Design, synthesis and AChE inhibitory activity of indanone and aurone derivatives

European Journal of Medicinal Chemistry

Volumn 44, Issue 1, 2009, Pages 7-17

  Sheng, Rong ^a   Xu, Yu ^a   Hu, Chunqi ^a   Zhang, Jing ^a   Lin, Xiao ^a   Li, Jingya ^b   Yang, Bo ^a   He, Qiaojun ^a   Hu, Yongzhou ^a  

^a ZHEJIANG UNIVERSITY   (China)

^b National Center for Drug Screening   (China)

Author keywords

AChE inhibitory activity; Aurone; Indanone; Synthesis

Indexed keywords

2 [4 [(DIETHYLAMINO)METHYL]BENZYLIDENE] 5,6 DIMETHOXY 2,3 DIHYDROINDEN 1 ONE; ACETYLCHOLINESTERASE; AURONE DERIVATIVE; CHOLINESTERASE INHIBITOR; DONEPEZIL; INDANONE DERIVATIVE; RIVASTIGMINE; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG DESIGN; DRUG EFFECT; DRUG EFFICACY; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; IC 50; MEMORY DISORDER; MOUSE; NONHUMAN; RAT;

ANIMALS; BENZOFURANS; CHOLINESTERASE INHIBITORS; DRUG DESIGN; INDANS; MEMORY; MICE; PAIN; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 57949086050     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2008.03.003     Document Type: Article

References (23)

1. Debomoy K.L., Martin R.F., Nigel H.G., and Kumar S. Drug Dev. Res. 56 (2003) 267-281
2. Sussman J.L., Harel M., Frolow F., Oefner C., Goldman A., Toker L., and Silman I. Science 253 (1991) 872-879
3. Hardy J., and Selkoe D.J. Science 297 (2002) 353-356
4. De Ferrari G.V., Canales M.A., Shin I., Weiner L.V., Silman I., and Inestrosa N.C. Biochemistry 40 (2001) 10447-10457
5. Bartolini M., Bertucci C., Cavrini C., and Andrisano V. Biochem. Pharmacol. 65 (2003) 407-416
6. Piazzi L., Rampa A., Bisi A., Gobbi S., Belluti F., Cavalli A., Bartolini M., Andrisano V., Valenti P., and Recanatini M. J. Med. Chem. 46 (2003) 2279-2282
7. He X.C., Feng S., Wang Z.F., Shi Y.F., Zheng S.X., Xia Y., Jiang H.L., Tang X.C., and Bai D.L. Bioorg. Med. Chem. 15 (2007) 1394-1408
8. Tang H., Ning F.X., Wei Y.B., Huang S.L., Huang Z.S., Chan A.S.C., and Gu L.Q. Bioorg. Med. Chem. Lett. 17 (2007) 3765-3768
9. Senapati S., Cheng Y.H., and McCammon J.A. J. Med. Chem. 49 (2006) 6222-6230
10. Sheng R., Lin X., Li J.Y., Jiang Y.K., Shang Z.C., and Hu Y.Z. Bioorg. Med. Chem. Lett. 15 (2005) 3834-3838
11. Masahiro O., Mamoru H., Hiroshi M., and Morio N. Bioorg. Med. Chem. 15 (2007) 6802-6809
12. Masahiro O., Yoshifumi M., Mamoru H., Kazuhiro I., Hiroshi M., and Morio N. Biochem. Biophys. Res. Commun. 361 (2007) 116-121
13. Dvornikovs V., and Smithrud D.B. J. Org. Chem. 67 (2002) 2160-2167
14. George Z., Gregory R.H., and Timothy M.S. J. Org. Chem. 52 (1987) 5486-5487
15. John K. J. Am. Chem. Soc. 75 (1953) 1891-1895
16. Jones G.H., Mackenzie J.B.D., Robertson A., and Whalley W.B. J. Chem. Soc. (1949) 562-569
17. Beney C., Mariotte A.M., and Boumendjel A. Heterocycles 55 (2001) 967-972
18. Varma R.S., and Varma M. Tetrahedron Lett. 33 (1992) 5937-5940
19. Kevill D.N., Weiler E.D., and Cromwell N.H. J. Org. Chem. 29 (1964) 1276-1278
20. Cheng D.H., and Tang X.C. Pharmacol. Biochem. Behav. 60 (1998) 377-386
21. Xu S.Y., Bian R.L., and Chen X. Methodology of Pharmacology Experiments (2002), People's Medical Publishing House, Beijing pp. 826-827
22. Morris G.M., Goodsell D.S., Halliday R.S., Huey R., Hart W.E., Belew R.K., and Olson A.J. J. Comput. Chem. 19 (1998) 1639-1662
23. Aizpurua J.M., Lecea B., and Palomo C. Can. J. Chem. 64 (1986) 2342-2347