-
1
-
-
11144233626
-
Regulation of WRN helicase activity in human base excision repair
-
Ahn B, Harrigan JA, Indig FE, Wilson DM III, Bohr VA (2004) Regulation of WRN helicase activity in human base excision repair. J Biol Chem 279:53465-53474
-
(2004)
J Biol Chem
, vol.279
, pp. 53465-53474
-
-
Ahn, B.1
Harrigan, J.A.2
Indig, F.E.3
Wilson III, D.M.4
Bohr, V.A.5
-
2
-
-
0141480945
-
WRN interacts physically and functionally with the recombination mediator protein RAD52
-
Baynton K, Otterlei M, Bjoras M, von KC, Bohr VA, Seeberg E (2003) WRN interacts physically and functionally with the recombination mediator protein RAD52. J Biol Chem 278:36476-36486
-
(2003)
J Biol Chem
, vol.278
, pp. 36476-36486
-
-
Baynton, K.1
Otterlei, M.2
Bjoras, M.3
Von, K.C.4
Bohr, V.A.5
Seeberg, E.6
-
3
-
-
45549093353
-
Molecular biology-refined view of the ends
-
Bianchi A, Shore D (2008) Molecular biology-refined view of the ends. Science 320:1301-1302
-
(2008)
Science
, vol.320
, pp. 1301-1302
-
-
Bianchi, A.1
Shore, D.2
-
4
-
-
0021151105
-
The molecular-structure of centromeres and telomeres
-
Blackburn EH, Szostak JW (1984) The molecular-structure of centromeres and telomeres. Annu Rev Biochem 53:163-194
-
(1984)
Annu Rev Biochem
, vol.53
, pp. 163-194
-
-
Blackburn, E.H.1
Szostak, J.W.2
-
5
-
-
2342569002
-
The Werner syndrome protein confers resistance to the DNA lesions N3-methyladenine and O6-methylguanine: Implications for WRN function
-
Blank A, Bobola MS, Gold B, Varadarajan S, Kolstoe D, Meade EH, Rabinovitch PS, Loeb LA, Silber JR (2004) The Werner syndrome protein confers resistance to the DNA lesions N3-methyladenine and O6-methylguanine: Implications for WRN function. DNA Repair (Amst) 3:629-638
-
(2004)
DNA Repair (Amst
, vol.3
, pp. 629-638
-
-
Blank, A.1
Bobola, M.S.2
Gold, B.3
Varadarajan, S.4
Kolstoe, D.5
Meade, E.H.6
Rabinovitch, P.S.7
Loeb, L.A.8
Silber, J.R.9
-
6
-
-
34548667973
-
Telomere length, stem cells and aging
-
Blasco MA (2007) Telomere length, stem cells and aging. Nat Chem Biol 3:640-649
-
(2007)
Nat Chem Biol
, vol.3
, pp. 640-649
-
-
Blasco, M.A.1
-
7
-
-
0030931491
-
Telomere shortening and tumor formation by mouse cells lacking telomerase RNA
-
Blasco MA, Lee HW, Hande MP, Samper E, Lansdorp PM, DePinho RA, Greider CW (1997) Telomere shortening and tumor formation by mouse cells lacking telomerase RNA. Cell 91:25-34
-
(1997)
Cell
, vol.91
, pp. 25-34
-
-
Blasco, M.A.1
Lee, H.W.2
Hande, M.P.3
Samper, E.4
Lansdorp, P.M.5
DePinho, R.A.6
Greider, C.W.7
-
8
-
-
56449090762
-
Rising from the RecQ-Age: The role of human RecQ helicases in genome maintenance
-
Bohr VA (2008) Rising from the RecQ-Age: The role of human RecQ helicases in genome maintenance. Trends Biochem Sci 33:609-620
-
(2008)
Trends Biochem Sci
, vol.33
, pp. 609-620
-
-
Bohr, V.A.1
-
10
-
-
33746644257
-
Ku70 stimulates fusion of dysfunctional telomeres yet protects chromosome ends from homologous recombination
-
885-U162
-
Celli GB, Denchi EL, de Lange T (2006) Ku70 stimulates fusion of dysfunctional telomeres yet protects chromosome ends from homologous recombination. Nat Cell Biol 8:885-U162
-
(2006)
Nat Cell Biol
, vol.8
-
-
Celli, G.B.1
Denchi, E.L.2
De Lange, T.3
-
11
-
-
3543043128
-
Essential role of limiting telomeres in the pathogenesis of Werner syndrome
-
Chang S, Multani AS, Cabrera NG, Naylor ML, Laud P, Lombard D, Pathak S, Guarente L, DePinho RA (2004) Essential role of limiting telomeres in the pathogenesis of Werner syndrome. Nat Genet 36:877-882
-
(2004)
Nat Genet
, vol.36
, pp. 877-882
-
-
Chang, S.1
Multani, A.S.2
Cabrera, N.G.3
Naylor, M.L.4
Laud, P.5
Lombard, D.6
Pathak, S.7
Guarente, L.8
DePinho, R.A.9
-
12
-
-
33646937737
-
Collaboration of Werner syndrome protein and BRCA1 in cellular responses to DNA interstrand cross-links
-
Cheng WH, Kusumoto R, Opresko PL, Sui X, Huang S, Nicolette ML, Paull TT, Campisi J, Seidman M, Bohr VA (2006) Collaboration of Werner syndrome protein and BRCA1 in cellular responses to DNA interstrand cross-links. Nucleic Acids Res 34:2751-2760
-
(2006)
Nucleic Acids Res
, vol.34
, pp. 2751-2760
-
-
Cheng, W.H.1
Kusumoto, R.2
Opresko, P.L.3
Sui, X.4
Huang, S.5
Nicolette, M.L.6
Paull, T.T.7
Campisi, J.8
Seidman, M.9
Bohr, V.A.10
-
13
-
-
55549147927
-
