Secretory phospholipases A2 isolated from Bothrops asper and from Crotalus durissus terrificus snake venoms induce distinct mechanisms for biosynthesis of prostaglandins E2 and D2 and expression of cyclooxygenases

Toxicon

Volumn 52, Issue 3, 2008, Pages 428-439

  Moreira, Vanessa ^a   Gutiérrez, José Maria ^b   Soares, Andreimar Martins ^c   Zamunér, Stella Regina ^a   Purgatto, Eduardo ^d   Teixeira, Catarina de Fátima Pereira ^a  

^a INSTITUTO BUTANTAN   (Brazil)

^b UNIVERSIDAD DE COSTA RICA   (Costa Rica)

^c Faculdade de Ciências Farmacêuticas   (Brazil)

^d UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Arachidonic acid; cPLA2; Crotoxin B; Cyclooxygenases; iPLA2; Macrophages; Prostaglandins; Venom phospholipase A2

Indexed keywords

ARACHIDONIC ACID; ARACHIDONYL TRIFLUOROMETHYL KETONE; CROTOXIN; CROTOXIN B; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; ENZYME INHIBITOR; MYOTOXIN 3; PHOSPHOLIPASE A2; PROSTAGLANDIN D2; PROSTAGLANDIN E2; SNAKE VENOM; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BOTROPHS ASPER; CELL ISOLATION; CONTROLLED STUDY; CROTALUS DURISSUS TERRIFICUS; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME ISOLATION; ENZYME MECHANISM; ENZYME RELEASE; IN VITRO STUDY; INCUBATION TIME; INFLAMMATORY CELL; LEUKOCYTE; MACROPHAGE; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROSTAGLANDIN RELEASE; PROSTAGLANDIN SYNTHESIS; PROTEIN EXPRESSION; SNAKE;

ANIMALS; ARACHIDONIC ACID; BOTHROPS; CELLS, CULTURED; CROTALID VENOMS; CROTALUS; CROTOXIN; DINOPROSTONE; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GROUP II PHOSPHOLIPASES A2; MACROPHAGES, PERITONEAL; MALE; MICE; PERITONEAL CAVITY; PROSTAGLANDIN D2; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; REPTILIAN PROTEINS; UP-REGULATION;

BOTHROPS ASPER; CROTALUS DURISSUS TERRIFICUS; MUS;

EID: 50549090862     PISSN: 00410101     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.toxicon.2008.06.012     Document Type: Article

References (75)

