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Volumn 15, Issue 2, 2014, Pages 233-249

Improvements in algorithms for phenotype inference: The NAT2 example

Author keywords

Anti tuberculosis drug induced hepatoxicity; Bladder cancer; Ethnic differences; Haplotype phasing; Haplotype reconstruction; Individualized medicine; NAT2 activity; Ultra slow acetylators

Indexed keywords

ARYLAMINE ACETYLTRANSFERASE; ISONIAZID; TUBERCULOSTATIC AGENT; DRUG; NAT2 PROTEIN, HUMAN;

EID: 84900856097     PISSN: 13892002     EISSN: 18755453     Source Type: Journal    
DOI: 10.2174/1389200215666140202215717     Document Type: Article
Times cited : (19)

References (202)
  • 1
    • 0006948626 scopus 로고
    • Metabolism of isoniazid in man as related to the occurrence of peripheral neuritis
    • Hughes, H.B.; Biehl, J.P.; Jones, A.P.; Schmidt L.H. Metabolism of isoniazid in man as related to the occurrence of peripheral neuritis. Am. Rev. Tuberc., 1954, 70, 266-273.
    • (1954) Am. Rev. Tuberc. , vol.70 , pp. 266-273
    • Hughes, H.B.1    Biehl, J.P.2    Jones, A.P.3    Schmidt, L.H.4
  • 2
    • 0037917384 scopus 로고
    • Clinical implications of isoniazid blood levels in pulmonary tuberculosis
    • Mitchell, R.S.; Bell, J.C. Clinical implications of isoniazid blood levels in pulmonary tuberculosis. N. Engl. J. Med., 1957, 257, 1066-1070.
    • (1957) N. Engl. J. Med. , vol.257 , pp. 1066-1070
    • Mitchell, R.S.1    Bell, J.C.2
  • 3
    • 0004751359 scopus 로고
    • Clinical implications of isoniazid, PAS and streptomycin blood levels in pulmonary tuberculosis. Trans
    • Mitchell, R.S.; Bell, J.C. Clinical implications of isoniazid, PAS and streptomycin blood levels in pulmonary tuberculosis. Trans. Am. Clin. Climatol. Assoc., 1957, 69, 98-102.
    • (1957) Am. Clin. Climatol. Assoc. , vol.69 , pp. 98-102
    • Mitchell, R.S.1    Bell, J.C.2
  • 4
    • 0018717158 scopus 로고
    • Clinical pharmacokinetics of isoniazid
    • Weber, W.W.; Hein, D.W. Clinical pharmacokinetics of isoniazid. Clin. Pharmacokinet., 1979, 4, 401-422.
    • (1979) Clin. Pharmacokinet. , vol.4 , pp. 401-422
    • Weber, W.W.1    Hein, D.W.2
  • 5
    • 0021813284 scopus 로고
    • N-Acetylation pharmacogenetics
    • Weber, W.W.; Hein, D.W. N-Acetylation pharmacogenetics. Pharmacol. Rev., 1985, 37, 25-79.
    • (1985) Pharmacol. Rev. , vol.37 , pp. 25-79
    • Weber, W.W.1    Hein, D.W.2
  • 6
    • 0025948280 scopus 로고
    • Molecular mechanism of slow acetylation of drugs and carcinogens in humans
    • Blum, M.; Demierre, A.; Grant, D.M.; Heim, M.; Meyer, U.A. Molecular mechanism of slow acetylation of drugs and carcinogens in humans. Proc. Natl. Acad. Sci. USA, 1991, 88, 5237-5241.
    • (1991) Proc. Natl. Acad. Sci. USA , vol.88 , pp. 5237-5241
    • Blum, M.1    Demierre, A.2    Grant, D.M.3    Heim, M.4    Meyer, U.A.5
  • 7
    • 0025887858 scopus 로고
    • N-Acetyltransferase polymorphism: Comparison of phenotype and genotype in humans
    • Hickman, D.; Sim, E. N-Acetyltransferase polymorphism: comparison of phenotype and genotype in humans. Biochem. Pharmacol., 1991, 42, 1007-1014.
    • (1991) Biochem. Pharmacol. , vol.42 , pp. 1007-1014
    • Hickman, D.1    Sim, E.2
  • 8
    • 0026768271 scopus 로고
    • Polymorphisms of Nacetyltransferase genes
    • Grant, D.M.; Blum, M.; Meyer, U.A. Polymorphisms of Nacetyltransferase genes. Xenobiotica, 1992, 22, 1073-1081.
    • (1992) Xenobiotica , vol.22 , pp. 1073-1081
    • Grant, D.M.1    Blum, M.2    Meyer, U.A.3
  • 9
    • 0027476961 scopus 로고
    • Molecular genetics of the N-acetyltransferases
    • Grant, D.M. Molecular genetics of the N-acetyltransferases. Pharmacogenetics, 1993, 3, 45-50.
    • (1993) Pharmacogenetics , vol.3 , pp. 45-50
    • Grant, D.M.1
  • 11
    • 0027281895 scopus 로고
    • Metabolic activation and deactivation of arylamine carcinogens by recombinant human NAT1 and polymorphic NAT2 acetyltransferases
    • Hein, D.W.; Doll, M.A.; Rustan, T.D.; Gray, K.; Feng, Y.; Ferguson, R.J.; Grant, D.M. Metabolic activation and deactivation of arylamine carcinogens by recombinant human NAT1 and polymorphic NAT2 acetyltransferases. Carcinogenesis, 1993, 14, 1633-1638.
    • (1993) Carcinogenesis , vol.14 , pp. 1633-1638
    • Hein, D.W.1    Doll, M.A.2    Rustan, T.D.3    Gray, K.4    Feng, Y.5    Ferguson, R.J.6    Grant, D.M.7
  • 13
    • 0028909978 scopus 로고
    • Slow N-acetylation genotype is a susceptibility factor in occupational and smoking related bladder cancer
    • Risch, A.; Wallace, D.M.; Bathers, S.; Sim, E. Slow N-acetylation genotype is a susceptibility factor in occupational and smoking related bladder cancer. Hum. Mol. Genet., 1995, 4, 231-236.
    • (1995) Hum. Mol. Genet. , vol.4 , pp. 231-236
    • Risch, A.1    Wallace, D.M.2    Bathers, S.3    Sim, E.4
  • 14
    • 0029815779 scopus 로고    scopus 로고
    • Combined analysis of inherited polymorphisms in arylamine N-acetyltransferase 2, glutathione S-transferases M1 and T1, microsomal epoxide hydrolase, and cytochrome P450 enzymes as modulators of bladder cancer risk
    • Brockmöller, J.; Cascorbi, I.; Kerb, R.; Roots, I. Combined analysis of inherited polymorphisms in arylamine N-acetyltransferase 2, glutathione S-transferases M1 and T1, microsomal epoxide hydrolase, and cytochrome P450 enzymes as modulators of bladder cancer risk. Cancer Res., 1996, 56, 3915-3925.
    • (1996) Cancer Res. , vol.56 , pp. 3915-3925
    • Brockmöller, J.1    Cascorbi, I.2    Kerb, R.3    Roots, I.4
  • 15
    • 0029837310 scopus 로고    scopus 로고
    • Homozygous rapid arylamine Nacetyltransferase NAT2 genotype as susceptibility factor for lung cancer
    • Cascorbi, I.; Brockmöller, J.; Mrozikiewicz, P.M.; Bauer, S.; Loddenkemper, R.; Roots, I. Homozygous rapid arylamine Nacetyltransferase NAT2 genotype as susceptibility factor for lung cancer. Cancer Res., 1996, 56, 3961-3966.
    • (1996) Cancer Res. , vol.56 , pp. 3961-3966
    • Cascorbi, I.1    Brockmöller, J.2    Mrozikiewicz, P.M.3    Bauer, S.4    Loddenkemper, R.5    Roots, I.6
  • 16
    • 0029827668 scopus 로고    scopus 로고
    • Occupational history and genetic N-acetyltransferase polymorphism in urothelial cancer patients of Leverkusen, Germany. Scand
    • Golka, K.; Prior, V.; Blaszkewicz, M.; Cascorbi, I.; Schöps, W.; Kierfeld, G; Roots, I.; Bolt, H.M. Occupational history and genetic N-acetyltransferase polymorphism in urothelial cancer patients of Leverkusen, Germany. Scand. J. Work Environ. Health, 1996, 22, 332-338.
    • (1996) J. Work Environ. Health , vol.22 , pp. 332-338
    • Golka, K.1    Prior, V.2    Blaszkewicz, M.3    Cascorbi, I.4    Schöps, W.5    Kierfeld, G.6    Roots, I.7    Bolt, H.M.8
  • 19
    • 0037051157 scopus 로고    scopus 로고
    • The enhanced bladder cancer susceptibility of NAT2 slow acetylators towards aromatic amines: A review considering ethnic differences
    • Golka, K.; Prior, V.; Blaszkewicz, M.; Bolt, H.M. The enhanced bladder cancer susceptibility of NAT2 slow acetylators towards aromatic amines: a review considering ethnic differences. Toxicol. Lett., 2002, 128, 229-241.
    • (2002) Toxicol. Lett. , vol.128 , pp. 229-241
    • Golka, K.1    Prior, V.2    Blaszkewicz, M.3    Bolt, H.M.4
  • 20
    • 0030940149 scopus 로고    scopus 로고
    • Arylamine Nacetyltransferase 1 (NAT1) and 2 (NAT2) polymorphisms in susceptibility to bladder cancer: The influence of smoking
    • Okkels, H.; Sigsgaard, T.; Wolf, H.; Autrup, H. Arylamine Nacetyltransferase 1 (NAT1) and 2 (NAT2) polymorphisms in susceptibility to bladder cancer: the influence of smoking. Cancer Epidemiol. Biomarkers Prev., 1997, 26, 225-231.
    • (1997) Cancer Epidemiol. Biomarkers Prev. , vol.26 , pp. 225-231
    • Okkels, H.1    Sigsgaard, T.2    Wolf, H.3    Autrup, H.4
  • 21
    • 0031845481 scopus 로고    scopus 로고
    • Influence of genetic admixture on polymorphisms of drug-metabolizing enzymes: Analyses of mutations on NAT2 and C gamma P2E1 genes in a mixed Hispanic population
    • Martínez, C.; Agúndez, J.A.; Olivera, M.; Llerena, A.; Ramirez, R.; Hernández, M.; Benítez, J. Influence of genetic admixture on polymorphisms of drug-metabolizing enzymes: analyses of mutations on NAT2 and C gamma P2E1 genes in a mixed Hispanic population. Clin. Pharmacol. Ther., 1998, 63, 623-628.
