Short dysfunctional telomeres impair the repair of arsenite-induced oxidative damage in mouse cells

Journal of Cellular Physiology

Volumn 214, Issue 3, 2008, Pages 796-809

  Newman, Jennifer P A ^a   Banerjee, Birendranath ^a   Fang, Wanru ^a   Poonepalli, Anuradha ^a   Balakrishnan, Lakshmidevi ^a   Low, Grace Kah Mun ^a   Bhattacharjee, Rabindra N ^b,c   Akira, Shizuo ^b,c   Jayapal, Manikandan ^a   Melendez, Alirio J ^a   Baskar, Rajamanickam ^a   Lee, Han Woong ^d   Hande, M Prakash ^a  

^a NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^b OSAKA UNIVERSITY   (Japan)

^c JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

^d Yonsei University   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

ARSENIC TRIOXIDE; ARSENITE SODIUM; REACTIVE OXYGEN METABOLITE; RNA; TELOMERASE; ARSENOUS ACID DERIVATIVE; TELOMERASE RNA; UNCLASSIFIED DRUG;

ANIMAL CELL; APOPTOSIS; ARTICLE; CANCER CHEMOTHERAPY; CELL CYCLE; CELL CYCLE ARREST; CELL GROWTH; CELL SURVIVAL; CELL VIABILITY; CHROMOSOMAL INSTABILITY; CHROMOSOME ABERRATION; COMET ASSAY; CONTROLLED STUDY; DNA DAMAGE; DNA REPAIR; FIBROBLAST; FLUORESCENCE IN SITU HYBRIDIZATION; GENOMIC INSTABILITY; MICROARRAY ANALYSIS; MICRONUCLEUS; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; OXIDATIVE STRESS; PRIORITY JOURNAL; RISK ASSESSMENT; SIGNAL TRANSDUCTION; TELOMERE; ANIMAL; CELL CULTURE; CELL DEATH; CHROMOSOME; CYTOLOGY; DRUG EFFECT; EMBRYO (ANATOMY); GENE EXPRESSION PROFILING; METABOLISM; PATHOLOGY;

MUS;

ANIMALS; ARSENITES; CELL DEATH; CELL SURVIVAL; CELLS, CULTURED; CHROMOSOMAL INSTABILITY; CHROMOSOMES, MAMMALIAN; COMET ASSAY; DNA DAMAGE; DNA REPAIR; EMBRYO, MAMMALIAN; FIBROBLASTS; GENE EXPRESSION PROFILING; IN SITU HYBRIDIZATION, FLUORESCENCE; MICE; MICROARRAY ANALYSIS; MICRONUCLEI, CHROMOSOME-DEFECTIVE; OXIDATIVE STRESS; RNA; TELOMERASE; TELOMERE;

EID: 38449097944     PISSN: 00219541     EISSN: None     Source Type: Journal    
DOI: 10.1002/jcp.21276     Document Type: Article

References (42)