1. Abushufa R., Reed P., and Weinkove C. Fatty acids in erythrocytes measured by isocratic HPLC. Clin. Chem. 40 (1994) 1707-1712
2. 2 by bromoenol lactone trifluoromethyl ketones. J. Biol. Chem. 270 (1995) 445-450
3. Anthonsen M.W., Solhaug A., and Johansen B. Functional coupling between secretory and cytosolic phospholipase A(2) modulates tumor necrosis factor-alpha-and interleukin-1 beta-induced NF-kappa B activation. J. Biol. Chem. 276 (2001) 30527-30536
4. 2. Proc. Natl. Acad. Sci. U.S.A. 95 (1998) 7951-7956
5. Barbour S.E., and Dennis E.A. Antisense inhibition of group II phospholipase A2 expression blocks the production of prostaglandin E2 by P388D1 cells. J. Biol. Chem. 268 (1993) 21875-21882
6. Barbour S.E., Al-Darmaki S., and Manguikian A.D. Phospholipase A2 and remodeling in inflammatory cells. In: Fonteh A.N., and Wykle R.L. (Eds). Arachidonate Remodeling and Inflammation (2004), Birkhäuser, Switzerland 13-36
7. Belich M.P., Salmeron A., Johnston L.H., and Ley S.C. TpL-2 kinase regulates the proteolysis of the NF-κB-inhibitory protein NF-κB1 p105. Nature 397 (1999) 363-368
8. Bidgood M.J., Jamal O.S., Cunningham A.M., Brooks P.M., and Scott K.F. Type IIA secretory phospholipase A2 up-regulates cyclooxygenase-2 and amplifies cytokine-mediated prostaglandin production in human rheumatoid synoviocytes. J. Immunol. 165 (2000) 2790-2797
9. Bon C., Bouchier C., Choumet V., Faure G., Jiang M.S., Lambezat M.P., Radvanyi F., and Saliou B. Crotoxin, half-century of investigations on a phospholipase A2 neurotoxin. Acta Physiol. Pharmacol. Latinoam. 39 (1989) 439-448
10. 2 Enzymes: Structure, Function and Mechanism (1997), Wiley, Chichester 269-285
11. Breyer M.D., Jacobson H.R., and Breyer R.M. Functional and molecular aspects of renal prostaglandin receptors. J. Am. Soc. Nephrol. 7 (1996) 8-17
12. 2 isolated from Bothrops asper (terciopelo) venom. Biochim. Biophys. Acta 1179 (1993) 253-259
13. 2 isolated from Crotalus durissus sp. in the rat dorsal skin: a role for mast cell and sensory C-fibers. Toxicon 41 (2003) 823-829
14. Chacur M., Longo I., Picolo G., Gutiérrez J.M., Lomonte B., Guerra J.L., Teixeira C.F., and Cury Y. Hyperalgesia induced by Asp49 and Lys49 phospholipases A2 from Bothrops asper snake venom: pharmacological mediation and molecular determinants. Toxicon 41 (2003) 667-678
15. 2 isoforms: a perspectiva. Cell Signal 15 (2003) 637-665
16. 2 isolated from the venom of snake Bothrops asper. Toxicon 36 (1998) 1861-1869
17. Chisari A., Spinedi E., Voirol M.J., Giovambattista A., and Gaillard R.C. A phospholipase A2-related snake venom (from Crotalus durissus terrificus) stimulates neuroendocrine and immune functions: determination of different sites of action. Endocrinology 139 (1998) 617-625
18. Falconi M., Desideri A., and Rufini S. Membrane-perturbing activity of Viperidae myotoxins: an electrostatic surface potential approach to a puzzling problem. J. Mol. Recognit. 13 (2000) 14-19
19. Fitzpatrick F.A. Cyclooxygenase enzymes: regulation and function. Curr. Pharm. Des. 10 (2004) 577-588
20. Fournier T., Fadok V., and Hendon P.M. Tumor necrosis factor-α inversely regulates prostaglandin D2 and prostaglandin E2 production in murine macrophages. J. Biol. Chem. 49 (1997) 31065-31072
21. Funk C.D., Funk L.B., Kennedy M.E., Pong A.S., and Fitzgerald G.A. Human platelet/erythroleukemia cell prostaglandin G/H synthase: cDNA cloning, expression, and gene chromosomal assignment. FASEB J. 5 (1991) 2304-2312
22. 2 myotoxins from Bothrops snake venoms. Toxicon 33 (1995) 1405-1424
23. 2: insights into the mechanisms of local and systemic myotoxicity. Toxicon 42 (2003) 915-931
24. Gutiérrez J.M., Ponce-Soto L.A., Maragoni S., and Lomonte B. Systemic and local myotoxicity induced by snake venom group II phospholipases A2: comparison between crotoxin, crotoxin B and a Lys49 PLA2 homologue. Toxicon 51 (2008) 80-92
25. Habermann E., and Breithaupt H. The crotoxin complex - an example of biochemical and pharmacological protein complementation. Toxicon 16 (1978) 19-30 (mini-review)
