메뉴 건너뛰기




Volumn 62, Issue 7, 2013, Pages 1137-1148

Immune-suppressive properties of the tumor microenvironment

Author keywords

A disintegrin and metalloproteinase (ADAM); Adenosine; Arginase; Hypoxia; Indoleamine 2,3 dioxygenase (IDO); Natural killer group 2 member D (NKG2D) ligands

Indexed keywords

ADAM PROTEIN; ADENOSINE; ADENOSINE A1 RECEPTOR; ADENOSINE A2A RECEPTOR; ADENOSINE A2B RECEPTOR; ADENOSINE A3 RECEPTOR; ADENOSINE DIPHOSPHATE; ADENOSINE TRIPHOSPHATE; ARGINASE; GELATINASE A; INDOLEAMINE 2,3 DIOXYGENASE; MATRIX METALLOPROTEINASE; NATURAL KILLER CELL RECEPTOR NKG2D; PROGRAMMED DEATH 1 RECEPTOR; SCLEROPROTEIN; TRYPTOPHAN 2,3 DIOXYGENASE;

EID: 84879515584     PISSN: 03407004     EISSN: 14320851     Source Type: Journal    
DOI: 10.1007/s00262-013-1434-6     Document Type: Review
Times cited : (174)

References (84)
  • 1
    • 79952284127 scopus 로고    scopus 로고
    • Hallmarks of cancer: The next generation
    • 10.1016/j.cell.2011.02.013 21376230 10.1016/j.cell.2011.02.013 1:CAS:528:DC%2BC3MXjsFeqtrk%3D
    • Hanahan D, Weinberg RA (2011) Hallmarks of cancer: the next generation. Cell 144:646-674. doi: 10.1016/j.cell.2011.02.013
    • (2011) Cell , vol.144 , pp. 646-674
    • Hanahan, D.1    Weinberg, R.A.2
  • 2
    • 77952568396 scopus 로고    scopus 로고
    • Hallmarks of cancer: Interactions with the tumor stroma
    • 10.1016/j.yexcr.2010.02.045 20211171 10.1016/j.yexcr.2010.02.045 1:CAS:528:DC%2BC3cXlvVartLs%3D
    • Pietras K, Östman A (2010) Hallmarks of cancer: interactions with the tumor stroma. Exp Cell Res 316:1324-1331. doi: 10.1016/j.yexcr.2010.02.045
    • (2010) Exp Cell Res , vol.316 , pp. 1324-1331
    • Pietras, K.1    Östman, A.2
  • 3
    • 0037180757 scopus 로고    scopus 로고
    • Inflammation and cancer
    • 10.1038/nature01322 12490959 10.1038/nature01322 1:CAS:528: DC%2BD38XpsFygtb4%3D
    • Coussens LM, Werb Z (2002) Inflammation and cancer. Nature 420:860-867. doi: 10.1038/nature01322
    • (2002) Nature , vol.420 , pp. 860-867
    • Coussens, L.M.1    Werb, Z.2
  • 4
    • 19344365408 scopus 로고    scopus 로고
    • De novo carcinogenesis promoted by chronic inflammation is B lymphocyte dependent
    • 10.1016/j.ccr.2005.04.014 15894262 10.1016/j.ccr.2005.04.014
    • de Visser KE, Korets LV, Coussens LM (2005) De novo carcinogenesis promoted by chronic inflammation is B lymphocyte dependent. Cancer Cell 7:411-423. doi: 10.1016/j.ccr.2005.04.014
    • (2005) Cancer Cell , vol.7 , pp. 411-423
    • De Visser, K.E.1    Korets, L.V.2    Coussens, L.M.3
  • 5
    • 67650151005 scopus 로고    scopus 로고
    • Cancer-related inflammation, the seventh hallmark of cancer: Links to genetic instability
    • 10.1093/carcin/bgp127 19468060 10.1093/carcin/bgp127 1:CAS:528: DC%2BD1MXot1CisL8%3D
    • Colotta F, Allavena P, Sica A, et al (2009) Cancer-related inflammation, the seventh hallmark of cancer: links to genetic instability. Carcinogenesis 30:1073-1081. doi: 10.1093/carcin/bgp127
    • (2009) Carcinogenesis , vol.30 , pp. 1073-1081
    • Colotta, F.1    Allavena, P.2    Sica, A.3
  • 6
    • 77955928161 scopus 로고    scopus 로고
    • Tumors as organs: Complex tissues that interface with the entire organism
    • 10.1016/j.devcel.2010.05.012 20627072 10.1016/j.devcel.2010.05.012 1:CAS:528:DC%2BC3cXos1Kqtrk%3D
    • Egeblad M, Nakasone ES, Werb Z (2010) Tumors as organs: complex tissues that interface with the entire organism. Dev Cell 18:884-901. doi: 10.1016/j.devcel.2010.05.012
    • (2010) Dev Cell , vol.18 , pp. 884-901
    • Egeblad, M.1    Nakasone, E.S.2    Werb, Z.3
  • 7
    • 84859153479 scopus 로고    scopus 로고
    • Raising the bar: The curative potential of human cancer immunotherapy
    • 10.1126/scitranslmed.3003634 22461638 10.1126/scitranslmed.3003634
    • Rosenberg SA (2012) Raising the bar: the curative potential of human cancer immunotherapy. Sci Transl Med 4:127ps8. doi: 10.1126/scitranslmed.3003634
    • (2012) Sci Transl Med , vol.4
    • Rosenberg, S.A.1
  • 8
    • 84863594742 scopus 로고    scopus 로고
    • Cellular constituents of immune escape within the tumor microenvironment
    • 10.1158/0008-5472.CAN-11-4094 22721837 10.1158/0008-5472.CAN-11-4094 1:CAS:528:DC%2BC38XpsFKkt7s%3D
    • Kerkar SP, Restifo NP (2012) Cellular constituents of immune escape within the tumor microenvironment. Cancer Res 72:3125-3130. doi: 10.1158/0008-5472.CAN-11-4094
    • (2012) Cancer Res , vol.72 , pp. 3125-3130
    • Kerkar, S.P.1    Restifo, N.P.2
  • 9
    • 65549138993 scopus 로고    scopus 로고
    • Suppressive influences in the immune response to cancer
    • 10.1097/CJI.0b013e3181837276 19307988 10.1097/CJI.0b013e3181837276
    • Bronte V, Mocellin S (2009) Suppressive influences in the immune response to cancer. J Immunother 32:1-11. doi: 10.1097/CJI.0b013e3181837276
    • (2009) J Immunother , vol.32 , pp. 1-11
    • Bronte, V.1    Mocellin, S.2
  • 10
    • 33644762939 scopus 로고    scopus 로고
    • PS-JID-5700001.indd
    • 10.1038/sj.jid.5700001 16417215 10.1038/sj.jid.5700001 1:CAS:528:DC%2BD28Xlt1Wjur4%3D
    • Andersen MH, Schrama D, thor Straten P, Becker JC (2006) PS-JID-5700001.indd. J Invest Dermatol 126:32-41. doi: 10.1038/sj.jid.5700001
    • (2006) J Invest Dermatol , vol.126 , pp. 32-41
    • Andersen, M.H.1    Schrama, D.2    Thor Straten, P.3    Becker, J.C.4
  • 11
    • 84871712393 scopus 로고    scopus 로고
    • Endogenous modulators of inflammatory cell recruitment
    • 10.1016/j.it.2012.08.003 22951309 10.1016/j.it.2012.08.003 1:CAS:528:DC%2BC38Xht1Ojtr7P
