메뉴 건너뛰기




Volumn 22, Issue 2, 2005, Pages 163-186

A hybrid mathematical model of solid tumour invasion: The importance of cell adhesion

Author keywords

[No Author keywords available]

Indexed keywords

CELL ADHESION; CELL CULTURE; CELL PROLIFERATION;

EID: 25144494216     PISSN: 14778599     EISSN: 14778602     Source Type: Journal    
DOI: 10.1093/imammb/dqi005     Document Type: Article
Times cited : (510)

References (61)
  • 1
    • 27244441939 scopus 로고    scopus 로고
    • A hybrid discrete-continuum technique for individual based migration models
    • (W. Alt, M. Chaplain, M. Griebel & J. Lenz eds). Basel, Switzerland: Birkhauser
    • Anderson, A. R. A. (2003) A hybrid discrete-continuum technique for individual based migration models. Polymer and Cell Dynamics (W. Alt, M. Chaplain, M. Griebel & J. Lenz eds). Basel, Switzerland: Birkhauser.
    • (2003) Polymer and Cell Dynamics
    • Anderson, A.R.A.1
  • 2
    • 0032170064 scopus 로고    scopus 로고
    • Continuous and discrete mathematical models of tumour-induced angiogenesis angiogenesis
    • Anderson, A. R. A. & Chaplain, M. A. J. (1998) Continuous and discrete mathematical models of tumour-induced angiogenesis angiogenesis. Bull. Math. Biol., 60, 857-899.
    • (1998) Bull. Math. Biol. , vol.60 , pp. 857-899
    • Anderson, A.R.A.1    Chaplain, M.A.J.2
  • 4
    • 21244483583 scopus 로고    scopus 로고
    • Application of the hybrid discrete-continuum technique
    • (W. Alt, M. Chaplain, M. Griebel & J. Lenz eds). Basel, Switzerland: Birkhauser
    • Anderson, A. R. A. & Pitcairn, A. (2003) Application of the hybrid discrete-continuum technique. Polymer and Cell Dynamics (W. Alt, M. Chaplain, M. Griebel & J. Lenz eds). Basel, Switzerland: Birkhauser.
    • (2003) Polymer and Cell Dynamics
    • Anderson, A.R.A.1    Pitcairn, A.2
  • 5
    • 0030944528 scopus 로고    scopus 로고
    • Nematode movement along a chemical gradient in a structurally heterogeneous environment: II. Theory
    • Anderson, A. R. A., Sleeman, B. D., Young, I. M. & Griffiths, B. S. (1997) Nematode movement along a chemical gradient in a structurally heterogeneous environment: II. Theory. Fundam. Appl. Nematol., 20, 165-172.
    • (1997) Fundam. Appl. Nematol. , vol.20 , pp. 165-172
    • Anderson, A.R.A.1    Sleeman, B.D.2    Young, I.M.3    Griffiths, B.S.4
  • 7
    • 0027524636 scopus 로고
    • The incidence of p53 mutations increases with progression of head and neck cancer
    • Boyle, J. O., Hakim, J. & Koch, W. (1993) The incidence of p53 mutations increases with progression of head and neck cancer. Cancer Res., 53, 4477-4480.
    • (1993) Cancer Res. , vol.53 , pp. 4477-4480
    • Boyle, J.O.1    Hakim, J.2    Koch, W.3
  • 8
    • 0004058896 scopus 로고
    • New York: Garland Publishing
    • Bray, D. (1992) Cell Movements. New York: Garland Publishing.
    • (1992) Cell Movements
    • Bray, D.1
  • 12
    • 0013850974 scopus 로고
    • Principles of cell motility: The direction of cell movement and cancer invasion
    • Carter, S. B. (1965) Principles of cell motility: The direction of cell movement and cancer invasion. Nature, 208, 1183-1187.
    • (1965) Nature , vol.208 , pp. 1183-1187
    • Carter, S.B.1
  • 13
    • 0030806173 scopus 로고    scopus 로고
    • Changing views of the role of matrix metalloproteinases in metastasis
    • Chambers, A. F. & Matrisian, L. M. (1997) Changing views of the role of matrix metalloproteinases in metastasis. J. Natl. Cancer Inst., 89, 1260-1270.