    • (1998) Clin. Pharmacol. Ther. , vol.63 , pp. 623-628
    • Martínez, C.1    Agúndez, J.A.2    Olivera, M.3    Llerena, A.4    Ramirez, R.5    Hernández, M.6    Benítez, J.7
  • 22
    • 0033520939 scopus 로고    scopus 로고
    • Novel human N-acetyltransferase 2 alleles that differ in mechanism for slow acetylator phenotype
    • Leff, M.A.; Fretland, A.J.; Doll, M.A.; Hein, D.W. Novel human N-acetyltransferase 2 alleles that differ in mechanism for slow acetylator phenotype. J. Biol. Chem., 1999, 274, 34519-34522.
    • (1999) J. Biol. Chem. , vol.274 , pp. 34519-34522
    • Leff, M.A.1    Fretland, A.J.2    Doll, M.A.3    Hein, D.W.4
  • 23
    • 0034653350 scopus 로고    scopus 로고
    • N-Acetyltransferase genetics and their role in predisposition to aromatic and heterocyclic amine-induced carcinogenesis
    • Hein, D.W. N-Acetyltransferase genetics and their role in predisposition to aromatic and heterocyclic amine-induced carcinogenesis. Toxicol. Lett., 2000, 112-113, 349-356.
    • (2000) Toxicol. Lett. , vol.112-113 , pp. 349-356
    • Hein, D.W.1
  • 24
    • 0037201542 scopus 로고    scopus 로고
    • Molecular genetics and function of NAT1 and NAT2: Role in aromatic amine metabolism and carcinogenesis
    • Hein, D.W. Molecular genetics and function of NAT1 and NAT2: role in aromatic amine metabolism and carcinogenesis. Mutat. Res., 2002, 506-507, 65-77.
    • (2002) Mutat. Res. , vol.506-507 , pp. 65-77
    • Hein, D.W.1
  • 25
    • 33645117090 scopus 로고    scopus 로고
    • N-Acetyltransferase 2 genetic polymorphism: Effects of carcinogen and haplotype on urinary bladder cancer risk
    • Hein, D.W. N-Acetyltransferase 2 genetic polymorphism: effects of carcinogen and haplotype on urinary bladder cancer risk. Oncogene, 2006, 25, 1649-1658.
    • (2006) Oncogene , vol.25 , pp. 1649-1658
    • Hein, D.W.1
  • 26
    • 67649243788 scopus 로고    scopus 로고
    • N-Acetyltransferase SNPs: Emerging concepts serve as a paradigm for understanding complexities of personalized medicine
    • Hein, D.W. N-Acetyltransferase SNPs: emerging concepts serve as a paradigm for understanding complexities of personalized medicine. Expert Opin. Drug Metab. Toxicol., 2009, 5, 353-366.
    • (2009) Expert Opin. Drug Metab. Toxicol. , vol.5 , pp. 353-366
    • Hein, D.W.1
  • 27
    • 4544376299 scopus 로고    scopus 로고
    • Polymorphism of N-acetyltransferase 2 (NAT2) gene polymorphism in Shanghai population: Occupational and nonoccupational bladder cancer patient groups
    • Ma, Q.W.; Lin, G.F.; Chen, J.G.; Xiang, C.Q.; Guo, W.C.; Golka, K.; Shen, J.H. Polymorphism of N-acetyltransferase 2 (NAT2) gene polymorphism in Shanghai population: occupational and nonoccupational bladder cancer patient groups. Biomed. Environ. Sci., 2004, 17, 291-298.
    • (2004) Biomed. Environ. Sci. , vol.17 , pp. 291-298
    • Ma, Q.W.1    Lin, G.F.2    Chen, J.G.3    Xiang, C.Q.4    Guo, W.C.5    Golka, K.6    Shen, J.H.7
  • 30
    • 33750351767 scopus 로고    scopus 로고
    • Polymorphisms in GSTT1, GSTM1, NAT1 and NAT2 genes and bladder cancer risk in men and women
    • McGrath, M.; Michaud, D.; De Vivo, I. Polymorphisms in GSTT1, GSTM1, NAT1 and NAT2 genes and bladder cancer risk in men and women. BMC Cancer, 2006, 6, 239.
    • (2006) BMC Cancer , vol.6 , pp. 239
    • McGrath, M.1    Michaud, D.2    De Vivo, I.3
  • 31
    • 34447522033 scopus 로고    scopus 로고
    • Commentary: Reflections on G. M. Lower and colleagues' 1979 study associating slow acetylator phenotype with urinary bladder cancer: Meta-analysis, historical refinements of the hypothesis, and lessons learned
    • Rothman, N.; Garcia-Closas, M.; Hein, D.W. Commentary: Reflections on G. M. Lower and colleagues' 1979 study associating slow acetylator phenotype with urinary bladder cancer: meta-analysis, historical refinements of the hypothesis, and lessons learned. Int. J. Epidemiol., 2007, 36, 23-28.
    • (2007) Int. J. Epidemiol. , vol.36 , pp. 23-28
    • Rothman, N.1    Garcia-Closas, M.2    Hein, D.W.3
  • 33
    • 34548721074 scopus 로고    scopus 로고
    • Joint effects of the Nacetyltransferase 1 and 2 (NAT1 and NAT2) genes and smoking on bladder carcinogenesis: A literature-based systematic HuGE review and evidence synthesis
    • Sanderson, S.; Salanti, G.; Higgins, J. Joint effects of the Nacetyltransferase 1 and 2 (NAT1 and NAT2) genes and smoking on bladder carcinogenesis: a literature-based systematic HuGE review and evidence synthesis. Am. J. Epidemiol., 2007, 166, 741-751.
    • (2007) Am. J. Epidemiol. , vol.166 , pp. 741-751
    • Sanderson, S.1    Salanti, G.2    Higgins, J.3
  • 34
    • 47749085094 scopus 로고    scopus 로고
    • Polymorphisms of human N-acetyltransferases and cancer risk
    • Agundez, J.A.G. Polymorphisms of human N-acetyltransferases and cancer risk. Curr. Drug Metab., 2008, 9, 520-531.
    • (2008) Curr. Drug Metab. , vol.9 , pp. 520-531
    • Agundez, J.A.G.1
  • 35
    • 71049183469 scopus 로고    scopus 로고
    • N-acetyltransferase 2 genotype modification of active cigarette smoking on breast cancer risk among hispanic and nonhispanic white women
    • Baumgartner, K.B.; Schlierf, T.J.; Yang, D.; Doll, M.A.; Hein, D.W. N-acetyltransferase 2 genotype modification of active cigarette smoking on breast cancer risk among hispanic and nonhispanic white women. Toxicol. Sci., 2009, 112, 211-220.
    • (2009) Toxicol. Sci. , vol.112 , pp. 211-220
    • Baumgartner, K.B.1    Schlierf, T.J.2    Yang, D.3    Doll, M.A.4    Hein, D.W.5
  • 37
    • 84867650304 scopus 로고    scopus 로고
    • Pharmacogenetic study of drugmetabolising enzyme polymorphisms on the risk of antituberculosis drug-induced liver injury: A meta-analysis
    • Cai, Y.; Yi, J.; Zhou, C.; Shen, X. Pharmacogenetic study of drugmetabolising enzyme polymorphisms on the risk of antituberculosis drug-induced liver injury: a meta-analysis. PLoS One, 2012, 7, e47769.
    • (2012) PLoS One , vol.7
    • Cai, Y.1    Yi, J.2    Zhou, C.3    Shen, X.4
  • 38
    • 84860874636 scopus 로고    scopus 로고
    • Bladder tumors and aromatic amines - Historical milestones from Ludwig Rehn to Wilhelm Hueper
    • Dietrich, H.G.; Golka, K. Bladder tumors and aromatic amines - historical milestones from Ludwig Rehn to Wilhelm Hueper. Front. Biosci. (Elite Ed.), 2012, 4, 279-288.
    • (2012) Front. Biosci. (Elite Ed.) , vol.4 , pp. 279-288
    • Dietrich, H.G.1    Golka, K.2
  • 40
    • 84878404733 scopus 로고    scopus 로고
    • Slow N-acetyltransferase 2 genotype contributes to antituberculosis drug-induced hepatotoxicity: A meta-analysis
    • Du, H.; Chen, X.; Fang, Y.; Yan, O.; Xu, H.; Li, L.; Li, W.; Huang, W. Slow N-acetyltransferase 2 genotype contributes to antituberculosis drug-induced hepatotoxicity: a meta-analysis. Mol. Biol. Rep., 2013, 40, 3591-3596.
    • (2013) Mol. Biol. Rep. , vol.40 , pp. 3591-3596
    • Du, H.1    Chen, X.2    Fang, Y.3    Yan, O.4    Xu, H.5    Li, L.6    Li, W.7    Huang, W.8
  • 41
    • 18044383306 scopus 로고    scopus 로고
    • Re-investigation of the concordance of human NAT2 phenotypes and genotypes
    • Bolt, H.M.; Selinski, S.; Dannappel, D.; Blaszkewicz, M.; Golka, K. Re-investigation of the concordance of human NAT2 phenotypes and genotypes. Arch. Toxicol., 2005, 79, 196-200.
    • (2005) Arch. Toxicol. , vol.79 , pp. 196-200
    • Bolt, H.M.1    Selinski, S.2    Dannappel, D.3    Blaszkewicz, M.4    Golka, K.5
  • 42
    • 25444438753 scopus 로고    scopus 로고
    • Inferring haplotypes at the NAT2 locus: The computational approach
    • Sabbagh, A.; Darlu, P. Inferring haplotypes at the NAT2 locus: the computational approach. BMC Genet., 2005, 6, 30.
    • (2005) BMC Genet. , vol.6 , pp. 30
    • Sabbagh, A.1    Darlu, P.2
  • 47
    • 34548063942 scopus 로고    scopus 로고
    • Functional characterization of single-nucleotide polymorphisms and haplotypes of human N-acetyltransferase 2
    • Zang, Y.; Doll, M.A.; Zhao, S.; States, J.C.; Hein, D.W.: Functional characterization of single-nucleotide polymorphisms and haplotypes of human N-acetyltransferase 2. Carcinogenesis, 2007, 28, 1665-1671.
