncytial virus vaccine adjuvanted with monophosphoryl lipid A in mice
    • doi:10.1371/journal.pone.0036812
    • Kamphuis T, Meijerhof T, Stegmann T, Lederhofer J, Wilschut J, De Haan A. Immunogenicity and protective capacity of a virosomal respiratory syncytial virus vaccine adjuvanted with monophosphoryl lipid A in mice. PLoS One (2012) 7:e36812. doi:10.1371/journal.pone.0036812.
    • (2012) PLoS One , vol.7
    • Kamphuis, T.1    Meijerhof, T.2    Stegmann, T.3    Lederhofer, J.4    Wilschut, J.5    De Haan, A.6
  • 97
    • 84859436059 scopus 로고    scopus 로고
    • Sustained viral load reduction in treatment-naive HCV genotype 1 infected patients after therapeutic peptide vaccination
    • doi:10.1016/j.vaccine.2012.02.070
    • Klade CS, Schuller E, Boehm T, Von Gabain A, Manns MP. Sustained viral load reduction in treatment-naive HCV genotype 1 infected patients after therapeutic peptide vaccination. Vaccine (2012) 30:2943-50. doi:10.1016/j.vaccine.2012.02.070.
    • (2012) Vaccine , vol.30 , pp. 2943-2950
    • Klade, C.S.1    Schuller, E.2    Boehm, T.3    Von Gabain, A.4    Manns, M.P.5
  • 98
    • 85042750982 scopus 로고    scopus 로고
    • Immunogenicity and safety of HCV E1E2 peptide vaccine in chronically HCV-infected patients who did not respond to interferon based therapy
    • doi:10.1016/j.vaccine.2013.07.074.
    • El-Awady MK, El Gendy M, Waked I, Tabll AA, El Abd Y, Bader El Din N, et al. Immunogenicity and safety of HCV E1E2 peptide vaccine in chronically HCV-infected patients who did not respond to interferon based therapy. Vaccine (2013). doi:10.1016/j.vaccine.2013.07.074.
    • (2013) Vaccine
    • El-Awady, M.K.1    El Gendy, M.2    Waked, I.3    Tabll, A.A.4    El Abd, Y.5    Bader El Din, N.6
  • 99
    • 0037135673 scopus 로고    scopus 로고
    • Intranasal administration of a synthetic peptide vaccine encapsulated in liposome together with an anti-CD40 antibody induces protective immunity against influenza A virus in mice
    • doi:10.1016/S0264-410X(02)00261-X
    • Ninomiya A, Ogasawara K, Kajino K, Takada A, Kida H. Intranasal administration of a synthetic peptide vaccine encapsulated in liposome together with an anti-CD40 antibody induces protective immunity against influenza A virus in mice. Vaccine (2002) 20:3123-9. doi:10.1016/S0264-410X(02)00261-X.
    • (2002) Vaccine , vol.20 , pp. 3123-3129
    • Ninomiya, A.1    Ogasawara, K.2    Kajino, K.3    Takada, A.4    Kida, H.5
  • 100
    • 84874608157 scopus 로고    scopus 로고
    • Enhanced Influenza VLP vaccines comprising matrix-2 ectodomain and nucleoprotein epitopes protects mice from lethal challenge
    • doi:10.1016/j.antiviral.2013.01.010
    • Gao X, Wang W, Li Y, Zhang S, Duan Y, Xing L, et al. Enhanced Influenza VLP vaccines comprising matrix-2 ectodomain and nucleoprotein epitopes protects mice from lethal challenge. Antiviral Res (2013) 98:4-11. doi:10.1016/j.antiviral.2013.01.010.
    • (2013) Antiviral Res , vol.98 , pp. 4-11
    • Gao, X.1    Wang, W.2    Li, Y.3    Zhang, S.4    Duan, Y.5    Xing, L.6
  • 101
    • 84900856783 scopus 로고    scopus 로고
    • The Jordan Report: Accelerated Development of Vaccines. Appendix A: Status of Vaccine Research and Development
    • NIAID
    • NIAID. The Jordan Report: Accelerated Development of Vaccines. Appendix A: Status of Vaccine Research and Development. National Institute of Allergy and Infectious Diseases (2012). p. 153-78.