    • Hajishengallis G, Chavakis T (2013) Endogenous modulators of inflammatory cell recruitment. Trends Immunol 34:1-6. doi: 10.1016/j.it.2012.08.003
    • (2013) Trends Immunol , vol.34 , pp. 1-6
    • Hajishengallis, G.1    Chavakis, T.2
  • 12
    • 84872943896 scopus 로고    scopus 로고
    • Invariant natural killer T cells: An innate activation scheme linked to diverse effector functions
    • 10.1038/nri3369 23334244 10.1038/nri3369 1:CAS:528:DC%2BC3sXhtV2rsbs%3D
    • Brennan PJ, Brigl M, Brenner MB (2013) Invariant natural killer T cells: an innate activation scheme linked to diverse effector functions. Nat Rev Immunol 13:101-117. doi: 10.1038/nri3369
    • (2013) Nat Rev Immunol , vol.13 , pp. 101-117
    • Brennan, P.J.1    Brigl, M.2    Brenner, M.B.3
  • 13
    • 69249242897 scopus 로고    scopus 로고
    • The yin-yang of tumor-associated neutrophils
    • 10.1016/j.ccr.2009.08.014 19732714 10.1016/j.ccr.2009.08.014 1:CAS:528:DC%2BD1MXhsVChs7rK
    • Mantovani A (2009) The yin-yang of tumor-associated neutrophils. Cancer Cell 16:173-174. doi: 10.1016/j.ccr.2009.08.014
    • (2009) Cancer Cell , vol.16 , pp. 173-174
    • Mantovani, A.1
  • 14
    • 79952126441 scopus 로고    scopus 로고
    • Tissue-based class control: The other side of tolerance
    • 10.1038/nri2940 21350581 10.1038/nri2940 1:CAS:528:DC%2BC3MXisVOnsrk%3D
    • Matzinger P, Kamala T (2011) Tissue-based class control: the other side of tolerance. Nat Rev Immunol 11:221-230. doi: 10.1038/nri2940
    • (2011) Nat Rev Immunol , vol.11 , pp. 221-230
    • Matzinger, P.1    Kamala, T.2
  • 15
    • 15244357105 scopus 로고    scopus 로고
    • Role of matrix metalloproteinases in melanoma cell invasion
    • 10.1016/j.biochi.2005.01.013 15781317 10.1016/j.biochi.2005.01.013 1:CAS:528:DC%2BD2MXisVWqt7c%3D
    • Hofmann UB, Houben R, Bröcker E-B, Becker JC (2005) Role of matrix metalloproteinases in melanoma cell invasion. Biochimie 87:307-314. doi: 10.1016/j.biochi.2005.01.013
    • (2005) Biochimie , vol.87 , pp. 307-314
    • Hofmann, U.B.1    Houben, R.2    Bröcker, E.-B.3    Becker, J.C.4
  • 16
    • 0034650486 scopus 로고    scopus 로고
    • Cell surface-localized matrix metalloproteinase-9 proteolytically activates TGF-beta and promotes tumor invasion and angiogenesis
    • Yu Q, Stamenkovic I (2000) Cell surface-localized matrix metalloproteinase-9 proteolytically activates TGF-beta and promotes tumor invasion and angiogenesis. Gen Dev 14:163-176
    • (2000) Gen Dev , vol.14 , pp. 163-176
    • Yu, Q.1    Stamenkovic, I.2
  • 17
    • 0035137707 scopus 로고    scopus 로고
    • A novel role of metalloproteinase in cancer-mediated immunosuppression
    • 11196168 1:CAS:528:DC%2BD3MXlsl2kuw%3D%3D
    • Sheu BC, Hsu SM, Ho HN, et al (2001) A novel role of metalloproteinase in cancer-mediated immunosuppression. Cancer Res 61:237-242
    • (2001) Cancer Res , vol.61 , pp. 237-242
    • Sheu, B.C.1    Hsu, S.M.2    Ho, H.N.3
  • 18
    • 59849101423 scopus 로고    scopus 로고
    • Cutting edge: The metalloproteinase ADAM17/TNF-alpha-converting enzyme regulates proteolytic shedding of the MHC class I-related chain B protein
    • 19109134 1:CAS:528:DC%2BD1cXhsFCisL%2FK
    • Boutet P, Agüera-González S, Atkinson S, et al (2009) Cutting edge: the metalloproteinase ADAM17/TNF-alpha-converting enzyme regulates proteolytic shedding of the MHC class I-related chain B protein. J Immunol 182:49-53
    • (2009) J Immunol , vol.182 , pp. 49-53
    • Boutet, P.1    Agüera-González, S.2    Atkinson, S.3
  • 19
    • 79960923986 scopus 로고    scopus 로고
    • ADAM17: A molecular switch to control inflammation and tissue regeneration
    • 10.1016/j.it.2011.05.005 21752713 10.1016/j.it.2011.05.005 1:CAS:528:DC%2BC3MXpvFGgs74%3D
    • Scheller J, Chalaris A, Garbers C, Rose-John S (2011) ADAM17: a molecular switch to control inflammation and tissue regeneration. Trends Immunol 32:380-387. doi: 10.1016/j.it.2011.05.005
    • (2011) Trends Immunol , vol.32 , pp. 380-387
    • Scheller, J.1    Chalaris, A.2    Garbers, C.3    Rose-John, S.4
  • 20
    • 79952508760 scopus 로고    scopus 로고
    • Matrix metalloproteinase-2 conditions human dendritic cells to prime inflammatory TH2 cells via an IL-12- and OX40L-dependent pathway
    • 10.1016/j.ccr.2011.01.037 21397857 10.1016/j.ccr.2011.01.037 1:CAS:528:DC%2BC3MXjtFKisro%3D
    • Godefroy E, Manches O, Dréno B, et al (2011) Matrix metalloproteinase-2 conditions human dendritic cells to prime inflammatory TH2 cells via an IL-12- and OX40L-dependent pathway. Cancer Cell 19:333-346. doi: 10.1016/j.ccr.2011.01.037
    • (2011) Cancer Cell , vol.19 , pp. 333-346
    • Godefroy, E.1    Manches, O.2    Dréno, B.3
  • 21
    • 81255138408 scopus 로고    scopus 로고
    • Indoleamine 2,3-dioxygenase expression in human cancers: Clinical and immunologic perspectives
    • 10.1158/1078-0432.CCR-11-1331 22068654 10.1158/1078-0432.CCR-11-1331 1:CAS:528:DC%2BC3MXhsVKht7rO
    • Godin-Ethier J, Hanafi LA, Piccirillo CA, Lapointe R (2011) Indoleamine 2,3-dioxygenase expression in human cancers: clinical and immunologic perspectives. Clin Cancer Res 17:6985-6991. doi: 10.1158/1078-0432.CCR-11-1331
    • (2011) Clin Cancer Res , vol.17 , pp. 6985-6991
    • Godin-Ethier, J.1    Hanafi, L.A.2    Piccirillo, C.A.3    Lapointe, R.4
  • 22
    • 84868220730 scopus 로고    scopus 로고
    • Tryptophan catabolism in cancer: Beyond IDO and tryptophan depletion
    • 10.1158/0008-5472.CAN-12-0569 23090118 10.1158/0008-5472.CAN-12-0569 1:CAS:528:DC%2BC38XhsF2jsL3I