    • (2007) Carcinogenesis , vol.28 , pp. 1665-1671
    • Zang, Y.1    Doll, M.A.2    Zhao, S.3    States, J.C.4    Hein, D.W.5
  • 48
    • 47749095050 scopus 로고    scopus 로고
    • Structure/ function evaluations of single nucleotide polymorphisms in human N-acetyltransferase 2
    • Walraven, J.M.; Zang, Y.; Trent, J.O.; Hein, D.W. Structure/ function evaluations of single nucleotide polymorphisms in human N-acetyltransferase 2. Curr. Drug Metab., 2008, 9, 471-486.
    • (2008) Curr. Drug Metab. , vol.9 , pp. 471-486
    • Walraven, J.M.1    Zang, Y.2    Trent, J.O.3    Hein, D.W.4
  • 51
    • 0034037485 scopus 로고    scopus 로고
    • Update on consensus arylamine N-acetyltransferase gene nomenclature
    • Hein, D.W.; Grant, D.M.; Sim, E. Update on consensus arylamine N-acetyltransferase gene nomenclature. Pharmacogenetics, 2000, 10, 291-292.
    • (2000) Pharmacogenetics , vol.10 , pp. 291-292
    • Hein, D.W.1    Grant, D.M.2    Sim, E.3
  • 52
    • 84900848233 scopus 로고    scopus 로고
    • Arylamine N-Acetyltransferase Nomenclature Committee Accessed Aug 8
    • Arylamine N-Acetyltransferase Nomenclature Committee. http://nat.mbg.duth.gr/ (Accessed Aug 8, 2013).
    • (2013)
  • 53
    • 0028286844 scopus 로고
    • Molecular genetics of human polymorphic N-acetyltransferase: Enzymatic analysis of 15 recombinant wild-type, mutant and chimeric NAT2 allozymes
    • Hein, D.W.; Ferguson, R.J.; Doll, M.A.; Rustan, T.D.; Gray, K. Molecular genetics of human polymorphic N-acetyltransferase: enzymatic analysis of 15 recombinant wild-type, mutant and chimeric NAT2 allozymes. Hum. Mol. Genet., 1994, 3, 729-734.
    • (1994) Hum. Mol. Genet. , vol.3 , pp. 729-734
    • Hein, D.W.1    Ferguson, R.J.2    Doll, M.A.3    Rustan, T.D.4    Gray, K.5
  • 54
    • 0029117480 scopus 로고
    • Metabolic activation of N-hydroxyarylamines and N-hydroxyarylamides by 16 recombinant human NAT2 allozymes: Effects of 7 specific NAT2 nucleic acid substitutions
    • Hein, D.W.; Doll, M.A.; Rustan, T.D.; Ferguson, R.J. Metabolic activation of N-hydroxyarylamines and N-hydroxyarylamides by 16 recombinant human NAT2 allozymes: effects of 7 specific NAT2 nucleic acid substitutions. Cancer Res., 1995, 55, 3531-3536.
    • (1995) Cancer Res. , vol.55 , pp. 3531-3536
    • Hein, D.W.1    Doll, M.A.2    Rustan, T.D.3    Ferguson, R.J.4
  • 55
    • 0029143503 scopus 로고
    • Enzyme kinetic properties of human recombinant arylamine Nacetyltransferase 2 allotypic variants expressed in Escherichia coli
    • Hickman, D.; Palamanda, J.R.; Unadkat, J.D.; Sim, E. Enzyme kinetic properties of human recombinant arylamine Nacetyltransferase 2 allotypic variants expressed in Escherichia coli. Biochem. Pharmacol., 1995, 50, 697-703.
    • (1995) Biochem. Pharmacol. , vol.50 , pp. 697-703
    • Hickman, D.1    Palamanda, J.R.2    Unadkat, J.D.3    Sim, E.4
  • 56
    • 33846631743 scopus 로고    scopus 로고
    • Functional characterization of the A411T (L137F) and G364A (D122N) genetic polymorphisms in human N-acetyltransferase 2
    • Zang, Y.; Zhao, S.; Doll, M.A.; States, J.C.; Hein, D.W. Functional characterization of the A411T (L137F) and G364A (D122N) genetic polymorphisms in human N-acetyltransferase 2. Pharmacogenet. Genomics, 2007, 17, 37-45.
    • (2007) Pharmacogenet. Genomics , vol.17 , pp. 37-45
    • Zang, Y.1    Zhao, S.2    Doll, M.A.3    States, J.C.4    Hein, D.W.5
  • 57
    • 0035052559 scopus 로고    scopus 로고
    • Functional characterization of human N-acetyltransferase 2 (NAT2) single nucleotide polymorphisms
    • Fretland, A.J.; Leff, M.A.; Doll, M.A.; Hein, D.W. Functional characterization of human N-acetyltransferase 2 (NAT2) single nucleotide polymorphisms. Pharmacogenetics, 2001, 11, 207-215.
    • (2001) Pharmacogenetics , vol.11 , pp. 207-215
    • Fretland, A.J.1    Leff, M.A.2    Doll, M.A.3    Hein, D.W.4
  • 58
    • 9244240756 scopus 로고    scopus 로고
    • The T341C (Ile114Thr) polymorphism of N-acetyltransferase 2 yields slow acetylator phenotype by enhanced protein degradation
    • Zang, Y.; Zhao, S.; Doll, M.A.; States, J.C.; Hein, D.W. The T341C (Ile114Thr) polymorphism of N-acetyltransferase 2 yields slow acetylator phenotype by enhanced protein degradation. Pharmacogenetics, 2004, 14, 717-723.
    • (2004) Pharmacogenetics , vol.14 , pp. 717-723
    • Zang, Y.1    Zhao, S.2    Doll, M.A.3    States, J.C.4    Hein, D.W.5
  • 59
    • 0025364134 scopus 로고
    • Correlation between acetylator phenotypes and genotypes of polymorphic arylamine Nacetyltransferase in human liver
    • Deguchi, T.; Mashimo, M.; Suzuki, T.J. Correlation between acetylator phenotypes and genotypes of polymorphic arylamine Nacetyltransferase in human liver. J. Biol. Chem., 1990, 265, 12757-12760.
    • (1990) J. Biol. Chem. , vol.265 , pp. 12757-12760
    • Deguchi, T.1    Mashimo, M.2    Suzuki, T.J.3
  • 60
    • 47749150680 scopus 로고    scopus 로고
    • Structures of human arylamine N-acetyltransferases
    • Grant, D.M. Structures of human arylamine N-acetyltransferases. Curr. Drug Metab., 2008, 9, 465-470.
    • (2008) Curr. Drug Metab. , vol.9 , pp. 465-470
    • Grant, D.M.1
  • 61
    • 0020574461 scopus 로고
    • Polymorphic N-acetylation of a caffeine metabolite
    • Grant, D.M.; Tang, B.K.; Kalow, W. Polymorphic N-acetylation of a caffeine metabolite. Clin. Pharmacol. Ther., 1983, 33, 355-359.
    • (1983) Clin. Pharmacol. Ther. , vol.33 , pp. 355-359
    • Grant, D.M.1    Tang, B.K.2    Kalow, W.3
  • 62
    • 0021151820 scopus 로고
    • A simple test for acetylator phenotype using caffeine
    • Grant, D.M.; Tang, B.K.; Kalow, W. A simple test for acetylator phenotype using caffeine. Br. J. Clin. Pharmacol., 1984, 17, 459-464.
    • (1984) Br. J. Clin. Pharmacol. , vol.17 , pp. 459-464
    • Grant, D.M.1    Tang, B.K.2    Kalow, W.3
  • 63
    • 0023245387 scopus 로고
    • Caffeine as a potential indicator for acetylator status
    • Rankin, R.B.; Hudson, S.A.; Fell, A.F. Caffeine as a potential indicator for acetylator status. J. Clin. Pharm. Ther., 1987, 12, 47-51.
    • (1987) J. Clin. Pharm. Ther. , vol.12 , pp. 47-51
    • Rankin, R.B.1    Hudson, S.A.2    Fell, A.F.3
  • 64
    • 0023472855 scopus 로고
    • An alternative test for acetylator phenotyping with caffeine
    • Tang, B.K.; Kadar, D.; Kalow, W. An alternative test for acetylator phenotyping with caffeine. Clin. Pharmacol. Ther., 1987, 42, 509-513.
    • (1987) Clin. Pharmacol. Ther. , vol.42 , pp. 509-513
    • Tang, B.K.1    Kadar, D.2    Kalow, W.3
  • 66
    • 0029163589 scopus 로고
    • Arylamine N-acetyltransferase (NAT2) mutations and their allelic linkage in unrelated Caucasian individuals: Correlation with phenotypic activity
    • Cascorbi, I.; Drakoulis, N.; Brockmöller, J.; Maurer, A.; Sperling, K.; Roots, I. Arylamine N-acetyltransferase (NAT2) mutations and their allelic linkage in unrelated Caucasian individuals: correlation with phenotypic activity. Am. J. Hum. Genet., 1995, 57, 581-592.
    • (1995) Am. J. Hum. Genet. , vol.57 , pp. 581-592
    • Cascorbi, I.1    Drakoulis, N.2    Brockmöller, J.3    Maurer, A.4    Sperling, K.5    Roots, I.6
  • 67
    • 0029999726 scopus 로고    scopus 로고
    • Predictors of Nacetyltransferase activity: Should caffeine phenotyping and NAT2 genotyping be used interchangeably in epidemiological studies
    • Le Marchand, L.; Sivaraman, L.; Franke, A.A.; Custer, L.J.; Wilkens, L.R.; Lau, A.F.; Cooney, R.V. Predictors of Nacetyltransferase activity: should caffeine phenotyping and NAT2 genotyping be used interchangeably in epidemiological studies? Cancer Epidemiol. Biomarkers Prev., 1996, 5, 449-455.
