Intra-arterial interleukin-12 gene delivery combined with chemoembolization: Anti-tumor effect in a rabbit hepatocellular carcinoma (HCC) model

Acta Radiologica

Volumn 54, Issue 6, 2013, Pages 684-689

  Xia, Xiangwen ^a   Li, Xin ^a   Feng, Gansheng ^a   Zheng, Chuansheng ^a   Liang, Huimin ^a   Zhou, Guofeng ^a  

^a HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

Anti tumor; Apoptotic index; Chemoembolization; Gene therapy; Interleukin 12; Liver cancer

Indexed keywords

COMPUTERIZED TOMOGRAPHY; DISEASES; GENE THERAPY; GENE TRANSFER; GROWTH RATE; LIVER;

ANTI-TUMORS; APOPTOTIC; CHEMOEMBOLIZATION; INTERLEUKIN-12; LIVER CANCERS;

TUMORS;

ETHIODIZED OIL; INTERLEUKIN 12; MITOMYCIN;

ANALYSIS OF VARIANCE; ANIMAL; ANTI-TUMOR; APOPTOSIS; APOPTOTIC INDEX; ARTICLE; CHEMOEMBOLIZATION; COMPARATIVE STUDY; COMPUTER ASSISTED TOMOGRAPHY; GENE THERAPY; HEPATIC ARTERY; INTRAARTERIAL DRUG ADMINISTRATION; LIVER CANCER; LIVER CELL CARCINOMA; LIVER TUMOR; METHODOLOGY; NICK END LABELING; RABBIT; RANDOMIZATION;

ANTI-TUMOR; APOPTOTIC INDEX; CHEMOEMBOLIZATION; GENE THERAPY; INTERLEUKIN-12; LIVER CANCER;

ANALYSIS OF VARIANCE; ANIMALS; APOPTOSIS; CARCINOMA, HEPATOCELLULAR; CHEMOEMBOLIZATION, THERAPEUTIC; ETHIODIZED OIL; GENETIC THERAPY; HEPATIC ARTERY; IN SITU NICK-END LABELING; INFUSIONS, INTRA-ARTERIAL; INTERLEUKIN-12; LIVER NEOPLASMS, EXPERIMENTAL; MITOMYCIN; RABBITS; RANDOM ALLOCATION; TOMOGRAPHY, X-RAY COMPUTED;

EID: 84886631100     PISSN: 02841851     EISSN: 16000455     Source Type: Journal    
DOI: 10.1177/0284185113480072     Document Type: Article

References (37)