    • (1997) J. Natl. Cancer Inst. , vol.89 , pp. 1260-1270
    • Chambers, A.F.1    Matrisian, L.M.2
  • 14
    • 0028987936 scopus 로고
    • Integrins and signal transduction pathways: The road taken
    • Clark, E. A. & Brugge, J. S. (1995) Integrins and signal transduction pathways: The road taken. Science, 268, 233-239.
    • (1995) Science , vol.268 , pp. 233-239
    • Clark, E.A.1    Brugge, J.S.2
  • 15
    • 0026568374 scopus 로고
    • Variation in tumour cell growth rates and metabolism with oxygen-concentration, glucose-concentration and extracellular pH
    • Casciari, J. J., Sotirchos, S. V. & Sutherland, R. M. (1992) Variation in tumour cell growth rates and metabolism with oxygen-concentration, glucose-concentration and extracellular pH. J. Cell. Physiol., 151, 386-394.
    • (1992) J. Cell. Physiol. , vol.151 , pp. 386-394
    • Casciari, J.J.1    Sotirchos, S.V.2    Sutherland, R.M.3
  • 16
    • 0002964937 scopus 로고    scopus 로고
    • Avascular growth, angiogenesis and vascular growth in solid tumours: The mathematical modelling of the stages of tumour development
    • Chaplain, M. A. J. (1996) Avascular growth, angiogenesis and vascular growth in solid tumours: The mathematical modelling of the stages of tumour development. Math. Comput. Model., 23, 47-87.
    • (1996) Math. Comput. Model , vol.23 , pp. 47-87
    • Chaplain, M.A.J.1
  • 17
    • 0027437155 scopus 로고
    • Modelling the growth of solid tumours and incorporating a method for their classification using nonlinear elasticity theory
    • Chaplain, M. A. J. & Sleeman, B. D. (1993) Modelling the growth of solid tumours and incorporating a method for their classification using nonlinear elasticity theory. J. Math. Biol., 31, 431-479.
    • (1993) J. Math. Biol. , vol.31 , pp. 431-479
    • Chaplain, M.A.J.1    Sleeman, B.D.2
  • 18
    • 0037015674 scopus 로고    scopus 로고
    • Bile acids stimulate invasion and haptotaxis in human corectal cancer cells through activation of multiple oncogenic signalling pathways
    • Debruyne, P. R., Bruyneel, E. A. & Karaguni, I.-M. et al. (2002) Bile acids stimulate invasion and haptotaxis in human corectal cancer cells through activation of multiple oncogenic signalling pathways. Oncogene, 21, 6740-6750.
    • (2002) Oncogene , vol.21 , pp. 6740-6750
    • Debruyne, P.R.1    Bruyneel, E.A.2    Karaguni, I.-M.3
  • 19
    • 1542344734 scopus 로고    scopus 로고
    • Modeling of self-organized avascular tumor growth with a hybrid cellular automaton
    • Dormann, S. & Deutsch, A. (2002) Modeling of self-organized avascular tumor growth with a hybrid cellular automaton. In Silico Biol., 2, 0035.
    • (2002) In Silico Biol. , vol.2 , pp. 0035
    • Dormann, S.1    Deutsch, A.2
  • 20
    • 0025545527 scopus 로고
    • Tumor growth simulation
    • Düchting, W. (1990) Tumor growth simulation. Comput. Graph., 14, 505-508.
    • (1990) Comput. Graph. , vol.14 , pp. 505-508
    • Düchting, W.1
  • 21
    • 0343010451 scopus 로고    scopus 로고
    • Cancer: A challenge for control theory and computer modelling
    • Düchting, W., Ulmer, W. & Ginsberg, T. (1996) Cancer: A challenge for control theory and computer modelling. Eur. J. Cancer, 32A, 1283-1292.
    • (1996) Eur. J. Cancer , vol.32 A , pp. 1283-1292
    • Düchting, W.1    Ulmer, W.2    Ginsberg, T.3
  • 22
    • 0021344144 scopus 로고
    • In situ consumption rates of cells in v-79 multicellular spheroids during growth
    • Freyer, J. P., Tustanoff, E., Franko, A. J. & Sutherland, R. M. (1984) In situ consumption rates of cells in v-79 multicellular spheroids during growth. J. Cell. Physiol., 118, 53-61.