    • (1996) Cancer Epidemiol. Biomarkers Prev. , vol.5 , pp. 449-455
    • Le Marchand, L.1    Sivaraman, L.2    Franke, A.A.3    Custer, L.J.4    Wilkens, L.R.5    Lau, A.F.6    Cooney, R.V.7
  • 68
    • 0039269095 scopus 로고    scopus 로고
    • Synthesis of the caffeine metabolites 5-acetylamino-6-formylamino-3- methyluracil (AFMU) and 5-acetylamino-6-amino-3-methyluracil (AAMU) on a preparative scale
    • Röhrkasten, R.; Raatz, P.; Kreher, R.P.; Blaszkewicz, M. Synthesis of the caffeine metabolites 5-acetylamino-6-formylamino-3- methyluracil (AFMU) and 5-acetylamino-6-amino-3-methyluracil (AAMU) on a preparative scale. Z. Naturforsch., 1997, 52b, 1526-1532.
    • (1997) Z. Naturforsch. , vol.52 B , pp. 1526-1532
    • Röhrkasten, R.1    Raatz, P.2    Kreher, R.P.3    Blaszkewicz, M.4
  • 69
    • 84900850861 scopus 로고    scopus 로고
    • N-Acetyltransferase 2 (phenotyping: caffeine test) [Biomonitoring Methods, 2004], Published Online: 31 JAN 2012, The MAK Collection for Occupational Health and Safety, DOI: 10.1002/3527600418.bi0nat2phne0009
    • Blaszkewicz, M. N-Acetyltransferase 2 (phenotyping: caffeine test) [Biomonitoring Methods, 2004], Published Online: 31 JAN 2012, The MAK Collection for Occupational Health and Safety, DOI: 10.1002/3527600418.bi0nat2phne0009
    • Blaszkewicz, M.1
  • 70
    • 33845287618 scopus 로고    scopus 로고
    • Concordance between the deduced acetylation status generated by high-speed: Real-time PCR based NAT2 genotyping of seven single nucleotide polymorphisms and human NAT2 phenotypes determined by a caffeine assay
    • Rihs, H.P.; John, A.; Scherenberg, M.; Seidel, A.; Brüning, T. Concordance between the deduced acetylation status generated by high-speed: real-time PCR based NAT2 genotyping of seven single nucleotide polymorphisms and human NAT2 phenotypes determined by a caffeine assay. Clin. Chim. Acta., 2007, 376, 240-243.
    • (2007) Clin. Chim. Acta. , vol.376 , pp. 240-243
    • Rihs, H.P.1    John, A.2    Scherenberg, M.3    Seidel, A.4    Brüning, T.5
  • 72
    • 0032939825 scopus 로고    scopus 로고
    • Pitfalls in N-acetyltransferase 2 genotyping
    • Cascorbi, I.; Roots, I. Pitfalls in N-acetyltransferase 2 genotyping. Pharmacogenetics, 1999, 9, 123-127.
    • (1999) Pharmacogenetics , vol.9 , pp. 123-127
    • Cascorbi, I.1    Roots, I.2
  • 74
    • 84866098991 scopus 로고    scopus 로고
    • The differential effect of NAT2 variant alleles permits refinement in phenotype inference and identifies a very slow acetylation genotype
    • Ruiz, J.D.; Martínez, C.; Anderson, K.; Gross, M.; Lang, N.P.; García-Martín, E.; Agúndez, J.A. The differential effect of NAT2 variant alleles permits refinement in phenotype inference and identifies a very slow acetylation genotype. PLoS One, 2012, 7, e44629.
    • (2012) PLoS One , vol.7
    • Ruiz, J.D.1    Martínez, C.2    Anderson, K.3    Gross, M.4    Lang, N.P.5    García-Martín, E.6    Agúndez, J.A.7
  • 80
    • 67650999336 scopus 로고    scopus 로고
    • Extracellular matrix modulates sensitivity of hepatocytes to fibroblastoid dedifferentiation and transforming growth factor beta-induced apoptosis
    • Godoy, P.; Hengstler, J.G.; Ilkavets, I.; Meyer, C.; Bachmann, A.; Müller, A.; Tuschl, G.; Mueller, S.O.; Dooley, S. Extracellular matrix modulates sensitivity of hepatocytes to fibroblastoid dedifferentiation and transforming growth factor beta-induced apoptosis. Hepatology, 2009, 49, 2031-2043.
    • (2009) Hepatology , vol.49 , pp. 2031-2043
    • Godoy, P.1    Hengstler, J.G.2    Ilkavets, I.3    Meyer, C.4    Bachmann, A.5    Müller, A.6    Tuschl, G.7    Mueller, S.O.8    Dooley, S.9
  • 82
    • 78049395199 scopus 로고    scopus 로고
    • Reversible manipulation of apoptosis sensitivity in cultured hepatocytes by matrix- mediated manipulation of signaling activities
    • Godoy, P.; Schug, M.; Bauer, A.; Hengstler, J.G. Reversible manipulation of apoptosis sensitivity in cultured hepatocytes by matrix- mediated manipulation of signaling activities. Methods Mol. Biol., 2010, 640, 139-155.
    • (2010) Methods Mol. Biol. , vol.640 , pp. 139-155
    • Godoy, P.1    Schug, M.2    Bauer, A.3    Hengstler, J.G.4
  • 84
    • 83755195441 scopus 로고    scopus 로고
    • Accuracy of various human NAT2 SNP genotyping panels to infer rapid, intermediate and slow acetylator phenotypes
    • Hein, D.W.; Doll, M.A. Accuracy of various human NAT2 SNP genotyping panels to infer rapid, intermediate and slow acetylator phenotypes. Pharmacogenomics, 2012, 13, 31-41.
    • (2012) Pharmacogenomics , vol.13 , pp. 31-41
    • Hein, D.W.1    Doll, M.A.2
  • 85
    • 0025237412 scopus 로고
    • Cloning and expression of cDNAs for polymorphic and monomorphic arylamine N-acetyltransferases from human liver
    • Ohsako, S.; Deguchi, T. Cloning and expression of cDNAs for polymorphic and monomorphic arylamine N-acetyltransferases from human liver. J. Biol. Chem., 1990, 265, 4630-4634.
    • (1990) J. Biol. Chem. , vol.265 , pp. 4630-4634
    • Ohsako, S.1    Deguchi, T.2
  • 86
    • 0025917067 scopus 로고
    • Diverse point mutations in the human gene for polymorphi N-acetyltransferase
    • Vatsis, K.P.; Martell, K.J.; Weber, W.W. Diverse point mutations in the human gene for polymorphic N-acetyltransferase. Proc. Natl. Acad. Sci. U S A, 1991, 88, 6333-6337.
    • (1991) Proc. Natl. Acad. Sci. U S A , vol.88 , pp. 6333-6337
    • Vatsis, K.P.1    Martell, K.J.2    Weber, W.W.3
  • 87
    • 0026935909 scopus 로고
    • Genotyping human polymorphic arylamine N-acetyltransferase: Identification of new slow allotypic variants
    • Hickman, D.; Risch, A.; Camilleri, J.P.; Sim, E. Genotyping human polymorphic arylamine N-acetyltransferase: identification of new slow allotypic variants. Pharmacogenetics, 1992, 2, 217-226.
    • (1992) Pharmacogenetics , vol.2 , pp. 217-226
    • Hickman, D.1    Risch, A.2    Camilleri, J.P.3    Sim, E.4
  • 88
    • 79953743009 scopus 로고    scopus 로고
    • Arylamine NAcetyltransferase 2 (NAT2) genetic diversity and traditional subsistence: A worldwide population survey
    • Sabbagh, A.; Darlu, P.; Crouau-Roy, B.; Poloni, E.S. Arylamine NAcetyltransferase 2 (NAT2) genetic diversity and traditional subsistence: a worldwide population survey. PLoS One, 2011, 6, e18507.
    • (2011) PLoS One , vol.6
    • Sabbagh, A.1    Darlu, P.2    Crouau-Roy, B.3    Poloni, E.S.4
  • 89
    • 0028270681 scopus 로고
    • Ethnic distribution of slow acetylator mutations in the polymorphic N-acetyltransferase (NAT2) gene
    • Lin, H.J.; Han, C-Y.; Lin, B.K.; Hardy S. Ethnic distribution of slow acetylator mutations in the polymorphic N-acetyltransferase (NAT2) gene. Pharmacogenetics, 1994, 4, 125-134.
    • (1994) Pharmacogenetics , vol.4 , pp. 125-134
    • Lin, H.J.1    Han, C.-Y.2    Lin, B.K.3    Hardy, S.4
  • 91
    • 84900859412 scopus 로고    scopus 로고
    • Nacetyltransferase 2: Slow, intermediate or fast? A booming question of the molecular epidemiology in cancer research
    • Pietro, G.; Gadelha, S.; Sousa, S.; Melo, P.; Santos, F. Nacetyltransferase 2: Slow, intermediate or fast? A booming question of the molecular epidemiology in cancer research. Open Journal of Genetics, 2012, 2, 221-235.
    • (2012) Open Journal of Genetics , vol.2 , pp. 221-235
    • Pietro, G.1    Gadelha, S.2    Sousa, S.3    Melo, P.4    Santos, F.5
  • 92
    • 0029834282 scopus 로고    scopus 로고
    • Predominance of slow acetylators of N-acetyltransferase in a Hmong population residing in the United States
    • Straka, R.J.; Hansen, S.R.; Benson, S.R.; Walker, P.F. Predominance of slow acetylators of N-acetyltransferase in a Hmong population residing in the United States. J. Clin. Pharmacol., 1996, 36, 740-747.
    • (1996) J. Clin. Pharmacol. , vol.36 , pp. 740-747
    • Straka, R.J.1    Hansen, S.R.2    Benson, S.R.3    Walker, P.F.4
  • 93
    • 33749355571 scopus 로고    scopus 로고
    • Verified predominance of slow acetylator phenotype Nacetyltransferase 2 (NAT2) in a Hmong population residing in Minnesota
    • Straka, R.J.; Burkhardt, R.T.; Lang, N.P.; Vang, T.; Hadsall, K.Z.; Tsai, M.Y. Verified predominance of slow acetylator phenotype Nacetyltransferase 2 (NAT2) in a Hmong population residing in Minnesota. Biopharm. Drug Dispos., 2006, 27, 299-304.