    • Platten M, Wick W, Van den Eynde BJ (2012) Tryptophan catabolism in cancer: beyond IDO and tryptophan depletion. Cancer Res 72:5435-5440. doi: 10.1158/0008-5472.CAN-12-0569
    • (2012) Cancer Res , vol.72 , pp. 5435-5440
    • Platten, M.1    Wick, W.2    Van Den Eynde, B.J.3
  • 23
    • 77950196277 scopus 로고    scopus 로고
    • TH17 cells in tumour immunity and immunotherapy
    • 10.1038/nri2742 20336152 10.1038/nri2742 1:CAS:528:DC%2BC3cXjvVGlt7k%3D
    • Zou W, Restifo NP (2010) TH17 cells in tumour immunity and immunotherapy. Nat Rev Immunol 10:248-256. doi: 10.1038/nri2742
    • (2010) Nat Rev Immunol , vol.10 , pp. 248-256
    • Zou, W.1    Restifo, N.P.2
  • 24
    • 33845920042 scopus 로고    scopus 로고
    • Decreased serum tryptophan concentration predicts poor prognosis in malignant melanoma patients
    • 10.1159/000096906 17191041 10.1159/000096906
    • Weinlich G, Murr C, Richardsen L, et al (2007) Decreased serum tryptophan concentration predicts poor prognosis in malignant melanoma patients. Dermatology 214:8-14. doi: 10.1159/000096906
    • (2007) Dermatology , vol.214 , pp. 8-14
    • Weinlich, G.1    Murr, C.2    Richardsen, L.3
  • 25
    • 84866242667 scopus 로고    scopus 로고
    • IDO is a nodal pathogenic driver of lung cancer and metastasis development
    • 10.1158/2159-8290.CD-12-0014 22822050 10.1158/2159-8290.CD-12-0014 1:CAS:528:DC%2BC38Xht1ygs7fO
    • Smith C, Chang MY, Parker KH, et al (2012) IDO is a nodal pathogenic driver of lung cancer and metastasis development. Cancer Discov 2:722-735. doi: 10.1158/2159-8290.CD-12-0014
    • (2012) Cancer Discov , vol.2 , pp. 722-735
    • Smith, C.1    Chang, M.Y.2    Parker, K.H.3
  • 26
    • 84865743717 scopus 로고    scopus 로고
    • The specific targeting of immune regulation: T-cell responses against indoleamine 2,3-dioxygenase
    • 10.1007/s00262-012-1234-4 22388712 10.1007/s00262-012-1234-4 1:CAS:528:DC%2BC38XhtVOhtL7L
    • Andersen MH (2012) The specific targeting of immune regulation: T-cell responses against indoleamine 2,3-dioxygenase. Cancer Immunol Immunother 61:1289-1297. doi: 10.1007/s00262-012-1234-4
    • (2012) Cancer Immunol Immunother , vol.61 , pp. 1289-1297
    • Andersen, M.H.1
  • 27
    • 84857136779 scopus 로고    scopus 로고
    • Reversal of tumoral immune resistance by inhibition of tryptophan 2,3-dioxygenase
    • 10.1073/pnas.1113873109 22308364 10.1073/pnas.1113873109 1:CAS:528:DC%2BC38XivVKnt7o%3D
    • Pilotte L, Larrieu P, Stroobant V, et al (2012) Reversal of tumoral immune resistance by inhibition of tryptophan 2,3-dioxygenase. Proc Nat Acad Sci 109:2497-2502. doi: 10.1073/pnas.1113873109
    • (2012) Proc Nat Acad Sci , vol.109 , pp. 2497-2502
    • Pilotte, L.1    Larrieu, P.2    Stroobant, V.3
  • 28
    • 84870281035 scopus 로고    scopus 로고
    • Tryptophan hydroxylase-1 regulates immune tolerance and inflammation
    • 10.1084/jem.20120408 23008335 10.1084/jem.20120408 1:CAS:528: DC%2BC38XhsFyitb3K
    • Nowak EC, de Vries VC, Wasiuk A, et al (2012) Tryptophan hydroxylase-1 regulates immune tolerance and inflammation. J Exp Med 209:2127-2135. doi: 10.1084/jem.20120408
    • (2012) J Exp Med , vol.209 , pp. 2127-2135
    • Nowak, E.C.1    De Vries, V.C.2    Wasiuk, A.3
  • 29
    • 23444456772 scopus 로고    scopus 로고
    • Regulation of immune responses by l-arginine metabolism
    • 10.1038/nri1668 16056256 10.1038/nri1668 1:CAS:528:DC%2BD2MXmvVClsLc%3D
    • Bronte V, Zanovello P (2005) Regulation of immune responses by l-arginine metabolism. Nat Rev Immunol 5:641-654. doi: 10.1038/nri1668
    • (2005) Nat Rev Immunol , vol.5 , pp. 641-654
    • Bronte, V.1    Zanovello, P.2
  • 30
    • 83855162802 scopus 로고    scopus 로고
    • The role of the EP receptors for prostaglandin E2 in skin and skin cancer
    • 10.1007/s10555-011-9317-9 22012553 10.1007/s10555-011-9317-9 1:CAS:528:DC%2BC3MXhs1emt7jP
    • Rundhaug JE, Simper MS, Surh I, Fischer SM (2011) The role of the EP receptors for prostaglandin E2 in skin and skin cancer. Cancer Metastasis Rev 30:465-480. doi: 10.1007/s10555-011-9317-9
    • (2011) Cancer Metastasis Rev , vol.30 , pp. 465-480
    • Rundhaug, J.E.1    Simper, M.S.2    Surh, I.3    Fischer, S.M.4
  • 31
    • 84864117497 scopus 로고    scopus 로고
    • Hypoxia promotes tumor growth in linking angiogenesis to immune escape
    • 10.3389/fimmu.2012.00021 22566905 10.3389/fimmu.2012.00021
    • Chouaib S, Messai Y, Couve S, et al (2012) Hypoxia promotes tumor growth in linking angiogenesis to immune escape. Front Immunol 3:21. doi: 10.3389/fimmu.2012.00021
    • (2012) Front Immunol , vol.3 , pp. 21
    • Chouaib, S.1    Messai, Y.2    Couve, S.3
  • 32
    • 79957862375 scopus 로고    scopus 로고
    • Nitric oxide and redox mechanisms in the immune response
    • 10.1189/jlb.1010550 10.1189/jlb.1010550 1:CAS:528:DC%2BC3MXnsFKqurg%3D
    • Wink DA, Hines HB, Cheng RYS, et al (2011) Nitric oxide and redox mechanisms in the immune response. J Leuk Biol 89:873-891. doi: 10.1189/jlb.1010550
    • (2011) J Leuk Biol , vol.89 , pp. 873-891
    • Wink, D.A.1    Hines, H.B.2    Cheng, R.Y.S.3
  • 33
    • 84862076074 scopus 로고    scopus 로고
    • Tumor-expressed inducible nitric oxide synthase controls induction of functional myeloid-derived suppressor cells through modulation of vascular endothelial growth factor release
    • 10.4049/jimmunol.1103553 22529296 10.4049/jimmunol.1103553 1:CAS:528:DC%2BC38Xnt1ais7g%3D
    • Jayaraman P, Parikh F, Lopez-Rivera E, et al (2012) Tumor-expressed inducible nitric oxide synthase controls induction of functional myeloid-derived suppressor cells through modulation of vascular endothelial growth factor release. J Immunol 188:5365-5376. doi: 10.4049/jimmunol.1103553