WRN is required for ATM activation and the S-phase checkpoint in response to interstrand cross-link-induced DNA double-strand breaks
-
Cheng WH, Muftic D, Muftuoglu M, Dawut L, Morris C, Helleday T, Shiloh Y, Bohr VA (2008) WRN is required for ATM activation and the S-phase checkpoint in response to interstrand cross-link-induced DNA double-strand breaks. Mol Biol Cell 19:3923-3933
-
(2008)
Mol Biol Cell
, vol.19
, pp. 3923-3933
-
-
Cheng, W.H.1
Muftic, D.2
Muftuoglu, M.3
Dawut, L.4
Morris, C.5
Helleday, T.6
Shiloh, Y.7
Bohr, V.A.8
-
14
-
-
2442660468
-
Linkage between Werner syndrome protein and the Mre11 complex via Nbs1
-
Cheng WH, von KC, Opresko PL, Arthur LM, Komatsu K, Seidman MM, Carney JP, Bohr VA (2004) Linkage between Werner syndrome protein and the Mre11 complex via Nbs1. J Biol Chem 279:21169-21176
-
(2004)
J Biol Chem
, vol.279
, pp. 21169-21176
-
-
Cheng, W.H.1
Von, K.C.2
Opresko, P.L.3
Arthur, L.M.4
Komatsu, K.5
Seidman, M.M.6
Carney, J.P.7
Bohr, V.A.8
-
15
-
-
3242709415
-
Telomere-Associated protein TIN2 is essential for early embryonic development through a telomerase-independent pathway
-
Chiang YJ, Kim SH, Tessarollo L, Campisi J, Hodes RJ (2004) Telomere-Associated protein TIN2 is essential for early embryonic development through a telomerase-independent pathway. Mol Cell Biol 24:6631-6634
-
(2004)
Mol Cell Biol
, vol.24
, pp. 6631-6634
-
-
Chiang, Y.J.1
Kim, S.H.2
Tessarollo, L.3
Campisi, J.4
Hodes, R.J.5
-
16
-
-
0035853104
-
Recombination-mediated lengthening of terminal telomeric repeats requires the Sgs1 DNA helicase
-
Cohen H, Sinclair DA (2001) Recombination-mediated lengthening of terminal telomeric repeats requires the Sgs1 DNA helicase. Proc Natl Acad Sci U S A 98:3174-3179
-
(2001)
Proc Natl Acad Sci U S A
, vol.98
, pp. 3174-3179
-
-
Cohen, H.1
Sinclair, D.A.2
-
17
-
-
0034655912
-
Ku complex interacts with and stimulates the Werner protein
-
Cooper MP, Machwe A, Orren DK, Brosh RM, Ramsden D, Bohr VA (2000) Ku complex interacts with and stimulates the Werner protein. Genes Dev 14:907-912
-
(2000)
Genes Dev
, vol.14
, pp. 907-912
-
-
Cooper, M.P.1
Machwe, A.2
Orren, D.K.3
Brosh, R.M.4
Ramsden, D.5
Bohr, V.A.6
-
18
-
-
33847790504
-
Telomere dysfunction as a cause of genomic instability in Werner syndrome
-
Crabbe L, Jauch A, Naeger CM, Holtgreve-Grez H, Karlseder J (2007) Telomere dysfunction as a cause of genomic instability in Werner syndrome. Proc Natl Acad Sci U S A 104: 2205-2210
-
(2007)
Proc Natl Acad Sci U S A
, vol.104
, pp. 2205-2210
-
-
Crabbe, L.1
Jauch, A.2
Naeger, C.M.3
Holtgreve-Grez, H.4
Karlseder, J.5
-
19
-
-
10344256183
-
Defective telomere lagging strand synthesis in cells lacking WRN helicase activity
-
Crabbe L, Verdun RE, Haggblom CI, Karlseder J (2004) Defective telomere lagging strand synthesis in cells lacking WRN helicase activity. Science 306:1951-1953
-
(2004)
Science
, vol.306
, pp. 1951-1953
-
-
Crabbe, L.1
Verdun, R.E.2
Haggblom, C.I.3
Karlseder, J.4
-
20
-
-
34548824343
-
The human Werner syndrome protein stimulates repair of oxidative DNA base damage by the DNA glycosylase Neil1
-
Das A, Boldogh I, Lee JW, Harrigan JA, Hegde ML, Piotrowski J, de Souza-Pinto N, Ramos W, Greenberg MM, Hazra TK, Mitra S, Bohr VA (2007) The human Werner syndrome protein stimulates repair of oxidative DNA base damage by the DNA glycosylase Neil1. J Biol Chem 282:26591-26602
-
(2007)
J Biol Chem
, vol.282
, pp. 26591-26602
-
-
Das, A.1
Boldogh, I.2
Lee, J.W.3
Harrigan, J.A.4
Hegde, M.L.5
Piotrowski, J.6
De Souza-Pinto, N.7
Ramos, W.8
Greenberg, M.M.9
Hazra, T.K.10
Mitra, S.11
Bohr, V.A.12
-
21
-
-
0037148277
-
Protection of mammalian telomeres
-
de Lange T (2002) Protection of mammalian telomeres. Oncogene 21:532-540
-
(2002)
Oncogene
, vol.21
, pp. 532-540
-
-
De Lange, T.1
-
22
-
-
24944460598
-
Shelterin: The protein complex that shapes and safeguards human telomeres
-
de Lange T (2005) Shelterin: The protein complex that shapes and safeguards human telomeres. Genes Dev 19:2100-2110
-
(2005)
Genes Dev
, vol.19
, pp. 2100-2110
-
-
De Lange, T.1
-
23
-
-
0344441890
-
A DNA damage checkpoint response in telomere-initiated senescence
-
di Fagagna FD, Reaper PM, Clay-Farrace L, Fiegler H, Carr P, von Zglinicki T, Saretzki G, Carter NP, Jackson SP (2003) A DNA damage checkpoint response in telomere-initiated senescence. Nature 426:194-198
