Neutral sphingomyelinase inhibition decreases ER stress-mediated apoptosis and inducible nitric oxide synthase in retinal pigment epithelial cells

Free Radical Biology and Medicine

Volumn 72, Issue , 2014, Pages 113-123

  Kucuksayan, Ertan ^a   Konuk, Esma Kirimlioglu ^a   Demir, Nejdet ^a   Mutus, Bülent ^b   Aslan, Mutay ^a  

^a AKDENIZ UNIVERSITY   (Turkey)

^b UNIVERSITY OF WINDSOR   (Canada)

Author keywords

Endoplasmic reticulum stress; Free radicals; Nitric oxide; Retinal pigment epithelial cells; Sphingomyelinase

Indexed keywords

3 NITROTYROSINE; 3,3' (1,4 PHENYLENE)BIS[N [4 (4,5 DIHYDRO 1H IMIDAZOL 2 YL)PHENYL]ACRYLAMIDE]; CCAAT ENHANCER BINDING PROTEIN; GLUCOSE REGULATED PROTEIN 78; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; NITRATE; NITRITE; PROTEIN KINASE R; SPHINGOMYELIN PHOSPHODIESTERASE; TUNICAMYCIN; NOS2 PROTEIN, HUMAN;

APOPTOSIS; ARTICLE; CELL LINE; CELL VIABILITY; CONTROLLED STUDY; ENDOPLASMIC RETICULUM STRESS; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME MECHANISM; EPITHELIUM CELL; HUMAN; HUMAN CELL; NITRATIVE STRESS; PIGMENT EPITHELIUM; PRIORITY JOURNAL; CYTOLOGY; ENZYMOLOGY; FLOW CYTOMETRY; FLUORESCENT ANTIBODY TECHNIQUE; METABOLISM; NICK END LABELING; PHYSIOLOGY; WESTERN BLOTTING;

APOPTOSIS; BLOTTING, WESTERN; CELL LINE; ENDOPLASMIC RETICULUM STRESS; FLOW CYTOMETRY; FLUORESCENT ANTIBODY TECHNIQUE; HUMANS; IN SITU NICK-END LABELING; NITRIC OXIDE SYNTHASE TYPE II; RETINAL PIGMENT EPITHELIUM; SPHINGOMYELIN PHOSPHODIESTERASE;

EID: 84900419758     PISSN: 08915849     EISSN: 18734596     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2014.04.013     Document Type: Article

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