    • (2012) J Immunol , vol.188 , pp. 5365-5376
    • Jayaraman, P.1    Parikh, F.2    Lopez-Rivera, E.3
  • 34
    • 79953827951 scopus 로고    scopus 로고
    • Suppression of T-cell responses by tumor metabolites
    • 10.1007/s00262-010-0967-1 21240484 10.1007/s00262-010-0967-1 1:CAS:528:DC%2BC3MXit1Gqsb8%3D
    • Singer K, Gottfried E, Kreutz M, Mackensen A (2011) Suppression of T-cell responses by tumor metabolites. Cancer Immunol Immunother 60:425-431. doi: 10.1007/s00262-010-0967-1
    • (2011) Cancer Immunol Immunother , vol.60 , pp. 425-431
    • Singer, K.1    Gottfried, E.2    Kreutz, M.3    Mackensen, A.4
  • 35
    • 81155126061 scopus 로고    scopus 로고
    • Lactate: A metabolic key player in cancer
    • 10.1158/0008-5472.CAN-11-1457 22084445 10.1158/0008-5472.CAN-11-1457 1:CAS:528:DC%2BC3MXhsVKhu7jK
    • Hirschhaeuser F, Sattler UGA, Mueller-Klieser W (2011) Lactate: a metabolic key player in cancer. Cancer Res 71:6921-6925. doi: 10.1158/0008-5472.CAN-11-1457
    • (2011) Cancer Res , vol.71 , pp. 6921-6925
    • Hirschhaeuser, F.1    Sattler, U.G.A.2    Mueller-Klieser, W.3
  • 36
    • 47249118348 scopus 로고    scopus 로고
    • Tumor-secreted lactic acid promotes IL-23/IL-17 proinflammatory pathway
    • 18490716 1:CAS:528:DC%2BD1cXmtVantLg%3D
    • Shime H, Yabu M, Akazawa T, et al (2008) Tumor-secreted lactic acid promotes IL-23/IL-17 proinflammatory pathway. J Immunol 180:7175-7183
    • (2008) J Immunol , vol.180 , pp. 7175-7183
    • Shime, H.1    Yabu, M.2    Akazawa, T.3
  • 37
    • 17044422629 scopus 로고    scopus 로고
    • Glucose availability regulates IFN-gamma production and p70S6 kinase activation in CD8+ effector T cells
    • 15814691 1:CAS:528:DC%2BD2MXivFKitLw%3D
    • Cham CM, Gajewski TF (2005) Glucose availability regulates IFN-gamma production and p70S6 kinase activation in CD8+ effector T cells. J Immunol 174:4670-4677
    • (2005) J Immunol , vol.174 , pp. 4670-4677
    • Cham, C.M.1    Gajewski, T.F.2
  • 38
    • 77956254094 scopus 로고    scopus 로고
    • Adenosine and prostaglandin E2 cooperate in the suppression of immune responses mediated by adaptive regulatory T cells
    • 10.1074/jbc.M110.127100 20558731 10.1074/jbc.M110.127100 1:CAS:528:DC%2BC3cXhtVOnsL7K
    • Mandapathil M, Szczepanski MJ, Szajnik M, et al (2010) Adenosine and prostaglandin E2 cooperate in the suppression of immune responses mediated by adaptive regulatory T cells. J Biol Chem 285:27571-27580. doi: 10.1074/jbc.M110.127100
    • (2010) J Biol Chem , vol.285 , pp. 27571-27580
    • Mandapathil, M.1    Szczepanski, M.J.2    Szajnik, M.3
  • 39
    • 77957564570 scopus 로고    scopus 로고
    • Extracellular adenosine triphosphate and adenosine in cancer
    • 10.1038/onc.2010.292 20661219 10.1038/onc.2010.292 1:CAS:528: DC%2BC3cXpt1GjtbY%3D
    • Stagg J, Smyth MJ (2010) Extracellular adenosine triphosphate and adenosine in cancer. Oncogene 29:5346-5358. doi: 10.1038/onc.2010.292
    • (2010) Oncogene , vol.29 , pp. 5346-5358
    • Stagg, J.1    Smyth, M.J.2
  • 40
    • 51049101334 scopus 로고    scopus 로고
    • Adenosine receptors: Therapeutic aspects for inflammatory and immune diseases
    • 10.1038/nrd2638 18758473 10.1038/nrd2638
    • Haskó G, Linden J, Cronstein B, Pacher P (2008) Adenosine receptors: therapeutic aspects for inflammatory and immune diseases. Nat Rev Drug Discov 7:759-770. doi: 10.1038/nrd2638
    • (2008) Nat Rev Drug Discov , vol.7 , pp. 759-770
    • Haskó, G.1    Linden, J.2    Cronstein, B.3    Pacher, P.4
  • 41
    • 84862317836 scopus 로고    scopus 로고
    • Enhancement of tumor immunotherapy by deletion of the A2A adenosine receptor
    • 10.1007/s00262-011-1155-7 22116345 10.1007/s00262-011-1155-7 1:CAS:528:DC%2BC38XnvFKqu7s%3D
    • Waickman AT, Alme A, Senaldi L, et al (2012) Enhancement of tumor immunotherapy by deletion of the A2A adenosine receptor. Cancer Immunol Immunother 61:917-926. doi: 10.1007/s00262-011-1155-7
    • (2012) Cancer Immunol Immunother , vol.61 , pp. 917-926
    • Waickman, A.T.1    Alme, A.2    Senaldi, L.3
  • 42
    • 79953764331 scopus 로고    scopus 로고
    • Receptor desensitization and blockade of the suppressive effects of prostaglandin E(2) and adenosine on the cytotoxic activity of human melanoma-infiltrating T lymphocytes
    • 10.1007/s00262-010-0924-z 20960188 10.1007/s00262-010-0924-z 1:CAS:528:DC%2BC3MXht12gtr0%3D
    • Su Y, Jackson EK, Gorelik E (2011) Receptor desensitization and blockade of the suppressive effects of prostaglandin E(2) and adenosine on the cytotoxic activity of human melanoma-infiltrating T lymphocytes. Cancer Immunol Immunother 60:111-122. doi: 10.1007/s00262-010-0924-z
    • (2011) Cancer Immunol Immunother , vol.60 , pp. 111-122
    • Su, Y.1    Jackson, E.K.2    Gorelik, E.3
  • 43
    • 80054109170 scopus 로고    scopus 로고
    • Ectonucleotidases CD39 and CD73 on OvCA cells are potent adenosine-generating enzymes responsible for adenosine receptor 2A-dependent suppression of T cell function and NK cell cytotoxicity
    • 10.1007/s00262-011-1040-4 21638125 10.1007/s00262-011-1040-4
    • Häusler SFM, Montalbán del Barrio I, Strohschein J, et al (2011) Ectonucleotidases CD39 and CD73 on OvCA cells are potent adenosine-generating enzymes responsible for adenosine receptor 2A-dependent suppression of T cell function and NK cell cytotoxicity. Cancer Immunol Immunother 60:1405-1418. doi: 10.1007/s00262-011-1040-4