-
(2003)
Nature
, vol.426
, pp. 194-198
-
-
Di Fagagna, F.D.1
Reaper, P.M.2
Clay-Farrace, L.3
Fiegler, H.4
Carr, P.5
Von Zglinicki, T.6
Saretzki, G.7
Carter, N.P.8
Jackson, S.P.9
-
24
-
-
3543056880
-
Functional links between telomeres and proteins of the DNA-damage response
-
di Fagagna FD, Teo SH, Jackson SP (2004) Functional links between telomeres and proteins of the DNA-damage response. Genes Dev 18:1781-1799
-
(2004)
Genes Dev
, vol.18
, pp. 1781-1799
-
-
Di Fagagna, F.D.1
Teo, S.H.2
Jackson, S.P.3
-
25
-
-
34247102690
-
The molecular role of the Rothmund-Thomson-, RAPADILINO- And Baller-Gerold-gene product, RECQL4: Recent progress
-
Dietschy T, Shevelev I, Stagljar I (2007) The molecular role of the Rothmund-Thomson-, RAPADILINO- And Baller-Gerold-gene product, RECQL4: Recent progress. Cell Mol Life Sci 64:796-802
-
(2007)
Cell Mol Life Sci
, vol.64
, pp. 796-802
-
-
Dietschy, T.1
Shevelev, I.2
Stagljar, I.3
-
26
-
-
33750048144
-
A role for WRN in telomere-based DNA damage responses
-
Eller MS, Liao XD, Liu SY, Hanna K, Backvall H, Opresko PL, Bohr VA, Gilchrest BA (2006) A role for WRN in telomere-based DNA damage responses. Proc Natl Acad Sci USA 103:15073-15078
-
(2006)
Proc Natl Acad Sci USA
, vol.103
, pp. 15073-15078
-
-
Eller, M.S.1
Liao, X.D.2
Liu, S.Y.3
Hanna, K.4
Backvall, H.5
Opresko, P.L.6
Bohr, V.A.7
Gilchrest, B.A.8
-
27
-
-
1942437469
-
Distinct dosage requirements for the maintenance of long and short telomeres in mTert heterozygous mice
-
Erdmann N, Liu Y, Harrington L (2004) Distinct dosage requirements for the maintenance of long and short telomeres in mTert heterozygous mice. Proc Natl Acad Sci USA 101: 6080-6085
-
(2004)
Proc Natl Acad Sci USA
, vol.101
, pp. 6080-6085
-
-
Erdmann, N.1
Liu, Y.2
Harrington, L.3
-
28
-
-
3543007196
-
Human RECQ5beta, a protein with DNA helicase and strand-Annealing activities in a single polypeptide
-
Garcia PL, Liu Y, Jiricny J, West SC, Janscak P (2004) Human RECQ5beta, a protein with DNA helicase and strand-Annealing activities in a single polypeptide. EMBO J 23: 2882-2891
-
(2004)
EMBO J
, vol.23
, pp. 2882-2891
-
-
Garcia, P.L.1
Liu, Y.2
Jiricny, J.3
West, S.C.4
Janscak, P.5
-
29
-
-
0030060521
-
Telomeres, telomerase and cancer
-
Greider CW, Blackburn EH (1996) Telomeres, telomerase and cancer. Sci Am 274:92-97
-
(1996)
Sci Am
, vol.274
, pp. 92-97
-
-
Greider, C.W.1
Blackburn, E.H.2
-
30
-
-
0033553536
-
Mammalian telomeres end in a large duplex loop
-
Griffith JD, Comeau L, Rosenfield S, Stansel RM, Bianchi A, Moss H, de Lange T (1999) Mammalian telomeres end in a large duplex loop. Cell 97:503-514
-
(1999)
Cell
, vol.97
, pp. 503-514
-
-
Griffith, J.D.1
Comeau, L.2
Rosenfield, S.3
Stansel, R.M.4
Bianchi, A.5
Moss, H.6
De Lange, T.7
-
31
-
-
0025279931
-
Telomeres shorten During aging of human fibroblasts
-
Harley CB, Futcher AB, Greider CW (1990) Telomeres shorten During aging of human fibroblasts. Nature 345:458-460
-
(1990)
Nature
, vol.345
, pp. 458-460
-
-
Harley, C.B.1
Futcher, A.B.2
Greider, C.W.3
-
32
-
-
33846875447
-
WRN exonuclease activity is blocked by DNA termini harboring 3' obstructive groups
-
Harrigan JA, Fan J, Momand J, Perrino FW, Bohr VA, Wilson DM III (2007) WRN exonuclease activity is blocked by DNA termini harboring 3' obstructive groups. Mech Ageing Dev 128:259-266
-
(2007)
Mech Ageing Dev
, vol.128
, pp. 259-266
-
-
Harrigan, J.A.1
Fan, J.2
Momand, J.3
Perrino, F.W.4
Bohr, V.A.5
Wilson III, D.M.6
-
33
-
-
0038681010
-
The Werner syndrome protein stimulates DNA polymerase beta strand displacement synthesis via its helicase activity
-
Harrigan JA, Opresko PL, von KC, Kedar PS, Prasad R, Wilson SH, Bohr VA (2003) The Werner syndrome protein stimulates DNA polymerase beta strand displacement synthesis via its helicase activity. J Biol Chem 278:22686-22695
-
(2003)
J Biol Chem
, vol.278
, pp. 22686-22695
-
-
Harrigan, J.A.1
Opresko, P.L.2
Von, K.C.3
Kedar, P.S.4
Prasad, R.5
Wilson, S.H.6
Bohr, V.A.7
-
34
-
-
32644449296
-
The Werner syndrome protein operates in base excision repair and cooperates with DNA polymerase beta
-
Harrigan JA, Wilson DM III, Prasad R, Opresko PL, Beck G, May A, Wilson SH, Bohr VA (2006) The Werner syndrome protein operates in base excision repair and cooperates with DNA polymerase beta. Nucleic Acids Res 34:745-754