    • (1984) J. Cell. Physiol. , vol.118 , pp. 53-61
    • Freyer, J.P.1    Tustanoff, E.2    Franko, A.J.3    Sutherland, R.M.4
  • 23
    • 0015804548 scopus 로고
    • Self-regulation of growth in three dimensions
    • Folkman, J. & Hochberg, M. (1973) Self-regulation of growth in three dimensions. J. Exp. Med., 138, 745-753.
    • (1973) J. Exp. Med. , vol.138 , pp. 745-753
    • Folkman, J.1    Hochberg, M.2
  • 24
    • 0029751950 scopus 로고    scopus 로고
    • A reaction-diffusion model of cancer invasion
    • Gatenby, R. A. & Gawlinski, E. T. (1996) A reaction-diffusion model of cancer invasion. Cancer Res., 56, 5745-5753.
    • (1996) Cancer Res. , vol.56 , pp. 5745-5753
    • Gatenby, R.A.1    Gawlinski, E.T.2
  • 25
    • 0038784546 scopus 로고    scopus 로고
    • Membrane type 1 matrix metalloproteinase usurps tumour growth control imposed by the three-dimensional extracellular matrix
    • Hotary, K., Allen, E. D., Brooks, P. C., Datta, N. S., Long, M. W. & Weiss, S. J. (2003) Membrane type 1 matrix metalloproteinase usurps tumour growth control imposed by the three-dimensional extracellular matrix. Cell, 114, 33-45.
    • (2003) Cell , vol.114 , pp. 33-45
    • Hotary, K.1    Allen, E.D.2    Brooks, P.C.3    Datta, N.S.4    Long, M.W.5    Weiss, S.J.6
  • 26
    • 0034641107 scopus 로고    scopus 로고
    • Regulation of cell invasion and morphogenesis in a 3-dimensional type I collagen matrix by membrane-type metalloproteinases 1, 2 and 3
    • Hotary, K., Allen, E. D., Punturieri, A., Yana, I. & Weiss, S. J. (2000) Regulation of cell invasion and morphogenesis in a 3-dimensional type I collagen matrix by membrane-type metalloproteinases 1, 2 and 3. J. Cell Biol., 149, 1309-1323.
    • (2000) J. Cell Biol. , vol.149 , pp. 1309-1323
    • Hotary, K.1    Allen, E.D.2    Punturieri, A.3    Yana, I.4    Weiss, S.J.5
  • 27
    • 0026770377 scopus 로고
    • Integrins: Versatility, modulation, and signalling in cell adhesion
    • Hynes, R. O. (1992) Integrins: Versatility, modulation, and signalling in cell adhesion. Cell, 69, 11-25.
    • (1992) Cell , vol.69 , pp. 11-25
    • Hynes, R.O.1
  • 29
  • 30
    • 0025951913 scopus 로고
    • Unequal cell division, growth regulation and colony size of mammalian cells: A mathematical model and analysis of experimental data
    • Kimmel, M. & Axelrod, D. E. (1991) Unequal cell division, growth regulation and colony size of mammalian cells: A mathematical model and analysis of experimental data. J. Theor. Biol., 153, 157-180.
    • (1991) J. Theor. Biol. , vol.153 , pp. 157-180
    • Kimmel, M.1    Axelrod, D.E.2
  • 31
    • 0027881807 scopus 로고
    • Chemotaxis and haptotaxis of human malignant mesothelioma cells: Effects of fibronectin, laminin, type IV collagen, and an autocrine motility factor-like substance
    • Klominek, J., Robert, K. H. & Sundqvist, K.-G. (1993) Chemotaxis and haptotaxis of human malignant mesothelioma cells: Effects of fibronectin, laminin, type IV collagen, and an autocrine motility factor-like substance. Cancer Res., 53, 4376-4382.
    • (1993) Cancer Res. , vol.53 , pp. 4376-4382
    • Klominek, J.1    Robert, K.H.2    Sundqvist, K.-G.3
  • 32
    • 0028858363 scopus 로고
    • Hyaluronic acid/CD44H interaction induces cell detachment and stimulates migration and invasion of human glioma cells in vitro
    • Koochekpour, S., Pilkington, G. J. & Merzak, A. (1995) Hyaluronic acid/CD44H interaction induces cell detachment and stimulates migration and invasion of human glioma cells in vitro. Int. J. Cancer, 63, 450-454.