    • (2011) Cancer Immunol Immunother , vol.60 , pp. 1405-1418
    • Häusler, S.F.M.1    Montalbán Del Barrio, I.2    Strohschein, J.3
  • 44
    • 79955040909 scopus 로고    scopus 로고
    • IL-17+ regulatory T Cells in the microenvironments of chronic inflammation and cancer
    • 10.4049/jimmunol.1003251 21357259 10.4049/jimmunol.1003251 1:CAS:528:DC%2BC3MXjvVKlsrY%3D
    • Kryczek I, Wu K, Zhao E, et al (2011) IL-17+ regulatory T Cells in the microenvironments of chronic inflammation and cancer. J Immunol 186:4388-4395. doi: 10.4049/jimmunol.1003251
    • (2011) J Immunol , vol.186 , pp. 4388-4395
    • Kryczek, I.1    Wu, K.2    Zhao, E.3
  • 45
    • 82755162136 scopus 로고    scopus 로고
    • Adenosinergic regulation of the expansion and immunosuppressive activity of CD11b+ Gr1+ Cells
    • 10.4049/jimmunol.1101225 22039302 10.4049/jimmunol.1101225 1:CAS:528:DC%2BC3MXhsV2hsLnL
    • Ryzhov S, Novitskiy SV, Goldstein AE, et al (2011) Adenosinergic regulation of the expansion and immunosuppressive activity of CD11b+ Gr1+ Cells. J Immunol 187:6120-6129. doi: 10.4049/jimmunol.1101225
    • (2011) J Immunol , vol.187 , pp. 6120-6129
    • Ryzhov, S.1    Novitskiy, S.V.2    Goldstein, A.E.3
  • 46
    • 84860388676 scopus 로고    scopus 로고
    • CD73: A potent suppressor of antitumor immune responses
    • 10.1016/j.it.2012.02.009 22487321 10.1016/j.it.2012.02.009 1:CAS:528:DC%2BC38Xlt1Kks78%3D
    • Beavis PA, Stagg J, Darcy PK, Smyth MJ (2012) CD73: a potent suppressor of antitumor immune responses. Trends Immunol 33:231-237. doi: 10.1016/j.it.2012.02.009
    • (2012) Trends Immunol , vol.33 , pp. 231-237
    • Beavis, P.A.1    Stagg, J.2    Darcy, P.K.3    Smyth, M.J.4
  • 47
    • 77950231071 scopus 로고    scopus 로고
    • CD73 on tumor cells impairs antitumor T-cell responses: A novel mechanism of tumor-induced immune suppression
    • 10.1158/0008-5472.CAN-09-3109 20179192 10.1158/0008-5472.CAN-09-3109 1:CAS:528:DC%2BC3cXjtFygt7w%3D
    • Jin D, Fan J, Wang L, et al (2010) CD73 on tumor cells impairs antitumor T-cell responses: a novel mechanism of tumor-induced immune suppression. Cancer Res 70:2245-2255. doi: 10.1158/0008-5472.CAN-09-3109
    • (2010) Cancer Res , vol.70 , pp. 2245-2255
    • Jin, D.1    Fan, J.2    Wang, L.3
  • 48
    • 84855520895 scopus 로고    scopus 로고
    • Beyond ipilimumab: New approaches target the immunological synapse
    • 10.1093/jnci/djr281 21737695 10.1093/jnci/djr281 1:CAS:528: DC%2BC3MXptlyqt7g%3D
    • Garber K (2011) Beyond ipilimumab: new approaches target the immunological synapse. J Nat Cancer Inst 103:1079-1082. doi: 10.1093/jnci/djr281
    • (2011) J Nat Cancer Inst , vol.103 , pp. 1079-1082
    • Garber, K.1
  • 49
    • 79958844438 scopus 로고    scopus 로고
    • Ipilimumab: First global approval
    • 10.2165/11594010-000000000-00000 21668044 10.2165/11594010-000000000- 00000
    • Cameron F, Whiteside G, Perry C (2011) Ipilimumab: first global approval. Drugs 71:1093-1104. doi: 10.2165/11594010-000000000-00000
    • (2011) Drugs , vol.71 , pp. 1093-1104
    • Cameron, F.1    Whiteside, G.2    Perry, C.3
  • 50
    • 78449243490 scopus 로고    scopus 로고
    • Anti-CTLA-4 antibody therapy: Immune monitoring during clinical development of a novel immunotherapy
    • 10.1053/j.seminoncol.2010.09.001 21074063 10.1053/j.seminoncol.2010.09. 001 1:CAS:528:DC%2BC3cXhsVWrur7M
    • Callahan MK, Wolchok JD, Allison JP (2010) Anti-CTLA-4 antibody therapy: immune monitoring during clinical development of a novel immunotherapy. Semin Oncol 37:473-484. doi: 10.1053/j.seminoncol.2010.09.001
    • (2010) Semin Oncol , vol.37 , pp. 473-484
    • Callahan, M.K.1    Wolchok, J.D.2    Allison, J.P.3
  • 51
    • 79959772576 scopus 로고    scopus 로고
    • Ipilimumab plus dacarbazine for previously untreated metastatic melanoma
    • 10.1056/NEJMoa1104621 21639810 10.1056/NEJMoa1104621 1:CAS:528: DC%2BC3MXosVegtro%3D
    • Robert C, Thomas L, Bondarenko I, et al (2011) Ipilimumab plus dacarbazine for previously untreated metastatic melanoma. N Engl J Med 364:2517-2526. doi: 10.1056/NEJMoa1104621
    • (2011) N Engl J Med , vol.364 , pp. 2517-2526
    • Robert, C.1    Thomas, L.2    Bondarenko, I.3
  • 52
    • 84871532643 scopus 로고    scopus 로고
    • Ipilimumab in combination with paclitaxel and carboplatin as first-line therapy in extensive-disease-small-cell lung cancer: Results from a randomized, double-blind, multicenter phase 2 trial
    • 10.1093/annonc/mds213 22858559 10.1093/annonc/mds213 1:STN:280: DC%2BC38fltFGrtw%3D%3D
    • Reck M, Bondarenko I, Luft A, et al (2013) Ipilimumab in combination with paclitaxel and carboplatin as first-line therapy in extensive-disease-small- cell lung cancer: results from a randomized, double-blind, multicenter phase 2 trial. Ann Oncol 24:75-83. doi: 10.1093/annonc/mds213
    • (2013) Ann Oncol , vol.24 , pp. 75-83
    • Reck, M.1    Bondarenko, I.2    Luft, A.3
  • 53
    • 84865567547 scopus 로고    scopus 로고
    • Ipilimumab and fotemustine in patients with advanced melanoma (NIBIT-M1): An open-label, single-arm phase 2 trial
    • 10.1016/S1470-2045(12)70324-8 22894884 10.1016/S1470-2045(12)70324-8
    • Di Giacomo AM, Ascierto PA, Pilla L, et al (2012) Ipilimumab and fotemustine in patients with advanced melanoma (NIBIT-M1): an open-label, single-arm phase 2 trial. Lancet Oncol 13:879-886. doi: 10.1016/S1470-2045(12) 70324-8
    • (2012) Lancet Oncol , vol.13 , pp. 879-886
    • Di Giacomo, A.M.1    Ascierto, P.A.2    Pilla, L.3
  • 54
    • 84857815877 scopus 로고    scopus 로고
