Novel tagging SNP rs1495741 and 2-SNPs (rs1041983 and rs1801280) yield a high prediction of the NAT2 genotype in HapMap samples

Pharmacogenetics and Genomics

Volumn 22, Issue 4, 2012, Pages 322-324

  He, Yi Jing ^a   Shapero, Michael H ^b   Mcleod, Howard L ^a  

^a University of North Carolina   (United States)

^b Thermo Fisher Scientific   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AREA UNDER THE CURVE; CONTROLLED STUDY; GENOTYPE; HAPLOTYPE MAP; HUMAN; LETTER; PHENOTYPE; PRIORITY JOURNAL; RECEIVER OPERATING CHARACTERISTIC; SINGLE NUCLEOTIDE POLYMORPHISM;

ACETYLATION; AFRICAN CONTINENTAL ANCESTRY GROUP; ARYLAMINE N-ACETYLTRANSFERASE; ASIAN CONTINENTAL ANCESTRY GROUP; EUROPEAN CONTINENTAL ANCESTRY GROUP; GENETICS, POPULATION; GENOTYPE; HAPLOTYPES; HUMANS; PHENOTYPE; POLYMORPHISM, SINGLE NUCLEOTIDE; PREDICTIVE VALUE OF TESTS;

EID: 84859030523     PISSN: 17446872     EISSN: 17446880     Source Type: Journal    
DOI: 10.1097/FPC.0b013e3283510a51     Document Type: Letter

References (3)

1. Selinski S, Blaszkewicz M, Lehmann ML, Ovsiannikov D, Moormann O, Guballa C, et al. Genotyping NAT2 with only two SNPs (rs1041983 and rs1801280) outperforms the tagging SNP rs1495741 and is equivalent to the conventional 7-SNP NAT2 genotype. Pharmacogenet Genomics 2011; 21:673-678.
2. Burmester JK, Sedova M, Shapero MH, Mansfield E. DMET microarray technology for pharmacogenomics-based personalized medicine. Methods Mol Biol 2010; 632:99-124.
3. Hein DW, Doll MA, Fretland AJ, Leff MA,Webb SJ, Xiao GH, et al. Molecular genetics and epidemiology of the NAT1 and NAT2 acetylation polymorphisms. Cancer Epidemiol Biomarkers Prev 2000; 9:29-42. (Pubitemid 30062907)