Novel antimalarial aminoquinolines: Heme binding and effects on normal or Plasmodium falciparum-parasitized human erythrocytes

Antimicrobial Agents and Chemotherapy

Volumn 53, Issue 10, 2009, Pages 4339-4344

  Omodeo Salè, Fausta ^a,b   Cortelezzi, Lucia ^a   Basilico, Nicoletta ^a   Casagrande, Manolo ^a   Sparatore, Anna ^a   Taramelli, Donatella ^a  

^a UNIVERSITY OF MILAN   (Italy)

^b Facolta di Farmacia   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

AMINOQUINOLINE DERIVATIVE; ANTIMALARIAL AGENT; AP 4B; CHLOROQUINE; ETHYLPHOSPHONOTHIOIC ACID S DIETHYLAMINOETHYL O ETHYL ESTER; HEMATIN; HEME; HEMOZOIN; UNCLASSIFIED DRUG;

ANTIMALARIAL ACTIVITY; ARTICLE; CELL DENSITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DISEASE MODEL; DRUG EFFICACY; DRUG PROTEIN BINDING; DRUG UPTAKE; ERYTHROCYTE; ERYTHROCYTE ADHESIVENESS; ERYTHROCYTE MEMBRANE; HEMOLYSIS; HUMAN; HUMAN CELL; HYDROPHOBICITY; IN VITRO STUDY; IN VIVO STUDY; INTERNALIZATION; LIPOPHILICITY; MALARIA FALCIPARUM; MEMBRANE STABILIZATION; PLASMODIUM FALCIPARUM; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; PROTEIN SYNTHESIS INHIBITION;

AMINOQUINOLINES; ANTIMALARIALS; CELLS, CULTURED; ERYTHROCYTES; HEME; HUMANS; MALARIA, FALCIPARUM; MOLECULAR STRUCTURE; PLASMODIUM FALCIPARUM;

EID: 70349320509     PISSN: 00664804     EISSN: 10986596     Source Type: Journal    
DOI: 10.1128/AAC.00536-09     Document Type: Article

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