-
(2006)
Nucleic Acids Res
, vol.34
, pp. 745-754
-
-
Harrigan, J.A.1
Wilson III, D.M.2
Prasad, R.3
Opresko, P.L.4
Beck, G.5
May, A.6
Wilson, S.H.7
Bohr, V.A.8
-
35
-
-
33750446640
-
POT1b protects telomeres from end-To-end chromosomal fusions and aberrant homologous recombination
-
He H, Multani AS, Cosme-Blanco W, Tahara H, Ma J, Pathak S, Deng YB, Chang S (2006) POT1b protects telomeres from end-To-end chromosomal fusions and aberrant homologous recombination. EMBO J 25:5180-5190
-
(2006)
EMBO J
, vol.25
, pp. 5180-5190
-
-
He, H.1
Multani, A.S.2
Cosme-Blanco, W.3
Tahara, H.4
Ma, J.5
Pathak, S.6
Deng, Y.B.7
Chang, S.8
-
36
-
-
33745685066
-
Recent expansion of the telomeric complex in rodents: Two distinct POT1 proteins protect mouse telomeres
-
Hockemeyer D, Daniels JP, Takai H, de Lange T (2006) Recent expansion of the telomeric complex in rodents: Two distinct POT1 proteins protect mouse telomeres. Cell 126:63-77
-
(2006)
Cell
, vol.126
, pp. 63-77
-
-
Hockemeyer, D.1
Daniels, J.P.2
Takai, H.3
De Lange, T.4
-
37
-
-
23044500389
-
POT1 protects telomeres from a transient DNA damage response and determines how human chromosomes end
-
Hockemeyer D, Sfeir AJ, Shay JW, Wright WE, de Lange T (2005) POT1 protects telomeres from a transient DNA damage response and determines how human chromosomes end. EMBO J 24:2667-2678
-
(2005)
EMBO J
, vol.24
, pp. 2667-2678
-
-
Hockemeyer, D.1
Sfeir, A.J.2
Shay, J.W.3
Wright, W.E.4
De Lange, T.5
-
38
-
-
28844478775
-
Repair of formamidopyrimidines in DNA involves different glycosylases: Role of the OGG1, NTH1, and NEIL1 enzymes
-
Hu J, de Souza-Pinto NC, Haraguchi K, Hogue BA, Jaruga P, Greenberg MM, Dizdaroglu M, Bohr VA (2005a) Repair of formamidopyrimidines in DNA involves different glycosylases: Role of the OGG1, NTH1, and NEIL1 enzymes. J Biol Chem 280:40544-40551
-
(2005)
J Biol Chem
, vol.280
, pp. 40544-40551
-
-
Hu, J.1
De Souza-Pinto, N.C.2
Haraguchi, K.3
Hogue, B.A.4
Jaruga, P.5
Greenberg, M.M.6
Dizdaroglu, M.7
Bohr, V.A.8
-
39
-
-
17644410077
-
Recql5 and Blm RecQ DNA helicases have nonredundant roles in suppressing crossoversHU2005
-
Hu Y, Lu X, Barnes E, Yan M, Lou H, Luo G (2005b) Recql5 and Blm RecQ DNA helicases have nonredundant roles in suppressing crossoversHU2005. Mol Cell Biol 25:3431-3442
-
(2005)
Mol Cell Biol
, vol.25
, pp. 3431-3442
-
-
Hu, Y.1
Lu, X.2
Barnes, E.3
Yan, M.4
Lou, H.5
Luo, G.6
-
40
-
-
36849013079
-
RECQL5/Recql5 helicase regulates homologous recombination and suppresses tumor formation via disruption of Rad51 presynaptic filaments
-
Hu Y, Raynard S, Sehorn MG, Lu X, Bussen W, Zheng L, Stark JM, Barnes EL, Chi P, Janscak P, Jasin M, Vogel H, Sung P, Luo G (2007) RECQL5/Recql5 helicase regulates homologous recombination and suppresses tumor formation via disruption of Rad51 presynaptic filaments. Genes Dev 21:3073-3084
-
(2007)
Genes Dev
, vol.21
, pp. 3073-3084
-
-
Hu, Y.1
Raynard, S.2
Sehorn, M.G.3
Lu, X.4
Bussen, W.5
Zheng, L.6
Stark, J.M.7
Barnes, E.L.8
Chi, P.9
Janscak, P.10
Jasin, M.11
Vogel, H.12
Sung, P.13
Luo, G.14
-
41
-
-
33750968484
-
Syn thesis, DNA polymerase incorporation, and enzymatic phosphate hydrolysis of formamidopyrimidine nucleoside triphosphates
-
Imoto S, Patro JN, Jiang YL, Oka N, Greenberg MM (2006) Synthesis, DNA polymerase incorporation, and enzymatic phosphate hydrolysis of formamidopyrimidine nucleoside triphosphates. J Am Chem Soc 128:14606-14611
-
(2006)
J Am Chem Soc
, vol.128
, pp. 14606-14611
-
-
Imoto, S.1
Patro, J.N.2
Jiang, Y.L.3
Oka, N.4
Greenberg, M.M.5
-
42
-
-
10844284635
-
Mouse NEIL1 protein is specific for excision of 2, 6-diamino-4-hydroxy-5- formamidopyrimidine and 4, 6-diamino-5-formamidopyrimidine from oxidatively damaged DNA
-
Jaruga P, Birincioglu M, Rosenquist TA, Dizdaroglu M (2004) Mouse NEIL1 protein is specific for excision of 2, 6-diamino-4-hydroxy-5-formamidopyrimidine and 4, 6-diamino-5-formamidopyrimidine from oxidatively damaged DNA. Biochemistry 43:15909-15914
-
(2004)
Biochemistry
, vol.43
, pp. 15909-15914
-
-
Jaruga, P.1
Birincioglu, M.2
Rosenquist, T.A.3
Dizdaroglu, M.4
-
43
-
-
0344861943
-
Deficiency of Caenorhabditis elegans RecQ5 homologue reduces life span and increases sensitivity to ionizing radiation
-
