Synthesis of the caffeine metabolites 5-acetylamino-6-formylamino-3-methyluracil (AFMU) and 5-acetylamino-6-amino-3-methyluracil (AAMU) on a preparative scale

Zeitschrift fur Naturforschung - Section B Journal of Chemical Sciences

Volumn 52, Issue 12, 1997, Pages 1526-1532

  Rohrkasten R ^a   Raatz, P ^a   Kreher, R P ^a   Blaszkewicz, M ^b  

^a TU DORTMUND UNIVERSITY   (Germany)

^b LEIBNIZ RESEARCH CENTRE FOR WORKING ENVIRONMENT AND HUMAN FACTORS   (Germany)

Author keywords

Caffeine metabolites; Pyrimidine diones; Synthesis

Indexed keywords

CAFFEINE; SYNTHESIS (CHEMICAL);

5-ACETYLAMINO-6-AMINO-3-METHYLURACIL; CHEMICAL TRANSFORMATIONS; ETHYL CYANOACETATE; PYRIMIDINE-DIONES; QUALITATIVE IDENTIFICATION; QUANTITATIVE DETERMINATIONS; STANDARD MATERIALS;

METABOLITES;

EID: 0039269095     PISSN: 09320776     EISSN: None     Source Type: Journal    
DOI: 10.1515/znb-1997-1214     Document Type: Article

References (15)

1. K. Fink, W. S. Adams, W. Pfleiderer, J. Biol. Chem. 239, 4250 (1964).
2. C. O. Johns, B. M. Hendrix, J. Biol. Chem. 20, 153 (1915).
3. V. I. Khmelevskii, E. I. Abramova, L. V. Variukhina, J. Gen. Chem. 28, 2016 (1958).
4. L. I. Krimen, Org. Synth. 50, 1 (1970).
5. C. G. Overberger, I. C. Kogon, W. J. Einstman, J. Am. Chem. Soc. 76, 1953 (1954).
6. W. Pfleiderer, Chem. Ber. 90, 2272 (1957).
7. W. Pfleiderer, E. Liedek, Justus Liebigs Ann. Chem. 612, 163 (1958).
8. G. L. Regnier, C. G. Guillonneau, J. L. Duhault, F. P. Tisserand, G. Saint-Romas, S. M. Holstorp, Eur. J. Med. Chem. 22, 243 (1987); C. A. 107, 228857 y (1987).
9. G. L. Regnier, C. G. Guillonneau, J. L. Duhault, F. P. Tisserand, G. Saint-Romas, S. M. Holstorp, Eur. J. Med. Chem. 22, 243 (1987): C. A. 107, 228857 y (1987).
10. C. V. Z. Smith, R. K. Robins, R. L. Tolman, J. Chem. Soc., Perkin Trans I 1855 (1973).
11. B. K. Tang, D. M. Grant, W. Kalow, Drug Metab. Dispos. 11, 218 (1983); C. A. 99, 33967 t (1983).
12. B. K. Tang, D. M. Grant, W. Kalow, Drug Metab. Dispos. 11, 218 (1983); C. A. 99, 33967 t (1983).
13. E. C. Taylor, J. W. Barton, W. W. Paudler, J. Org. Chem. 26, 4961 (1961).
14. E. C. Taylor, C. C. Cheng, J. Org. Chem. 25, 148 (1960).
15. W. Traube, F. Winter, Chem. Zentralbl. 10, 1336 (1906).