1. Carr BI. Hepatic artery chemoembolization for advanced stage HCC: experience of 650 patients. Hepatogastroenterology 2002;49:79-86.
2. Murata S, Tajima H, Ichikawa K, et al. Oily chemoembolization combined with degradable starch microspheres for HCC with cirrhosis. Hepatogastroenterology 2008;55:1041-6.
3. Forner A, Llovet JM, Bruix J. Chemoembolization for intermediate HCC: Is there proof of survival benefit? J Hepatol 2011;56:984-6.
4. Gerolami R, Uch R, Brechot C, et al. Gene therapy of hepatocarcinoma: A long way from the concept to the therapeutical impact. Cancer Gene Ther 2003;10:649-60.
5. Graepler F, Verbeek B, Graeter T, et al. Combined endostatin/sFlt-1 antiangiogenic gene therapy is highly effective in a rat model of HCC. Hepatology 2005;41:879-86.
6. Imagawa Y, Satake K, Kato Y, et al. Antitumor and antiangiogenic effects of interleukin 12 gene therapy in murine head and neck carcinoma model. Auris Nasus Larynx 2004;31:239-45.
7. Sangro B, Herraiz M, Prieto J. Gene therapy of neoplastic liver diseases. Int J Biochem Cell Biol 2003;35:135-48.
8. Barajas M, Mazzolini G, Genove G, et al. Gene therapy of orthotopic hepatocellular carcinoma in rats using adenovirus coding for interleukin 12. Hepatology 2001;33:52-61.
9. Itoh H, Sashihara T, Hosono A, et al. Interleukin-12 inhibits development of ectopic endometriotic tissues in peritoneal cavity via activation of NK cells in a murine endometriosis model. Cytotechnology 2011;63:133-41.
10. Kanagawa N, Gao JQ, Motomura Y, et al. Antitumor mechanism of intratumoral injection with IL-12-expressing adenoviral vector against IL-12-unresponsive tumor. Biochem Biophys Res Commun 2008;372:821-5.
11. Kremer M, Thomas E, Milton RJ, et al. Kupffer cell and interleukin-12-dependent loss of natural killer T cells in hepatosteatosis. Hepatology 2010;51:130-41.
12. Chen L, Chen D, Block E, et al. Eradication of murine bladder carcinoma by intratumor injection of a bicistronic adenoviral vector carrying cDNAs for the IL-12 heterodimer and its inhibition by the IL-12 p40 subunit homodimer. J Immunol 1997;159:351-9.
13. Leonard JP, Sherman ML, Fisher GL, et al. Effects of single-dose interleukin-12 exposure on interleukin-12-associated toxicity and interferon-gamma production. Blood 1997;90:2541-8.
14. Kim YI, Chung JW, Park JH, et al. Intraarterial gene delivery in rabbit hepatic tumors: Transfection with nonviral vector by using iodized oil emulsion. Radiology 2006;240:771-7.
15. Xia XW, Li X, Feng GS, et al. Construction and expression of a human interleukin 12 double-submit co-expressing eukarya plasmid pEGFP-C1-IL-12. Acta Med Univ Sci Technol Huazhong 2009;38:83-6.
16. Xia XW, Li X, Feng GS, et al. Feasibility of a polysaccharide isolated from Bletilla striata used as a gene vector administered through an interventional pathway. World Chinese Journal of Digestology 2009;17:1832-5.
17. Xia XW, Li X, Feng GS, et al. Preparation and characterization of a non-viral gene vector from a polysaccharide isolated from the Chinese medicinal herb Bletilla striata. Chinese Pharmaceutical Journal 2008;43:1369-73.
18. Mao HQ, Roy K, Troung-Le VL, et al. Chitosan-DNA nanoparticles as gene carriers: synthesis, characterization and transfection efficiency. J Control Release 2001;70:399-421.
19. Sun X, Vale M, Jiang X, et al. Antisense HIF-1alpha prevents acquired tumor resistance to angiostatin gene therapy. Cancer Gene Ther 2010;17:532-40.
20. Wang ZX, Bian HB, Yang JS, et al. Adenovirus-mediated suicide gene therapy under the control of Cox-2 promoter for colorectal cancer. Cancer Biol Ther 2009;8:1480-8.
21. Wang C, Zhao Y. Application of gene therapy in tumor adoptive immunotherapy. Sheng Wu Yi Xue Gong Cheng Xue Za Zhi 2008;25: 482-6.
22. Mao CQ, Du JZ, Sun TM, et al. A biodegradable amphiphilic and cationic triblock copolymer for the delivery of siRNA targeting the acid ceramidase gene for cancer therapy. Biomaterials 2011;32:3124-33.
23. Delbende C, Verwaerde C, Mougel A, et al. Induction of therapeutic antibodies by vaccination against external loops of tumor-associated viral latent membrane protein. J Virol 2009;83:11734-45.
24. Ochsenbein AF. Immunological ignorance of solid tumors. Springer Semin Immunopathol 2005;27:19-35.
25. Stagg J, Johnstone RW, Smyth MJ. From cancer immunosurveillance to cancer immunotherapy. Immunol Rev 2007;220:82-101.
26. Stefani AL, Barzon L, Castagliuolo I, et al. Systemic efficacy of combined suicide/cytokine gene therapy in a murine model of hepatocellular carcinoma. J Hepatol 2005;42:728-35.
27. Ha SJ, Lee SB, Kim CM, et al. Rapid recruitment of macrophages in interleukin-12-mediated tumour regression. Immunology 1998;95: 156-63.
28. Harada N, Shimada M, Okano S, et al. IL-12 gene therapy is an effective therapeutic strategy for hepatocellular carcinoma in immunosuppressed mice. J Immunol 2004;173:6635-44.
29. Andrews KJ, Ribas A, Butterfield LH, et al. Adenovirus-interleukin-12- mediated tumor regression in a murine hepatocellular carcinoma model is not dependent on CD1-restricted natural killer T cells. Cancer Res 2000;60:6457-64.
30. Zabala M, Lasarte JJ, Perret C, et al. Induction of immunosuppressive molecules and regulatory T cells counteracts the antitumor effect of interleukin-12-based gene therapy in a transgenic mouse model of liver cancer. J Hepatol 2007;47:807-15.
31. Uehara K, Ichida T, Sugahara S, et al. Systemic administration of liposome-encapsulated OK-432 prolongs the survival of rats with hepatocellular carcinoma through the induction of IFN-gamma-producing hepatic lymphocytes. J Gastroenterol Hepatol 2002;17:81-90.
32. Nio Y, Nagami H, Tamura K, et al. Multi-institutional randomized clinical study on the comparative effects of intracavital chemotherapy alone versus immunotherapy alone versus immunochemotherapy for malignant effusion. Br J Cancer 1999;80:775-85.
33. Oka M, Hazama S, Yoshino S, et al. Intraarterial combined immunochemotherapy for unresectable hepatocellular carcinoma: preliminary results. Cancer Immunol Immunother 1994;38:194-200.
34. Maataoui A, Qian J, Vossoughi D, et al. Transarterial chemoembolization alone and in combination with other therapies: A comparative study in an animal HCC model. Eur Radiol 2005;15:127-33.
35. Cao W, Wan Y, Liang ZH, et al. Heated lipiodol as an embolization agent for transhepatic arterial embolization in VX2 rabbit liver cancer model. Eur J Radiol 2010;73:412-9.
36. Yoon CJ, Chung JW, Park JH, et al. Transcatheter arterial chemoembolization with paclitaxel-lipiodol solution in rabbit VX2 liver tumor. Radiology 2003;229:126-31.
37. Takayasu K, Arii S, Ikai I, et al. Overall survival after transarterial lipiodol infusion chemotherapy with or without embolization for unresectable hepatocellular carcinoma: propensity score analysis. Am J Roentgenol 2010;194:830-7.