    • (1995) Int. J. Cancer , vol.63 , pp. 450-454
    • Koochekpour, S.1    Pilkington, G.J.2    Merzak, A.3
  • 33
    • 0021247533 scopus 로고
    • Fibronectin enhancement of directed migration of B16 melanoma cells
    • Lacovara, J., Cramer, E. B. & Quigley, J.P. (1984) Fibronectin enhancement of directed migration of B16 melanoma cells. Cancer Res., 44, 1657-1663.
    • (1984) Cancer Res. , vol.44 , pp. 1657-1663
    • Lacovara, J.1    Cramer, E.B.2    Quigley, J.P.3
  • 34
    • 0028231086 scopus 로고
    • The regulation of p53 function
    • Steiner Award Lecture
    • Lane, D. P. (1994) The regulation of p53 function. Steiner Award Lecture. Int. J. Cancer, 57, 623-627.
    • (1994) Int. J. Cancer , vol.57 , pp. 623-627
    • Lane, J.P.1
  • 35
    • 0029681993 scopus 로고    scopus 로고
    • Mechanisms of tumour invasion and metastasis
    • Lawrence, J. A. & Steeg, P. S. (1996) Mechanisms of tumour invasion and metastasis. World J. Urol., 14, 124-130.
    • (1996) World J. Urol. , vol.14 , pp. 124-130
    • Lawrence, J.A.1    Steeg, P.S.2
  • 36
    • 0021079540 scopus 로고
    • Tumour invasion and the extracellular matrix
    • Liotta, L. A., Rao, C. N. & Barsky, S. H. (1983) Tumour invasion and the extracellular matrix. Lab. Invest., 49, 636-649.
    • (1983) Lab. Invest. , vol.49 , pp. 636-649
    • Liotta, L.A.1    Rao, C.N.2    Barsky, S.H.3
  • 37
    • 0028120986 scopus 로고
    • Analysis of growth of multicellular tumour spheroids by mathematical models
    • Marusic, M., Bajzer, Z., Freyer, J. P. & Vuk-Pavlovic, S. (1994) Analysis of growth of multicellular tumour spheroids by mathematical models. Cell Prolif., 27, 73-94.
    • (1994) Cell Prolif. , vol.27 , pp. 73-94
    • Marusic, M.1    Bajzer, Z.2    Freyer, J.P.3    Vuk-Pavlovic, S.4
  • 38
    • 0026896029 scopus 로고
    • The matrix-degrading metalloproteinases
    • Matrisian, L. M. (1992) The matrix-degrading metalloproteinases. Bioessays, 14, 455-463.
    • (1992) Bioessays , vol.14 , pp. 455-463
    • Matrisian, L.M.1
  • 39
    • 0021274153 scopus 로고
    • Laminin and fibronectin promote the directed migration of B16 melanoma cells in vitro
    • McCarthy, J. B. & Furcht, L. T. (1984) Laminin and fibronectin promote the directed migration of B16 melanoma cells in vitro. J. Cell Biol., 98, 1474-1480.
    • (1984) J. Cell Biol. , vol.98 , pp. 1474-1480
    • McCarthy, J.B.1    Furcht, L.T.2
  • 40
    • 0020044887 scopus 로고
    • The three-steps to cancer: A new concept of carcinogenesis
    • Melicow, M. M. (1982) The three-steps to cancer: A new concept of carcinogenesis. J. Theor. Biol., 94, 471-511.
    • (1982) J. Theor. Biol. , vol.94 , pp. 471-511
    • Melicow, M.M.1
  • 41
    • 0027535914 scopus 로고
    • Biology and biochemistry of proteinases in tumor invasion
    • Mignatti, P. & Rifkin, D. B. (1993) Biology and biochemistry of proteinases in tumor invasion. Physiol. Rev., 73, 161-195.
    • (1993) Physiol. Rev. , vol.73 , pp. 161-195
    • Mignatti, P.1    Rifkin, D.B.2
  • 42
    • 0002670122 scopus 로고    scopus 로고
    • A mathematical model of vascular tumour growth and invasion
    • Orme, M. E. & Chaplain, M. A. J. (1996) A mathematical model of vascular tumour growth and invasion. Math. Comput. Model., 23, 43-60.