Jeong YS, Kang Y, Lim KH, Lee MH, Lee J, Koo HS (2003) Deficiency of Caenorhabditis elegans RecQ5 homologue reduces life span and increases sensitivity to ionizing radiation. DNA Repair (Amst) 2:1309-1319
-
(2003)
DNA Repair (Amst
, vol.2
, pp. 1309-1319
-
-
Jeong, Y.S.1
Kang, Y.2
Lim, K.H.3
Lee, M.H.4
Lee, J.5
Koo, H.S.6
-
44
-
-
45049086666
-
Sensitivity of RECQL4-deficient fibroblasts from Rothmund-Thomson syndrome patients to genotoxic agents
-
Jin W, Liu H, Zhang Y, Otta SK, Plon SE, Wang LL (2008) Sensitivity of RECQL4-deficient fibroblasts from Rothmund-Thomson syndrome patients to genotoxic agents. Hum Genet 123:643-653
-
(2008)
Hum Genet
, vol.123
, pp. 643-653
-
-
Jin, W.1
Liu, H.2
Zhang, Y.3
Otta, S.K.4
Plon, S.E.5
Wang, L.L.6
-
45
-
-
0035844242
-
Interactions between the Werner syndrome helicase and DNA polymerase delta specifically facilitate copying of tetraplex and hairpin structures of the d(CGG)(n) trinucleotide repeat sequence
-
Kamath-Loeb AS, Loeb LA, Johansson E, Burgers PMJ, Fry M (2001) Interactions between the Werner syndrome helicase and DNA polymerase delta specifically facilitate copying of tetraplex and hairpin structures of the d(CGG)(n) trinucleotide repeat sequence. J Biol Chem 276:16439-16446
-
(2001)
J Biol Chem
, vol.276
, pp. 16439-16446
-
-
Kamath-Loeb, A.S.1
Loeb, L.A.2
Johansson, E.3
Burgers, P.M.J.4
Fry, M.5
-
46
-
-
0037192462
-
Senescence induced by altered telomere state, not telomere loss
-
Karlseder J, Smogorzewska A, de Lange T (2002) Senescence induced by altered telomere state, not telomere loss. Science 295:2446-2449
-
(2002)
Science
, vol.295
, pp. 2446-2449
-
-
Karlseder, J.1
Smogorzewska, A.2
De Lange, T.3
-
47
-
-
0037166306
-
Werner protein is a target of DNA-dependent protein kinase in vivo and in vitro, and its catalytic activities are regulated by phosphorylation
-
Karmakar P, Piotrowski J, Brosh RM Jr, Sommers JA, Miller SP, Cheng WH, Snowden CM, Ramsden DA, Bohr VA (2002a) Werner protein is a target of DNA-dependent protein kinase in vivo and in vitro, and its catalytic activities are regulated by phosphorylation. J Biol Chem 277:18291-18302
-
(2002)
J Biol Chem
, vol.277
, pp. 18291-18302
-
-
Karmakar, P.1
Piotrowski, J.2
Brosh Jr., R.M.3
Sommers, J.A.4
Miller, S.P.5
Cheng, W.H.6
Snowden, C.M.7
Ramsden, D.A.8
Bohr, V.A.9
-
48
-
-
0037102588
-
Ku heterodimer binds to both ends of the Werner protein and functional interaction occurs at the Werner N-Terminus
-
Karmakar P, Snowden CM, Ramsden DA, Bohr VA (2002b) Ku heterodimer binds to both ends of the Werner protein and functional interaction occurs at the Werner N-Terminus. Nucleic Acids Res 30:3583-3591
-
(2002)
Nucleic Acids Res
, vol.30
, pp. 3583-3591
-
-
Karmakar, P.1
Snowden, C.M.2
Ramsden, D.A.3
Bohr, V.A.4
-
50
-
-
47249106520
-
Werner protein cooperates with the XRCC4-DNA ligase IV complex in end-processing
-
Kusumoto R, Dawut L, Marchetti C, Wan LJ, Vindigni A, Ramsden D, Bohr VA (2008) Werner protein cooperates with the XRCC4-DNA ligase IV complex in end-processing. Biochemistry 47:7548-7556
-
(2008)
Biochemistry
, vol.47
, pp. 7548-7556
-
-
Kusumoto, R.1
Dawut, L.2
Marchetti, C.3
Wan, L.J.4
Vindigni, A.5
Ramsden, D.6
Bohr, V.A.7
-
51
-
-
0026735646
-
Telomere end-replication problem and cell aging
-
Levy MZ, Allsopp RC, Futcher AB, Greider CW, Harley CB (1992) Telomere end-replication problem and cell aging. J Mol Biol 225:951-960
-
(1992)
J Mol Biol
, vol.225
, pp. 951-960
-
-
Levy, M.Z.1
Allsopp, R.C.2
Futcher, A.B.3
Greider, C.W.4
Harley, C.B.5
-
52
-
-
0027278557
-
Instability and decay of the primary structure of DNA
-
Lindahl T (1993) Instability and decay of the primary structure of DNA. Nature 362:709-715
-
(1993)
Nature
, vol.362
, pp. 709-715
-
-
Lindahl, T.1
-
53
-
-
17844373798
-
The telomerase reverse transcriptase is limiting and necessary for telomerase function in vivo
-
Liu Y, Snow BE, Hande MP, Yeung D, Erdmann NJ, Wakeham A, Itie A, Siderovski DP, Lansdorp PM, Robinson MO, Harrington L (2000) The telomerase reverse transcriptase is limiting and necessary for telomerase function in vivo. Curr Biol 10:1459-1462
-
(2000)
Curr Biol
, vol.10
, pp. 1459-1462
-
-
Liu, Y.1
Snow, B.E.2
Hande, M.P.3
Yeung, D.4
Erdmann, N.J.5
Wakeham, A.6
Itie, A.7
Siderovski, D.P.8
Lansdorp, P.M.9
Robinson, M.O.10
Harrington, L.11
-
54
-
-
0038451396
-