    • (2006) Biopharm. Drug Dispos. , vol.27 , pp. 299-304
    • Straka, R.J.1    Burkhardt, R.T.2    Lang, N.P.3    Vang, T.4    Hadsall, K.Z.5    Tsai, M.Y.6
  • 94
    • 38449121822 scopus 로고    scopus 로고
    • Population genetic diversity of the NAT2 gene supports a role of acetylation in human adaptation to farming in Central Asia
    • Magalon, H.; Patin, E.; Austerlitz, F.; Hegay, T.; Aldashev, A.; Quintana-Murci, L.; Heyer, E. Population genetic diversity of the NAT2 gene supports a role of acetylation in human adaptation to farming in Central Asia. Eur. J. Hum. Genet., 2008, 16, 243-251.
    • (2008) Eur. J. Hum. Genet. , vol.16 , pp. 243-251
    • Magalon, H.1    Patin, E.2    Austerlitz, F.3    Hegay, T.4    Aldashev, A.5    Quintana-Murci, L.6    Heyer, E.7
  • 96
    • 0036155404 scopus 로고    scopus 로고
    • Analysis of six SNPs of NAT2 in Ngawbe and Embera Amer indians of Panama and determination of the Embera acetylation phenotype using caffeine
    • Jorge-Nebert, L.F.; Eichelbaum, M.; Griese, E.U.; Inaba, T.; Arias, T.D. Analysis of six SNPs of NAT2 in Ngawbe and Embera Amer indians of Panama and determination of the Embera acetylation phenotype using caffeine. Pharmacogenetics, 2002, 12, 39-48.
    • (2002) Pharmacogenetics , vol.12 , pp. 39-48
    • Jorge-Nebert, L.F.1    Eichelbaum, M.2    Griese, E.U.3    Inaba, T.4    Arias, T.D.5
  • 98
    • 47849124636 scopus 로고    scopus 로고
    • Interethnic and intraethnic variability of NAT2 single nucleotide polymorphisms
    • García-Martín, E. Interethnic and intraethnic variability of NAT2 single nucleotide polymorphisms. Curr. Drug Metab., 2008, 9, 487-497.
    • (2008) Curr. Drug Metab. , vol.9 , pp. 487-497
    • García-Martín, E.1
  • 99
    • 0029927489 scopus 로고    scopus 로고
    • Determination and allelic allocation of seven nucleotide transitions within the arylamine N-acetyltransferase gene in the Polish population
    • Mrozikiewicz, P.M.; Cascorbi, I.; Brockmöller, J.; Roots, I. Determination and allelic allocation of seven nucleotide transitions within the arylamine N-acetyltransferase gene in the Polish population. Clin. Pharmacol. Ther., 1996, 59, 376-382.
    • (1996) Clin. Pharmacol. Ther. , vol.59 , pp. 376-382
    • Mrozikiewicz, P.M.1    Cascorbi, I.2    Brockmöller, J.3    Roots, I.4
  • 104
    • 0027183777 scopus 로고
    • Genotype/phenotype discordance for human arylamine N-acetyltransferase (NAT2) reveals a new slow-acetylator allele common in African-Americans
    • Bell, D.A.; Taylor, J.A.; Butler, M.A.; Stephens, E.A.; Wiest, J.; Brubaker, L.H.; Kadlubar, F.F.; Lucier, G.W. Genotype/phenotype discordance for human arylamine N-acetyltransferase (NAT2) reveals a new slow-acetylator allele common in African-Americans. Carcinogenesis, 1993, 14, 1689-1692.
    • (1993) Carcinogenesis , vol.14 , pp. 1689-1692
    • Bell, D.A.1    Taylor, J.A.2    Butler, M.A.3    Stephens, E.A.4    Wiest, J.5    Brubaker, L.H.6    Kadlubar, F.F.7    Lucier, G.W.8
  • 105
    • 0029989541 scopus 로고    scopus 로고
    • Genotyping of the polymorphic N-acetyltransferase (NAT2- 2) gene locus in two native African populations
    • Delomenie, C.; Sica, L.; Grant, D.M.; Krishnamoorthy, R.; Dupret, J-M. Genotyping of the polymorphic N-acetyltransferase (NAT2- 2) gene locus in two native African populations. Pharmacogenetics, 1996, 6, 177-185.
    • (1996) Pharmacogenetics , vol.6 , pp. 177-185
    • Delomenie, C.1    Sica, L.2    Grant, D.M.3    Krishnamoorthy, R.4    Dupret, J.-M.5
  • 111
    • 3042662702 scopus 로고    scopus 로고
    • N-Acetyltransferase 2 genotyping: An accurate and feasible approach for simultaneous detection of the most common NAT2 alleles
    • Brans, R.; Laizane, D.; Khan, A.; Blömeke, B. N-Acetyltransferase 2 genotyping: an accurate and feasible approach for simultaneous detection of the most common NAT2 alleles. Clin. Chem., 2004, 50, 1264-1266.
    • (2004) Clin. Chem. , vol.50 , pp. 1264-1266
    • Brans, R.1    Laizane, D.2    Khan, A.3    Blömeke, B.4
  • 112
    • 84900837768 scopus 로고    scopus 로고
    • LightCycler - NAT2 Mutation Detection Kit. Roche Molecular Biochemicals, Biochemica No 1
    • LightCycler - NAT2 Mutation Detection Kit. Roche Molecular Biochemicals, Biochemica No 1; 2001. pp. 15-16. http://www.rocheapplied-science.com/PROD-INF/ BIOCHEMI/No1-01/PDF/b101l ehmann.pdf
    • (2001) , pp. 15-16
  • 113
    • 0141792604 scopus 로고    scopus 로고
    • NAT2 genotyping: Equilibrium between accuracy and feasibility in routine analyses
    • Agúndez, J.A.G. NAT2 genotyping: equilibrium between accuracy and feasibility in routine analyses. J. Appl. Res., 2003, 3, 1-6.
    • (2003) J. Appl. Res. , vol.3 , pp. 1-6
    • Agúndez, J.A.G.1
  • 114
    • 84859030523 scopus 로고    scopus 로고
    • Novel tagging SNP rs1495741 and 2-SNPs (rs1041983 and rs1801280) yield a high prediction of the NAT2 genotype in HapMap samples
    • He, Y.J.; Shapero, M.H.; McLeod, H.L. Novel tagging SNP rs1495741 and 2-SNPs (rs1041983 and rs1801280) yield a high prediction of the NAT2 genotype in HapMap samples. Pharmacogenet. Genomics, 2012, 22, 322-324.
    • (2012) Pharmacogenet. Genomics , vol.22 , pp. 322-324
    • He, Y.J.1    Shapero, M.H.2    McLeod, H.L.3
  • 116
    • 0029798504 scopus 로고    scopus 로고
    • Genetic analysis of the NAT2 and CYP2D6 polymorphisms in white patients with non-insulin-dependent diabetes mellitus
    • Agúndez, J.A.; Menaya, J.G.; Tejeda, R.; Lago, F.; Chávez, M.; Benítez, J. Genetic analysis of the NAT2 and CYP2D6 polymorphisms in white patients with non-insulin-dependent diabetes mellitus. Pharmacogenetics, 1996, 6, 465-472.
    • (1996) Pharmacogenetics , vol.6 , pp. 465-472
    • Agúndez, J.A.1    Menaya, J.G.2    Tejeda, R.3    Lago, F.4    Chávez, M.5    Benítez, J.6
  • 117
    • 84862006775 scopus 로고    scopus 로고
    • Accuracy of NAT2 SNP genotyping panels to infer acetylator phenotypes in African, Asian, Amerindian and admixed populations
    • Suarez-Kurtz, G.; Vargens, D.D.; Sortica, V.A.; Hutz, M.H. Accuracy of NAT2 SNP genotyping panels to infer acetylator phenotypes in African, Asian, Amerindian and admixed populations. Pharmacogenomics, 2012, 13, 851-854.
    • (2012) Pharmacogenomics , vol.13 , pp. 851-854
    • Suarez-Kurtz, G.1    Vargens, D.D.2    Sortica, V.A.3    Hutz, M.H.4
  • 118
    • 10044232695 scopus 로고    scopus 로고
    • Algorithms for inferring haplotypes
    • Niu, T. Algorithms for inferring haplotypes. Genet. Epidemiol., 2004, 27, 334-347.
    • (2004) Genet. Epidemiol. , vol.27 , pp. 334-347
    • Niu, T.1
  • 119
    • 27544473944 scopus 로고    scopus 로고
    • A comprehensive literature review of haplotyping software and methods for use with unrelated individuals
    • Salem, R.M.; Wessel, J.; Schork, N.J. A comprehensive literature review of haplotyping software and methods for use with unrelated individuals. Hum. Genomics, 2005, 2, 39-66.
    • (2005) Hum. Genomics , vol.2 , pp. 39-66
    • Salem, R.M.1    Wessel, J.2    Schork, N.J.3
  • 120
    • 62649155943 scopus 로고    scopus 로고
    • A unified approach to genotype imputation and haplotype-phase inference for large data sets of trios and unrelated individuals
    • Browning, B.L.; Browning, S.R. A unified approach to genotype imputation and haplotype-phase inference for large data sets of trios and unrelated individuals. Am. J. Hum. Genet., 2009, 84, 210-223.
    • (2009) Am. J. Hum. Genet. , vol.84 , pp. 210-223
    • Browning, B.L.1    Browning, S.R.2
  • 121
    • 80053019891 scopus 로고    scopus 로고
    • Haplotype phasing: Existing methods and new developments
    • Browning, S.R.; Browning, B.L. Haplotype phasing: existing methods and new developments. Nat. Rev. Genet., 2011, 12, 703-714.
    • (2011) Nat. Rev. Genet. , vol.12 , pp. 703-714
    • Browning, S.R.1    Browning, B.L.2
  • 122
    • 0035071957 scopus 로고    scopus 로고
    • A new statistical method for haplotype reconstruction from population data
    • Stephens, M.; Smith, N.J.; Donnelly, P. A new statistical method for haplotype reconstruction from population data. Am. J. Hum. Genet., 2001, 68, 978-989.
    • (2001) Am. J. Hum. Genet. , vol.68 , pp. 978-989
    • Stephens, M.1    Smith, N.J.2    Donnelly, P.3
  • 123
    • 0242691208 scopus 로고    scopus 로고
    • A comparison of Bayesian methods for haplotype reconstruction
    • Stephens, M.; Donnelly, P. A comparison of Bayesian methods for haplotype reconstruction. Am. J. Hum. Genet., 2003, 73, 1162-1169.
