Recruitment of hepatic NK cells by IL-12 is dependent on IFN-γ, and VCAM-1 and is rapidly down-regulated by a mechanism involving T cells and expression of Fas

Journal of Immunology

Volumn 161, Issue 11, 1998, Pages 6014-6021

  Fogler, William E ^a,e   Volker, Kirk ^b   Watanabe, Morihiro ^a   Wigginton, Jon M ^c   Roessler, Philip ^a   Brunda, Michael J ^d   Ortaldo, John R ^a   Wiltrout, Robert H ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b SAIC FREDERICK INC   (United States)

^c NATIONAL INSTITUTES OF HEALTH   (United States)

^d HOFFMANN LA ROCHE INC   (United States)

^e ENTREMED INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA INTERFERON; GAMMA INTERFERON; INTERLEUKIN 12; VASCULAR CELL ADHESION MOLECULE 1;

ANIMAL CELL; ANTIGEN SPECIFICITY; ARTICLE; CELL ISOLATION; COMBINED IMMUNODEFICIENCY; CYTOLYSIS; DISEASE PREDISPOSITION; DOWN REGULATION; GENE EXPRESSION; IMMUNE RESPONSE; IMMUNOTHERAPY; LIVER CELL; MOUSE; NONHUMAN; NORTHERN BLOTTING; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; T LYMPHOCYTE; VIRUS INFECTION;

ANIMALS; ANTIGENS, CD95; CELL MOVEMENT; CYTOTOXICITY, IMMUNOLOGIC; DOWN-REGULATION; FAS LIGAND PROTEIN; INTEGRIN ALPHA4BETA1; INTEGRINS; INTERCELLULAR ADHESION MOLECULE-1; INTERFERON TYPE II; INTERLEUKIN-12; INTERLEUKIN-2; KILLER CELLS, NATURAL; LIGANDS; LIVER; LYMPHOCYTE ACTIVATION; LYMPHOCYTE COUNT; MEMBRANE GLYCOPROTEINS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICE, SCID; RECEPTORS, LYMPHOCYTE HOMING; T-LYMPHOCYTE SUBSETS; VASCULAR CELL ADHESION MOLECULE-1;

EID: 0032400932     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (62)

