메뉴 건너뛰기




Volumn 30, Issue 19, 2012, Pages 2943-2950

Sustained viral load reduction in treatment-naive HCV genotype 1 infected patients after therapeutic peptide vaccination

Author keywords

IC41 peptide vaccine; Therapeutic HCV vaccination

Indexed keywords

HEPATITIS C VACCINE; HLA A2 ANTIGEN; IC41 PEPTIDE VACCINE; IMIQUIMOD; UNCLASSIFIED DRUG; VIRUS RNA;

EID: 84859436059     PISSN: 0264410X     EISSN: 18732518     Source Type: Journal    
DOI: 10.1016/j.vaccine.2012.02.070     Document Type: Article
Times cited : (24)

References (26)
  • 1
    • 0033916804 scopus 로고    scopus 로고
    • Epidemiology of hepatitis C: geographic differences and temporal trends
    • Wasley A., Alter M.J. Epidemiology of hepatitis C: geographic differences and temporal trends. Semin Liver Dis 2000, 20(1):1-16.
    • (2000) Semin Liver Dis , vol.20 , Issue.1 , pp. 1-16
    • Wasley, A.1    Alter, M.J.2
  • 2
    • 23944506014 scopus 로고    scopus 로고
    • Global epidemiology of hepatitis C virus infection
    • Shepard C.W., Finelli L., Alter M.J. Global epidemiology of hepatitis C virus infection. Lancet Infect Dis 2005, 5(9):558-567.
    • (2005) Lancet Infect Dis , vol.5 , Issue.9 , pp. 558-567
    • Shepard, C.W.1    Finelli, L.2    Alter, M.J.3
  • 3
    • 0032102889 scopus 로고    scopus 로고
    • Correlation between virus genotype and chronicity rate in acute hepatitis C
    • Amoroso P., Rapicetta M., Tosti M.E., Mele A., Spada E., Buonocore S., et al. Correlation between virus genotype and chronicity rate in acute hepatitis C. J Hepatol 1998, 28(6):939-944.
    • (1998) J Hepatol , vol.28 , Issue.6 , pp. 939-944
    • Amoroso, P.1    Rapicetta, M.2    Tosti, M.E.3    Mele, A.4    Spada, E.5    Buonocore, S.6
  • 4
    • 84859421791 scopus 로고    scopus 로고
    • Management of Hepatitis C. In: Consensus Development Conference statement, National Institutes of Health Consensus Development Conference (2002 June 10-12). NIH Consensus Development Program. Available online: [accessed January 2010].
    • Management of Hepatitis C: 2002. In: Consensus Development Conference statement, National Institutes of Health Consensus Development Conference (2002 June 10-12). NIH Consensus Development Program. Available online: [accessed January 2010]. http://consensus.nih.gov/2002/2002HepatitisC2002116html.htm.
    • (2002)
  • 5
    • 0030470530 scopus 로고    scopus 로고
    • Hepatitis C virus: molecular biology and genetic variability
    • Brechot C. Hepatitis C virus: molecular biology and genetic variability. Dig Dis Sci 1996, 41(12 Suppl.):6S-21S.
    • (1996) Dig Dis Sci , vol.41 , Issue.12 SUPPL.
    • Brechot, C.1
  • 6
    • 0030885467 scopus 로고    scopus 로고
    • The hepatitis C virus: overview
    • Purcell R. The hepatitis C virus: overview. Hepatology 1997, 26(3 Suppl. 1):11S-14S.
    • (1997) Hepatology , vol.26 , Issue.3 SUPPL. 1
    • Purcell, R.1
  • 7
    • 0032841846 scopus 로고    scopus 로고
    • Pathogenesis of chronic hepatitis C: immunological features of hepatic injury and viral persistence
    • Cerny A., Chisari F.V. Pathogenesis of chronic hepatitis C: immunological features of hepatic injury and viral persistence. Hepatology 1999, 30(3):595-601.
    • (1999) Hepatology , vol.30 , Issue.3 , pp. 595-601
    • Cerny, A.1    Chisari, F.V.2
  • 8
    • 34548050436 scopus 로고    scopus 로고
    • CD8 T cell dysfunction during chronic viral infection
    • Shin H., Wherry E.J. CD8 T cell dysfunction during chronic viral infection. Curr Opin Immunol 2007, 19(4):408-415.
    • (2007) Curr Opin Immunol , vol.19 , Issue.4 , pp. 408-415
    • Shin, H.1    Wherry, E.J.2
  • 9
    • 0028087985 scopus 로고
    • Prevention of hepatitis C virus infection in chimpanzees after antibody-mediated in vitro neutralization
    • Farci P., Alter H.J., Wong D.C., Miller R.H., Govindarajan S., Engle R., et al. Prevention of hepatitis C virus infection in chimpanzees after antibody-mediated in vitro neutralization. Proc Natl Acad Sci USA 1994, 91(16):7792-7796.
