Thrombin induces cyclooxygenase-2 expression and prostaglandin E 2 release via PAR1 activation and ERK1/2- and p38 MAPK-dependent pathway in murine macrophages

Journal of Cellular Biochemistry

Volumn 108, Issue 5, 2009, Pages 1143-1152

  Lo, Huey Ming ^a,b   Chen, Chih Li ^a   Tsai, Yih Jeng ^b   Wu, Pi Hui ^a   Wu, Wen Bin ^a  

^a FU JEN CATHOLIC UNIVERSITY   (Taiwan)

^b SHIN KONG WU HO SU MEMORIAL HOSPITAL   (Taiwan)

Author keywords

Cyclooxygenase; Macrophage; MAPK; PAR; PGE; Prostaglandin; Thrombin

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 4 (4 FLUOROPHENYL) 2 (4 HYDROXYPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; CYCLOOXYGENASE 2; LIPOPOLYSACCHARIDE; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; POLYMYXIN B; PROSTACYCLIN; PROSTAGLANDIN E2; PROTEINASE ACTIVATED RECEPTOR 1; THROMBIN; THROMBOXANE A2; TRYPSIN;

ANIMAL CELL; ARTICLE; CELL VIABILITY; CONTROLLED STUDY; ENZYME ACTIVITY; HUMAN; HUMAN CELL; NONHUMAN; NUCLEOTIDE SEQUENCE; PERITONEUM MACROPHAGE; PRIORITY JOURNAL; PROSTAGLANDIN RELEASE; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION;

ANIMALS; CELL LINE; CYCLOOXYGENASE 2; DINOPROSTONE; ENZYME INDUCTION; ENZYME INHIBITORS; EPOPROSTENOL; FLAVONOIDS; IMIDAZOLES; MACROPHAGES, PERITONEAL; MICE; MITOGEN-ACTIVATED PROTEIN KINASE 3; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PYRIDINES; PYRROLES; QUINAZOLINES; RECEPTOR, PAR-1; SIGNAL TRANSDUCTION; THROMBIN; THROMBOXANE A2;

MURINAE;

EID: 72449173512     PISSN: 07302312     EISSN: 10974644     Source Type: Journal    
DOI: 10.1002/jcb.22341     Document Type: Article

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