26. Hammad H., de Heer H.J., Soullie T., Hoogsteden H.C., Trottein F., and Lambrecht B.N. Prostaglandin D2 inhibits airway dendritic cell migration and function in steady state conditions by selective activation in the D prostanóide receptor 1. J. Immunol. 171 (2003) 3936-3940
27. Hara S., Kudo I., and Inoue K. Augmentation of prostaglandin E2 production by mammalian phospholipase A2 added exogenously. J. Biochem. 110 (1991) 163-165
28. 2 isoforms in rat kidney: their role in eicosanoid synthesis. Biochim. Biophys. Acta 1257 (1995) 11-17
29. Hata A.N., and Breyer R.M. Pharmacology and signaling of prostaglandin receptors: multiple roles in inflammation and immune modulation. Pharmacol. Ther. 103 (2004) 147-166
30. Hendon R.A., and Fraenkel-Conrat H. Biological roles of the two components of crotoxin. Proc. Natl. Acad. Sci. U.S.A 68 (1971) 1560-1563
31. Herlong J.L., and Scott T.R. Positioning prostanoids of the D and J series in the immunopathogenic scheme. Immunol. Lett. 102 (2006) 121-131
32. 2 elicits proinflammatory changes and upregulates the surface expression of fas ligand in monocytic cells: potential relevance for atherogenesis. Circ. Res. 90 (2002) 38-45
33. Hsieh H.L., Wang H.H., Wu C.Y., Jou M.J., Yen M.H., Parker P., and Yang C.M. BK-induced COX-2 expression via PKC-δ-dependent activation of p42/p44 MAPK and NF-κB in astrocytes. Cell Signal 19 (2007) 330-340
34. Kaiser I.I., Gutiérrez J.M., Plummer D., Aird S.D., and Odell G.D. The amino acid sequence of a myotoxic phospholipase from the venom of Bothrops asper. Arch. Biochem. Biophys. 278 (1990) 319-325
35. Kay A.B. Leucocytes in asthma. Immunol. Invest. 17 (1988) 679-705
36. Kini R.M. Venom Phospholipase A2 Enzymes: Structure, Function and Mechanisms (1997), Wiley, New York
37. Kouyoumdjian J.A., Harris J.B., and Johnson M.A. Muscle necrosis caused by the sub-units of crotoxin. Toxicon 24 (1986) 575-583
38. Kudo I., and Murakami M. Phospholipase A2 enzymes. Prostaglandins Other Lipid Mediat. 68-69 (2002) 3-58
39. Kuwata H., Nakatani Y., Murakami M., and Kudo I. Cytosolic phospholipase A2 is required for cytokine-induced expression of type IIA secretory phospholipase A2 that mediates optimal cyclooxygenase-2-dependent delayed prostaglandin E2 generation in rat 3Y1 fibroblasts. J. Biol. Chem. 273 (1998) 1733-1740
40. Kuwata H., Fujimoto C., Yoda E., Shimbara S., Nakatani N., Hara S., Murakami M., and Kudo I. A novel role of group VIB calcium-independent phospholipase A2 (iPLA2γ) in the inducible expression of group IIA secretory PLA2 in rat fibroblastic cells. J. Biol. Chem. 282 (2007) 20124-20132
41. Landucci E.C., Castro R.C., Pereira M.F., Cintra A.C., Giglio J.R., Marangoni S., Oliveira B., Cirino G., Antunes E., and De Nucci G. Mast cell degranulation induced by two phospholipase A2 homologues: dissociation between enzymatic and biological activities. Eur. J. Pharmacol. 343 (1998) 257-263
42. 2. Toxicon 38 (2000) 199-208
43. Lomonte B., and Gutiérrez J.M. A new muscle damaging toxin, myotoxin II, from the venom of the snake Bothrops asper (terciopelo). Toxicon 27 (1989) 725-733
44. Lomonte B., Tarkaweshi A., and Hanson L.A. Host response to Bothorps asper snake venom. Analysis of oedema formation, inflammatory cells and cytokine release in a mouse model. Inflammation 17 (1993) 93-105
45. 2 of Bothrops asper snake venom. Toxicon 32 (1994) 1359-1369
46. 2 on mouse endothelial (tEnd) and skeletal muscle (C2C12) cells in vitro. Toxicon 37 (1999) 145-158
47. 2formed by two isoforms of crotoxin B from Crotalus durissus terrificus venom. Proteins 72 (2008) 883-891
48. 2 does not alter leukotriene formation. J. Biol. Chem. 272 (1997) 759-765
49. Matsumoto H., Naraba H., Murakami M., Kudo I., Yamaki K., Ueno A., and Oh-ishi S. Concordant induction of prostaglandin E2 synthase with cyclooxygenase-2 leads to preferred production of prostaglandin E2 over thromboxane and prostaglandin D2 in lipopolysaccharide-stimulated rat peritoneal macrophages. Biochem. Biophys. Res. Commun. 230 (1997) 110-114
50. Matsuoka T., Hirata M., Tanaka H., Takashi Y., Murata T., kabashima K., Sugimoto Y., Kobayashi T., Ushikubi F., Aze Y., Eguchi N., Urade Y., Yoshida N., Kimura K., Mizoguchi A., Honda Y., Nagai H., and Narumiya S. Prostaglandin D2 as a mediator of allergic asthma. Science 287 (2000) 2013-2017
