An asp49 phospholipase A2 from snake venom induces cyclooxygenase-2 expression and prostaglandin E2 production via activation of NF- κ B, p38MAPK, and PKC in macrophages

Mediators of Inflammation

Volumn 2014, Issue , 2014, Pages

  Moreira, Vanessa ^a   Lomonte, Bruno ^b   Vinolo, Marco Aurélio Ramirez ^c   Curi, Rui ^d   Gutiérrez, José María ^b   Teixeira, Catarina ^a  

^a INSTITUTO BUTANTAN   (Brazil)

^b UNIVERSIDAD DE COSTA RICA   (Costa Rica)

^c UNIVERSITY OF CAMPINAS   (Brazil)

^d UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

[No Author keywords available]

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; 4 (4 FLUOROPHENYL) 2 (4 HYDROXYPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; CYCLOOXYGENASE 2; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE P38; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHOLIPASE A2; PROSTAGLANDIN E2; PROTEIN KINASE C; SNAKE VENOM; 2-(4-MORPHOLINYL)-8-PHENYL-4H-1-BENZOPYRAN-4-ONE; 4-(4-FLUOROPHENYL)-2-(4-HYDROXYPHENYL)-5-(4-PYRIDYL)IMIDAZOLE; CHROMONE DERIVATIVE; IMIDAZOLE DERIVATIVE; MORPHOLINE DERIVATIVE; PYRIDINE DERIVATIVE;

ANIMAL CELL; ARTICLE; BIOSYNTHESIS; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; GEL MOBILITY SHIFT ASSAY; MALE; MOUSE; NONHUMAN; PERITONEUM MACROPHAGE; PROSTAGLANDIN RELEASE; PROTEIN EXPRESSION; STIMULATION; WESTERN BLOTTING; ANIMAL; ANTAGONISTS AND INHIBITORS; CELL CULTURE; DRUG EFFECTS; ENZYMOLOGY; GENETICS; MACROPHAGE; METABOLISM;

ANIMALS; CELLS, CULTURED; CHROMONES; CYCLOOXYGENASE 2; DINOPROSTONE; IMIDAZOLES; MACROPHAGES; MALE; MICE; MORPHOLINES; NF-KAPPA B; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHOLIPASES A2; PROTEIN KINASE C; PYRIDINES; SNAKE VENOMS;

EID: 84899949347     PISSN: 09629351     EISSN: 14661861     Source Type: Journal    
DOI: 10.1155/2014/105879     Document Type: Article

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