Influence of the microenvironment on cell fate determination and migration

Physiological Genomics

Volumn 46, Issue 9, 2014, Pages 309-314

  Bloom, Alexander B ^a,b   Zaman, Muhammad H ^b  

^a BOSTON UNIVERSITY   (United States)

^b Boston University   (United States)

Author keywords

Cell adhesion; Cell fate; Cell migration; Computational modeling; Extracellular matrix

Indexed keywords

ADAPTOR PROTEIN; BETA CATENIN; CELL SURFACE RECEPTOR; COLLAGEN TYPE 1; FIBRONECTIN; FOCAL ADHESION KINASE; GELATINASE A; GELATINASE B; INTEGRIN; LAMININ; MATRIX METALLOPROTEINASE 14; NERVE CELL ADHESION MOLECULE; NEURAL WISKOTT ALDRICH SYNDROME PROTEIN; PAXILLIN; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLSERINE; PROTEIN KINASE B; TALIN; UVOMORULIN; VASCULOTROPIN; VASCULOTROPIN RECEPTOR 2; VIMENTIN; VINCULIN;

ANGIOGENESIS; APOPTOSIS; BONE DEVELOPMENT; CARTILAGE CELL; CELL ADHESION; CELL AGGREGATION; CELL CONTACT; CELL DIFFERENTIATION; CELL FATE; CELL MIGRATION; CELL PH; CELL PROLIFERATION; CELL STRUCTURE; CELL SURVIVAL; EPITHELIUM CELL; HUMAN; MECHANOTRANSDUCTION; MESENCHYMAL STEM CELL; METASTASIS; MUSCLE DEVELOPMENT; NERVOUS SYSTEM DEVELOPMENT; NEURAL STEM CELL; NONHUMAN; PRIORITY JOURNAL; REVIEW; TUMOR MICROENVIRONMENT; UPREGULATION; BIOLOGICAL MODEL; CELL MOTION; CULTURE TECHNIQUE; PHYSIOLOGY; PROCEDURES;

CELL ADHESION; CELL CULTURE TECHNIQUES; CELL DIFFERENTIATION; CELL MOVEMENT; CELLULAR MICROENVIRONMENT; MECHANOTRANSDUCTION, CELLULAR; MODELS, BIOLOGICAL;

EID: 84900820976     PISSN: 10948341     EISSN: 15312267     Source Type: Journal    
DOI: 10.1152/physiolgenomics.00170.2013     Document Type: Review

References (80)

