p38 MAPK activation and mitochondrial depolarization mediate the cytotoxicity of Taiwan cobra phospholipase A2 on human neuroblastoma SK-N-SH cells

Toxicology Letters

Volumn 180, Issue 1, 2008, Pages 53-58

  Chen, Ku Chung ^a   Kao, Pei Hsiu ^a   Lin, Shinne Ren ^b   Chang, Long Sen ^a  

^a NATIONAL SUN YAT SEN UNIVERSITY   (Taiwan)

^b KAOHSIUNG MEDICAL UNIVERSITY   (Taiwan)

Author keywords

Conformational distortion; Cytotoxicity; Mitochondrial depolarization; Modification of histidine; p38 MAPK activation; Phospholipase A2

Indexed keywords

4 (4 FLUOROPHENYL) 2 (4 HYDROXYPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; CYCLOSPORIN A; CYTOCHROME C; MITOGEN ACTIVATED PROTEIN KINASE P38; PHOSPHOLIPASE A2;

ARTICLE; CELL VIABILITY; CONTROLLED STUDY; CYTOTOXICITY; DEPOLARIZATION; ENZYME ACTIVATION; HUMAN; HUMAN CELL; MEMBRANE POTENTIAL; NEUROBLASTOMA; PRIORITY JOURNAL; SNAKE;

ANIMALS; CELL LINE, TUMOR; CELL SURVIVAL; COBRA; COBRA VENOMS; CYTOCHROMES C; ENZYME INHIBITORS; HUMANS; IMIDAZOLES; MEMBRANE POTENTIAL, MITOCHONDRIAL; NECROSIS; NEUROBLASTOMA; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHOLIPASES A2; PYRIDINES;

NAJA ATRA;

EID: 47049088244     PISSN: 03784274     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.toxlet.2008.05.014     Document Type: Article

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