    • Immunologic correlates of the abscopal effect in a patient with melanoma
    • 10.1056/NEJMoa1112824 22397654 10.1056/NEJMoa1112824 1:CAS:528: DC%2BC38XktFOgurw%3D
    • Postow MA, Callahan MK, Barker CA, et al (2012) Immunologic correlates of the abscopal effect in a patient with melanoma. N Engl J Med 366:925-931. doi: 10.1056/NEJMoa1112824
    • (2012) N Engl J Med , vol.366 , pp. 925-931
    • Postow, M.A.1    Callahan, M.K.2    Barker, C.A.3
  • 55
    • 84874116175 scopus 로고    scopus 로고
    • T cell profiling reveals high CD4(+)CTLA-4 (+) T cell frequency as dominant predictor for survival after prostate GVAX/ipilimumab treatment
    • 10.1007/s00262-012-1330-5 22878899
    • Santegoets SJAM, Stam AGM, Lougheed SM, et al (2012) T cell profiling reveals high CD4(+)CTLA-4 (+) T cell frequency as dominant predictor for survival after prostate GVAX/ipilimumab treatment. Cancer Immunol Immunother. doi: 10.1007/s00262-012-1330-5
    • (2012) Cancer Immunol Immunother
    • Santegoets, S.1    Stam, A.G.M.2    Lougheed, S.M.3
  • 56
    • 84864258996 scopus 로고    scopus 로고
    • A landscape of driver mutations in melanoma
    • 10.1016/j.cell.2012.06.024 22817889 10.1016/j.cell.2012.06.024 1:CAS:528:DC%2BC38XhtVymsrfO
    • Hodis R, Watson IR, Kryukov GV, et al (2012) A landscape of driver mutations in melanoma. Cell 150:251-263. doi: 10.1016/j.cell.2012.06.024
    • (2012) Cell , vol.150 , pp. 251-263
    • Hodis, R.1    Watson, I.R.2    Kryukov, G.V.3
  • 57
    • 36748999428 scopus 로고    scopus 로고
    • Prognostic factors related to clinical response in patients with metastatic melanoma treated by CTL-associated antigen-4 blockade
    • 10.1158/1078-0432.CCR-07-0187 17982122 10.1158/1078-0432.CCR-07-0187 1:CAS:528:DC%2BD2sXhtlSmu7bN
    • Downey SG, Klapper JA, Smith FO, et al (2007) Prognostic factors related to clinical response in patients with metastatic melanoma treated by CTL-associated antigen-4 blockade. Clin Cancer Res 13:6681-6688. doi: 10.1158/1078-0432.CCR-07-0187
    • (2007) Clin Cancer Res , vol.13 , pp. 6681-6688
    • Downey, S.G.1    Klapper, J.A.2    Smith, F.O.3
  • 58
    • 54449091476 scopus 로고    scopus 로고
    • CTLA-4 blockade increases IFNgamma-producing CD4+ ICOShi cells to shift the ratio of effector to regulatory T cells in cancer patients
    • 10.1073/pnas.0806075105 18818309 10.1073/pnas.0806075105 1:CAS:528:DC%2BD1cXht1aqurzI
    • Liakou CI, Kamat A, Tang DN, et al (2008) CTLA-4 blockade increases IFNgamma-producing CD4+ ICOShi cells to shift the ratio of effector to regulatory T cells in cancer patients. Proc Nat Acad Sci 105:14987-14992. doi: 10.1073/pnas.0806075105
    • (2008) Proc Nat Acad Sci , vol.105 , pp. 14987-14992
    • Liakou, C.I.1    Kamat, A.2    Tang, D.N.3
  • 59
    • 84862769116 scopus 로고    scopus 로고
    • An immune-active tumor microenvironment favors clinical response to ipilimumab
    • 10.1007/s00262-011-1172-6 22146893 10.1007/s00262-011-1172-6 1:CAS:528:DC%2BC38XptVGnu7w%3D
    • Ji R-R, Chasalow SD, Wang L, et al (2012) An immune-active tumor microenvironment favors clinical response to ipilimumab. Cancer Immunol Immunother 61:1019-1031. doi: 10.1007/s00262-011-1172-6
    • (2012) Cancer Immunol Immunother , vol.61 , pp. 1019-1031
    • Ji, R.-R.1    Chasalow, S.D.2    Wang, L.3
  • 60
    • 82155168544 scopus 로고    scopus 로고
    • A prospective phase II trial exploring the association between tumor microenvironment biomarkers and clinical activity of ipilimumab in advanced melanoma
    • 10.1186/1479-5876-9-204 22123319 10.1186/1479-5876-9-204 1:CAS:528:DC%2BC38Xms1Cquw%3D%3D
    • Hamid O, Schmidt H, Nissan A, et al (2011) A prospective phase II trial exploring the association between tumor microenvironment biomarkers and clinical activity of ipilimumab in advanced melanoma. J Transl Med 9:204. doi: 10.1186/1479-5876-9-204
    • (2011) J Transl Med , vol.9 , pp. 204
    • Hamid, O.1    Schmidt, H.2    Nissan, A.3
  • 61
    • 84862494584 scopus 로고    scopus 로고
    • Assessment of association between BRAF-V600E mutation status in melanomas and clinical response to ipilimumab
    • 10.1007/s00262-012-1227-3 22382362 10.1007/s00262-012-1227-3 1:CAS:528:DC%2BC38XmtlCqsbs%3D
    • Shahabi V, Whitney G, Hamid O, et al (2012) Assessment of association between BRAF-V600E mutation status in melanomas and clinical response to ipilimumab. Cancer Immunol Immunother 61:733-737. doi: 10.1007/s00262-012-1227-3
    • (2012) Cancer Immunol Immunother , vol.61 , pp. 733-737
    • Shahabi, V.1    Whitney, G.2    Hamid, O.3
  • 62
    • 84864912315 scopus 로고    scopus 로고
    • Immunoregulatory molecules are master regulators of inflammation during the immune response
    • 10.1016/j.febslet.2012.07.032 10.1016/j.febslet.2012.07.032
    • la Fuente de H, Cibrián D, Sánchez-Madrid F (2012) Immunoregulatory molecules are master regulators of inflammation during the immune response. FEBS Lett 586:2897-2905. doi: 10.1016/j.febslet.2012.07.032
    • (2012) FEBS Lett , vol.586 , pp. 2897-2905
    • De, L.F.H.1    Cibrián, D.2    Sánchez-Madrid, F.3
  • 63
    • 84862859820 scopus 로고    scopus 로고
    • Safety, activity, and immune correlates of anti-PD-1 antibody in cancer
    • 10.1056/NEJMoa1200690 22658127 10.1056/NEJMoa1200690 1:CAS:528: DC%2BC38XhtV2rs7fN
    • Topalian SL, Hodi FS, Brahmer JR, et al (2012) Safety, activity, and immune correlates of anti-PD-1 antibody in cancer. N Engl J Med 366:2443-2454. doi: 10.1056/NEJMoa1200690
    • (2012) N Engl J Med , vol.366 , pp. 2443-2454