1. Trinchieri, G. 1989. Biology of natural killer cells. Adv. Immunol. 47:187.
2. Biron, C. A. 1997. Activation and function of natural killer cells responses during viral infections. Curr. Opin. Immunol. 9:24.
3. Scott, P., and G. Trinchieri. 1995. The role of natural killer cells in host-parasite interactions. Curr. Opin. Immunol. 7:34.
4. Robertson, M. J., and J. Ritz. 1990. Biology and clinical relevance of human natural killer cells. Blood 76:2421.
5. Johnston, J. A., C. M. Bacon, M. C. Riedy, and J. J. O'Shea. 1996. Signaling by IL-2 and related cytokines: JAKs, STATs, and relationship to immunodeficiency. J. Leukocyte Biol. 60:441.
6. Moretta, L., M. C. Mirgani, D. Pevele, C. Bottino, R. Biassoni, and A. Moretta. 1996. The molecular basis of natural killer (NK) cell recognition and function. J. Clin. Immunol. 16:243.
7. Lanier, L. 1997. Natural killer cells: from no receptors to too many. Immunity 6:371.
8. Liu, C.-C., L. H. Y. Young, and J. D.-E. Young. 1996. Lymphocyte-mediated cytolysis and disease. N. Engl. J. Med. 335:1651.
9. Nagata, S. 1996. A death factor: the other side of the coin. Behring Inst. Mitt. 97:1.
10. Pilaro, A. M., D. D. Taub, K. L. McCormick, H. M. Williams, T. J. Sayers, W. E. Fogler, and R. H. Wiltrout. 1994. TNF-α is a principal cytokine involved in the recruitment of NK cells to liver parenchyma. J. Immunol. 153:333.
11. Fogler, W. E., K. Volker, K. L. McCormick, M. Watanabe, J. R. Ortaldo, and R. H. Wiltrout. 1996. NK cell infiltration into lung, liver and subcutaneous B16 melanoma is mediated by VCAM-1/VLA-4 interaction. J. Immunol. 156:4707.
12. Salazar-Mather, T. P., R. Ishikawa, and C. A. Biron. 1996. NK cell trafficking and cytokine expression in splenic compartments after IFN induction and viral infection. J. Immunol. 157:3054.
13. Wiltrout, R. H., A. M. Pilaro, M. E. Gruys, J. E. Talmadge, D. L. Longo, J. R. Ortaldo, and C. W. Reynolds. 1989. Augmentation of mouse liver-associated NK activity by biological response modifiers occurs largely via rapid recruitment of LGL from the bone marrow. J. Immunol. 143:372.
14. Ishikawa, R., and C. A. Biron. 1993. IFN induction and associated changes in splenic leukocyte distribution. J. Immunol. 150:3713.
15. Orange, J. S., and C. A. Biron. 1996. An absolute and restricted requirement for IL-12 in natural killer cell IFN-γ production and antiviral defense. J. Immunol. 156:1138.
16. Bukowski, J. F., B. A. Woda, S. Hubu, K. Okumura, and R. M. Welsh. 1983. Natural killer cell depletion enhances virus synthesis and virus-induced hepatitis in vivo. J. Immunol. 131:1531.
17. Habu, S., K. Akamatsu, H. Tamaoki, and K. Okumura. 1984. In vivo significance of NK cells on resistance against virus (HSV-1) infections in mice. J. Immunol. 133:2743.
18. Cousens, L. P., J. S. Orange, H. C. Su, and C. A. Biron. 1997. Interferon α/β inhibition of interleukin 12 and interferon-γ production in vitro and endogenously during viral infection. Proc. Natl. Acad. Sci. USA 94:634.
19. Trinchieri, G., and F. Gerosa. 1996. Immunoregulation of interleukin 12. J. Leukocyte Biol. 59: 59:505.
20. Bacon, C. M., D. W. McVicar, J. R. Ortaldo, R. C. Rees, J. J. O'Shea, and J. A. Johnson. 1995. Interleukin 12 (IL-12) induces tyrosine phosphorylation of JAK2 and TYK2: differential use of Janus family tyrosine kinases by IL-2 and IL-12. J. Exp. Med. 181:399.
21. Desai, B. B., P. M. Quinn, A. G. Wolitzky, P. K. Mongiri, R. Chizzonite, and M. K. Gately. 1992. IL-12 receptor. II. Distribution and regulation of receptor expression. J. Immunol. 148:3125.
22. Gately, M. K., D. E. Wilson, and H. L. Wong. 1996. Synergy between recombinant interleukin 2 (rIL-2) and IL-2-depleted lymphokine-containing supernatants in facilitating allogeneic human cytolytic T lymphocyte responses in vitro. J. Immunol. 136:1274.
23. Aste-Amezaga, M., A. D'Andrea, M. Kubin, and G. Trinchieri. 1994. Cooperation of natural killer cell stimulatory factor/interleukin-12 with other stimuli in the induction of cytokines and cytotoxic cell-associated molecules in human T and NK cells. Cell. Immunol. 156:480.
