Probing the aurone scaffold against Plasmodium falciparum: Design, synthesis and antimalarial activity

European Journal of Medicinal Chemistry

Volumn 80, Issue , 2014, Pages 523-534

  Carrasco, Marta P ^a   Newton, Ana S ^a   Gonçalves, Lídia ^a   Góis, Ana ^b   Machado, Marta ^c   Gut, Jiri ^d   Nogueira, Fátima ^c   Hänscheid, Thomas ^b   Guedes, Rita C ^a   Dos Santos, Daniel J V A ^a   Rosenthal, Philip J ^d   Moreira, Rui ^a  

^a RESEARCH INSTITUTE FOR MEDICINES IMED ULISBOA   (Portugal)

^b INSTITUTO DE MEDICINA MOLECULAR   (Portugal)

^c INSTITUTO DE HIGIENE E MEDICINA TROPICAL   (Portugal)

^d UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Aurones; Cross coupling reactions; Malaria; Plasmodium falciparum

Indexed keywords

2 (2 BROMOBENZYLIDENE)BENZOFURAN 3(2H) ONE; 2 (2,4 DICHLOROBENZYLIDENE) 6 HYDROXYBENZOFURAN 3(2H) ONE; 2 (2,4 DICHLOROBENZYLIDENE) 7 METHOXYBENZOFURAN 3(2H) ONE; 2 (2,4 DICHLOROBENZYLIDENE)BENZOFURAN 3(2H) ONE; 2 (2,4 DIFLUOROBENZYLIDENE) 6 HYDROXYBENZOFURAN 3(2H) ONE; 2 (2,4 DIFLUOROBENZYLIDENE) 7 METHOXYBENZOFURAN 3(2H) ONE; 2 (2,4 DIFLUOROBENZYLIDENE)BENZOFURAN 3(2H) ONE; 2 (3 BROMOBENZYLIDENE)BENZOFURAN 3(2H) ONE; 2 (3,4,5 TRIMETHOXYBENZYLIDENE)BENZOFURAN 3(2H) ONE; 2 (4 BENZYLBENZYLIDENE)BENZOFURAN 3(2H) ONE; 2 (4 BROMOBENZYLIDENE)BENZOFURAN 3(2H) ONE; 2 (BIPHENYL 4 YLMETHYLENE)BENZOFURAN 3(2H) ONE; 2 BENZYLIDENE 6 HYDROXYBENZOFURAN 3(2H) ONE; 2 BENZYLIDENE 7 METHOXYBENZOFURAN 3(2H) ONE; 2 BENZYLIDENEBENZOFURAN 3(2H) ONE; 2 [(4' CHLOROBIPHENYL 4 YL)METHYLENE]BENZOFURAN 3(2H) ONE; 2 [(4' FLUOROBIPHENYL 4 YL)METHYLENE]BENZOFURAN 3(2H) ONE; 2 [4 (4 CHLOROPHENOXY)BENZYLIDENE]BENZOFURAN 3(2H) ONE; 2 [4 (4 CHLOROPHENOXY)BENZYLIDINE] 6 HYDROXYBENZOFURAN 3(2H) ONE; 2 [4 (4 TOLYLOXY)BENZYLIDENE]BENZOFURAN 3(2H) ONE; 2 [4 (DIMETHYLAMINO)BENZYLIDENE] 6 HYDROXYBENZOFURAN 3(2H) ONE; 2 [4 (DIMETHYLAMINO)BENZYLIDENE]BENZOFURAN 3(2H) ONE; 4' [(3 OXOBENZOFURAN 2(3H) YLIDENE)METHYL]BIPHENYL 4 CARBALDEHYDE; 6 HYDROXY 2 (3,4,5 TRIMETHOXYBENZYLIDENE)BENZOFURAN 3(2H) ONE; 6 HYDROXY 2 [4 (4 TOLYLOXY)BENZYLIDENE]BENZOFURAN 3(2H) ONE; 7 METHOXY 2 (3,4,5 TRIMETHOXYBENZYLIDENE)BENZOFURAN 3(2H) ONE; ANTIMALARIAL AGENT; BENZOFURAN DERIVATIVE; CHLOROQUINE; UNCLASSIFIED DRUG; UNINDEXED DRUG; AURONE;

ALDOL REACTION; ANTIMALARIAL ACTIVITY; ARTICLE; CATALYSIS; CELL VACUOLE; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG DESIGN; DRUG POTENCY; DRUG RESISTANCE; DRUG SYNTHESIS; EMBRYO; HEK293 CELL LINE; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; MALARIA FALCIPARUM; MICROWAVE RADIATION; NONHUMAN; PLASMODIUM FALCIPARUM; SUZUKI REACTION; CELL SURVIVAL; CHEMISTRY; CYTOLOGY; DRUG EFFECTS; DRUG INTERACTION; IC50; TOXICITY; TUMOR CELL LINE;

ANTIMALARIALS; BENZOFURANS; CELL LINE, TUMOR; CELL SURVIVAL; DRUG DESIGN; DRUG INTERACTIONS; HUMANS; INHIBITORY CONCENTRATION 50; PLASMODIUM FALCIPARUM; VACUOLES;

EID: 84899988228     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2014.04.076     Document Type: Article

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