Accuracy of haplotype frequency estimation for biallelic loci, via the expectation-maximization algorithm for unphased diploid genotype data

American Journal of Human Genetics

Volumn 67, Issue 4, 2000, Pages 947-959

  Fallin, Daniele ^a   Schork, Nicholas J ^a,b,c  

^a CASE WESTERN RESERVE UNIVERSITY   (United States)

^b HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^c JACKSON LABORATORY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACCURACY; ALGORITHM; ARTICLE; ASSAY; DIPLOIDY; GENE FREQUENCY; GENE LINKAGE DISEQUILIBRIUM; GENE LOCUS; GENOTYPE; HAPLOTYPE; MAXIMUM LIKELIHOOD METHOD; PRIORITY JOURNAL; SIMULATION;

EID: 0033794938     PISSN: 00029297     EISSN: None     Source Type: Journal    
DOI: 10.1086/303069     Document Type: Article

References (10)

1. Inference of haplotypes from PCR-amplified samples of diploid populations
2. Maximum-likelihood estimation of molecular haplotype frequencies in a diploid population
3. HAPLO: A program using the EM algorithm to estimate the frequencies of multi-site haplotypes
4. The interaction of selection and linkage. I. General considerations: Heterotic models
5. An E-M algorithm and testing strategy for multiple-locus haplotypes
6. Molecular haplotyping of genetic markers 10 kb apart by allele-specific long-range PCR
7. Detecting marker-disease association by testing for Hardy-Weinberg disequilibrium at a marker locus
8. Linkage disequilibrium at the ADH2 and ADH3 loci and risk of alcoholism
9. Genetic analysis of case/control data using estimated haplotype frequencies: Application to APOE locus variation and Alzheimer's disease