Progressive liver injury in chronic hepatitis C infection correlates with increased intrahepatic expression of Th1-associated cytokines

Hepatology

Volumn 24, Issue 4 I, 1996, Pages 759-765

  Napoli, John ^a   Bishop, G Alex ^a   Mcguinness, Peter H ^a   Painter, Dorothy M ^a   Mccaughan, Geoffrey W ^a  

^a ROYAL PRINCE ALFRED HOSPITAL   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 2; INTERLEUKIN 4; VIRUS RNA;

ARTICLE; CHRONIC HEPATITIS; CLINICAL ARTICLE; CONTROLLED STUDY; HELPER CELL; HEPATITIS C; HEPATITIS C VIRUS; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMMUNOMODULATION; IMMUNOPATHOGENESIS; LIVER BIOPSY; LIVER CELL DAMAGE; PRIORITY JOURNAL;

EID: 0029810790     PISSN: 02709139     EISSN: None     Source Type: Journal    
DOI: 10.1053/jhep.1996.v24.pm0008855173     Document Type: Article

References (31)

1. Cerny A, Chisari FV. Immunological aspects of HCV infection. Intervirology 1994;37:119-125.
2. Gonzalez-Peralta RP, Davis GL, Lau JY. Pathogenetic mechanisms of hepatocellular damage in chronic hepatitis C. J Hepatol 1994;21:255-259.
3. Mosnier JF, Scoazec JY, Marcellin P, Degott C, Benhamou JP, Feldmann G. Expression of cytokine-dependent immune adhesion molecules by hepatocytes. Gastroenterology 1994;107:1457-1468.
4. Makris M, Preston FE, Ralph S. Increased soluble IL-2 receptor levels in HCV-infected haemophiliacs: a possible indicator of liver disease severity. Br J Haematol 1994;87:419-421.
5. Mosmann TR, Cherwinski H, Bond MW, Giedlin MA, Coffman RL. Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins. J Immunol 1986;136:2348-2357.
6. Clerici M, Shearer GM. The Th1-Th2 hypothesis of HIV infection: new insights. Immunology Today 1994;15:575-581.
7. Clerici M, Shearer GM. A TH1 → TH2 switch is a critical step in the etiology of HIV infection. Immunol Today 1993;14:107-111.
8. Yamamura M, Uyemura K, Deans RJ, Weinberg K, Rea TH, Bloom BR, Modin RL, et al. Defining protective responses to pathogens: cytokine profiles in leprosy lesions. Science 1992;254:277-279.
9. Sher A, Coffman RL. Regulation of immunity to parasites by T cells and T cell-derived cytokines. Annu Rev Immunol 1992;10:385-409.
10. Pirmez C, Cooper C, Paes-Oliveira M, Schubach A, Torigian VK, Modlin RL. Immunologic responsiveness in American cutaneous leishmaniasis lesions. J Immunol 1990;145:3100-3104.
11. Scheuer PJ, Ashrafzadeh P, Sherlock S, Brown D, Dusheiko GM. The pathology of hepatitis C. HEPATOLOGY 1992;15:567-571.
12. Chomczynski P, Sacchi N. Single step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Annals of Biochemistry 1987;162:156-158.
13. Bishop GA, Rokahr KL, Napoli J, McCaughan GW. Intragraft cytokine mRNA levels in human liver allograft rejection analysed by reverse transcriptase-PCR. Transpl Immunol 1993;1:253-261.
14. Napoli J, Bishop GA, McCaughan GW. Increased intrahepatic messenger RNA expression of interleukins 2, 6, and 8 in human cirrhosis. Gastroenterology 1994;107:789-798.
15. Dallman MJ, Larsen CP, Morris PJ. Cytokine gene transcription in vascularised organ grafts: analysis using semiquantitative polymerase chain reaction. J Exp Med 1991;174:493-496.
16. Ehlers S, Smith KA. Differentiation of T cell lymphokine gene expression: the in vitro acquisition of T cell memory. J Exp Med 1991;173:25-36.
17. de Maeyer E, de Maeyer-Guignard J. Interferons. In: Thomson A, ed. The cytokine handbook. London: Academic 1991:215-239.
18. Kovacs EJ. Fibrogenic cytokines: the role of immune mediators in the development of scar tissue. Immunol Today 1991;12:17-23.
19. Male D, Champion B, Cooke A, Owen M. Advanced immunology. London: Gower Medical, 1991.
20. Morshed SA, Fukuma H, Kimura Y, Watanabe S, Nishioka M. Interferon-gamma, interleukin (IL)-2 and IL-2 receptor expressions in hepatitis C virus-infected liver. Gastroenterol Jpn 1993;5:59-66.
21. Sun J, McCaughan GW, Matsumoto Y, Sheil AG, Gallagher ND, Bishop GA. Tolerance to rat liver allografts. I. Differences between tolerance and rejection are more marked in the B cell compared with the T cell or cytokine response. Transplantation 1994;57:1349-1357.
22. Tovey MG, Gugenheim J, Guymarho J, Blanchard B, Vanden-Broecke C, Gresser I. Genes for interleukin-1, interleukin-6, and tumor necrosis factor are expressed at markedly reduced levels in the livers of patients with severe liver disease. Autoimmunity 1991;10:297-310.
23. McCulloch RK, Choong CS, Hurley DM. An evaluation of competitor type and size for use in the determination of mRNA by competitive PCR. PCR Methods Applic 1995;4:219-226.
24. Romagnani S. Lymphokine production by human T cells in disease states. Annu Rev Immunol 1994;12:227-257.
25. McGuiness PH, Bishop GA, Painter DM, Chan R, McCaughan GW. Intrahepatic hepatitis C RNA levels do not correlate with degree of liver injury in patients with chronic hepatitis C. HEPATOLOGY 1996;23:676-687.
26. Howard M, O'Garra A. Biological properties of interleukin 10. Immunol Today 1992;13:198-200.
27. Sun J, Matsumoto Y, McCaughan GW, Gallagher ND, Sheil AG, Bishop GA. Levels of cytokine expression in rat liver allograft rejection compared to allograft tolerance. Transplant Proc 1992;24:2309.
28. Mosmann TR, Moore KW. The role of IL-10 in crossregulation of TH1 and TH2 responses. Immunol Today 1991;12:49-53.
29. Quiroga JA, Martin J, Pardo M, Carreno V. Serum levels of soluble immune factors and pathogenesis of chronic hepatitis. Dig Dis Sci 1994;39: 2485-2496.
30. Weiner A, Erickson AL, Kansopon J, Crawford K, Muchmore E, Hughes AL, Houghton M, Walker CM, et al. Persistent hepatitis C virus infection in a chimpanzee is associated with emergence of a cytotoxic T lymphocyte escape variant. PNAS 1995;92:2755-2759.
31. Unutmaz D, Pileri P, Abrignani S. Antigen-independent activation of naive and memory resting T cells by a cytokine combination. J Exp Med 1994; 180:1159-1164.