POT1 as a terminal transducer of TRF1 telomere length control
-
Loayza D, de Lange T (2003) POT1 as a terminal transducer of TRF1 telomere length control. Nature 423:1013-1018
-
(2003)
Nature
, vol.423
, pp. 1013-1018
-
-
Loayza, D.1
De Lange, T.2
-
55
-
-
14044251500
-
Expression of a RecQ helicase homolog affects progression through crisis in fission yeast lacking telomerase
-
Mandell JG, Goodrich KJ, Bahler J, Cech TR (2005) Expression of a RecQ helicase homolog affects progression through crisis in fission yeast lacking telomerase. J Biol Chem 280:5249-5257
-
(2005)
J Biol Chem
, vol.280
, pp. 5249-5257
-
-
Mandell, J.G.1
Goodrich, K.J.2
Bahler, J.3
Cech, T.R.4
-
56
-
-
0035393720
-
The Bloom's and Werner's syndrome proteins are DNA structure-specific helicases
-
Mohaghegh P, Karow JK, Brosh JR Jr, Bohr VA, Hickson ID (2001) The Bloom's and Werner's syndrome proteins are DNA structure-specific helicases. Nucleic Acids Res 29:2843-2849
-
(2001)
Nucleic Acids Res
, vol.29
, pp. 2843-2849
-
-
Mohaghegh, P.1
Karow, J.K.2
Brosh Jr., J.R.3
Bohr, V.A.4
Hickson, I.D.5
-
57
-
-
38449097944
-
Short dysfunctional telomeres impair the repair of arsenite-induced oxidative damage in mouse cells
-
Newman JPA, Banerjee B, Fang WR, Poonepalli A, Balakrishnan L, Low GKM, Bhattacharjee RN, Akira S, Jayapal M, Melendez AJ, Baskar R, Lee HW, Hande MP (2008) Short dysfunctional telomeres impair the repair of arsenite-induced oxidative damage in mouse cells. J Cell Physiol 214:796-809
-
(2008)
J Cell Physiol
, vol.214
, pp. 796-809
-
-
Newman, J.P.A.1
Banerjee, B.2
Fang, W.R.3
Poonepalli, A.4
Balakrishnan, L.5
Low, G.K.M.6
Bhattacharjee, R.N.7
Akira, S.8
Jayapal, M.9
Melendez, A.J.10
Baskar, R.11
Lee, H.W.12
Hande, M.P.13
-
58
-
-
38949094875
-
Telomere ResQue and preservation-roles for the Werner syndrome protein and other RecQ helicases
-
Opresko PL (2008) Telomere ResQue and preservation-roles for the Werner syndrome protein and other RecQ helicases. Mech Ageing Dev 129:79-90
-
(2008)
Mech Ageing Dev
, vol.129
, pp. 79-90
-
-
Opresko, P.L.1
-
59
-
-
0037530653
-
Werner syndrome and the function of the Werner protein; what they can teach us about the molecular aging process
-
Opresko PL, Cheng WH, von Kobbe C, Harrigan JA, Bohr VA (2003) Werner syndrome and the function of the Werner protein; what they can teach us about the molecular aging process. Carcinogenesis 24:791-802
-
(2003)
Carcinogenesis
, vol.24
, pp. 791-802
-
-
Opresko, P.L.1
Cheng, W.H.2
Von Kobbe, C.3
Harrigan, J.A.4
Bohr, V.A.5
-
60
-
-
25444533047
-
POT1 stimulates RecQ helicases WRN and BLM to unwind telomeric DNA substrates
-
Opresko PL, Mason PA, Podell ER, Lei M, Hickson ID, Cech TR, Bohr VA (2005) POT1 stimulates RecQ helicases WRN and BLM to unwind telomeric DNA substrates. J Biol Chem 280:32069-32080
-
(2005)
J Biol Chem
, vol.280
, pp. 32069-32080
-
-
Opresko, P.L.1
Mason, P.A.2
Podell, E.R.3
Lei, M.4
Hickson, I.D.5
Cech, T.R.6
Bohr, V.A.7
-
61
-
-
2942637828
-
The Werner syndrome helicase and exonuclease cooperate to resolve telomeric D loops in a manner regulated by TRF1 and TRF2
-
Opresko PL, Otterlei M, Graakjaer J, Bruheim P, Dawut L, Kolvraa S, May A, Seidman MM, Bohr VA (2004) The Werner syndrome helicase and exonuclease cooperate to resolve telomeric D loops in a manner regulated by TRF1 and TRF2. Mol Cell 14:763-774
-
(2004)
Mol Cell
, vol.14
, pp. 763-774
-
-
Opresko, P.L.1
Otterlei, M.2
Graakjaer, J.3
Bruheim, P.4
Dawut, L.5
Kolvraa, S.6
May, A.7
Seidman, M.M.8
Bohr, V.A.9
-
62
-
-
0037175018
-
Telomere-binding protein TRF2 binds to and stimulates the Werner and Bloom syndrome helicases
-
Opresko PL, von Kobbe C, Laine JP, Harrigan J, Hickson ID, Bohr VA (2002) Telomere-binding protein TRF2 binds to and stimulates the Werner and Bloom syndrome helicases. J Biol Chem 277:41110-41119
-
(2002)
J Biol Chem
, vol.277
, pp. 41110-41119
-
-
Opresko, P.L.1
Von Kobbe, C.2
Laine, J.P.3
Harrigan, J.4
Hickson, I.D.5
Bohr, V.A.6
-
63
-
-
33846141125
-
Werner syndrome protein participates in a complex with RAD51, RAD54, RAD54B and ATR in response to ICL-induced replication arrest
-
Otterlei M, Bruheim P, Ahn B, Bussen W, Karmakar P, Baynton K, Bohr VA (2006) Werner syndrome protein participates in a complex with RAD51, RAD54, RAD54B and ATR in response to ICL-induced replication arrest. J Cell Sci 119:5137-5146
