A catalytically-inactive snake venom Lys49 phospholipase A2 homolog induces expression of cyclooxygenase-2 and production of prostaglandins through selected signaling pathways in macrophages

European Journal of Pharmacology

Volumn 708, Issue 1-3, 2013, Pages 68-79

  Moreira, Vanessa ^a   De Castro Souto, Pollyana Cristina Maggio ^a   Ramirez Vinolo, Marco Aurélio ^b   Lomonte, Bruno ^c   María Gutiérrez, José ^c   Curi, Rui ^b   Teixeira, Catarina ^a  

^a INSTITUTO BUTANTAN   (Brazil)

^b UNIVERSITY OF SÃO PAULO   (Brazil)

^c UNIVERSIDAD DE COSTA RICA   (Costa Rica)

Author keywords

Cyclooxygenase; Macrophage; NF B; Prostaglandin; Signaling pathway; Snake venom sPLA2 homolog

Indexed keywords

1 (5 ISOQUINOLINESULFONYL) 2 METHYLPIPERAZINE; 2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 2 MORPHOLINO 8 PHENYLCHROMONE; 4 (4 FLUOROPHENYL) 2 (4 HYDROXYPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; CALCIUM INDEPENDENT PHOSPHOLIPASE A2; CYCLOOXYGENASE 2; CYTOSOLIC PHOSPHOLIPASE A2; HERBIMYCIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; MITOGEN ACTIVATED PROTEIN KINASE P38 INHIBITOR; MYOTOXIN II; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHOLIPASE A2; PROSTAGLANDIN; PROSTAGLANDIN D2; PROSTAGLANDIN E SYNTHASE 1; PROSTAGLANDIN E2; PROTEIN KINASE C INHIBITOR; PROTEIN TYROSINE KINASE INHIBITOR; SNAKE VENOM; TOSYLPHENYLALANYL CHLOROMETHYL KETONE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL CULTURE; CELL LEVEL; CELL STIMULATION; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; EX VIVO STUDY; IN VIVO STUDY; INTRACELLULAR SIGNALING; MACROPHAGE; MALE; MOUSE; NONHUMAN; PERITONEUM CELL; PRIORITY JOURNAL; PROSTAGLANDIN RELEASE; PROSTAGLANDIN SYNTHESIS; PROTEIN EXPRESSION;

ANIMALS; CELLS, CULTURED; CROTALID VENOMS; CYCLOOXYGENASE 2; DINOPROSTONE; GROUP II PHOSPHOLIPASES A2; MACROPHAGES, PERITONEAL; MALE; MICE; NF-KAPPA B; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHATIDYLINOSITOL 3-KINASES; PHOSPHOLIPASES A2, CALCIUM-INDEPENDENT; PHOSPHOLIPASES A2, CYTOSOLIC; PROSTAGLANDIN D2; PROSTAGLANDINS; PROTEIN KINASE C; REPTILIAN PROTEINS; SIGNAL TRANSDUCTION;

EID: 84877819474     PISSN: 00142999     EISSN: 18790712     Source Type: Journal    
DOI: 10.1016/j.ejphar.2013.01.061     Document Type: Article

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