    • Topalian, S.L.1    Hodi, F.S.2    Brahmer, J.R.3
  • 64
    • 84862903106 scopus 로고    scopus 로고
    • Safety and activity of anti-PD-L1 antibody in patients with advanced cancer
    • 10.1056/NEJMoa1200694 22658128 10.1056/NEJMoa1200694 1:CAS:528: DC%2BC38XhtV2rsbnJ
    • Brahmer JR, Tykodi SS, Chow LQM, et al (2012) Safety and activity of anti-PD-L1 antibody in patients with advanced cancer. N Engl J Med 366:2455-2465. doi: 10.1056/NEJMoa1200694
    • (2012) N Engl J Med , vol.366 , pp. 2455-2465
    • Brahmer, J.R.1    Tykodi, S.S.2    Chow, L.Q.M.3
  • 65
    • 84874107823 scopus 로고    scopus 로고
    • Improving dendritic cell vaccine immunogenicity by silencing PD-1 ligands using siRNA-lipid nanoparticles combined with antigen mRNA electroporation
    • 10.1007/s00262-012-1334-1 22903385
    • Hobo W, Novobrantseva TI, Fredrix H, et al (2012) Improving dendritic cell vaccine immunogenicity by silencing PD-1 ligands using siRNA-lipid nanoparticles combined with antigen mRNA electroporation. Cancer Immunol Immunother. doi: 10.1007/s00262-012-1334-1
    • (2012) Cancer Immunol Immunother
    • Hobo, W.1    Novobrantseva, T.I.2    Fredrix, H.3
  • 66
    • 84865750471 scopus 로고    scopus 로고
    • The expression, function, and clinical relevance of B7 family members in cancer
    • 10.1007/s00262-012-1293-6 22695874 10.1007/s00262-012-1293-6 1:CAS:528:DC%2BC38XhtVOhtL%2FE
    • Seliger B, Quandt D (2012) The expression, function, and clinical relevance of B7 family members in cancer. Cancer Immunol Immunother 61:1327-1341. doi: 10.1007/s00262-012-1293-6
    • (2012) Cancer Immunol Immunother , vol.61 , pp. 1327-1341
    • Seliger, B.1    Quandt, D.2
  • 67
    • 65349130644 scopus 로고    scopus 로고
    • Fine tuning the immune response through B7-H3 and B7-H4
    • 10.1111/j.1600-065X.2009.00768.x 19426220 10.1111/j.1600-065X.2009.00768. x 1:CAS:528:DC%2BD1MXhsFGls7jF
    • Yi KH, Chen L (2009) Fine tuning the immune response through B7-H3 and B7-H4. Immunol Rev 229:145-151. doi: 10.1111/j.1600-065X.2009.00768.x
    • (2009) Immunol Rev , vol.229 , pp. 145-151
    • Yi, K.H.1    Chen, L.2
  • 68
    • 80052793188 scopus 로고    scopus 로고
    • Human NK cells are alerted to induction of p53 in cancer cells by upregulation of the NKG2D ligands ULBP1 and ULBP2
    • 10.1158/0008-5472.CAN-10-3211 21764762 10.1158/0008-5472.CAN-10-3211 1:CAS:528:DC%2BC3MXhtFKntb3N
    • Textor S, Fiegler N, Arnold A, et al (2011) Human NK cells are alerted to induction of p53 in cancer cells by upregulation of the NKG2D ligands ULBP1 and ULBP2. Cancer Res 71:5998-6009. doi: 10.1158/0008-5472.CAN-10-3211
    • (2011) Cancer Res , vol.71 , pp. 5998-6009
    • Textor, S.1    Fiegler, N.2    Arnold, A.3
  • 69
    • 0036229870 scopus 로고    scopus 로고
    • Expression of stress-induced MHC class i related chain molecules on human melanoma
    • 10.1046/j.1523-1747.2002.01700.x 11918705 10.1046/j.1523-1747.2002.01700. x 1:CAS:528:DC%2BD38Xjt1Cju7g%3D
    • Vetter CS, Groh V, thor Straten P, et al (2002) Expression of stress-induced MHC class I related chain molecules on human melanoma. J Invest Dermatol 118:600-605. doi: 10.1046/j.1523-1747.2002.01700.x
    • (2002) J Invest Dermatol , vol.118 , pp. 600-605
    • Vetter, C.S.1    Groh, V.2    Thor Straten, P.3
  • 70
    • 77951683908 scopus 로고    scopus 로고
    • Effect of NKG2D ligand expression on host immune responses
    • 10.1111/j.0105-2896.2010.00893.x 20536569 1:CAS:528:DC%2BC3cXnt1Kjt78%3D
    • Champsaur M, Lanier LL (2010) Effect of NKG2D ligand expression on host immune responses. Immunol Rev 235:267-285. doi: 10.1111/j.0105-2896.2010.00893.x
    • (2010) Immunol Rev , vol.235 , pp. 267-285
    • Champsaur, M.1    Lanier, L.L.2
  • 71
    • 51049103630 scopus 로고    scopus 로고
    • Tumor-associated MICA is shed by ADAM proteases
    • 10.1158/0008-5472.CAN-07-6768 18676862 10.1158/0008-5472.CAN-07-6768 1:CAS:528:DC%2BD1cXpt1Wjtrs%3D
    • Waldhauer I, Goehlsdorf D, Gieseke F, et al (2008) Tumor-associated MICA is shed by ADAM proteases. Cancer Res 68:6368-6376. doi: 10.1158/0008-5472.CAN- 07-6768
    • (2008) Cancer Res , vol.68 , pp. 6368-6376
    • Waldhauer, I.1    Goehlsdorf, D.2    Gieseke, F.3
  • 72
    • 49649105571 scopus 로고    scopus 로고
    • Hypoxia increases tumor cell shedding of MHC class i chain-related molecule: Role of nitric oxide
    • 10.1158/0008-5472.CAN-08-0054 18559521 10.1158/0008-5472.CAN-08-0054 1:CAS:528:DC%2BD1cXnt1ejsro%3D
    • Siemens DR, Hu N, Sheikhi AK, et al (2008) Hypoxia increases tumor cell shedding of MHC class I chain-related molecule: role of nitric oxide. Cancer Res 68:4746-4753. doi: 10.1158/0008-5472.CAN-08-0054
    • (2008) Cancer Res , vol.68 , pp. 4746-4753
    • Siemens, D.R.1    Hu, N.2    Sheikhi, A.K.3
  • 73
    • 84255170452 scopus 로고    scopus 로고
    • Hypoxia induces escape from innate immunity in cancer cells via increased expression of ADAM10: Role of nitric oxide
    • 10.1158/0008-5472.CAN-11-2104 22006996 10.1158/0008-5472.CAN-11-2104 1:CAS:528:DC%2BC3MXhs1agtr3L
    • Barsoum IB, Hamilton TK, Li X, et al (2011) Hypoxia induces escape from innate immunity in cancer cells via increased expression of ADAM10: role of nitric oxide. Cancer Res 71:7433-7441. doi: 10.1158/0008-5472.CAN-11-2104
    • (2011) Cancer Res , vol.71 , pp. 7433-7441
    • Barsoum, I.B.1    Hamilton, T.K.2    Li, X.3
  • 74
    • 63649105591 scopus 로고    scopus 로고
    • The good, the bad and the ugly substrates for ADAM10 and ADAM17 in brain pathology, inflammation and cancer