1. Banerjee M, Sarkar J, Das JK, Mukherjee A, Sarkar AK, Mondal L, Giri AK. 2007. Polymorphism in the ERCC2 codon 751 is associated with arsenic-induced premalignant hyperkeratosis and significant chromosome aberrations. Carcinogenesis 28:672-676.
2. Barrett JC, Lamb PW, Wang TC, Lee TC. 1989. Mechanisms of arsenic-induced cell transformation. Biol Trace Elem Res 21:421-429.
3. Blackburn EH. 1991a. Structure and function of telomeres. Nature 350:569-573.
4. Blackburn EH. 1991b. Telomeres. Trends Biochem Sci 16:378-381.
5. Blasco MA, Lee HW, Hande MP, Samper E, Lansdorp PM, DePinho RA, Greider CW. 1997. Telomere shortening and tumor formation by mouse cells lacking telomerase RNA. Cell 91:25-34.
6. Fagagna Fd, Hande MP, Tong WM, Lansdorp PM, Wang ZQ, Jackson SP. 1999. Functions of poly(ADP-ribose) polymerase in controlling telomere length and chromosomal stability. Nat Genet 23:76-80.
7. Fan SR, Ho IC, Yeoh FL, Lin CJ, Lee TC. 1996. Squalene inhibits sodium arsenite-induced sister chromatid exchanges and micronuclei in Chinese hamster ovary-K1 cells. Mutat Res 368:165-169.
8. Fenech M. 2002a. Biomarkers of genetic damage for cancer epidemiology. Toxicology 181-182:411-416.
9. Fenech M. 2002b. Chromosomal biomarkers of genomic instability relevant to cancer. Drug Discov Today 7:1128-1137.
10. Francia S, Weiss RS, Hande MP, Freire R, ddadi FF. 2006. Telomere and telomerase modulation by the mammalian Rad9/Rad1/Hus1 DNA-damage-checkpoint complex. Curr Biol 16:1551-1558.
11. Gilley D, Tanaka H, Hande MP, Kurimasa A, Li GC, Oshimura M, Chen DJ. 2001. DNA-PKcs is critical for telomere capping. Proc Natl Acad Sci USA 98:15084-15088.
12. Greider CW. 1999. Telomerase activation. One step on the road to cancer? Trends Genet 15:109-112.
13. Greider CW, Blackburn EH. 2004. Tracking telomerase. Cell 116:S83-S86.
14. Greulich KM, Kreja L, Heinze B, Rhein AP, Weier HG, Bruckner M, Fuchs P, Molls M. 2000. Rapid detection of radiation-induced chromosomal aberrations in lymphocytes and hematopoietic progenitor cells by mFISH. Mutat Res 452:73-81.
15. Hande MP, Boei JJ, Natarajan AT. 1996. Induction and persistence of cytogenetic damage in mouse splenocytes following whole-body X-irradiation analysed by fluorescence in situ hybridization. II. Micronuclei. Int J Radiat Biol 70:375-383.
16. Hande MP, Boei JJ, Natarajan AT. 1997. Induction and persistence of cytogenetic damage in mouse splenocytes following whole-body X-irradiation analysed by fluorescence in situ hybridization. III. Chromosome malsegregation/aneuploidy. Mutagenesis 12:125-131.
17. Hande MP, Samper E, Lansdorp P, Blasco MA. 1999. Telomere length dynamics and chromosomal instability in cells derived from telomerase null mice. J Cell Biol 144:589-601.
18. Hande MP, Balajee AS, Tchirkov A, Wynshaw-Boris A, Lansdorp PM. 2001. Extrachromosomal telomeric DNA in cells from Atm(-/-) mice and patients with ataxia-telangiectasia. Hum Mol Genet 10:519-528.
19. Hande MP, Azizova TV, Geard CR, Burak LE, Mitchell CR, Khokhryakov VF, Vasilenko EK, Brenner DJ. 2003. Past exposure to densely ionizing radiation leaves a unique permanent signature in the genome. Am J Hum Genet 72:1162-1170.
20. Hande MP, Azizova TV, Burak LE, Khokhryakov VF, Geard CR, Brenner DJ. 2005. Complex chromosome aberrations persist in individuals many years after occupational exposure to densely ionizing radiation: An mFISH study. Genes Chromosomes Cancer 44:1-9.
21. Hei TK, Liu SX, Waldren C. 1998. Mutagenicity of arsenic in mammalian cells: Role of reactive oxygen species. Proc Natl Acad Sci USA 95:8103-8107.