1. Allen J, Cooke M, Alliston T. ECM stiffness primes the TGFfj pathway to promote chondrocyte differentiation. Mol Biol Cell 23: 3731-3742, 2012.
2. Andasari V, Gerisch A, Lolas G, South AP, Chaplain MA. Mathematical modeling of cancer cell invasion of tissue: biological insight from mathematical analysis and computational simulation. J Math Biol 63: 141-171, 2011.
3. Anderson ARA. A hybrid mathematical model of solid tumour invasion: the importance of cell adhesion. Math Med Biol 22: 163-186, 2005.
4. Anderson ARA, Weaver AM, Cummings PT, Quaranta V. Tumor morphology and phenotypic evolution driven by selective pressure from the microenvironment. Cell 127: 905-915, 2006.
5. Aoudjit F, Vuori K. Integrin signaling inhibits paclitaxel-induced apo-ptosis in breast cancer cells. Oncogene 20: 4995-5004, 2001.
6. Arnadóttir J, Chalfie M. Eukaryotic mechanosensitive channels. Annu Rev Biophys 39: 111-137, 2010.
7. Baker BM, Chen CS. Deconstructing the third dimension: how 3D culture microenvironments alter cellular cues. J Cell Sci 125: 3015-3024, 2012.
8. Bearer E, Lowengrub J, Frieboes H. Multiparameter computational modeling of tumor invasion. Cancer Res 69: 4493-4501, 2009.
9. Gilbert PM, Havenstrite KL, Magnusson KEG, Sacco A, Leonardi NA, Kraft P, Nguyen NK, Thrun S, Lutolf MP, Blau HM. Substrate elasticity regulates skeletal muscle stem cell self-renewal in culture. Science 329: 1078-1081, 2010.
10. Birgersdotter A, Sandberg R, Ernberg I. Gene expression perturbation in vitro-a growing case for three-dimensional (3D) culture systems. Semin Cancer Biol 15: 405-412, 2005.
11. Boudreau NJ, Jones PL. Extracellular matrix and integrin signalling: the shape of things to come. Biochem J 339: 481-488, 1999.
12. Cai Y, Xu S, Wu J, Long Q. Coupled modelling of tumour angiogenesis, tumour growth and blood perfusion. J Theor Biol 279: 90-101, 2011.
13. Castells M, Thibault B, Delord JP, Couderc B. Implication of tumor microenvironment in chemoresistance: tumor-associated stromal cells protect tumor cells from cell death. Int J Mol Sci 13: 9545-9571, 2012.
14. Christofori G. New signals from the invasive front. Nature 441: 444-450, 2006.
15. Cukierman E, Pankov R, Stevens DR, Yamada KM. Taking cell-matrix adhesions to the third dimension. Science 294: 1708-1712, 2001.
16. Dangi-Garimella S, Krantz SB, Barron MR, Shields MA, Heiferman MJ, Grippo PJ, Bentrem DJ, Munshi HG. Three-dimensional collagen I promotes gemcitabine resistance in pancreatic cancer through MT1-MMP-mediated expression of HMGA2. Cancer Res 71: 1019-1028, 2011.
17. Di Lullo GA, Sweeney SM, Korkko J, Ala-Kokko L, San Antonio JD. Mapping the ligand-binding sites and disease-associated mutations on the most abundant protein in the human, type I collagen. J Biol Chem 277: 4223-4231, 2002.
18. Domachuk P, Tsioris K, Omenetto FG, Kaplan DL. Bio-microfluidics: biomaterials and biomimetic designs. Adv Mater 22: 249-260, 2010.
19. Dupont S, Morsut L, Aragona M, Enzo E, Giulitti S, Cordenonsi M, Zanconato F, Le Digabel J, Forcato M, Bicciato S, Elvassore N, Piccolo S. Role of YAP/TAZ in mechanotransduction. Nature 474: 179 -183, 2011.
20. Earls JK, Jin S, Ye K. Mechanobiology of human pluripotent stem cells. Tissue Eng 19: 420-430, 2013.
21. Engler A, Sen S, Sweeney H, Discher D. Matrix elasticity directs stem cell lineage specification. Cell 126: 677-689, 2006.
22. Estrella V, Chen T, Lloyd M, Wojtkowiak J, Cornnell HH, Ibrahim-Hashim A, Bailey K, Balagurunathan Y, Rothberg JM, Sloane BF, Johnson J, Gatenby RA, Gillies RJ. Acidity generated by the tumor microenvironment drives local invasion. Cancer Res 73: 1524-1535, 2013.
23. Fessart D, Begueret H, Delom F. Three-dimensional culture model to distinguish normal from malignant human bronchial epithelial cells. Eur Respir J 42: 1345-1356, 2013.
24. Fraley SI, Feng Y, Krishnamurthy R, Kim DH, Celedon A, Longmorev Wirtz D. A distinctive role for focal adhesion proteins in three-dimensional cell motility. Nat Cell Biol 12: 598-604, 2010.
25. Griffith LG, Swartz MA. Capturing complex 3D tissue physiology in vitro. Nat Rev Mol Cell Biol 7: 211-224, 2006.
26. Gupta K, Kim DH, Ellison D, Smith C, Kundu A, Tuan J, Suhc KY, Levchenko A. Lab-on-a-chip devices as an emerging platform for stem cell biology. Lab Chip 10: 2019-2031, 2010.
27. Hadjipanayi E, Brown RA, Mudera V. Interface integration of layered collagen scaffolds with defined matrix stiffness: implications for sheet-based tissue engineering. J Tissue Eng Regen Med 3: 230-241, 2009.