-
(2006)
J Cell Sci
, vol.119
, pp. 5137-5146
-
-
Otterlei, M.1
Bruheim, P.2
Ahn, B.3
Bussen, W.4
Karmakar, P.5
Baynton, K.6
Bohr, V.A.7
-
64
-
-
0035349905
-
Werner syndrome cells are sensitive to DNA cross-linking drugs
-
Poot M, Yom JS, Whang SH, Kato JT, Gollahon KA, Rabinovitch PS (2001) Werner syndrome cells are sensitive to DNA cross-linking drugs. FASEB J 15:1224-1226
-
(2001)
FASEB J
, vol.15
, pp. 1224-1226
-
-
Poot, M.1
Yom, J.S.2
Whang, S.H.3
Kato, J.T.4
Gollahon, K.A.5
Rabinovitch, P.S.6
-
65
-
-
43949086522
-
Association between oxidative DNA damage and telomere shortening in circulating endothelial progenitor cells obtained from metabolic syndrome patients with coronary artery disease
-
Satoh M, Ishikawa Y, Takahashi Y, Itoh T, Minami Y, Nakamura M (2008) Association between oxidative DNA damage and telomere shortening in circulating endothelial progenitor cells obtained from metabolic syndrome patients with coronary artery disease. Atherosclerosis 198:347-353
-
(2008)
Atherosclerosis
, vol.198
, pp. 347-353
-
-
Satoh, M.1
Ishikawa, Y.2
Takahashi, Y.3
Itoh, T.4
Minami, Y.5
Nakamura, M.6
-
66
-
-
39049092675
-
The role of telomere biology in bone marrow failure and other disorders
-
Savage SA, Alter BP (2008) The role of telomere biology in bone marrow failure and other disorders. Mech Ageing Dev 129:35-47
-
(2008)
Mech Ageing Dev
, vol.129
, pp. 35-47
-
-
Savage, S.A.1
Alter, B.P.2
-
67
-
-
33748744378
-
Mechanisms of RecQ helicases in pathways of DNA metabolism and maintenance of genomic stability
-
Sharma S, Doherty KM, Brosh RM Jr (2006) Mechanisms of RecQ helicases in pathways of DNA metabolism and maintenance of genomic stability. Biochem J 398:319-337
-
(2006)
Biochem J
, vol.398
, pp. 319-337
-
-
Sharma, S.1
Doherty, K.M.2
Brosh Jr., R.M.3
-
68
-
-
0742288051
-
WRN helicase and FEN-1 form a complex upon replication arrest and together process branchmigrating DNA structures associated with the replication fork
-
Sharma S, Otterlei M, Sommers JA, Driscoll HC, Dianov GL, Kao HI, Bambara RA, Brosh RM Jr (2004) WRN helicase and FEN-1 form a complex upon replication arrest and together process branchmigrating DNA structures associated with the replication fork. Mol Biol Cell 15:734-750
-
(2004)
Mol Biol Cell
, vol.15
, pp. 734-750
-
-
Sharma, S.1
Otterlei, M.2
Sommers, J.A.3
Driscoll, H.C.4
Dianov, G.L.5
Kao, H.I.6
Bambara, R.A.7
Brosh Jr., R.M.8
-
69
-
-
0034283889
-
Werner syndrome exonuclease catalyzes structure-dependent degradation of DNA
-
Shen JC, Loeb LA (2000) Werner syndrome exonuclease catalyzes structure-dependent degradation of DNA. Nucleic Acids Res 28:3260-3268
-
(2000)
Nucleic Acids Res
, vol.28
, pp. 3260-3268
-
-
Shen, J.C.1
Loeb, L.A.2
-
70
-
-
0034687248
-
Tankyrase promotes telomere elongation in human cells
-
Smith S, de Lange T (2000) Tankyrase promotes telomere elongation in human cells. Curr Biol 10:1299-1302
-
(2000)
Curr Biol
, vol.10
, pp. 1299-1302
-
-
Smith, S.1
De Lange, T.2
-
71
-
-
0032489012
-
TRF2 protects human telomeres from endto-end fusions
-
Van Steensel B, Smogorzewska A, de Lange T (1998) TRF2 protects human telomeres from endto-end fusions. Cell 92:401-413
-
(1998)
Cell
, vol.92
, pp. 401-413
-
-
Van Steensel, B.1
Smogorzewska, A.2
De Lange, T.3
-
72
-
-
0242721664
-
Central role for the Werner syndrome protein/poly(ADP-ribose) polymerase 1 complex in the poly(ADP-ribosyl)ation pathway after DNA damage
-
von Kobbe C, Harrigan JA, May A, Opresko PL, Dawut L, Cheng WH, Bohr VA (2003) Central role for the Werner syndrome protein/poly(ADP-ribose) polymerase 1 complex in the poly(ADP-ribosyl)ation pathway after DNA damage. Mol Cell Biol 23:8601-8613
-
(2003)
Mol Cell Biol
, vol.23
, pp. 8601-8613
-
-
Von Kobbe, C.1
Harrigan, J.A.2
May, A.3
Opresko, P.L.4
Dawut, L.5
Cheng, W.H.6
Bohr, V.A.7
-
73
-
-
0037077223
-
Colocalization, physical, and functional interaction between Werner and Bloom syndrome proteins
-
von Kobbe C, Karmakar P, Dawut L, Opresko P, Zeng X, Brosh RM Jr, Hickson ID, Bohr VA (2002) Colocalization, physical, and functional interaction between Werner and Bloom syndrome proteins. J Biol Chem 277:22035-22044
-
(2002)
J Biol Chem
, vol.277
, pp. 22035-22044
-
-
Von Kobbe, C.1
Karmakar, P.2
Dawut, L.3
Opresko, P.4
Zeng, X.5
Brosh Jr., R.M.6