22. Karagas MR, Tosteson TD, Morris JS, Demidenko E, Mott LA, Heaney J, Schned A. 2004. Incidence of transitional cell carcinoma of the bladder and arsenic exposure in New Hampshire. Cancer Causes Control 15:465-472.
23. Kessel M, Liu SX, Xu A, Santella R, Hei TK. 2002. Arsenic induces oxidative DNA damage in mammalian cells. Mol Cell Biochem 234-235:301-308.
24. Kitchin KT. 2001. Recent advances in arsenic carcinogenesis: Modes of action, animal model systems, and methylated arsenic metabolites. Toxicol Appl Pharmacol 172:249-261.
25. Kitchin KT, Ahmad S. 2003. Oxidative stress as a possible mode of action for arsenic carcinogenesis. Toxicol Lett 137:3-13.
26. Lee TC, Oshimura M, Barrett JC. 1985. Comparison of arsenic-induced cell transformation, cytotoxicity, mutation and cytogenetic effects in Syrian hamster embryo cells in culture. Carcinogenesis 6:1421-1426.
27. Lee HW, Blasco MA, Gottlieb GJ, Horner JW, Greider CW, DePinho RA. 1998. Essential role of mouse telomerase in highly proliferative organs. Nature 392:569-574.
28. Leonard A, Lauwerys RR. 1980. Carcinogenicity, teratogenicity and mutagenicity of arsenic. Mutat Res 75:49-62.
29. Liu L, Trimarchi JR, Navarro P, Blasco MA, Keefe DL. 2003. Oxidative stress contributes to arsenic-induced telomere attrition, chromosome instability, and apoptosis. J Biol Chem 278:31998-32004.
30. Moore MM, Harrington-Brock K, Doerr CL. 1997. Relative genotoxic potency of arsenic and its methylated metabolites. Mutat Res 386:279-290.
31. Oikawa S, Kawanishi S. 1999. Site-specific DNA damage at GGG sequence by oxidative stress may accelerate telomere shortening. FEBS Lett 453:365-368.
32. Opresko PL, Fan J, Danzy S, Wilson DM III, Bohr VA. 2005. Oxidative damage in telomeric DNA disrupts recognition by TRF1 and T RF2. Nucleic Acids Res 33:1230-1239.
33. Petersen S, Saretzki G, von ZT. 1998. Preferential accumulation of single-stranded regions in telomeres of human fibroblasts. Exp Cell Res 239:152-160.
34. Poonepalli A, Balakrishnan L, Khaw AK, Low GK, Jayapal M, Bhattacharjee RN, Akira S, Balajee AS, Hande MP. 2005. Lack of poly(ADP-ribose) polymerase-1 gene product enhances cellular sensitivity to arsenite. Cancer Res 65:10977-10983.
35. Rubio MA, Davalos AR, Campisi J. 2004. Telomere length mediates the effects of telomerase on the cellular response to genotoxic stress. Exp Cell Res 298:17-27.
36. Sharma GG, Gupta A, Wang H, Scherthan H, Dhar S, Gandhi V, Iliakis G, Shay JW, Young CS, Pandita TK. 2003. hTERT associates with human telomeres and enhances genomic stability and DNA repair. Oncogene 22:131-146.
37. Shay JW, Bacchetti S. 1997. A survey of telomerase activity in human cancer. Eur J Cancer 33:787-791.
38. Tong WM, Hande MP, Lansdorp PM, Wang ZQ. 2001. DNA strand break-sensing molecule poly(ADP-Ribose) polymerase cooperates with p53 in telomere function, chromosome stability, and tumor suppression. Mol Cell Biol 21:4046-4054.
39. von Zglinicki T. 2000. Role of oxidative stress in telomere length regulation and replicative senescence. Ann N Y Acad Sci 908:99-110.
40. von Zglinicki T. 2002. Oxidative stress shortens telomeres. Trends Biochem Sci 27: 339-344.
41. Zhang TC, Schmitt MT, Mumford JL. 2003. Effects of arsenic on telomerase and telomeres in relation to cell proliferation and apoptosis in human keratinocytes and leukemia cells in vitro. Carcinogenesis 24:1811-1817.
42. Zijlmans JM, Martens UM, Poon SS, Raap AK, Tanke HJ, Ward RK, Lansdorp PM. 1997. Telomeres in the mouse have large inter-chromosomal variations in the number of T2AG3 repeats. Proc Natl Acad Sci USA 94:7423-7428.