28. Harjanto D, Zaman MH. Computational study of proteolysis-driven single cell migration in a three-dimensional matrix. Ann Biomed Eng 38: 1815-1825, 2010.
29. Harjanto D, Zaman MH. Matrix mechanics and receptor-ligand interactions in cell adhesion. Org Biomol Chem 8: 299-304, 2010.
30. Hsu TY, Wu YC. Engulfment of apoptotic cells in C. elegans is mediated by integrin alpha/SRC signaling. Curr Biol 20: 477-486, 2010.
31. Huang NF, Li S. Regulation of the matrix microenvironment for stem cell engineering and regenerative medicine. Ann Biomed Eng 39: 1201-1214, 2011.
32. Huebsch N, Arany PR, Mao AS, Shvartsman D, Alil OA, Bencherif SA, Rivera-Feliciano J, Mooney DJ. Harnessing traction-mediated manipulation of the cell/matrix interface to control stem-cell fate. Nat Mater 9: 518-526, 2010.
33. Jeon J, Quaranta V, Cummings PT. An off-lattice hybrid discrete-continuum model of tumor growth and invasion. Biophys J 98: 37-47, 2010.
34. Jiao Y, Torquato S. Emergent behaviors from a cellular automaton model for invasive tumor growth in heterogeneous microenvironments. PLoS Comput Biol 7: e1002314, 2011.
35. Justice BA, Badr NA, Felder RA. 3D cell culture opens new dimensions in cell-based assays. Drug Discov Today 14: 102-107, 2009.
36. Kalluri R, Weinberg RA. The basics of epithelial-mesenchymal transition. J Clin Invest 119: 1420-1428, 2009.
37. Kato S, Shiratsuchi A, Nagaosa K, Nakanishi Y. Phosphatidylserine-and integrin-mediated phagocytosis of apoptotic luteal cells by macrophages of the rat. Dev Growth Differ 47: 153-161, 2005.
38. Kim DH, Provenzano PP, Smith CL, Levchenko A. Matrix nanotopog-raphy as a regulator of cell function. J Cell Biol 197: 351-360, 2012.
39. Kim H, Guo TW, Wu AP, Wells A, Gertler FB, Lauffenburger DA. Epidermal growth factor - induced enhancement of glioblastoma cell migration in 3D arises from an intrinsic increase in speed but an extrinsic matrix- and proteolysis-dependent increase in persistence. Mol Biol 19: 4249-4259, 2008.
40. Kim HN, Jiao A, Hwang NS, Kim MS, Kang DH, Kim DH, Suh KY. Nanotopography-guided tissue engineering and regenerative medicine. Adv Drug Deliv Rev 65: 536-558, 2013.
41. Kim JB. Three-dimensional tissue culture models in cancer biology. Semin Cancer Biol 15: 365-77, 2005.
42. Kim MC, Neal DM, Kamm RD, Asada HH. Dynamic modeling of cell migration and spreading behaviors on fibronectin coated planar substrates and micropatterned geometries. PLoS Comput Biol 9: e1002926, 2013.
43. Kim S, Park SY, Kim SY, Bae DJ, Pyo JH, Hong M, In-San Kim IS. Cross talk between engulfment receptors stabilin-2 and integrin av|35 orchestrates engulfment of phosphatidylserine-exposed erythrocytes. Mol Cell Biol 32: 2698-2708, 2012.
44. Kim YN, Koo KH, Sung JY, Yun UJ, Kim H. Anoikis resistance: an essential prerequisite for tumor metastasis. Int J Cell Biol 2012: 306879, 2012.
45. Kobel S, Lutolf MP. Biomaterials meet microfluidics: building the next generation of artificial niches. Curr Opin Biotechnol 22: 690-697, 2011.
46. Kolitz SE, Lauffenburger DA. Measurement and modeling of signaling at the single-cell level. Biochemistry 51: 7433-7443, 2012.
47. Kshitiz, Kim DH, Beebe DJ, Levchenko A. Micro- and nanoengineering for stem cell biology: the promise with a caution. Trends Biotechnol 29: 399-408, 2011.
48. Kshitiz, Hubbi ME, Ahn EH, Downey J, Afzal J, Kim DH, Rey S, Chang C, Kundu A, Semenza GL, Abraham RM, Levchenko A. Matrix rigidity controls endothelial differentiation and morphogenesis of cardiac precursors. Sci Signal 5: ra41, 2012.
49. Kshitiz, Park J, Kim P, Helen W, Engler AJ, Levchenko A, Kim DH. Control of stem cell fate and function by engineering physical microen-vironments. Integr Biol 4: 1008, 2012.
50. Kumar N, Zaman MH, Kim HD, Lauffenburger DA. A high-throughput migration assay reveals HER2-mediated cell migration arising from increased directional persistence. Biophys J 91: L32-L34, 2006.
51. Lai Y, Asthana A, Kisaalita WS. Biomarkers for simplifying HTS 3D cell culture platforms for drug discovery: the case for cytokines. Drug Discov Today 16: 293-297, 2011.
52. Liu S, Leask A. Integrin p1 is required for dermal homeostasis. J Invest Dermatol 133: 899-906, 2013.
53. Lukashev ME, Werb Z. ECM signalling: orchestrating cell behaviour and misbehaviour. Trends Cell Biol 8: 437-441, 1998.
