Imidazopurinones are markers of physiological genomic damage linked to DNA instability and glyoxalase 1-associated tumour multidrug resistance

Nucleic Acids Research

Volumn 38, Issue 16, 2010, Pages 5432-5442

  Thornalley, Paul J ^a,b   Waris, Sahar ^a   Fleming, Thomas ^b   Santarius, Thomas ^c,d   Larkin, Sarah J ^a,b   Winklhofer Roob, Brigitte M ^e   Stratton, Michael R ^c   Rabbani, Naila ^a,b  

^a UNIVERSITY OF WARWICK   (United Kingdom)

^b UNIVERSITY OF ESSEX   (United Kingdom)

^c WELLCOME TRUST SANGER INSTITUTE   (United Kingdom)

^d UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^e UNIVERSITY OF GRAZ   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; ENZYME INHIBITOR; GLYOXAL; IMIDAZOPURINONE DERIVATIVE; LACTOYLGLUTATHIONE LYASE; METHYLGLYOXAL; PURINE DERIVATIVE; UNCLASSIFIED DRUG; BIOLOGICAL MARKER; DNA ADDUCT; NUCLEOSIDE;

APOPTOSIS; ARTICLE; CELL MEMBRANE PERMEABILITY; CELL STRAIN HL 60; CONTROLLED STUDY; DNA CONTENT; DNA DAMAGE; DNA STRAND BREAKAGE; GENE OVEREXPRESSION; GENOMIC INSTABILITY; GLYCATION; GLYCOLYSIS; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; LIQUID CHROMATOGRAPHY; MONONUCLEAR CELL; MULTIDRUG RESISTANCE; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; TANDEM MASS SPECTROMETRY; TUMOR CELL LINE; BLOOD; CHEMISTRY; DNA ADDUCT; DRUG RESISTANCE; METABOLISM; URINE;

BIOLOGICAL MARKERS; CELL LINE, TUMOR; CHROMATOGRAPHY, LIQUID; DNA ADDUCTS; DNA BREAKS; DNA, NEOPLASM; DRUG RESISTANCE, MULTIPLE; DRUG RESISTANCE, NEOPLASM; GLYOXAL; HUMANS; LACTOYLGLUTATHIONE LYASE; NUCLEOSIDES; PURINONES; PYRUVALDEHYDE; TANDEM MASS SPECTROMETRY;

EID: 77956522537     PISSN: 03051048     EISSN: 13624962     Source Type: Journal    
DOI: 10.1093/nar/gkq306     Document Type: Article

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