    • (1994) Proc Natl Acad Sci USA , vol.91 , Issue.16 , pp. 7792-7796
    • Farci, P.1    Alter, H.J.2    Wong, D.C.3    Miller, R.H.4    Govindarajan, S.5    Engle, R.6
  • 10
    • 0028270794 scopus 로고
    • Challenges for development of hepatitis C virus vaccines
    • Prince A.M. Challenges for development of hepatitis C virus vaccines. FEMS Microbiol Rev 1994, 14(3):273-277.
    • (1994) FEMS Microbiol Rev , vol.14 , Issue.3 , pp. 273-277
    • Prince, A.M.1
  • 11
    • 12644289313 scopus 로고    scopus 로고
    • Prevention of hepatitis C virus infection in chimpanzees by hyperimmune serum against the hypervariable region 1 of the envelope 2 protein
    • Farci P., Shimoda A., Wong D., Cabezon T., De Gioannis D., Strazzera A., et al. Prevention of hepatitis C virus infection in chimpanzees by hyperimmune serum against the hypervariable region 1 of the envelope 2 protein. Proc Natl Acad Sci USA 1996, 93(26):15394-15399.
    • (1996) Proc Natl Acad Sci USA , vol.93 , Issue.26 , pp. 15394-15399
    • Farci, P.1    Shimoda, A.2    Wong, D.3    Cabezon, T.4    De Gioannis, D.5    Strazzera, A.6
  • 12
    • 56649112957 scopus 로고    scopus 로고
    • Maternal neutralizing antibody and transmission of hepatitis C virus to infants
    • Dowd K.A., Hershow R.C., Yawetz S., Larussa P., Diaz C., Landesman S.H., et al. Maternal neutralizing antibody and transmission of hepatitis C virus to infants. J Infect Dis 2008, 198(11):1651-1655.
    • (2008) J Infect Dis , vol.198 , Issue.11 , pp. 1651-1655
    • Dowd, K.A.1    Hershow, R.C.2    Yawetz, S.3    Larussa, P.4    Diaz, C.5    Landesman, S.H.6
  • 13
    • 34347230939 scopus 로고    scopus 로고
    • Rapid induction of virus-neutralizing antibodies and viral clearance in a single-source outbreak of hepatitis C
    • Pestka J.M., Zeisel M.B., Bläser E., Schürmann P., Bartosch B., Cosset F.L., et al. Rapid induction of virus-neutralizing antibodies and viral clearance in a single-source outbreak of hepatitis C. Proc Natl Acad Sci USA 2007, 104(14):6025-6030.
    • (2007) Proc Natl Acad Sci USA , vol.104 , Issue.14 , pp. 6025-6030
    • Pestka, J.M.1    Zeisel, M.B.2    Bläser, E.3    Schürmann, P.4    Bartosch, B.5    Cosset, F.L.6
  • 14
    • 19944432537 scopus 로고    scopus 로고
    • Characterization of host-range and cell entry properties of the major genotypes and subtypes of hepatitis C virus
    • Lavillette D., Tarr A.W., Voisset C., Donot P., Bartosch B., Bain C., et al. Characterization of host-range and cell entry properties of the major genotypes and subtypes of hepatitis C virus. Hepatology 2005, 41(2):265-274.
    • (2005) Hepatology , vol.41 , Issue.2 , pp. 265-274
    • Lavillette, D.1    Tarr, A.W.2    Voisset, C.3    Donot, P.4    Bartosch, B.5    Bain, C.6
  • 17
    • 33646144429 scopus 로고    scopus 로고
    • Immunogenicity and safety of a novel therapeutic hepatitis C virus (HCV) peptide vaccine: a randomized, placebo controlled trial for dose optimization in 128 healthy subjects
    • Firbas C., Jilma B., Tauber E., Buerger V., Jelovcan S., Lingnau K. Immunogenicity and safety of a novel therapeutic hepatitis C virus (HCV) peptide vaccine: a randomized, placebo controlled trial for dose optimization in 128 healthy subjects. Vaccine 2006, 24(20):4343-4353.
    • (2006) Vaccine , vol.24 , Issue.20 , pp. 4343-4353
    • Firbas, C.1    Jilma, B.2    Tauber, E.3    Buerger, V.4    Jelovcan, S.5    Lingnau, K.6
  • 18
    • 42949111104 scopus 로고    scopus 로고
    • Therapeutic vaccination of chronic hepatitis C nonresponder patients with the peptide vaccine IC41
    • Klade C.S., Wedemeyer H., Berg T., Buerger V., Jelovcan S., Lingnau K. Therapeutic vaccination of chronic hepatitis C nonresponder patients with the peptide vaccine IC41. Gastroenterology 2008, 134(5):1385-1395.