    • (2003) Am. J. Hum. Genet. , vol.73 , pp. 1162-1169
    • Stephens, M.1    Donnelly, P.2
  • 124
    • 0347361674 scopus 로고    scopus 로고
    • Modelling linkage disequilibrium, and identifying recombination hotspots using SNP data
    • Li, N.; Stephens, M. Modelling linkage disequilibrium, and identifying recombination hotspots using SNP data. Genetics, 2003, 165, 2213-2233.
    • (2003) Genetics , vol.165 , pp. 2213-2233
    • Li, N.1    Stephens, M.2
  • 125
    • 0025269067 scopus 로고
    • Inference of haplotypes from PCR-amplified samples of diploid populations
    • Clark, A. Inference of haplotypes from PCR-amplified samples of diploid populations. J. Mol. Biol. Evol., 1990, 7, 111-122.
    • (1990) J. Mol. Biol. Evol. , vol.7 , pp. 111-122
    • Clark, A.1
  • 127
    • 0034812677 scopus 로고    scopus 로고
    • Inference of haplotypes from samples of diploid populations: Complexity and algorithms
    • Gusfield, D. Inference of haplotypes from samples of diploid populations: complexity and algorithms. J. Comput. Biol., 2001, 8, 305- 323.
    • (2001) J. Comput. Biol. , vol.8 , pp. 305-323
    • Gusfield, D.1
  • 128
    • 0001935493 scopus 로고
    • Gene genealogies and the coalescent process
    • Hudson, R. Gene genealogies and the coalescent process. Oxford Surv. Evol. Biol., 1990, 7, 1-44.
    • (1990) Oxford Surv. Evol. Biol. , vol.7 , pp. 1-44
    • Hudson, R.1
  • 130
    • 4444367508 scopus 로고    scopus 로고
    • Haplotype reconstruction from genotype data using Imperfect Phylogeny
    • Halperin, E.; Eskin, E. Haplotype reconstruction from genotype data using Imperfect Phylogeny. Bioinformatics, 2004, 20, 1842-1849.
    • (2004) Bioinformatics , vol.20 , pp. 1842-1849
    • Halperin, E.1    Eskin, E.2
  • 131
    • 0036138183 scopus 로고    scopus 로고
    • Bayesian haplotype inference for multiple linked single-nucleotide polymorphisms
    • Niu, T.; Qin, Z.S.; Xu, X.; Liu, J.S. Bayesian haplotype inference for multiple linked single-nucleotide polymorphisms. Am. J. Hum. Genet., 2002, 70, 157-169.
    • (2002) Am. J. Hum. Genet. , vol.70 , pp. 157-169
    • Niu, T.1    Qin, Z.S.2    Xu, X.3    Liu, J.S.4
  • 132
    • 0002629270 scopus 로고
    • Maximum likelihood from incomplete data via the em algorithm
    • Dempster, A.; Laird, N.; Rubin, D. Maximum likelihood from incomplete data via the EM algorithm. JASA, 1977, 39, 1-22.
    • (1977) JASA , vol.39 , pp. 1-22
    • Dempster, A.1    Laird, N.2    Rubin, D.3
  • 134
    • 0029130796 scopus 로고
    • Maximum-likelihood estimation of molecular haplotype frequencies in a diploid population
    • Excoffier, L.; Slatkin, M. Maximum-likelihood estimation of molecular haplotype frequencies in a diploid population. Mol. Biol. Evol., 1995, 12, 921-927.
    • (1995) Mol. Biol. Evol. , vol.12 , pp. 921-927
    • Excoffier, L.1    Slatkin, M.2
  • 135
    • 85007110786 scopus 로고    scopus 로고
    • Arlequin ver. 3.0: An integrated software package for population genetics data analysis
    • Excoffier, L.; Laval, G.; Schneider, S. Arlequin ver. 3.0: An integrated software package for population genetics data analysis. Evolutionary Bioinformatics Online, 2005, 1, 47-50.
    • (2005) Evolutionary Bioinformatics Online , vol.1 , pp. 47-50
    • Excoffier, L.1    Laval, G.2    Schneider, S.3
  • 136
    • 0029372419 scopus 로고
    • Haplo: A program using the em algorithm to estimate the frequencies of multi-site haplotypes
    • Hawley, M.; Kidd, K. Haplo: a program using the EM algorithm to estimate the frequencies of multi-site haplotypes. J. Heredity, 1995, 86, 409-411.
    • (1995) J. Heredity , vol.86 , pp. 409-411
    • Hawley, M.1    Kidd, K.2
  • 137
    • 25444442089 scopus 로고    scopus 로고
    • Comparison of the accuracy of methods of computational haplotype inference using a large empirical dataset
    • Adkins, R.M. Comparison of the accuracy of methods of computational haplotype inference using a large empirical dataset. BMC Genet., 2004, 5, 22.
    • (2004) BMC Genet. , vol.5 , pp. 22
    • Adkins, R.M.1
  • 138
    • 0036155283 scopus 로고    scopus 로고
    • Score tests for association between traits and haplotypes when linkage phase is ambiguous
    • Schaid, D.J.; Rowland, C.M.; Tines, D.E.; Jacobson, R.M.; Poland, G.A. Score tests for association between traits and haplotypes when linkage phase is ambiguous. Am. J. Hum. Genet., 2002, 70, 425-434.
    • (2002) Am. J. Hum. Genet. , vol.70 , pp. 425-434
    • Schaid, D.J.1    Rowland, C.M.2    Tines, D.E.3    Jacobson, R.M.4    Poland, G.A.5
  • 139
    • 33846584121 scopus 로고    scopus 로고
    • HaploRec: Efficient and accurate large-scale reconstruction of haplotypes
    • Eronen, L.; Geerts, F.; Toivonen, H. HaploRec: efficient and accurate large-scale reconstruction of haplotypes. BMC Bioinformatics, 2006, 7, 542.
    • (2006) BMC Bioinformatics , vol.7 , pp. 542
    • Eronen, L.1    Geerts, F.2    Toivonen, H.3
  • 140
    • 0028913523 scopus 로고
    • An E-M algorithm and testing strategy for multiple-locus haplotypes
    • Long, J.; Williams, R.; Urbanek, M. An E-M algorithm and testing strategy for multiple-locus haplotypes. Am. J. Hum. Genet., 1995, 56, 799-810.
    • (1995) Am. J. Hum. Genet. , vol.56 , pp. 799-810
    • Long, J.1    Williams, R.2    Urbanek, M.3
  • 141
    • 0033794938 scopus 로고    scopus 로고
    • Accuracy of haplotype frequency estimation for biallelic loci, via the Expectation-Maximization algorithm for unphased diploid genotype data
    • Fallin, D.; Schork, N.J. Accuracy of haplotype frequency estimation for
    • (2000) Am. J. Hum. Genet. , vol.67 , pp. 947-959
    • Fallin, D.1    Schork, N.J.2
  • 143
    • 0036844521 scopus 로고    scopus 로고
    • Partition-ligation-expectation- maximization algorithm for haplotype inference with singlenucleotide polymorphisms
    • Qin, Z.S.; Nui, T.; Liu, J.S. Partition-ligation-expectation- maximization algorithm for haplotype inference with singlenucleotide polymorphisms. Am. J. Hum. Genet., 2002, 71, 1242-1247.
    • (2002) Am. J. Hum. Genet. , vol.71 , pp. 1242-1247
    • Qin, Z.S.1    Nui, T.2    Liu, J.S.3
  • 144
    • 13844270527 scopus 로고    scopus 로고
    • Accounting for decay of linkage disequilibrium in haplotype inference and missing-data imputation
    • Stephens, M.; Scheet, P. Accounting for decay of linkage disequilibrium in haplotype inference and missing-data imputation. Am. J. Hum. Genet., 2005, 76, 449-462.
    • (2005) Am. J. Hum. Genet. , vol.76 , pp. 449-462
    • Stephens, M.1    Scheet, P.2
  • 145
    • 21044434656 scopus 로고    scopus 로고
    • Haplotype reconstruction for diploid populations
    • Zhang, J.; Vingron, M.; Hoehe, M.R. Haplotype reconstruction for diploid populations. Hum. Hered., 2005, 59, 144-156.
    • (2005) Hum. Hered. , vol.59 , pp. 144-156
    • Zhang, J.1    Vingron, M.2    Hoehe, M.R.3
  • 148
    • 33644974019 scopus 로고    scopus 로고
    • A fast and flexible statistical model for large-scale population genotype data: Applications to inferring missing genotypes and haplotypic phase
    • Scheet, P.; Stephens, M. A fast and flexible statistical model for large-scale population genotype data: applications to inferring missing genotypes and haplotypic phase. Am. J. Hum. Genet., 2006, 78, 629-644.
    • (2006) Am. J. Hum. Genet. , vol.78 , pp. 629-644
    • Scheet, P.1    Stephens, M.2
  • 150
    • 78649508578 scopus 로고    scopus 로고
    • MaCH: Using sequence and genotype data to estimate haplotypes and unobserved genotypes
    • Li, Y.; Willer, C.J.; Ding, J.; Scheet, P.; Abecasis, G.R. MaCH: using sequence and genotype data to estimate haplotypes and unobserved genotypes. Genet. Epidemiol., 2010, 34, 816-834.
    • (2010) Genet. Epidemiol. , vol.34 , pp. 816-834
    • Li, Y.1    Willer, C.J.2    Ding, J.3    Scheet, P.4    Abecasis, G.R.5
  • 151
    • 34347344976 scopus 로고    scopus 로고
    • A new multipoint method for genome-wide association studies by imputation of genotypes
    • Marchini, J.; Howie, B.; Myers, S.; McVean, G.; Donnelly, P. A new multipoint method for genome-wide association studies by imputation of genotypes. Nat. Genet., 2007, 39, 906-913.
    • (2007) Nat. Genet. , vol.39 , pp. 906-913
    • Marchini, J.1    Howie, B.2    Myers, S.3    McVean, G.4    Donnelly, P.5
  • 152
    • 67651222400 scopus 로고    scopus 로고
    • A flexible and accurate genotype imputation method for the next generation of genome- wide association studies
    • Howie, B. N.; Donnelly, P.; Marchini, J. A Flexible and Accurate Genotype Imputation Method for the Next Generation of Genome- Wide Association Studies. PLoS Genet., 2009, 5, e1000529.