    • (1996) Math. Comput. Model , vol.23 , pp. 43-60
    • Orme, M.E.1    Chaplain, M.A.J.2
  • 43
    • 0031207030 scopus 로고    scopus 로고
    • Aggregation, blowup and collapse: The ABCs of taxis and reinforced random walks
    • Othmer, H. & Stevens, A. (1997) Aggregation, blowup and collapse: The ABCs of taxis and reinforced random walks. SIAM J. Appl. Math., 57, 1044-1081.
    • (1997) SIAM J. Appl. Math. , vol.57 , pp. 1044-1081
    • Othmer, H.1    Stevens, A.2
  • 44
    • 0030407429 scopus 로고    scopus 로고
    • Biological inferences from a mathematical model of malignant invasion
    • Perumpanani, A. J., Sherratt, J. A., Norbury, J. & Byrne, H. M. (1996) Biological inferences from a mathematical model of malignant invasion. Invasion Metastasis, 16, 209-221.
    • (1996) Invasion Metastasis , vol.16 , pp. 209-221
    • Perumpanani, A.J.1    Sherratt, J.A.2    Norbury, J.3    Byrne, H.M.4
  • 45
    • 0027289179 scopus 로고
    • A cellular automaton model of cancerous growth
    • Qi, A., Zheng, X., Du, C. & An, B. (1993) A cellular automaton model of cancerous growth. J. Theor. Biol., 161, 1-12.
    • (1993) J. Theor. Biol. , vol.161 , pp. 1-12
    • Qi, A.1    Zheng, X.2    Du, C.3    An, B.4
  • 46
    • 4244146857 scopus 로고
    • The directed migration of B-16 melanoma-cells in response to a haptotactic chemotactic gradient of fibronectin
    • Quigley, J. P., Lacovara, J. & Cramer, E. B. (1983) The directed migration of B-16 melanoma-cells in response to a haptotactic chemotactic gradient of fibronectin. J. Cell Biol., 97, A450-A451.
    • (1983) J. Cell Biol. , vol.97
    • Quigley, J.P.1    Lacovara, J.2    Cramer, E.B.3
  • 47
    • 0028106756 scopus 로고
    • CD44 plays a role in adhesive interactions between glioma cells and extracellular matrix components
    • Radotra, B., McCormick, D. & Cockard, A. (1994) CD44 plays a role in adhesive interactions between glioma cells and extracellular matrix components. Neuropathol. Appl. Neurobiol., 20, 399-405.
    • (1994) Neuropathol. Appl. Neurobiol. , vol.20 , pp. 399-405
    • Radotra, B.1    McCormick, D.2    Cockard, A.3
  • 48
    • 0024996017 scopus 로고
    • Is gompertzian or exponential kinetics a valid description of individual human cancer growth?
    • Retsky, M. W., Swartzendruber, D. E., Wardwell, R. H. & Bame, P. D. (1990) Is gompertzian or exponential kinetics a valid description of individual human cancer growth? Med. Hypotheses, 33, 95-106.
    • (1990) Med. Hypotheses , vol.33 , pp. 95-106
    • Retsky, M.W.1    Swartzendruber, D.E.2    Wardwell, R.H.3    Bame, P.D.4
  • 49
    • 0026773381 scopus 로고
    • Oncogenes, anti-oncogenes and the immune response to cancer: A mathematical model
    • Sherratt, J. A. & Nowak, M. A. (1992) Oncogenes, anti-oncogenes and the immune response to cancer: A mathematical model. Proc. R. Soc. Lond. B, 248, 261-271.
    • (1992) Proc. R. Soc. Lond. B , vol.248 , pp. 261-271
    • Sherratt, J.A.1    Nowak, M.A.2
  • 51
    • 2342461756 scopus 로고    scopus 로고
    • To die or not to die: How does p53 decide?
    • Slee, E. A., O'Connor, D. J. & Lu, X. (2004) To die or not to die: How does p53 decide? Oncogene, 23, 2809-2818.
    • (2004) Oncogene , vol.23 , pp. 2809-2818
    • Slee, E.A.1    O'Connor, D.J.2    Lu, X.3
  • 52
    • 0027481607 scopus 로고
    • Computer simulation of tumour cell invasion by a stochastic growth model
    • Smolle, J. & Stettner, H. (1993) Computer simulation of tumour cell invasion by a stochastic growth model. J. Theor. Biol., 160, 63-72.
