Discovery of naturally occurring aurones that are potent allosteric inhibitors of hepatitis C virus RNA-dependent RNA polymerase

Journal of Medicinal Chemistry

Volumn 54, Issue 15, 2011, Pages 5395-5402

  Haudecoeur, Romain ^a   Ahmed Belkacem, Abdelhakim ^b   Yi, Wei ^a   Fortuné, Antoine ^a   Brillet, Rozenn ^b   Belle, Catherine ^c   Nicolle, Edwige ^a   Pallier, Coralie ^b,d   Pawlotsky, Jean Michel ^b   Boumendjel, Ahcène ^a  

^a Université Joseph Fourier   (France)

^b HENRI MONDOR HOSPITAL   (France)

^c UNIV GRENOBLE ALPES   (France)

^d BICÊTRE HOSPITAL   (France)

Author keywords

[No Author keywords available]

Indexed keywords

2 BENZYLIDENEBENZOFURAN 3 ONE; 2 [(1 BUTYL 1H INDOL 3 YL)METHYLENE] 4,6 DIHYDROXYBENZOFURAN 3 (2H)ONE; RNA DIRECTED RNA POLYMERASE; RNA DIRECTED RNA POLYMERASE INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DRUG BINDING; DRUG CYTOTOXICITY; DRUG IDENTIFICATION; DRUG POTENCY; DRUG SELECTIVITY; DRUG TARGETING; ENZYME ASSAY; HEPATITIS C VIRUS; HUMAN; HUMAN CELL; IC 50; INHIBITION KINETICS; MOLECULAR DOCKING; SITE DIRECTED MUTAGENESIS;

EID: 79961245561     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm200242p     Document Type: Article

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