Evaluating NAT2PRED for inferring the individual acetylation status from unphased genotype data

BMC Medical Genetics

Volumn 10, Issue , 2009, Pages

  Sabbagh, Audrey ^a,b   Darlu, Pierre ^c,d   Vidaud, Michel ^a,b  

^a INSERM   (France)

^b BEAUJON HOSPITAL   (France)

^c HÔPITAL PAUL BROUSSE   (France)

^d UNIVERSITÉ PARIS SACLAY   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ARYLAMINE ACETYLTRANSFERASE; NAT2 PROTEIN, HUMAN;

ACCURACY; ACETYLATION; AFRICA; ANALYTICAL ERROR; ARTICLE; BIOINFORMATICS; CLIENT SERVER APPLICATION; CONTROLLED STUDY; GENOTYPE; HUMAN; POPULATION GENETICS; SENSITIVITY ANALYSIS; GENETIC DATABASE; GENETICS; INTERNET; SINGLE NUCLEOTIDE POLYMORPHISM;

ACETYLATION; ARYLAMINE N-ACETYLTRANSFERASE; DATABASES, GENETIC; GENOTYPE; HUMANS; INTERNET; POLYMORPHISM, SINGLE NUCLEOTIDE;

EID: 74549168266     PISSN: None     EISSN: 14712350     Source Type: Journal    
DOI: 10.1186/1471-2350-10-148     Document Type: Article

References (15)

1. Meisel P. Arylamine N-acetyltransferases and drug response. Pharmacogenomics 2002, 3(3):349-366. 10.1517/14622416.3.3.349, 12052143.
2. Ladero JM. Influence of polymorphic N-acetyltransferases on non-malignant spontaneous disorders and on response to drugs. Curr Drug Metab 2008, 9(6):532-537. 10.2174/138920008784892038, 18680473.
3. Agúndez JA. Polymorphisms of human N-acetyltransferases and cancer risk. Curr Drug Metab 2008, 9(6):520-531. 10.2174/138920008784892083, 18680472.
4. García-Closas M, Malats N, Silverman D, Dosemeci M, Kogevinas M, Hein DW, Tardón A, Serra C, Carrato A, García-Closas R, Lloreta J, Castaño-Vinyals G, Yeager M, Welch R, Chanock S, Chatterjee N, Wacholder S, Samanic C, Torà M, Fernández F, Real FX, Rothman N. NAT2 slow acetylation, GSTM1 null genotype, and risk of bladder cancer: results from the Spanish Bladder Cancer Study and meta-analyses. Lancet 2005, 366(9486):649-659. 10.1016/S0140-6736(05)67137-1, 1459966, 16112301.
5. Hein DW. N-acetyltransferase 2 genetic polymorphism: effects of carcinogen and haplotype on urinary bladder cancer risk. Oncogene 2006, 25(11):1649-1658. 10.1038/sj.onc.1209374, 1434721, 16550165.
6. Batra J, Ghosh B. N-acetyltransferases as markers for asthma and allergic/atopic disorders. Curr Drug Metab 2008, 9(6):546-553. 10.2174/138920008784892074, 18680475.
7. Agúndez JA, Golka K, Martínez C, Selinski S, Blaszkewicz M, García-Martín E. Unraveling ambiguous NAT2 genotyping data. Clin Chem 2008, 54(8):1390-1394. 10.1373/clinchem.2008.105569, 18664443.
8. Sabbagh A, Darlu P. Inferring haplotypes at the NAT2 locus: the computational approach. BMC Genet 2005, 6(1):30. 10.1186/1471-2156-6-30, 1173101, 15932650.
9. Golka K, Blaszkewicz M, Samimi M, Bolt HM, Selinski S. Reconstruction of N-acetyltransferase 2 haplotypes using PHASE. Arch Toxicol 2008, 82(4):265-270. 10.1007/s00204-007-0247-9, 17879084.
10. Kuznetsov IB, McDuffie M, Moslehi R. A web-server for inferring the human N-acetyltransferase-2 (NAT2) enzymatic phenotype from NAT2 genotype. Bioinformatics 2009, 25(9):1185-1186. 10.1093/bioinformatics/btp121, 2672629, 19261719.
11. Sabbagh A, Langaney A, Darlu P, Gérard N, Krishnamoorthy R, Poloni ES. Worldwide distribution of NAT2 diversity: implications for NAT2 evolutionary history. BMC Genet 2008, 9:21. 10.1186/1471-2156-9-21, 2292740, 18304320.
12. Patin E, Harmant C, Kidd KK, Kidd J, Froment A, Mehdi SQ, Sica L, Heyer E, Quintana-Murci L. Sub-Saharan African coding sequence variation and haplotype diversity at the NAT2 gene. Hum Mutat 2006, 27(7):720. 10.1002/humu.9438, 16786516.
13. García-Martín E. Interethnic and intraethnic variability of NAT2 single nucleotide polymorphisms. Curr Drug Metab 2008, 9(6):487-497. 10.2174/138920008784892155, 18680468.
14. Fuselli S, Gilman RH, Chanock SJ, Bonatto SL, De Stefano G, Evans CA, Labuda D, Luiselli D, Salzano FM, Soto G, Vallejo G, Sajantila A, Pettener D, Tarazona-Santos E. Analysis of nucleotide diversity of NAT2 coding region reveals homogeneity across Native American populations and high intra-population diversity. Pharmacogenomics J 2007, 7(2):144-152. 10.1038/sj.tpj.6500407, 16847467.
15. Teixeira RL, Miranda AB, Pacheco AG, Lopes MQ, Fonseca-Costa J, Rabahi MF, Melo HM, Kritski AL, Mello FC, Suffys PN, Santos AR. Genetic profile of the arylamine N-acetyltransferase 2 coding gene among individuals from two different regions of Brazil. Mutat Res 2007, 624(1-2):31-40.