1-Azaaurones derived from the naturally occurring aurones as potential antimalarial drugs

Bioorganic and Medicinal Chemistry

Volumn 18, Issue 15, 2010, Pages 5724-5731

  Souard, Florence ^a   Okombi, Sabrina ^a   Beney, Chantal ^a   Chevalley, Séverine ^b   Valentin, Alexis ^b   Boumendjel, Ahcne ^b  

^a UNIV GRENOBLE ALPES   (France)

^b UNIVERSITÉ DE TOULOUSE   (France)

Author keywords

Aurones; Azaaurones; Malaria; Plasmodium falciparum

Indexed keywords

2 (2 CHLORO 6 FLUOROBENZYLIDENE) 4,6 DIMETHOXY 2,3 DIHYDRO 1H INDOL 3 ONE; 2 (2 CHLOROBENZYLIDENE) 4,6 DIMETHOXY 2,3 DIHYDRO 1H INDOL 3 ONE; 2 (2 ETHYLBENZYLIDENE) 4,6 DIMETHOXY 2,3 DIHYDRO 1H INDOL 3 ONE; 2 (2,3,5,6 TETRAMETHYLBENZYLIDENE) 4,6 DIMETHOXY 2,3 DIHYDRO 1H INDOL 3 ONE; 2 (2,4 DICHLOROBENZYLIDENE) 4,6 DIMETHOXY 2,3 DIHYDRO 1H INDOL 3 ONE; 2 (2,4 DIMETHYLBENZYLIDENE) 4,6 DIMETHOXY 2,3 DIHYDRO 1H INDOL 3 ONE; 2 (2,4,5 TRIMETHYLBENZYLIDENE) 4,6 DIMETHOXY 2,3 DIHYDRO 1H INDOL 3 ONE; 2 (2,6 DIMETHYLBENZYLIDENE) 4,6 DIMETHOXY 2,3 DIHYDRO 1H INDOL 3 ONE; 2 (4 BROMOBENZYLIDENE) 4,6 DIMETHOXY 2,3 DIHYDRO 1H INDOL 3 ONE; 2 (4 BROMOBENZYLIDENE) 4,6 DIMETHOXYBENZOFURAN 3(2H)ONE; 2 (4 BUTYLBENZYLIDENE) 4,6 DIMETHOXYBENZOFURAN 3(2H)ONE; 2 (4 CHLOROBENZYLIDENE) 4,6 DIMETHOXY 2,3 DIHYDRO 1H INDOL 3 ONE; 2 (4 ETHYLBENZYLIDENE) 6 HYDROXYBENZOFURAN 3(2H)ONE; 2 (4 FLUOROBENZYLIDENE) 4,6 DIMETHOXYBENZOFURAN 3(2H)ONE; 2 (4 HYDROXYBENZYLIDENE) 6 HYDROXYBENZOFURAN 3(2H)ONE; 2 (4 ISOPROPYLBENZYLIDENE) 4,6 DIMETHOXY 2,3 DIHYDRO 1H INDOL 3 ONE; 2 (4 METHOXYBENZYLIDENE) 6 HYDROXYBENZOFURAN 3(2H)ONE; 2 (4 PHENYLBENZYLIDENE) 6 HYDROXYBENZOFURAN 3(2H)ONE; 2 (4 TERT BUTHYLBENZYLIDENE) 4,6 DIMETHOXY 2,3 DIHYDRO 1H INDOL 3 ONE; 2 (4 TERT BUTYLBENZYLIDENE) 4,6 DIMETHOXYBENZOFURAN 3 (2H)ONE; 2 BENZYLIDENE 4,6 DIHYDROXYBENZOFURAN 3(2H)ONE; 2 BENZYLIDENE 4,6 DIMETHOXYBENZOFURAN 3(2H)ONE; 4,6 DIHYDROXY 2 (2 ETHYLBENZYLIDENE)BENZOFURAN 3(2H)ONE; 4,6 DIHYDROXY 2 (4 ETHYLBENZYLIDENE)BENZOFURAN 3(2H)ONE; 4,6 DIHYDROXY 2 (4 METHYLBENZYLIDENE)BENZOFURAN 3(2H)ONE; 4,6 DIMETHOXY 2 (PYRIDIN 4 YLMETHYLENE)BENZOFURAN 3(2H)ONE; 4,6 DIMETHOXY 4' ETHYLAZAAURONE; ANTIMALARIAL AGENT; CHLOROQUINE; UNCLASSIFIED DRUG; UNINDEXED DRUG; (Z)-2-(4-ETHYLBENZYLIDENE)-4,6-DIMETHOXY-2,3-DIHYDRO-1H-INDOL-3-ONE; AURONE; BENZOFURAN DERIVATIVE; HETEROCYCLIC COMPOUND; INDOLE DERIVATIVE;

ANIMAL EXPERIMENT; ANTIMALARIAL ACTIVITY; ANTIMALARIAL DRUG RESISTANCE; ARTICLE; CELL CULTURE; CONTROLLED STUDY; DRUG ACTIVITY; DRUG DESIGN; DRUG POTENCY; DRUG SYNTHESIS; ERYTHROCYTE; FEMALE; HUMAN; HUMAN CELL; IN VITRO STUDY; MOUSE; NONHUMAN; PLASMODIUM FALCIPARUM; STRUCTURE ACTIVITY RELATION; CHEMISTRY; DRUG EFFECTS; PARASITOLOGY; SYNTHESIS;

PLASMODIUM FALCIPARUM;

ANTIMALARIALS; AZA COMPOUNDS; BENZOFURANS; ERYTHROCYTES; HUMANS; INDOLES; PLASMODIUM FALCIPARUM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 77955428448     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2010.06.008     Document Type: Article

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