    • (1993) J. Theor. Biol. , vol.160 , pp. 63-72
    • Smolle, J.1    Stettner, H.2
  • 53
    • 0027333411 scopus 로고
    • Tumor cell interactions with the extracellular matrix during invasion and metastasis
    • Stetler-Stevenson, W. G., Aznavoorian, S. & Liotta, L. A. (1993) Tumor cell interactions with the extracellular matrix during invasion and metastasis. Annu. Rev. Cell Biol., 9, 541-573.
    • (1993) Annu. Rev. Cell Biol. , vol.9 , pp. 541-573
    • Stetler-Stevenson, W.G.1    Aznavoorian, S.2    Liotta, L.A.3
  • 54
    • 0029903248 scopus 로고    scopus 로고
    • Matrix metallo-proteinases and tumour invasion: From correlation to causality to the clinic
    • Stetler-Stevenson, W. G., Hewitt, R. & Corcoran, M. (1996) Matrix metallo-proteinases and tumour invasion: From correlation to causality to the clinic. Cancer Biol., 7, 147-154.
    • (1996) Cancer Biol. , vol.7 , pp. 147-154
    • Stetler-Stevenson, W.G.1    Hewitt, R.2    Corcoran, M.3
  • 55
    • 0027685701 scopus 로고
    • Cadherins in cancer: Implications for invasion and metastasis
    • Takeichi, M. (1993) Cadherins in cancer: Implications for invasion and metastasis. Curr. Opin. Cell Biol., 5, 806-811.
    • (1993) Curr. Opin. Cell Biol. , vol.5 , pp. 806-811
    • Takeichi, M.1
  • 56
    • 0022374927 scopus 로고
    • Human endothelial cells are chemotactic to endothelial cell growth factor and heparin
    • Terranova, V. P., Diflorio, R., Lyall, R. M., Hic, S., Friesel, R. & Maciag, T. (1985) Human endothelial cells are chemotactic to endothelial cell growth factor and heparin. J. Cell Biol., 101, 2330-2334.
    • (1985) J. Cell Biol. , vol.101 , pp. 2330-2334
    • Terranova, V.P.1    Diflorio, R.2    Lyall, R.M.3    Hic, S.4    Friesel, R.5    Maciag, T.6
  • 58
    • 0029422390 scopus 로고
    • From passive diffusion to active cellular migration in mathematical models of tumour invasion
    • Tracqui, P. (1995) From passive diffusion to active cellular migration in mathematical models of tumour invasion. Acta Biotheor., 43, 443-464.
    • (1995) Acta Biotheor. , vol.43 , pp. 443-464
    • Tracqui, P.1
  • 59
    • 0033028947 scopus 로고    scopus 로고
    • Mathematical modelling of avascular-tumour growth II: Modelling growth saturation
    • Ward, J. P. & King, J. R. (1999) Mathematical modelling of avascular-tumour growth II: Modelling growth saturation. IMA J. Math. Appl. Med. Biol., 16, 171-211.
    • (1999) IMA J. Math. Appl. Med. Biol. , vol.16 , pp. 171-211
    • Ward, J.P.1    King, J.R.2
  • 60
    • 27244451617 scopus 로고
    • Mathematical models in experimental and clinical oncology
    • (D. Ingram & R. F. Bloch eds). London: J. Wiley & Sons
    • Wheldon, T. E. (1986) Mathematical models in experimental and clinical oncology. Mathematical Methods in Medicine (D. Ingram & R. F. Bloch eds). London: J. Wiley & Sons, pp. 1-32.
    • (1986) Mathematical Methods in Medicine , pp. 1-32
    • Wheldon, T.E.1
  • 61
    • 1442274816 scopus 로고    scopus 로고
    • 2+ channel antagonists on plasma concentrations of matrix metalloproteinase-2 and -9 in essential hypertension
    • 2+ channel antagonists on plasma concentrations of matrix metalloproteinase-2 and -9 in essential hypertension. Am. J. Hypertens., 17, 273-276.
    • (2004) Am. J. Hypertens. , vol.17 , pp. 273-276
    • Zervoudaki, A.1    Economou, E.2    Pitsavos, C.3    Vasiliadou, K.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.