4-Hydroxy-6-methoxyaurones with high-affinity binding to cytosolic domain of P-glycoprotein

Chemical and Pharmaceutical Bulletin

Volumn 50, Issue 6, 2002, Pages 854-856

  Boumendjel, Ahcène ^a   Beney, Chantal ^a   Deka, Nabajyoti ^a   Mariotte, Anne Marie ^a   Lawson, Martin Ata ^a   Trompier, Doriane ^b   Baubichon Cortay, Hélène ^b   Di Pietro, Attilio ^b  

^a Université Joseph Fourier   (France)

^b INSTITUT DE BIOLOGIE ET CHIMIE DES PROTÉINES   (France)

Author keywords

Aurone; Binding affinity; Multidrug resistance; P glycoprotein

Indexed keywords

(4' BROMOBENZYLIDENE) 4 HYDROXY 6 METHOXYBENZOFURAN 3(2H)ONE; (4' CHLOROBENZYLIDENE) 4 HYDROXY 6 METHOXYBENZOFURAN 3(2H)ONE; (4' CYANOBENZYLIDENE) 4 HYDROXY 6 METHOXYBENZOFURAN 3(2H)ONE; (4' CYANOBENZYLIDENE) 4,6 DIMETHOXYBENZOFURAN 3(2H)ONE; (4' FLUOROBENZYLIDENE) 4 HYDROXY 6 METHOXYBENZOFURAN 3(2H)ONE; (4' IODOOBENZYLIDENE) 4 HYDROXY 6 METHOXYBENZOFURAN 3(2H)ONE; 4,6 DIMETHOXY (4'IODOBENZYLIDENE)BENZOFURAN 3(2H)ONE; BENZYLIDENE 4 HYDROXY 6 METHOXYBENZOFURAN 3(2H)ONE; FURANONE DERIVATIVE; GLYCOPROTEIN P; UNCLASSIFIED DRUG; 4' BROMO 4 HYDROXY 6 METHOXYAURONE; 4'-BROMO-4-HYDROXY-6-METHOXYAURONE; BENZOFURAN DERIVATIVE;

ARTICLE; BINDING AFFINITY; CYTOSOL; DRUG BINDING SITE; DRUG PROTEIN BINDING; DRUG STRUCTURE; DRUG SYNTHESIS; PROTEIN DOMAIN; STRUCTURE ACTIVITY RELATION; BINDING SITE; CHEMISTRY; DRUG EFFECT; DRUG RESISTANCE; METABOLISM; PHYSIOLOGY; PROTEIN TERTIARY STRUCTURE; SYNTHESIS;

BENZOFURANS; BINDING SITES; CYTOSOL; DRUG RESISTANCE, NEOPLASM; P-GLYCOPROTEIN; PROTEIN STRUCTURE, TERTIARY;

EID: 0036595526     PISSN: 00092363     EISSN: 13475223     Source Type: Journal    
DOI: 10.1248/cpb.50.854     Document Type: Article

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