    • (2009) PLoS Genet. , vol.5
    • Howie, B.N.1    Donnelly, P.2    Marchini, J.3
  • 153
    • 33646869900 scopus 로고    scopus 로고
    • Multilocus association mapping using variablelength Markov chains
    • Browning, S.R. Multilocus association mapping using variablelength Markov chains. Am. J. Hum. Genet., 2006, 78, 903-193.
    • (2006) Am. J. Hum. Genet. , vol.78 , pp. 903-193
    • Browning, S.R.1
  • 154
    • 35348817330 scopus 로고    scopus 로고
    • Rapid and accurate haplotype phasing and missing data inference for whole genome association studies by use of localized haplotype clustering
    • Browning, S.R.; Browning, B.L. Rapid and accurate haplotype phasing and missing data inference for whole genome association studies by use of localized haplotype clustering. Am. J. Hum. Genet., 2007, 81, 1084-1097.
    • (2007) Am. J. Hum. Genet. , vol.81 , pp. 1084-1097
    • Browning, S.R.1    Browning, B.L.2
  • 156
    • 84871952176 scopus 로고    scopus 로고
    • Improved wholechromosome phasing for disease and population genetic studies
    • Delaneau, O.; Zagury, J.F.; Marchini, J. Improved wholechromosome phasing for disease and population genetic studies. Nat. Methods, 2012, 10, 5-6.
    • (2012) Nat. Methods , vol.10 , pp. 5-6
    • Delaneau, O.1    Zagury, J.F.2    Marchini, J.3
  • 157
    • 34547498552 scopus 로고    scopus 로고
    • Association of genetic polymorphisms of N-acetyltransferase 2 and susceptibility to esophageal cancer in north Indian population
    • Jain, M.; Kumar, S.; Lal, P.; Tiwari, A.; Ghoshal, U.C.; Mittal, B. Association of genetic polymorphisms of N-acetyltransferase 2 and susceptibility to esophageal cancer in north Indian population. Cancer Invest., 2007, 25, 340-346.
    • (2007) Cancer Invest. , vol.25 , pp. 340-346
    • Jain, M.1    Kumar, S.2    Lal, P.3    Tiwari, A.4    Ghoshal, U.C.5    Mittal, B.6
  • 160
    • 84867504367 scopus 로고    scopus 로고
    • Polymorphism of the N-acetyltransferase 2 gene as a susceptibility risk factor for antituberculosis drug-induced hepatotoxicity in Tunisian patients with tuberculosis
    • Ben Mahmoud, L.; Ghozzi, H.; Kamoun, A.; Hakim, A.; Hachicha, H.; Hammami, S.; Sahnoun, Z.; Zalila, N.; Makni, H.; Zeghal, K. Polymorphism of the N-acetyltransferase 2 gene as a susceptibility risk factor for antituberculosis drug-induced hepatotoxicity in Tunisian patients with tuberculosis. Pathol. Biol. (Paris), 2012, 60, 324-330.
    • (2012) Pathol. Biol. (Paris) , vol.60 , pp. 324-330
    • Ben Mahmoud, L.1    Ghozzi, H.2    Kamoun, A.3    Hakim, A.4    Hachicha, H.5    Hammami, S.6    Sahnoun, Z.7    Zalila, N.8    Makni, H.9    Zeghal, K.10
  • 163
    • 65449153930 scopus 로고    scopus 로고
    • A web server for inferring the human N-acetyltransferase-2 (NAT2) enzymatic phenotype from NAT2 genotype
    • Kuznetsov, I.B.; McDuffie, M.; Moslehi, R. A web server for inferring the human N-acetyltransferase-2 (NAT2) enzymatic phenotype from NAT2 genotype. Bioinformatics, 2009, 25, 1185-1186.
    • (2009) Bioinformatics , vol.25 , pp. 1185-1186
    • Kuznetsov, I.B.1    McDuffie, M.2    Moslehi, R.3
  • 164
    • 74549168266 scopus 로고    scopus 로고
    • Evaluating NAT2PRED for inferring the individual acetylation status from unphased genotype data
    • Sabbagh, A.; Darlu, P.; Vidaud, M. Evaluating NAT2PRED for inferring the individual acetylation status from unphased genotype data. BMC Med. Genet., 2009, 10, 148.
    • (2009) BMC Med. Genet. , vol.10 , pp. 148
    • Sabbagh, A.1    Darlu, P.2    Vidaud, M.3
  • 165
    • 0032235209 scopus 로고    scopus 로고
    • Polymorphisms of N-acetyltransferases, glutathione S-transferases, microsomal epoxide hydrolase and sulfotransferases: Influence on cancer susceptibility
    • Hengstler, J.G.; Arand, M.; Herrero, M.E.; Oesch, F. Polymorphisms of N-acetyltransferases, glutathione S-transferases, microsomal epoxide hydrolase and sulfotransferases: influence on cancer susceptibility. Recent Results Cancer Res., 1998, 154, 47-85.
    • (1998) Recent Results Cancer Res. , vol.154 , pp. 47-85
    • Hengstler, J.G.1    Arand, M.2    Herrero, M.E.3    Oesch, F.4
  • 167
    • 0037772635 scopus 로고    scopus 로고
    • Markers of genetic susceptibility in human environmental hygiene and toxicology: The role of selected CYP, NAT and GST genes
    • Thier, R.; Brüning, T.; Roos, P.H.; Rihs, H.P.; Golka, K.; Ko, Y.; Bolt, H.M. Markers of genetic susceptibility in human environmental hygiene and toxicology: the role of selected CYP, NAT and GST genes. Int. J. Hyg. Environ. Health, 2003, 206, 149-171.
    • (2003) Int. J. Hyg. Environ. Health , vol.206 , pp. 149-171
    • Thier, R.1    Brüning, T.2    Roos, P.H.3    Rihs, H.P.4    Golka, K.5    Ko, Y.6    Bolt, H.M.7
  • 169
    • 26244468297 scopus 로고    scopus 로고
    • Occupational and nonoccupational risk factors in bladder cancer patients in an industrialized area located in former East-Germany
    • Golka, K.; Seidel, T.; Dietrich, H.; Roth, G.; Rötzel, C.; Thier, R.; Geller, F.; Reckwitz, T.; Schulze, H. Occupational and nonoccupational risk factors in bladder cancer patients in an industrialized area located in former East-Germany. Aktuelle Urol., 2005, 36, 417-422.
    • (2005) Aktuelle Urol. , vol.36 , pp. 417-422
    • Golka, K.1    Seidel, T.2    Dietrich, H.3    Roth, G.4    Rötzel, C.5    Thier, R.6    Geller, F.7    Reckwitz, T.8    Schulze, H.9
  • 170
    • 47349128668 scopus 로고    scopus 로고
    • NAcetyltransferase- 2 and medical history in bladder cancer cases with a suspected occupational disease (BK 1301) in Germany
    • Weistenhöfer, W.; Blaszkewicz, M.; Bolt, H.M.; Golka, K. NAcetyltransferase- 2 and medical history in bladder cancer cases with a suspected occupational disease (BK 1301) in Germany. J. Toxicol. Environ. Health A, 2008, 71, 906-910.
    • (2008) J. Toxicol. Environ. Health A , vol.71 , pp. 906-910
    • Weistenhöfer, W.1    Blaszkewicz, M.2    Bolt, H.M.3    Golka, K.4
  • 171
    • 47349131318 scopus 로고    scopus 로고
    • Bladder cancer and occupational exposures in North Rhine-Westphalia, Germany
    • Geller, F.; Urfer, W.; Golka, K. Bladder cancer and occupational exposures in North Rhine-Westphalia, Germany. J. Toxicol. Environ. Health A, 2008, 71, 856-858.
    • (2008) J. Toxicol. Environ. Health A , vol.71 , pp. 856-858
    • Geller, F.1    Urfer, W.2    Golka, K.3
  • 173
    • 84872919376 scopus 로고    scopus 로고
    • Genetic variants confer susceptibility to urinary bladder cancer: An updated list of confirmed polymorphisms
    • Selinski, S. Genetic variants confer susceptibility to urinary bladder cancer: an updated list of confirmed polymorphisms. EXCLI J., 2012, 11, 743-747.
    • (2012) EXCLI J. , vol.11 , pp. 743-747
    • Selinski, S.1
  • 174
    • 84878849566 scopus 로고    scopus 로고
    • Human bladder cancer risk calculation based on genome- wide analysis of genetic variants
    • Bolt, H.M. Human bladder cancer risk calculation based on genome- wide analysis of genetic variants. Arch. Toxicol., 2013, 87, 397-399.
    • (2013) Arch. Toxicol. , vol.87 , pp. 397-399
    • Bolt, H.M.1
  • 175
    • 84873377742 scopus 로고    scopus 로고
    • Relevance of genetic disposition versus environmental exposure for cancer risk: An old controversy revisited with novel methods
    • Bolt, H.M. Relevance of genetic disposition versus environmental exposure for cancer risk: an old controversy revisited with novel methods. EXCLI J., 2013, 12, 79-80.
    • (2013) EXCLI J. , vol.12 , pp. 79-80
    • Bolt, H.M.1
  • 176
    • 0036174095 scopus 로고    scopus 로고
    • A prospective study on active and environmental tobacco smoking and bladder cancer risk
    • Zeegers, M.P.; Goldbohm, R.A.; Van Den Brandt, P.A. A prospective study on active and environmental tobacco smoking and bladder cancer risk. Cancer Causes Control, 2002, 13, 83-90.
    • (2002) Cancer Causes Control , vol.13 , pp. 83-90
    • Zeegers, M.P.1    Goldbohm, R.A.2    Van Den Brandt, P.A.3
  • 177
    • 0034255538 scopus 로고    scopus 로고
    • The impact of characteristics of cigarette smoking on urinary tract cancer risk: A meta-analysis of epidemiologic studies
    • Zeegers, M.P.; Tan, F.E.; Dorant, E.; Van Den Brandt, P.A. The impact of characteristics of cigarette smoking on urinary tract cancer risk: a meta-analysis of epidemiologic studies. Cancer, 2000, 89, 630-639.