    • 10.1016/j.semcdb.2008.09.005 18951988 10.1016/j.semcdb.2008.09.005 1:CAS:528:DC%2BD1MXksVajtrw%3D
    • Pruessmeyer J, Ludwig A (2009) The good, the bad and the ugly substrates for ADAM10 and ADAM17 in brain pathology, inflammation and cancer. Semin Cell Dev Biol 20:164-174. doi: 10.1016/j.semcdb.2008.09.005
    • (2009) Semin Cell Dev Biol , vol.20 , pp. 164-174
    • Pruessmeyer, J.1    Ludwig, A.2
  • 75
    • 69349104067 scopus 로고    scopus 로고
    • Differential clinical significance of individual NKG2D ligands in melanoma: Soluble ULBP2 as an indicator of poor prognosis superior to S100B
    • 10.1158/1078-0432.CCR-09-0886 19671853 10.1158/1078-0432.CCR-09-0886 1:CAS:528:DC%2BD1MXpvFeitrs%3D
    • Paschen A, Sucker A, Hill B, et al (2009) Differential clinical significance of individual NKG2D ligands in melanoma: soluble ULBP2 as an indicator of poor prognosis superior to S100B. Clin Cancer Res 15:5208-5215. doi: 10.1158/1078-0432.CCR-09-0886
    • (2009) Clin Cancer Res , vol.15 , pp. 5208-5215
    • Paschen, A.1    Sucker, A.2    Hill, B.3
  • 76
    • 79952768178 scopus 로고    scopus 로고
    • Expression, signaling proficiency, and stimulatory function of the NKG2D lymphocyte receptor in human cancer cells
    • 10.1073/pnas.1018603108 21321202 10.1073/pnas.1018603108 1:CAS:528:DC%2BC3MXjs1Wqtbw%3D
    • Benitez AC, Dai Z, Mann HH, et al (2011) Expression, signaling proficiency, and stimulatory function of the NKG2D lymphocyte receptor in human cancer cells. Proc Nat Acad Sci 108:4081-4086. doi: 10.1073/pnas.1018603108
    • (2011) Proc Nat Acad Sci , vol.108 , pp. 4081-4086
    • Benitez, A.C.1    Dai, Z.2    Mann, H.H.3
  • 77
    • 84879535955 scopus 로고    scopus 로고
    • Extracellular vesicles - Biomarkers and effectors of the cellular interactome in cancer
    • 10.3389/fphar.2013.00021 23508692 10.3389/fphar.2013.00021
    • Rak J (2013) Extracellular vesicles - biomarkers and effectors of the cellular interactome in cancer. Front Pharmacol 4:21. doi: 10.3389/fphar.2013. 00021
    • (2013) Front Pharmacol , vol.4 , pp. 21
    • Rak, J.1
  • 78
    • 0018792137 scopus 로고
    • Quantitation of peroxidase-antibody binding to membrane fragments using column chromatography
    • 396817 10.1016/0003-2697(79)90704-8 1:CAS:528:DyaE1MXmtVKis7o%3D
    • Taylor DD, Doellgast GJ (1979) Quantitation of peroxidase-antibody binding to membrane fragments using column chromatography. Anal Biochem 98:53-59
    • (1979) Anal Biochem , vol.98 , pp. 53-59
    • Taylor, D.D.1    Doellgast, G.J.2
  • 79
    • 85028098813 scopus 로고    scopus 로고
    • Exosomes/microvesicles: Mediators of cancer-associated immunosuppressive microenvironments
    • 10.1007/s00281-010-0234-8 21688197 10.1007/s00281-010-0234-8 1:CAS:528:DC%2BC3MXht1WktrrN
    • Taylor DD, Gercel-Taylor C (2011) Exosomes/microvesicles: mediators of cancer-associated immunosuppressive microenvironments. Semin Immunopathol 33:441-454. doi: 10.1007/s00281-010-0234-8
    • (2011) Semin Immunopathol , vol.33 , pp. 441-454
    • Taylor, D.D.1    Gercel-Taylor, C.2
  • 80
    • 84862117665 scopus 로고    scopus 로고
    • Recent advances on the role of tumor exosomes in immunosuppression and disease progression
    • 10.1016/j.semcancer.2012.02.005 10.1016/j.semcancer.2012.02.005 1:CAS:528:DC%2BC38XosVKjtbc%3D
    • Filipazzi P, Bürdek M, Villa A, et al (2012) Recent advances on the role of tumor exosomes in immunosuppression and disease progression. Sem Cancer Biol 22:342-349. doi: 10.1016/j.semcancer.2012.02.005
    • (2012) Sem Cancer Biol , vol.22 , pp. 342-349
    • Filipazzi, P.1    Bürdek, M.2    Villa, A.3
  • 81
    • 57249105222 scopus 로고    scopus 로고
    • More insights into the immunosuppressive potential of tumor exosomes
    • 10.1186/1479-5876-6-63 18973649 10.1186/1479-5876-6-63
    • Huber V, Filipazzi P, Iero M, et al (2008) More insights into the immunosuppressive potential of tumor exosomes. J Transl Med 6:63. doi: 10.1186/1479-5876-6-63
    • (2008) J Transl Med , vol.6 , pp. 63
    • Huber, V.1    Filipazzi, P.2    Iero, M.3
  • 82
    • 79956257434 scopus 로고    scopus 로고
    • Flow cytometric analysis of microparticles
    • 10.1007/978-1-61737-950-5-16 21116991 10.1007/978-1-61737-950-5-16
    • van der Heyde HC, Gramaglia I, Combes V, et al (2011) Flow cytometric analysis of microparticles. Methods Mol Biol 699:337-354. doi: 10.1007/978-1-61737-950-5-16
    • (2011) Methods Mol Biol , vol.699 , pp. 337-354
    • Van Der Heyde, H.C.1    Gramaglia, I.2    Combes, V.3
  • 83
    • 84873149964 scopus 로고    scopus 로고
    • Immune modulation of T-cell and NK (natural killer) cell activities by TEXs (tumour-derived exosomes)
    • 10.1042/BST20120265 23356291 10.1042/BST20120265 1:CAS:528: DC%2BC3sXhs1eiurg%3D
    • Whiteside TL (2013) Immune modulation of T-cell and NK (natural killer) cell activities by TEXs (tumour-derived exosomes). Biochem Soc Trans 41:245-251. doi: 10.1042/BST20120265
    • (2013) Biochem Soc Trans , vol.41 , pp. 245-251
    • Whiteside, T.L.1
  • 84
    • 64249115813 scopus 로고    scopus 로고
    • Induction of myeloid-derived suppressor cells by tumor exosomes
    • 10.1002/ijc.24249 19235923 10.1002/ijc.24249 1:CAS:528: DC%2BD1MXltlegu7s%3D
    • Xiang X, Poliakov A, Liu C, et al (2009) Induction of myeloid-derived suppressor cells by tumor exosomes. Int J Cancer 124:2621-2633. doi: 10.1002/ijc.24249
    • (2009) Int J Cancer , vol.124 , pp. 2621-2633
    • Xiang, X.1    Poliakov, A.2    Liu, C.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.