    • (2008) Gastroenterology , vol.134 , Issue.5 , pp. 1385-1395
    • Klade, C.S.1    Wedemeyer, H.2    Berg, T.3    Buerger, V.4    Jelovcan, S.5    Lingnau, K.6
  • 19
    • 34548210447 scopus 로고    scopus 로고
    • Functional and phenotypic characterization of peptide-vaccine-induced HCV-specific CD8+ T cells in healthy individuals and chronic hepatitis C patients
    • Schlaphoff V., Klade C.S., Jilma B., Jelovcan S.B., Cornberg M., Tauber E. Functional and phenotypic characterization of peptide-vaccine-induced HCV-specific CD8+ T cells in healthy individuals and chronic hepatitis C patients. Vaccine 2007, 25(37-38):6793-6806.
    • (2007) Vaccine , vol.25 , Issue.37-38 , pp. 6793-6806
    • Schlaphoff, V.1    Klade, C.S.2    Jilma, B.3    Jelovcan, S.B.4    Cornberg, M.5    Tauber, E.6
  • 20
    • 77549085401 scopus 로고    scopus 로고
    • Immunogenicity and safety of different injection routes and schedules of IC41, a hepatitis C virus (HCV) peptide vaccine
    • Firbas C., Boehm T., Buerger V., Schuller E., Sabarth N., Jilma B. Immunogenicity and safety of different injection routes and schedules of IC41, a hepatitis C virus (HCV) peptide vaccine. Vaccine 2010, 28(12):2397-2407.
    • (2010) Vaccine , vol.28 , Issue.12 , pp. 2397-2407
    • Firbas, C.1    Boehm, T.2    Buerger, V.3    Schuller, E.4    Sabarth, N.5    Jilma, B.6
  • 21
    • 0036199280 scopus 로고    scopus 로고
    • Immunologic monitoring of cancer vaccine therapy: results of a workshop sponsored by the Society for Biological Therapy
    • Keilholz U., Weber J., Finke J.H., Gabrilovich D.I., Kast W.M., Disis M.L. Immunologic monitoring of cancer vaccine therapy: results of a workshop sponsored by the Society for Biological Therapy. J Immunother 2002, 25(2):97-138.
    • (2002) J Immunother , vol.25 , Issue.2 , pp. 97-138
    • Keilholz, U.1    Weber, J.2    Finke, J.H.3    Gabrilovich, D.I.4    Kast, W.M.5    Disis, M.L.6
  • 23
    • 65449127754 scopus 로고    scopus 로고
    • A step forward in therapy for hepatitis C
    • Hoofnagle J.H. A step forward in therapy for hepatitis C. N Engl J Med 2009, 360(18):1899-1901.
    • (2009) N Engl J Med , vol.360 , Issue.18 , pp. 1899-1901
    • Hoofnagle, J.H.1
  • 24
    • 67650734950 scopus 로고    scopus 로고
    • Therapeutic vaccine IC41 as late add-on to standard treatment in patients with chronic hepatitis C
    • Wedemeyer H., Schuller E., Schlaphoff V., Stauber R.E., Wiegand J., Schiefke I., et al. Therapeutic vaccine IC41 as late add-on to standard treatment in patients with chronic hepatitis C. Vaccine 2009, 27(37):5142-5151.
    • (2009) Vaccine , vol.27 , Issue.37 , pp. 5142-5151
    • Wedemeyer, H.1    Schuller, E.2    Schlaphoff, V.3    Stauber, R.E.4    Wiegand, J.5    Schiefke, I.6
  • 25
    • 37449014458 scopus 로고    scopus 로고
    • Nitazoxanide, tizoxanide and other thiazolides are potent inhibitors of hepatitis B virus and hepatitis C virus replication
    • Korba B.E., Montero A.B., Farrar K., Gaye K., Mukerjee S., Ayers M.S., et al. Nitazoxanide, tizoxanide and other thiazolides are potent inhibitors of hepatitis B virus and hepatitis C virus replication. Antiviral Res 2008, 77(1):56-63.
    • (2008) Antiviral Res , vol.77 , Issue.1 , pp. 56-63
    • Korba, B.E.1    Montero, A.B.2    Farrar, K.3    Gaye, K.4    Mukerjee, S.5    Ayers, M.S.6
  • 26
    • 60449108708 scopus 로고    scopus 로고
    • Improved virologic response in chronic hepatitis C genotype 4 treated with nitazoxanide, peginterferon, and ribavirin
    • Rossignol J.F., Elfert A., El-Gohary Y., Keeffe E.B. Improved virologic response in chronic hepatitis C genotype 4 treated with nitazoxanide, peginterferon, and ribavirin. Gastroenterology 2009, 136(3):856-862.
    • (2009) Gastroenterology , vol.136 , Issue.3 , pp. 856-862
    • Rossignol, J.F.1    Elfert, A.2    El-Gohary, Y.3    Keeffe, E.B.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.