51. Mead J.F. The non-eicosanoid functions of the essential fatty acids. J. Lipid. Res. 25 (1984) 1517-1521
52. Merlie J.P., Fagan D., Mudd J., and Needleman P. Isolation and characterization of the complementary DNA for sheep seminal vesicle prostaglandin endoperoxide synthase (cyclooxygenase). J. Biol. Chem. 263 (1988) 3550-3553
53. 2. FEBS Lett. 294 (1991) 247-251
54. 2. J. Biol. Chem. 272 (1997) 19891-19897
55. 2s. Biochim. Biophys. Acta 1488 (2000) 159-166
56. Murakami M., Das S., Young-Jun K., Cho W., and Kudo I. Perinuclear localization of cytosolic phospholipase A(2)alpha is important but not obligatory for coupling with cyclooxygenases. FEBS Lett. 546 (2003) 251-256
57. 2s. Toxicon 42 (2003) 903-913
58. Nataraj C., Thomas D.W., Tilley S.L., Nguyen M.T., Mannon R., Koller B.H., and Coffman T.M. Receptors for prostaglandin E2 that regulate cellular immune responses in the mouse. J. Clin. Invest. 108 (2001) 1229-1235
59. O'Neill G.P., and Ford-Hutchinson A.W. Expression of mRNA for cyclooxygenase-1 and cyclooxygenase-2 in human tissues. FEBS Lett. 330 (1993) 156-160
60. 2 from snake venom. Toxicon 42 (2003) 841-854
61. 2 by rat mesanglial cells: its contribution to arachidonic acid release and prostaglandin synthesis by cultured rat glomerular cells. J. Clin. Invest. 92 (1993) 2516-2523
62. Pradelles P., Grassi J., and Mac Louf J. Enzyme immunoassays of eicosanoids using acetylcholine esterase as label: an alternative to radioimmunoassay. Anal. Chem. 57 (1985) 1170-1173
63. Rangel-Santos A., Lima C., Lopes-Ferreira M., and Cardoso D.F. Immunosuppresive role of principal toxin (crotoxin) of Crotalus durissus terrificus venom. Toxicon 44 (2004) 609-616
64. 2 in activated mast cells. J. Biol. Chem. 272 (1997) 3231-3237
65. Roshak A.K., Capper E.A., Stevenson C., Eichman C., and Marshall L.A. Human calcium-independent phospholipase A2 mediates lymphocyte proliferation. J. Biol. Chem. 275 (2000) 35692-35698
66. Sampaio S.C., Rangel-Santos A.C., Peres C.M., Curi R., and Cury Y. Inhibitory effect of phospholipase A(2) isolated from Crotalus durissus terrificus venom on macrophage function. Toxicon 45 (2005) 671-676
67. Sampaio S.C., Alba-Loureiro T.C., Brigatte P., Landgraf R.G., dos Santos E.C., Curi R., and Cury Y. Lipoxygenase-derived eicosanoids are involved in the inhibitory effect of Crotalus durissus terrificus venom or crotoxin on rat macrophage pahgocytosis. Toxicon 47 (2006) 313-321
68. Soares A.M., Rodrigues V.M., Homsi-Brandeburgo M.I., Toyama M.H., Lombardi F.R., Arni R.K., and Giglio J.R. A rapid procedure for the isolation of the Lys-49 myotoxin II from Bothrops moojeni (caissaca) venom: biochemical characterization, crystallization, myotoxic and edematogênica activities. Toxicon 36 (1998) 503-514
69. Soares A.M., Mancin A.C., Cecchini A.L., Arantes E.C., França S.C., Gutiérrez J.M., and Giglio J.R. Effects of chemical modifications of crotoxin B, the phospholipase A(2) subunit of crotoxin from Crotalus durissus terrificus snake venom, on its enzymatic and pharmacological activities. Int. J. Biochem. Cell Biol. 33 (2001) 877-888
70. Stock J.L., Shinjo K., Burkhardt J., Roach M., Taniguchi K., Ishikawa T., Kim H.S., Flannery P.J., Coffman T.M., McNeish J.D., and Audoly L.P. The prostaglandin E2 EP1 receptor mediates pain perception and regulates blood pressure. J. Clin. Invest. 107 (2001) 325-331
71. 2 in nerve growth factor-stimulated rat serosal mast cells is facilitated by independent of their enzymatic functions. J. Immunol. 161 (1998) 5008-5015
72. Takayama K., Garcia-Cardena G., Sudova G.K., Comander J., Gimbrone Jr. M.A., and Libby P. Prostaglandin E2 suppresses chemokine production in human macrophages through the EP4 receptor. J. Biol. Chem. 277 (2002) 44147-44154
73. Ueno N., Murakami M., Tanioka T., Fujimori K., Tanabe T., Urade Y., and Kudo I. Coupling between cyclooxygenase, terminal prostanoid synthase, and phospholipase A2. J. Biol. Chem. 276 (2001) 34918-34927
74. 2 isolated from Bothrops asper snake venom: role of catalytic activity. Toxicon 45 (2005) 335-346
75. 2. Toxicon 46 (2005) 523-532