24. + T lymphocytes, and NK cells. J. Immunol. 149:3495.
25. Gately, M. K., B. B. Desai, A. G. Wolitzky, P. M. Quinn, C. M. Dwyer, F. J. Podlaski, P. C. Familletti, F. Sinigaglia, R. Chizonnite, and U. Gubler. 1991. Regulation of human lymphocyte proliferation by a heterodimeric cytokine, IL-12 (cytotoxic lymphocyte maturation factor). J. Immunol. 147:874.
26. Wigginton, J. M., K. L. Komschlies, T. C. Back, J. L. Franco, M. J. Brunda, and R. W. Wiltrout. 1996. Administration of interleukin-12 with pulse interleukin-2 induces rapid and complete regression of established tumor. J. Natl. Cancer Inst. 88:38.
27. Wigginton, J. M., D. B. Kuhns, T. C. Back, M. J. Brunda, R. H. Wiltrout, and G. W. Cox. 1996. Interleukin-12 primes macrophages for nitric oxide production in vivo and restores depressed nitric oxide production by macrophages from tumor-bearing mice: implications for the antitumor activity of interleukin 12 and/or interleukin-2. Cancer Res. 56:1131.
28. Zitvogel, L., H. Tahara, P. D. Robbins, W. J. Storkus, M. R. Clarke, M. A. Nalesnik, and M. T. Lotze. 1995. Cancer immunotherapy of established tumors with IL-12. Effective delivery by genetically engineered fibroblasts. J. Immunol. 155:1393.
29. Vaglianai, M., M. Rodolfo, F. Cavallo, M. Parenza, C. Melani, G. Parmiani, G. Forni, and M. P. Colombo. 1996. Interleukin 12 potentiates the curative effect of a vaccine based on interleukin 2-transduced tumor cells. Cancer Res. 56:467.
30. Brunda, M. T., L. Luitro, L. Rummenik, R. B. Wright, J. M. Wigginton, R. H. Wiltrout, J. A. Hendrzak, and A. V. Palleroni. 1996. Interleukin-12: murine models of a potent antitumor agent. Ann. NY Acad. Sci. 795:266.
31. Watanabe, M., K. L. McCormick, K. Volker, J. R. Ortaldo, J. M. Wigginton, M. J. Brunda, R. H. Wiltrout, and W. E. Fogler. 1997. Regulation of local host mediated anti-tumor mechanisms by cytokines: direct and indirect effects on leukocyte recruitment and angiogenesis. Am. J. Pathol. 150:1869.
32. Wiltrout, R. H., B. J. Mathieson, J. E. Talmadge, C. W. Reynolds, S. R. Zhang, R. B. Herberman, and J. R. Ortaldo. 1984. Augmentation of organ-associated NK activity by biological response modifiers: isolation and characterization of large granular lymphocytes from the liver. J. Exp. Med. 160:1431.
33. Car, B. D., V. M. Eng, B. Schnyder, M. LeHir, A. N. Shakhov, G. Woerly, S. Huang, M. Aguet, T. D. Anderson, and B. Ryffel. 1995. Role of interferon-γ in interleukin 12-induced pathology in mice. Am. J. Pathol. 147:1693.
34. Trinchieri, G. 1995. Interleukin-12 and interferon-γ: do they always go together? Am. J. Pathol. 147:1534.
35. Suda, T., T. Okazaki, Y. Naito, T. Yokota, N. Arai, S. Ozaki, K. Nakao, and S. Nagata. 1995. Expression of the Fas ligand in cells of T cell lineage. J. Immunol. 154:3806.
36. Griffith, T. S., T. Brunner, S. M. Fletcher, D. R. Green, and T. A. Ferguson. 1995. Fas ligand-induced apoptosis as a mechanism of immune privilege. Science 270: 1189.
37. Hunt, J. S., D. Vassmer, T. A. Ferguson, and L. Miller. 1997. Fas ligand is positioned in mouse uterus and placenta to prevent trafficking of activated leukocytes between the mother and the conceptus. J. Immunol. 158:4122.
38. Gately, M. K., R. R. Warner, S. Honasoge, D. M. Carvajal, D. A. Faherty, S. E. Connaughton, T. D. Anderson, U. Sarmiento, B. R. Hubbard, and M. Murphy. 1994. Administration of recombinant IL-12 to normal mice enhances cytolytic lymphocyte activity and induces production of IFN-γ in vivo. Int. Immunol. 6:157.
39. Perussia, B. 1991. Lymphokine activated killer cells, natural killer cells, and cytokines. Curr. Opin. Immunol. 3:49.
40. Anderson, J. A., A. B. Lentsch, D. J. Hadjiminas, F. N. Miller, A. W. Martin, K. Nakagawa, and M. J. Edwards. 1996. The role of cytokines, adhesion molecules, and chemokines in interleukin-2-induced lymphocytic infiltration in C57BL/6 mice. J. Clin. Invest. 97:1952.