    • (2000) Cancer , vol.89 , pp. 630-639
    • Zeegers, M.P.1    Tan, F.E.2    Dorant, E.3    Van Den Brandt, P.A.4
  • 178
    • 52949139856 scopus 로고    scopus 로고
    • Tobacco smoking and risk of bladder cancer
    • Boffetta, P. Tobacco smoking and risk of bladder cancer. Scand. J. Urol. Nephrol. Suppl., 2008, 42, 45-54.
    • (2008) Scand. J. Urol. Nephrol. Suppl. , vol.42 , pp. 45-54
    • Boffetta, P.1
  • 179
    • 59249101715 scopus 로고    scopus 로고
    • The global burden of urinary bladder cancer. Scand
    • Parkin, D.M. The global burden of urinary bladder cancer. Scand. J. Urol. Nephrol. Suppl., 2008, 42, 12-20.
    • (2008) J. Urol. Nephrol. Suppl. , vol.42 , pp. 12-20
    • Parkin, D.M.1
  • 182
    • 0032850119 scopus 로고    scopus 로고
    • Genotypes of N-acetyltransferase-2 and risk of bladder cancer: A case-control study
    • Filiadis, I.F.; Georgiou, I.; Alamanos, Y.; Kranas, V.; Giannakopoulos, X.; Lolis, D. Genotypes of N-acetyltransferase-2 and risk of bladder cancer: a case-control study. J. Urol., 1999, 161, 1672-1675.
    • (1999) J. Urol. , vol.161 , pp. 1672-1675
    • Filiadis, I.F.1    Georgiou, I.2    Alamanos, Y.3    Kranas, V.4    Giannakopoulos, X.5    Lolis, D.6
  • 185
    • 84872936239 scopus 로고    scopus 로고
    • Pharmacogenomics of adverse drug reactio
    • Daly, A.K. Pharmacogenomics of adverse drug reactions. Genome Med., 2013, 5, 5.
    • (2013) Genome Med. , vol.5 , pp. 5
    • Daly, A.K.1
  • 188
    • 84869228598 scopus 로고    scopus 로고
    • Relationship of NAT2, CYP2E1 and GSTM1/GSTT1 polymorphisms with mild elevation of liver enzymes in Brazilian individuals under anti-tuberculosis drug therapy
    • Forestiero, F.J.; Cecon, L.; Hirata, M.H.; de Melo, F.F.; Cardoso, R.F.; Cerda, A.; Hirata, R.D. Relationship of NAT2, CYP2E1 and GSTM1/GSTT1 polymorphisms with mild elevation of liver enzymes in Brazilian individuals under anti-tuberculosis drug therapy. Clin. Chim. Acta, 2013, 415, 215-219.
    • (2013) Clin. Chim. Acta , vol.415 , pp. 215-219
    • Forestiero, F.J.1    Cecon, L.2    Hirata, M.H.3    De Melo, F.F.4    Cardoso, R.F.5    Cerda, A.6    Hirata, R.D.7
  • 190
    • 0036202380 scopus 로고    scopus 로고
    • Polymorphism of the Nacetyltransferase 2 gene as a susceptibility risk factor for antituberculosis drug-induced hepatitis
    • Huang, Y.S.; Chern, H.D.; Su, W.J.; Wu, J.C.; Lai, S.L.; Yang, S.Y.; Chang, F.Y.; Lee, S.D. Polymorphism of the Nacetyltransferase 2 gene as a susceptibility risk factor for antituberculosis drug-induced hepatitis. Hepatology, 2002, 35, 883-889.
    • (2002) Hepatology , vol.35 , pp. 883-889
    • Huang, Y.S.1    Chern, H.D.2    Su, W.J.3    Wu, J.C.4    Lai, S.L.5    Yang, S.Y.6    Chang, F.Y.7    Lee, S.D.8
  • 192
    • 35348922264 scopus 로고    scopus 로고
    • Genetic polymorphisms of NAT2 and CYP2E1 associated with antituberculosis drug-induced hepatotoxicity in Korean patients with pulmonary tuberculosis
    • Cho, H.J.; Koh, W.J.; Ryu, Y.J.; Ki, C.S.; Nam, M.H.; Kim, J.W.; Lee, S.Y. Genetic polymorphisms of NAT2 and CYP2E1 associated with antituberculosis drug-induced hepatotoxicity in Korean patients with pulmonary tuberculosis. Tuberculosis, 2007, 87, 551-556.
    • (2007) Tuberculosis , vol.87 , pp. 551-556
    • Cho, H.J.1    Koh, W.J.2    Ryu, Y.J.3    Ki, C.S.4    Nam, M.H.5    Kim, J.W.6    Lee, S.Y.7
  • 194
    • 45749141585 scopus 로고    scopus 로고
    • Effects of N-acetyltransferase 2 (NAT2), CYP2E1 and glutathione-S- transferase (GST) genotypes on the serum concentrations of isoniazid and metabolites in tuberculosis patients
    • Fukino, K.; Sasaki, Y.; Hirai, S.; Nakamura, T.; Hashimoto, M.; Yamagishi, F.; Ueno, K. Effects of N-acetyltransferase 2 (NAT2), CYP2E1 and glutathione-S-transferase (GST) genotypes on the serum concentrations of isoniazid and metabolites in tuberculosis patients. J. Toxicol. Sci., 2008, 33, 187-195.
    • (2008) J. Toxicol. Sci. , vol.33 , pp. 187-195
    • Fukino, K.1    Sasaki, Y.2    Hirai, S.3    Nakamura, T.4    Hashimoto, M.5    Yamagishi, F.6    Ueno, K.7
  • 196
    • 77950881900 scopus 로고    scopus 로고
    • NAT2 and CYP2E1 polymorphisms and susceptibility to first-line anti-tuberculosis drug-induced hepatitis
    • Lee, S.W.; Chung, L.S.; Huang, H.H.; Chuang, T.Y.; Liou, Y.H.; Wu, L.S. NAT2 and CYP2E1 polymorphisms and susceptibility to first-line anti-tuberculosis drug-induced hepatitis. Int. J. Tuberc. Lung Dis., 2010, 14, 622-626.
    • (2010) Int. J. Tuberc. Lung Dis. , vol.14 , pp. 622-626
    • Lee, S.W.1    Chung, L.S.2    Huang, H.H.3    Chuang, T.Y.4    Liou, Y.H.5    Wu, L.S.6
  • 197
    • 78851470285 scopus 로고    scopus 로고
    • Role of polymorphic N-acetyl transferase2 and cytochrome P4502E1 gene in antituberculosis treatment-induced hepatit
    • Bose, P.D.; Sarma, M.P.; Medhi, S.; Das, B.C.; Husain, S.A.; Kar, P. Role of polymorphic N-acetyl transferase2 and cytochrome P4502E1 gene in antituberculosis treatment-induced hepatitis. J. Gastroenterol. Hepatol., 2011, 26, 312-318.
    • (2011) . J. Gastroenterol. Hepatol. , vol.26 , pp. 312-318
    • Bose, P.D.1    Sarma, M.P.2    Medhi, S.3    Das, B.C.4    Husain, S.A.5    Kar, P.6
  • 198
    • 79960620587 scopus 로고    scopus 로고
    • Association of isoniazid-metabolizing enzyme genotypes and isoniazidinduced hepatotoxicity in tuberculosis patien
    • Sotsuka, T.; Sasaki, Y.; Hirai, S.; Yamagishi, F.; Ueno, K. Association of isoniazid-metabolizing enzyme genotypes and isoniazidinduced hepatotoxicity in tuberculosis patients. In vivo, 2011, 25, 803-812.
    • (2011) . in Vivo , vol.25 , pp. 803-812
    • Sotsuka, T.1    Sasaki, Y.2    Hirai, S.3    Yamagishi, F.4    Ueno, K.5
  • 199
    • 84861678115 scopus 로고    scopus 로고
    • NAT2 and CYP2E1 polymorphisms associated with antituberculosis druginduced hepatotoxicity in Chinese patients
    • An, H.R.; Wu, X.Q.; Wang, Z.Y.; Zhang, J.X.; Liang, Y. NAT2 and CYP2E1 polymorphisms associated with antituberculosis druginduced hepatotoxicity in Chinese patients. Clin. Exp. Pharmacol. Physiol., 2012, 39, 535-543.
    • (2012) Clin. Exp. Pharmacol. Physiol. , vol.39 , pp. 535-543
    • An, H.R.1    Wu, X.Q.2    Wang, Z.Y.3    Zhang, J.X.4    Liang, Y.5
  • 200
    • 84879461332 scopus 로고    scopus 로고
    • Pharmacogenetics-based tuberculosis therapy research group. NAT2 genotype guided regimen reduces isoniazid-induced liver injury and early treatment failure in the 6-month four-drug standard treatment of tuberculosis: A randomized controlled trial for pharmacogenetics-based therapy
    • Azuma, J.; Ohno, M.; Kubota, R.; Yokota, S.; Nagai, T.; Tsuyuguchi, K.; Okuda, Y.; Takashima, T.; Kamimura, S.; Fujio, Y.; Kawase, I. Pharmacogenetics-based tuberculosis therapy research group. NAT2 genotype guided regimen reduces isoniazid-induced liver injury and early treatment failure in the 6-month four-drug standard treatment of tuberculosis: A randomized controlled trial for pharmacogenetics-based therapy. Eur. J. Clin. Pharmacol., 2013, 69, 1091-1101.
    • (2013) Eur. J. Clin. Pharmacol. , vol.69 , pp. 1091-1101
    • Azuma, J.1    Ohno, M.2    Kubota, R.3    Yokota, S.4    Nagai, T.5    Tsuyuguchi, K.6    Okuda, Y.7    Takashima, T.8    Kamimura, S.9    Fujio, Y.10    Kawase, I.11
  • 201
    • 84859706085 scopus 로고    scopus 로고
    • NAT2 polymorphisms and susceptibility to anti-tuberculosis drug-induced liver injury: A meta-analysis
    • Wang, P.Y.; Xie, S.Y.; Hao, Q.; Zhang, C.; Jiang, B.F. NAT2 polymorphisms and susceptibility to anti-tuberculosis drug-induced liver injury: a meta-analysis. Int. J. Tuberc. Lung Dis., 2012, 16, 589-595.
    • (2012) Int. J. Tuberc. Lung Dis. , vol.16 , pp. 589-595
    • Wang, P.Y.1    Xie, S.Y.2    Hao, Q.3    Zhang, C.4    Jiang, B.F.5


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