    • (2012) National Institute of Allergy and Infectious Diseases , pp. 153-178
  • 102
    • 84861963299 scopus 로고    scopus 로고
    • Synthetic Influenza vaccine (FLU-v) stimulates cell mediated immunity in a double-blind, randomised, placebo-controlled Phase I trial
    • doi:10.1016/j.vaccine.2012.04.089
    • Pleguezuelos O, Robinson S, Stoloff GA, Caparros-Wanderley W. Synthetic Influenza vaccine (FLU-v) stimulates cell mediated immunity in a double-blind, randomised, placebo-controlled Phase I trial. Vaccine (2012) 30:4655-60. doi:10.1016/j.vaccine.2012.04.089.
    • (2012) Vaccine , vol.30 , pp. 4655-4660
    • Pleguezuelos, O.1    Robinson, S.2    Stoloff, G.A.3    Caparros-Wanderley, W.4
  • 103
    • 84862508744 scopus 로고    scopus 로고
    • Mucosal immunity and nasal influenza vaccination
    • doi:10.1586/erv.12.31
    • Rose MA, Zielen S, Baumann U. Mucosal immunity and nasal influenza vaccination. Expert Rev Vaccines (2012) 11:595-607. doi:10.1586/erv.12.31.
    • (2012) Expert Rev Vaccines , vol.11 , pp. 595-607
    • Rose, M.A.1    Zielen, S.2    Baumann, U.3
  • 105
    • 0028925535 scopus 로고
    • The cytotoxic T lymphocyte response to multiple hepatitis B virus polymerase epitopes during and after acute viral hepatitis
    • doi:10.1084/jem.181.3.1047
    • Rehermann B, Fowler P, Sidney J, Person J, Redeker A, Brown M, et al. The cytotoxic T lymphocyte response to multiple hepatitis B virus polymerase epitopes during and after acute viral hepatitis. J Exp Med (1995) 181:1047-58. doi:10.1084/jem.181.3.1047.
    • (1995) J Exp Med , vol.181 , pp. 1047-1058
    • Rehermann, B.1    Fowler, P.2    Sidney, J.3    Person, J.4    Redeker, A.5    Brown, M.6
  • 106
    • 84883005575 scopus 로고    scopus 로고
    • Impact of transient elastography on clinical decision-making in patients with chronic viral hepatitis
    • doi:10.3109/00365521.2013.819441
    • Feuth T, Arends JE, Lieveld FI, Mundt MW, Hoepelman AI, Siersema PD, et al. Impact of transient elastography on clinical decision-making in patients with chronic viral hepatitis. Scand J Gastroenterol (2013) 48:1074-81. doi:10.3109/00365521.2013.819441.
    • (2013) Scand J Gastroenterol , vol.48 , pp. 1074-1081
    • Feuth, T.1    Arends, J.E.2    Lieveld, F.I.3    Mundt, M.W.4    Hoepelman, A.I.5    Siersema, P.D.6
  • 107
    • 0034678435 scopus 로고    scopus 로고
    • +) cells in liver damage and viral control during persistent hepatitis B virus infection
    • doi:10.1084/jem.191.8.1269
    • +) cells in liver damage and viral control during persistent hepatitis B virus infection. J Exp Med (2000) 191:1269-80. doi:10.1084/jem.191.8.1269.
