Aurones as Modulators of ABCG2 and ABCB1: Synthesis and Structure-Activity Relationships

ChemMedChem

Volumn 6, Issue 4, 2011, Pages 713-724

  Sim, Hong May ^a   Loh, Ker Yun ^a   Yeo, Wee Kiang ^a,b   Lee, Chong Yew ^a   Go, Mei Lin ^a  

^a NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^b NOVARTIS INSTITUTE FOR TROPICAL DISEASES   (Singapore)

Author keywords

ABCB1; ABCG2; Aurones; Free Wilson analysis; Modulators; Structure activity relationships

Indexed keywords

4,5,6 TRIMETHOXYAURONE DERIVATIVE; 4,6 DIMETHOXYAURONE DERIVATIVE; 4,6 DIMETHOXYAZAAURONE DERIVATIVE; 4,6 DIMETHOXYINDANONE DERIVATIVE; 5,7 DIMETHOXYFLAVONE DERIVATIVE; AURONE DERIVATIVE; BREAST CANCER RESISTANCE PROTEIN; CALCEIN; FLAVONOID; FUMITREMORGIN C; MULTIDRUG RESISTANCE PROTEIN 1; PHEOPHORBIDE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; CHEMICAL BOND; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG TARGETING; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; NONHUMAN; PHARMACOPHORE; PRIORITY JOURNAL; PROTEIN MODIFICATION; PROTEIN PROTEIN INTERACTION; STEREOCHEMISTRY; STRUCTURE ACTIVITY RELATION;

ANTINEOPLASTIC AGENTS; ATP-BINDING CASSETTE TRANSPORTERS; BENZOFURANS; CELL LINE, TUMOR; DRUG RESISTANCE, NEOPLASM; HUMANS; NEOPLASM PROTEINS; P-GLYCOPROTEIN; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 79953058073     PISSN: 18607179     EISSN: 18607187     Source Type: Journal    
DOI: 10.1002/cmdc.201000520     Document Type: Article

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