41. Tannenbaum, C. S., N. Wicker, D. Armstrong, R. Tubbs, J. Finke, R. M. Bukowski, and T. A. Hamilton. 1996. Cytokine and chemokine expression in tumors of mice receiving therapy with IL-12. J. Immunol. 156:693.
42. Salcedo, T. W., L. Azzoni, S. F. Wolf, and B. Perussia. 1993. Modulation of perform and granzymes expression in human NK cells. J. Immunol. 151:2511.
43. Cesano, A., S. Visonneau, S. C. Clark, and D. Santoli. 1993. Cellular and molecular mechanisms of activation of MHC-nonrestricted cytotoxic cells by IL-12. J. Immunol. 151:2943.
44. Allavena, P., C. Paginin, I. Martin Padura, G. Peri, M. Gaboli, E. Dejana, P. C. Marchisio, and A. Mantovani. 1991. Molecules and structures involved in the adhesion of natural killer cells to vascular endothelium. J. Exp. Med. 173:439.
45. Rabinowich, H., R. B. Herberman, and T. L. Whiteside. 1993. Differential effects of IL-12 and IL-2 on expression and function of cellular adhesion molecules on purified human natural killer cells. Cell. Immunol. 152:481.
46. Robertson, M. J., R. J Soiffer, S. F. Wolf, T. J. Manley, C. Donahue, D. Young, S. H. Herberman, and J. Ritz. 1992. Response of human natural killer (NK) cells to NK cells stimulatory factors (NKSF): cytolytic activity and proliferation of NK cells are differentially regulated by NKSF. J. Exp. Med. 175:779.
47. Biron, C. A., H. A. Young, and M. T. Kasaian. 1990. Interleukin-12-induced proliferation of murine natural killer cells in vivo. J. Exp. Med. 171:173.
48. Azzoni, L., P. Kanakaraj, O. Zatsepina, and B. Perussia. 1996. IL-12-induced activation of NK and T cells occurs in the absence of immediate-early activation gene expression. J. Immunol. 157:3235.
49. + T cells through IL-12 produced by Listeria-induce macrophages. Science 260:547.
50. Magram, J., S. E. Connaughton, R. R. Warrier, D. M. Carvajal, C. Wu, J. Ferrante, C. Stewart, U. Sarmiento, D. A. Faherty, and M. K. Gately. 1996. IL-12-deficient mice are defective in IFN-γ production and type 1 cytokine responses. Immunity 4:471.
51. Wang, Z. E., S. Zheng, D. B. Corry, D. K. Dalton, R. A. Seder, S. L. Reiner, and R. M. Locksley. 1994. Interferon γ-independent eifects of interleukin-12 administered during acute or established infection due to Leishmania major. Proc. Natl. Acad. Sci. USA 91:12932.
52. Wyn, T. A., D. Jankovic, S. Hieny, K. Zioncheck, P. Jardieu, A. W. Cheever, and A. Sher. 1995. IL-12 exacerbates rather than suppresses T helper 2-dependent pathology in the absence of endogenous IFN-γ. J. Immunol. 154:3999.
53. Tay, C. H., and R. M. Welsh. 1997. Distinct organ-dependent mechanisms for the control of murine cytomegalovirus infection by natural killer cells. J. Virol. 71: 267.
54. Hahne, M., D. Rimoldi, M. Schröter, P. Romero, M. Schreier, L. E. French, P. Schneider, T. Bornand, A. Fontana, D. Lienard, et al. 1996. Melanoma cell expression of Fas (Apo-1/CD95) ligand: implications for tumor immune escape. Science 274:1363.
55. O'Connell, J., G. C. O'Sullivan, J. K. Collins, and F. Shanahan. 1996. The Fas counter attack: Fas-mediated T cell killing by colon cancer cells expressing Fas ligand. J. Exp. Med. 184:1075.
56. Saas, P., P. R. Walker, M. Hahne, A.-L. Quiguerez, V. Schnuriger, G. Perrin, L. French, E. G. VanMeir, N. deTribolet, J. Tschopp, et al. 1997. Fas ligand expression by astrocytoma in vivo: maintaining immune privilege in the brain. J. Clin. Invest. 99:1173.
57. Nagata, S., and T. Suda. 1995. Fas and Fas ligand: lpr and gld mutations. Immunol. Today 16:39.
58. Abbas, A. K. 1996. Die and let live: eliminating dangerous lymphocytes. Cell 84:655.
59. + CTL. J. Immunol. 159:2728.
60. + T cells via a Fas/FasL ligand-mediated apoptosis. J. Immunol. 158:1503.
61. Welsh, R. M., L. K. Selin, and E. S. Razvi. 1996. Role of apoptosis in the regulation of virus-induced T cell responses, immune suppression, and memory. J. Cell. Biochem. 59:135.
62. Brunda, M. J., L. Luistro, R. R. Warrier, R. B. Wright, B. R. Hubbard, M. Murphy, S. F. Wolf, and M. K. Gately. 1993. Antitumor and antimetastatic activity of interleukin 12 against murine tumors. J. Exp. Med. 178:1223.