    • (2000) J Exp Med , vol.191 , pp. 1269-1280
    • Maini, M.K.1    Boni, C.2    Lee, C.K.3    Larrubia, J.R.4    Reignat, S.5    Ogg, G.S.6
  • 109
    • 80052240886 scopus 로고    scopus 로고
    • Live and inactivated influenza vaccines induce similar humoral responses, but only live vaccines induce diverse T-cell responses in young children
    • doi:10.1093/infdis/jir436
    • Hoft DF, Babusis E, Worku S, Spencer CT, Lottenbach K, Truscott SM, et al. Live and inactivated influenza vaccines induce similar humoral responses, but only live vaccines induce diverse T-cell responses in young children. J Infect Dis (2011) 204:845-53. doi:10.1093/infdis/jir436.
    • (2011) J Infect Dis , vol.204 , pp. 845-853
    • Hoft, D.F.1    Babusis, E.2    Worku, S.3    Spencer, C.T.4    Lottenbach, K.5    Truscott, S.M.6
  • 110
    • 33646468500 scopus 로고    scopus 로고
    • T cell responses are better correlates of vaccine protection in the elderly
    • McElhaney JE, Xie D, Hager WD, Barry MB, Wang Y, Kleppinger A, et al. T cell responses are better correlates of vaccine protection in the elderly. J Immunol (2006) 176:6333-9.
    • (2006) J Immunol , vol.176 , pp. 6333-6339
    • McElhaney, J.E.1    Xie, D.2    Hager, W.D.3    Barry, M.B.4    Wang, Y.5    Kleppinger, A.6
  • 114
    • 79960984193 scopus 로고    scopus 로고
    • Quantity, not quality, of antibody response decreased in the elderly
    • doi:10.1172/JCI58406
    • Blomberg BB, Frasca D. Quantity, not quality, of antibody response decreased in the elderly. J Clin Invest (2011) 121:2981-3. doi:10.1172/JCI58406.
    • (2011) J Clin Invest , vol.121 , pp. 2981-2983
    • Blomberg, B.B.1    Frasca, D.2
  • 115
    • 78649740931 scopus 로고    scopus 로고
    • Murine neutralizing antibody response and toxicity to synthetic peptides derived from E1 and E2 proteins of hepatitis C virus
    • doi:10.1016/j.vaccine.2009.11.059
    • El-Awady MK, Tabll AA, Yousif H, El-Abd Y, Reda M, Khalil SB, et al. Murine neutralizing antibody response and toxicity to synthetic peptides derived from E1 and E2 proteins of hepatitis C virus. Vaccine (2010) 28:8338-44. doi:10.1016/j.vaccine.2009.11.059.
    • (2010) Vaccine , vol.28 , pp. 8338-8344
    • El-Awady, M.K.1    Tabll, A.A.2    Yousif, H.3    El-Abd, Y.4    Reda, M.5    Khalil, S.B.6
  • 116
    • 84868695189 scopus 로고    scopus 로고
    • MHC class I-presented T cell epitopes identified by immunoproteomics analysis are targets for a cross reactive influenza-specific T cell response
    • doi:10.1371/journal.pone.0048484
    • Testa JS, Shetty V, Hafner J, Nickens Z, Kamal S, Sinnathamby G, et al. MHC class I-presented T cell epitopes identified by immunoproteomics analysis are targets for a cross reactive influenza-specific T cell response. PLoS One (2012) 7:e48484. doi:10.1371/journal.pone.0048484.
    • (2012) PLoS One , vol.7
    • Testa, J.S.1    Shetty, V.2    Hafner, J.3    Nickens, Z.4    Kamal, S.5    Sinnathamby, G.6
  • 117
    • 84859824268 scopus 로고    scopus 로고
    • Immunization with high epitope density of M2e derived from 2009 pandemic H1N1 elicits protective immunity in mice
    • doi:10.1016/j.vaccine.2012.03.021
    • Zhou C, Zhou L, Chen YH. Immunization with high epitope density of M2e derived from 2009 pandemic H1N1 elicits protective immunity in mice. Vaccine (2012) 30:3463-9. doi:10.1016/j.vaccine.2012.03.021.
    • (2012) Vaccine , vol.30 , pp. 3463-3469
    • Zhou, C.1    Zhou, L.2    Chen, Y.H.3


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