54. Mammoto A, Connor KM, Tadanori Mammoto T, Yung CW, Huh D, Aderman CM, Mostoslavsky G, Smith LEH, Ingber DE. A mechano-sensitive transcriptional mechanism that controls angiogenesis. Nature 457: 1103-1108, 2009.
55. Mammoto T, Mammoto A, Ingber DE. Mechanobiology and developmental control. Annu Rev Cell Dev Biol 29: 27-61, 2013.
56. Nagaprashantha LD, Vatsyayan R, Lelsani PCR, Awasthi S, Singhal SS. The sensors and regulators of cell-matrix surveillance in anoikis resistance of tumors. Int J Cancer 128: 743-752, 2011.
57. Nawrocki-Raby B, Gilles C, Polette M, Bruyeel E, Laronze JY, Bonnet N, Jean-Michel Foidart JM, Mareel M, Birembaut P. Upregu-lation of MMPs by soluble E-cadherin in human lung tumor cells. Int J Cancer 105: 790-795, 2003.
58. Noë V, Fingleton B, Jacobs K, Crawford HC, Vermeulen S, Steelant W, Bruyneel E, Matrisian LM, Mareel M. Release of an invasion promoter E-cadherin fragment by matrilysin and stromelysin-1. J Cell Sci 114: 111-118, 2001.
59. Osses N, Brandan E. ECM is required for skeletal muscle differentiation independently of muscle regulatory factor expression. Am J Physiol Cell Physiol 282: C383-C394, 2002.
60. Paraiso KHT, Smalley KSM. Fibroblast-mediated drug resistance in cancer. Biochem Pharmacol 85: 1033-1041, 2013.
61. Pedersen JA, Swartz MA. Mechanobiology in the third dimension. Ann Biomed Eng 33: 1469-1490, 2005.
62. Plotnikov SV, Pasapera AM, Sabass B, Waterman CM. Force fluctuations within focal adhesions mediate ECM-rigidity sensing to guide directed cell migration. Cell 151: 1513-1527, 2012.
63. Polacheck WJ, Li R, Uzel SGM, Kamm RD. Microfluidic platforms for mechanobiology. Lab Chip 13: 2252-2267, 2013.
64. Rangarajan R, Zaman MH. Modeling cell migration in 3D: status and challenges. Cell Adh Migr 2: 106-109, 2008.
65. Rhoads DS, Guan JL. Analysis of directional cell migration on defined FN gradients: role of intracellular signaling molecules. Exp Cell Res 313: 3859-3867, 2007.
66. Saha K, Keung A, Irwin E, Li Y, Little L. Substrate modulus directs neural stem cell behavior. Biophys J 95: 4426-4438, 2008.
67. Schultz GS, Wysocki A. Interactions between extracellular matrix and growth factors in wound healing. Wound Repair Regen 17: 153-162, 2009.
68. Serebriiskii I, Castelló-Cros R, Lamb A, Golemis EA, Cukierman E. Fibroblast-derived 3D matrix differentially regulates the growth and drug-responsiveness of human cancer cells. Matrix Biol 27: 573-585, 2008.
69. Spiegel A, Kalinkovich A, Shivtiel S, Kollet O, Lapidot T. Stem cell regulation via dynamic interactions of the nervous and immune systems with the microenvironment. Cell Stem Cell 3: 484-492, 2008.
70. Stupack DG. Get a ligand, get a life: integrins, signaling and cell survival. J Cell Sci 115: 3729-3738, 2002.
71. Takahashi K, Yamanaka S. Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell 126: 663-676, 2006.
72. Takahashi K, Tanabe K, Ohnuki M, Narita M, Ichisaka T, Tomoda K, Yamanaka S. Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell 131: 861-872, 2007.
73. Teo BKK, Wong ST, Lim CK, Kung TYS, Yap CH, Yamini Ramagopal Y, Romer LH, Yim EKF. Nanotopography modulates mechano-transduction of stem cells and induces differentiation through focal adhesion kinase. ACS Nano 7: 4785-4598, 2013.
74. Tseng Q, Wang I, Duchemin-Pelletier E, Azioune A, Carpi N, Gao J, Filhol O, Piel M, Thery M, Martial Balland M. A new micropatterning method of soft substrates reveals that different tumorigenic signals can promote or reduce cell contraction levels. Lab Chip 11: 2231-2240, 2011.
75. Viswanathan S, Zandstra PW. Towards predictive models of stem cell fate. Cytotechnology 41: 75-92, 2003.
76. Watt FM, Huck WTS. Role of the extracellular matrix in regulating stem cell fate. Nat Rev Mol Cell Biol 14: 467-473, 2013.
77. Wang PY, Tsai WB, Voelcker NH. Screening of rat mesenchymal stem cell behaviour on polydimethylsiloxane stiffness gradients. Acta Biomater 8: 519-530, 2012.
78. Yim EKF, Darling EM, Kulangara K, Guilak F, Leong KW. Nano-topography-induced changes in focal adhesions, cytoskeletal organization, and mechanical properties of human mesenchymal stem cells. Biomateri-als 31: 1299-1306, 2010.
79. Zhang H, Dai S, Bi J, Liu KK. Biomimetic three-dimensional microen-vironment for controlling stem cell fate. Interface Focus 1: 792-803, 2011.
80. Zhang Z, Nagrath S. Microfluidics and cancer: are we there yet? Biomed Microdevices 15: 595-609, 2013.