Hickson, I.D.7
Bohr, V.A.8
-
74
-
-
0037107539
-
A nucleolar targeting sequence in the Werner syndrome protein resides within residues 949-1092
-
von KC, Bohr VA (2002) A nucleolar targeting sequence in the Werner syndrome protein resides within residues 949-1092. J Cell Sci 115:3901-3907
-
(2002)
J Cell Sci
, vol.115
, pp. 3901-3907
-
-
Von, K.C.1
Bohr, V.A.2
-
75
-
-
33846691378
-
The POT1-TPP1 telomere complex is a telomerase processivity factor
-
Wang F, Podell ER, Zaug AJ, Yang YT, Baciu P, Cech TR, Lei M (2007) The POT1-TPP1 telomere complex is a telomerase processivity factor. Nature 445:506-510
-
(2007)
Nature
, vol.445
, pp. 506-510
-
-
Wang, F.1
Podell, E.R.2
Zaug, A.J.3
Yang, Y.T.4
Baciu, P.5
Cech, T.R.6
Lei, M.7
-
76
-
-
0037965769
-
Functional relation among RecQ family helicases RecQL1, RecQL5, and BLM in cell growth and sister chromatid exchange formation
-
Wang W, Seki M, Narita Y, Nakagawa T, Yoshimura A, Otsuki M, Kawabe Y, Tada S, Yagi H, Ishii Y, Enomoto T (2003) Functional relation among RecQ family helicases RecQL1, RecQL5, and BLM in cell growth and sister chromatid exchange formation. Mol Cell Biol 23:3527-3535
-
(2003)
Mol Cell Biol
, vol.23
, pp. 3527-3535
-
-
Wang, W.1
Seki, M.2
Narita, Y.3
Nakagawa, T.4
Yoshimura, A.5
Otsuki, M.6
Kawabe, Y.7
Tada, S.8
Yagi, H.9
Ishii, Y.10
Enomoto, T.11
-
77
-
-
0015515155
-
Origin of concatemeric T7 DNA
-
Watson JD (1972) Origin of concatemeric T7 DNA. Nat New Biol 239:197-201
-
(1972)
Nat New Biol
, vol.239
, pp. 197-201
-
-
Watson, J.D.1
-
78
-
-
0035377356
-
Potential role for the BLM helicase in recombinational repair via a conserved interaction with RAD51
-
Wu L, Davies SL, Levitt NC, Hickson ID (2001) Potential role for the BLM helicase in recombinational repair via a conserved interaction with RAD51. J Biol Chem 276: 19375-19381
-
(2001)
J Biol Chem
, vol.276
, pp. 19375-19381
-
-
Wu, L.1
Davies, S.L.2
Levitt, N.C.3
Hickson, I.D.4
-
79
-
-
33751426143
-
DNA helicases required for homologous recombination and repair of damaged replication forks
-
Wu L, Hickson ID (2006) DNA helicases required for homologous recombination and repair of damaged replication forks. Annu Rev Genet 40:279-306
-
(2006)
Annu Rev Genet
, vol.40
, pp. 279-306
-
-
Wu, L.1
Hickson, I.D.2
-
80
-
-
33745713451
-
Pot1 deficiency initiates DNA damage checkpoint activation and aberrant homologous recombination at telomeres
-
Wu L, Multani AS, He H, Cosme-Blanco W, Deng Y, Deng JM, Bachilo O, Pathak S, Tahara H, Bailey SM, Deng YB, Behringer RR, Chang S (2006) Pot1 deficiency initiates DNA damage checkpoint activation and aberrant homologous recombination at telomeres. Cell 126:49-62
-
(2006)
Cell
, vol.126
, pp. 49-62
-
-
Wu, L.1
Multani, A.S.2
He, H.3
Cosme-Blanco, W.4
Deng, Y.5
Deng, J.M.6
Bachilo, O.7
Pathak, S.8
Tahara, H.9
Bailey, S.M.10
Deng, Y.B.11
Behringer, R.R.12
Chang, S.13
-
81
-
-
33846692105
-
TPP1 is a homologue of ciliate TEBP-beta and interacts with POT1 to recruit telomerase
-
Xin HW, Liu D, Wan M, Safari A, Kim H, Sun W, O'Connor MS, Zhou SY (2007) TPP1 is a homologue of ciliate TEBP-beta and interacts with POT1 to recruit telomerase. Nature 445:559-562
-
(2007)
Nature
, vol.445
, pp. 559-562
-
-
Xin, H.W.1
Liu, D.2
Wan, M.3
Safari, A.4
Kim, H.5
Sun, W.6
O'Connor, M.S.7
Zhou, S.Y.8
-
82
-
-
19544366597
-
RECQL4, mutated in the Rothmund-Thomson and RAPADILINO syndromes, interacts with ubiquitin ligases UBR1 and UBR2 of the N-end rule pathway
-
Yin J, Kwon YT, Varshavsky A, Wang W (2004) RECQL4, mutated in the Rothmund-Thomson and RAPADILINO syndromes, interacts with ubiquitin ligases UBR1 and UBR2 of the N-end rule pathway. Hum Mol Genet 13:2421-2430
-
(2004)
Hum Mol Genet
, vol.13
, pp. 2421-2430
-
-
Yin, J.1
Kwon, Y.T.2
Varshavsky, A.3
Wang, W.4
-
83
-
-
0347416975
-
ERCC1/XPF removes the 3' overhang from uncapped telomeres and represses formation of telomeric DNAcontaining double minute chromosomes
-
Zhu XD, Niedernhofer L, Kuster B, Mann M, Hoeijmakers JHJ, de Lange T (2003) ERCC1/XPF removes the 3' overhang from uncapped telomeres and represses formation of telomeric DNAcontaining double minute chromosomes. Mol Cell 12:1489-1498
-
(2003)
Mol Cell
, vol.12
, pp. 1489-1498
-
-
Zhu, X.D.1
Niedernhofer, L.2
Kuster, B.3
Mann, M.4
Hoeijmakers, J.H.J.5
De Lange, T.6
|